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41. 发明授权

EP2972333B1 A BIOSENSOR DEVICE TO TARGET ANALYTES IN SITU, IN VIVO, AND/OR IN REAL TIME, AND METHODS OF MAKING AND USING THE SAME 有权
公开(公告)号：EP2972333B1
公开(公告)日：2018-09-19
申请号：EP14779197.4
申请日：2014-03-11
申请人： The University of Toledo
发明人： AGARWAL, Anand, K. , GOEL, Vijay, K. , KIM, Dong-Shik , YOON, Do-Young , LIN, Boren , FEYZIZARNAGH, Hamid
IPC分类号： G01N33/50
CPC分类号： A61B5/14735 , A61B5/14546 , A61B5/4547 , A61B2503/40 , A61B2562/125 , G01N27/3272 , G01N27/3276 , G01N33/5438 , G01N33/56911 , G01N33/56938 , Y02A50/52 , Y02A50/57
摘要： A biosensor device for the real-time detection of a target analyte includes a receptor component operatively connected to a transducer component which is adapted to interpret and transmit a detectable signal. The receptor component includes a sensing element capable of detecting and binding to at least one target analyte, and a self-assembled monolayer (SAM) layer. The SAM layer is positioned between and in contact with the sensing element and an electrode such that the sensing element, in the presence of the target analyte, causes a detectable signal capable of being transmitted to the electrode. The transducer component includes the electrode and microprocessor configured to screen noise and to pick up impedance change at a very low frequency range.

42. 发明授权

EP2499296B1 LIQUID RECOVERY AND PURIFICATION IN BIOMASS PRETREATMENT PROCESS 有权
标题翻译：生物质预处理过程中的液体回收和净化
公开(公告)号：EP2499296B1
公开(公告)日：2017-07-05
申请号：EP10829304.4
申请日：2010-11-09
申请人： The University of Toledo
发明人： LIPSCOMB, Glenn , VARANASI, Sasidhar
IPC分类号： D21C11/00
CPC分类号： D21C11/00

43. 发明公开

EP3160548A2 APPARATUS AND METHOD FOR INJECTING BONE GRAFT SUBSTITUTE AND OTHER MATERIALS 审中-公开
标题翻译：装置和方法注入骨移植替代品及其他材料
公开(公告)号：EP3160548A2
公开(公告)日：2017-05-03
申请号：EP15811190.6
申请日：2015-06-24
申请人： The University of Toledo
发明人： AGARWAL, Anand K. , GOEL, Vijay K. , GERBER, Joel M. , AGARWAL, Aakash
IPC分类号： A61M5/20
CPC分类号： A61F2/4601 , A61B17/8822 , A61B17/8825 , A61B17/8827 , A61M5/14526 , A61M5/172 , A61M5/20 , A61M5/2053 , A61M5/486 , A61M2005/14513
摘要： A metering delivery apparatus for injecting bone graft cement includes a body portion, a material containment vessel, an actuator, and a control unit. The body portion includes a drive housing that supports an actuator drivetrain and receiver end that supports the material containment vessel. The actuator has a first end connected to the actuator drivetrain and a second end that supports a moveable portion of the vessel to dispense material in the vessel and a retracting movement that relieves pressure applied to the material. The control unit receives actuator parameter inputs and includes a sensor to detect a signal of at least one of a pressure level and a time period. The sensor provides the detected signal to the control unit such that the control unit operates the actuator between the dispensing and retracting movements based on the detected signal and the actuator parameter inputs.
摘要翻译：用于注射骨水泥接枝的计量传送装置包括主体部，在致动器的材料容器，和一个控制单元。所述主体部分包括一个驱动器壳体支撑在致动器的传动系和接收机端做确实支持材料储存容器。致动器具有一个第一端连接到所述致动器的传动系和第二端部做支撑所述容器的可移动部分在所述容器分配材料和缩回运动并释放压力施加到材料。控制单元接收致动器的参数的输入和包括传感器以检测压力水平的至少一个和一个时间段的信号。该传感器提供所检测到的信号到控制单元检查所做的控制单元操作的分配和基于检测到的信号伸缩运动与致动器参数输入之间的致动器。

44. 发明公开

EP3071140A2 MACROPOROUS GRANULES OF ALKALINE EARTH PHOSPHATES USING CEMENT TECHNOLOGY AND GAS EVOLVING POROGEN 失效
标题翻译： MACRO多孔粒状USING水泥工艺碱土金属磷酸盐和天然气生产的成孔剂的
公开(公告)号：EP3071140A2
公开(公告)日：2016-09-28
申请号：EP14863173.2
申请日：2014-11-21
申请人： The University of Toledo
发明人： BHADURI, Sarit, B. , ZHOU, Huan , AGARWAL, Anand, K. , GOEL, Vijay, K. , SALEH, Sameh
IPC分类号： A61C5/04
CPC分类号： A61L24/0036 , A61K6/0631 , A61K6/0643 , A61L24/0015 , A61L24/02 , A61L24/08 , A61L27/047 , A61L27/12 , A61L27/20 , A61L27/54 , A61L27/56 , A61L2430/02 , C04B28/34 , C04B38/02 , C04B2111/00836 , C04B12/04 , C04B22/04 , C04B22/066 , C04B40/0014 , C04B2103/0012
摘要： Macroporous cement compositions, methods of making the same, and methods of using the same, are described.
摘要翻译：大孔水泥组合物，制备它们的方法，并使用相同的方法，进行说明。

45. 发明公开

EP2988685A1 STABILIZED SPINAL FIXATION DEVICE 审中-公开
标题翻译：固定装置稳定化的脊柱
公开(公告)号：EP2988685A1
公开(公告)日：2016-03-02
申请号：EP14788930.7
申请日：2014-04-25
申请人： The University of Toledo
发明人： AGARWAL, Anand, K. , GOEL, Vijay, K. , D'ONOFRIO, John, R. , DUBOIS, Nathaniel, E. , PACK, Jared, R. , TAYLOR, David, J.
IPC分类号： A61B17/56 , A61B17/70 , A61B17/84
CPC分类号： A61B17/7049 , A61B17/7032 , A61B17/7035 , A61B17/7056 , A61B2017/00867
摘要： A spinal fixation device includes a device body configured for implantation in a human body and a clamp that is formed from shape memory material and attached to the device body.

46. 发明公开

EP2758008A2 EXPANDABLE INTER-VERTEBRAL CAGE AND METHOD OF INSTALLING SAME 有权
标题翻译：可膨胀椎间融合器和安装方法
公开(公告)号：EP2758008A2
公开(公告)日：2014-07-30
申请号：EP12834152.6
申请日：2012-09-20
申请人： The University of Toledo
发明人： ELAHINIA, Mohammad , AGARWAL, Anand , GOEL, Vijay , ANDERSON, Walter , CHAPMAN, Cory
IPC分类号： A61F2/44
CPC分类号： A61F2/4465 , A61B1/018 , A61F2/447 , A61F2/4611 , A61F2002/2835 , A61F2002/30047 , A61F2002/30092 , A61F2002/30464 , A61F2002/30471 , A61F2002/30472 , A61F2002/30542 , A61F2002/30545 , A61F2002/30556 , A61F2002/30604 , A61F2002/30607 , A61F2002/30609 , A61F2002/30611 , A61F2002/30612 , A61F2002/30616 , A61F2002/30637 , A61F2002/30878 , A61F2002/4415 , A61F2002/4475 , A61F2310/00017 , A61F2310/00023 , A61F2310/00976
摘要： An inter-vertebral cage for use in repairing a damaged inter-vertebral disc includes a plurality of cage sections and a hinge element that connects adjacent ones of the cage sections together for relative movement. The hinge elements automatically urge the cage sections to move from an extended orientation to an installed orientation.

47. 发明授权

EP1934377B1 METHODS FOR IDENTIFYING BIOMARKERS USEFUL IN DIAGNOSIS OF BIOLOGICAL STATES 失效
标题翻译：一种用于识别的生物标志物健身诊断性生物态的
公开(公告)号：EP1934377B1
公开(公告)日：2012-03-07
申请号：EP06814191.0
申请日：2006-09-05
申请人： The University of Toledo
发明人： WILLEY, James, C. , CRAWFORD, Erin, L. , MULLINS, D'Anna, N.
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/16 , G01N33/6842 , Y02A90/26
摘要： The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological state. The biomarkers and polymorphisms identified find use in diagnostic and treatment approaches, e.g., some embodiments the invention provide methods and kits for detecting bronchogenic carcinoma and risks thereof.

48. 发明公开

EP2408382A1 MINIMALLY INVASIVE COLLAPSIBLE CAGE 审中-公开
标题翻译： MINIMAL INVASIVER KOLLABIERBARERKÄFIG
公开(公告)号：EP2408382A1
公开(公告)日：2012-01-25
申请号：EP10751488.7
申请日：2010-03-12
申请人： The University of Toledo
发明人： GOEL, Vijay, K. , MATYAS, Aaron
IPC分类号： A61B17/56
CPC分类号： A61F2/4455 , A61F2/4425 , A61F2/447 , A61F2002/30125 , A61F2002/30154 , A61F2002/30507 , A61F2002/30523 , A61F2002/30579 , A61F2002/30624 , A61F2002/3093 , A61F2002/4475 , A61F2220/0025
摘要： An articulating fusible support cage comprises a first support member having a first and second end and a second support member having a first and second end. A first end cap is pivotally connected to the first and second support members at the first ends. The first end cap supports a jackscrew for rotation. A second end cap is pivotally connected to the first and second support members at the second ends opposite the first ends. The second end cap has a threaded sleeve configured to engage a portion of the jackscrew. Rotation of the jackscrew into the threaded sleeve causes the first and second support members to extend outwardly from a collapsed condition to a deployed condition.
摘要翻译：铰接式可熔支撑架包括具有第一端和第二端的第一支撑构件和具有第一端和第二端的第二支撑构件。第一端盖在第一端处枢转地连接到第一和第二支撑构件。第一个端盖支撑旋转螺丝。第二端盖在与第一端相对的第二端枢转地连接到第一和第二支撑构件。第二端盖具有构造成接合一部分顶起螺丝的螺纹套筒。将起重螺丝旋转到螺纹套筒中使得第一和第二支撑构件从折叠状态向外延伸到展开状态。

49. 发明公开

EP2361097A2 NA/K-ATPASE-DERIVED PEPTIDE SRC INHIBITORS AND OUABAIN ANTAGONISTS AND USES THEREOF 审中-公开
标题翻译：的Na / K-ATP酶的SCR-缝边MIT衍生肽与哇巴因拮抗剂及其用途
公开(公告)号：EP2361097A2
公开(公告)日：2011-08-31
申请号：EP09833816.3
申请日：2009-12-14
申请人： The University of Toledo
发明人： XIE, Zi-Jian , LI, Zhichuan , SHAPIRO, Joseph, I.
IPC分类号： A61K39/395
CPC分类号： A61K38/46 , A61K38/00 , C07K14/4703 , C12N9/14 , Y02A50/473
摘要： A novel Src inhibitor that targets the Na/K-ATPase/Src receptor complex and antagonizes ouabain-induced protein kinase cascades and uses thereof are disclosed.

50. 发明公开

EP1912711A2 TRUNK ROTATION 审中-公开
标题翻译： RUMPFDREHUNG
公开(公告)号：EP1912711A2
公开(公告)日：2008-04-23
申请号：EP06789026.9
申请日：2006-08-01
申请人： The University of Toledo , THE TURNING POINT, LLC.
发明人： GOEL, Vijay, K. , PINCIVERO, Danny, M. , DICK, David , JAEGLY, John , SCHULTHEIS, F., Alan , HERNDON, Kathleen
IPC分类号： A63B71/00
CPC分类号： A63B23/0233 , A63B15/00 , A63B21/0051 , A63B21/015 , A63B23/0211 , A63B69/0026 , A63B69/0057 , A63B69/36 , A63B69/38 , A63B2023/003 , A63B2023/006 , A63B2069/0008 , A63B2209/08 , A63B2220/16 , A63B2220/54
摘要： This trunk rotation device uses dynamic movement of one's body such as, shoulder, hip, knee, back, thigh, and abdominal musculature. The device provides a method for exercising the spinal column and the muscles of the torso, including those in the abdominal lumbar and thoracic regions involving rotational torque. In a preferred embodiment, the device is a golf exercise and flexibility apparatus. The golf exercise apparatus provides resistance to a golfer during a golf swing to strengthen and condition the muscles of the axial skeleton of the golfer in a functional posture.

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