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41. 发明授权

EP1981914B1 CONSTRUCTION OF NEW VARIANTS OF DEXTRANSUCRASE DSR-S BY GENETIC ENGINEERING 有权
标题翻译：基因工程技术构建DEXTRANSUCRASE DSR-S新变异体
公开(公告)号：EP1981914B1
公开(公告)日：2016-05-11
申请号：EP07734270.7
申请日：2007-02-08
申请人： Centre National de la Recherche Scientifique , Institut National de Recherche Agronomique , Institut National des Sciences Appliquées de Toulouse
发明人： MONSAN, Pierre , REMAUD-SIMEON, Magali , POTOCKI-VERONESE, Gabrielle , MOULIS, Claire
IPC分类号： C07K19/00 , C12N15/54 , C12N9/10 , C12P19/04 , C12P19/18
CPC分类号： C12N9/1051 , C07H3/06 , C07K2319/35 , C08B37/0021 , C12P19/04 , C12P19/08 , C12P19/12 , C12P19/18 , C12Y204/01005 , Y02P20/52
摘要： The present invention relates to a recombinant process for the production of truncated and/or mutated dextransucrases while conserving their enzymatic activity and/or their specificity in the synthesis of the ±-1,6 bonds. More precisely, the present invention relates to nucleic acid sequences of truncated and/or mutated dextransucrases, vectors containing said nucleic acid sequences and host cells transformed by sequences encoding truncated and/or mutated dextransucrases. In a further aspect, the invention concerns a method for producing, in a recombinant manner, truncated and/or mutated dextransucrases which conserve their enzymatic activity and/or which conserve their specificity in the synthsis of ±-1,6 bonds and however can produce, from saccharose, dextrans with high molar mass and with modified rheological properties, compared with the properties of dextran obtained with the native enzyme in the same conditions and isomalto-oligosaccharides with a controlled molar mass and dextrans. The dextrans and IMO of the invention can be used namely as texturing agents or as prebiotics.

42. 发明授权

EP1863468B1 A TOPICAL ANAESTHETIC COMPOSITION 有权
标题翻译：局部麻醉剂成分
公开(公告)号：EP1863468B1
公开(公告)日：2016-05-11
申请号：EP06705008.8
申请日：2006-03-15
申请人： Animal Ethics Pty Ltd
发明人： SHEIL, Meredith , GIFFARD, Allan , OLSSON, Charles, Robert
IPC分类号： A61K31/167 , A61K31/53 , A61K9/00 , A61K9/06 , A61P17/02 , A61K31/137 , A61K47/38
CPC分类号： A61L26/0066 , A61K9/0014 , A61K9/0017 , A61K9/06 , A61K31/137 , A61K31/14 , A61K31/167 , A61K31/245 , A61K31/445 , A61K33/04 , A61K47/26 , A61K47/38 , A61L26/0076 , A61L26/008 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/418 , A61L2300/442 , A61L2300/45

43. 发明授权

EP1737963B1 UTILISATION DU GENE CODANT LA CHAINE BETA DE LA PROTEINE C4BP DANS LA PRODUCTION DE PROTEINES DIMERIQUES RECOMBINANTES 失效
标题翻译： C4bp结构蛋白β链编码基因生产重组蛋白二聚体USE
公开(公告)号：EP1737963B1
公开(公告)日：2016-05-11
申请号：EP05762398.5
申请日：2005-04-22
申请人： Université De Reims Champagne-Ardenne
发明人： COHEN, Jacques, Henri, Max , OUDIN, Stéphane , DERVILLEZ, Xavier , GIMENEZ, Annelise , DONVITO, Béatrice , TONYE-LIBYH, Marcelle
IPC分类号： C12N15/79 , C12N15/866 , C07K19/00 , C07K16/00
CPC分类号： C07K16/2896 , C07K2317/622 , C07K2319/00

44. 发明授权

EP2677037B1 Simultaneous measurement of thrombin generation and clot strength in plasma and whole blood 有权
标题翻译：在血浆和全血中凝血酶生成和凝块强度的同时测量
公开(公告)号：EP2677037B1
公开(公告)日：2016-04-13
申请号：EP12173053.5
申请日：2012-06-21
申请人： Synapse B.V.
发明人： De Laat, H. Bas , Hemker, Hendrik Coenraad , Pelkmans, Leonie , Kelchtermans, Hilde
IPC分类号： C12Q1/56 , G01N33/86 , G01N11/14 , G01N33/49
CPC分类号： C12Q1/56 , G01N11/14 , G01N33/4905 , G01N33/582 , G01N33/86 , G01N2333/974

45. 发明公开

EP2999461A1 TARGETED DELIVERY OF DRUGS TO THE MYOMETRIUM 有权转让
标题翻译： GEZIELTE VERABREICHUNG VON ARZNEIMITTELN在DAS MYOMETRIUM
公开(公告)号：EP2999461A1
公开(公告)日：2016-03-30
申请号：EP14800670.3
申请日：2014-05-23
申请人： Newcastle Innovation Limited
发明人： HUA, Susan , PAUL, Jonathan , SMITH, Roger
IPC分类号： A61K9/00 , A61K9/127 , A61P15/14
摘要： Provided herein are methods and compositions for the targeted delivery to myometrial tissue of one or more agents capable of regulating contractility of myometrial tissue, wherein the one or more agents are contained or encapsulated within a polymeric delivery vehicle conjugated with one or more molecules that recognizes and/or is capable of binding, directly or indirectly, to the oxytocin receptor.
摘要翻译：本文提供了用于靶向递送到子宫肌层组织中的一种或多种能够调节子宫肌层组织收缩力的试剂的方法和组合物，其中所述一种或多种药剂包含或包封在与一种或多种分子共轭的聚合物递送载体中， /或能够直接或间接地结合催产素受体。

46. 发明公开

EP2756833A3 Table d'opération destinée à équiper un bloc opératoire 有权转让
标题翻译：用于装备手术室手术台
公开(公告)号：EP2756833A3
公开(公告)日：2015-12-23
申请号：EP14151764.9
申请日：2014-01-20
申请人： Steris
发明人： L'Hegarat, Jean-Marie , Choisnet, Guillaume , Deguyenne, Alex
IPC分类号： A61G13/02 , A61G13/08 , A61G13/04
CPC分类号： A61G13/02 , A61G13/04 , A61G13/08 , A61G2203/12 , A61G2203/20
摘要： L'invention concerne une table d'opération (1) comportant un plateau mobile (3) par rapport à une embase (2), le plateau (3) pouvant être déplacé par translation dans le plan horizontal (x, y), caractérisée en ce qu'elle comporte des moyens d'affichage de la position du plateau (3) dans le plan horizontal (x, y).

47. 发明公开

EP2949745A1 METHOD FOR PRODUCING AMINO ACID-RICH YEAST 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VONAMINOSÄUREREICHERHEFE
公开(公告)号：EP2949745A1
公开(公告)日：2015-12-02
申请号：EP15175951.1
申请日：2009-11-17
申请人： Asahi Group Holdings, Ltd.
发明人： SHIBUYA, Ichiro , ODANI, Tetsuji
IPC分类号： C12N1/16 , A23L1/221 , A23L1/28 , A23L1/39 , C12N1/18 , C12P13/04 , A23L1/30 , A23L1/305
CPC分类号： C12P13/04 , A23L33/145 , A23L33/175 , C12N1/16 , C12N1/18
摘要： An object of the present invention is to provide a method for producing an amino acid-rich yeast which contains free amino acid in a high concentration. The present invention provides a method for producing an amino acid-rich yeast, which includes liquid-culturing a yeast in a stationary phase of proliferation under the condition that the pH of a liquid medium is equal to or higher than 7.5 and lower than 11; a method for producing an amino acid-rich yeast, which includes adjusting the pH of a liquid medium of the yeast in a stationary phase of proliferation to equal to or higher than 7.5 and lower than 11, and further culturing the yeast in the above pH range; a method for producing an amino acid-rich yeast, wherein the yeast is Saccharomyces cerevisiae or Candida utilis; an amino acid-rich yeast obtained by any one of the above methods for producing an amino acid-rich yeast; the amino acid-rich yeast extract wherein the amount of a free amino acid is from 7.5 to 18.0% by weight per dry yeast cell; and an amino acid-rich yeast extract extracted from the above amino acid-rich yeast.
摘要翻译：本发明的目的是提供一种含有高浓度游离氨基酸的富含氨基酸的酵母的方法。本发明提供一种富含氨基酸的酵母的制造方法，其特征在于，在液体介质的pH等于或高于7.5且低于11的条件下，在增殖的固定相中液体培养酵母; 一种富含氨基酸的酵母的制造方法，其特征在于，将所述酵母的液体培养基的pH值调节至7.5以上且低于11倍，进一步培养上述pH值的酵母范围; 一种生产富含氨基酸的酵母的方法，其中酵母是酿酒酵母或产朊假丝酵母; 通过上述任一种制备富含氨基酸的酵母的方法获得的富含氨基酸的酵母; 富含氨基酸的酵母提取物，其中游离氨基酸的量为每干酵母细胞7.5至18.0重量％; 和从上述富含氨基酸的酵母提取的富含氨基酸的酵母提取物。

48. 发明授权

EP2324383B1 SLIDE ACTUATED FIELD INSTALLABLE FIBER OPTIC CONNECTOR 有权
标题翻译：滑动机构来操作AT操作安装光纤连接器的底座
公开(公告)号：EP2324383B1
公开(公告)日：2015-05-27
申请号：EP09807791.0
申请日：2009-08-19
申请人： Belden CDT Canada Inc.
发明人： MILETTE, Luc , LEVY, Moise , DEMERS, Yannick
IPC分类号： G02B6/24 , G02B6/38
CPC分类号： G02B6/36 , G02B6/3656 , G02B6/366 , G02B6/3821 , G02B6/3838 , G02B6/3846 , G02B6/3858

49. 发明公开

EP2873728A1 A subunit vaccine platform based on multimeric ribonucleoproteins comprising nucleoproteins of a non-segmented negative-strand RNA virus as carriers of heterologous polypeptides 审中-公开
标题翻译：亚单位疫苗平台基于与非节段负链RNA病毒核蛋白的多聚核糖异源多肽的载体
公开(公告)号：EP2873728A1
公开(公告)日：2015-05-20
申请号：EP13306577.1
申请日：2013-11-18
申请人： INSTITUT PASTEUR , Centre National de la Recherche Scientifique
发明人： Sala, Monica , Jacob, Daria , Tangy, Frédéric
IPC分类号： C12N7/00 , C12N15/81
CPC分类号： A61K39/165 , A61K39/015 , A61K39/125 , A61K2039/521 , A61K2039/523 , A61K2039/542 , A61K2039/545 , A61K2039/57 , A61K2039/575 , A61K2039/6031 , A61K2039/6075 , A61K2039/70 , C07K14/005 , C07K14/445 , C07K2319/85 , C12N7/00 , C12N15/815 , C12N2760/18422 , C12N2760/18434 , C12N2760/18451 , C12N2760/18471 , C12N2770/32322 , C12N2770/32334 , C12N2770/32351 , Y02A50/412
摘要： The present invention relates to a subunit vaccine platform based on multimeric ribonucleoproteins (RNPs) comprising nucleoproteins of a non-segmented negative-strand ribonucleic acid (RNA) virus as carriers of heterologous polypeptides. The present invention also relates to multimeric RNPs resulting from the assembly of at least 200 fusion proteins with a cellular RNA, or to recombinant yeasts or yeast lysates expressing these multimeric RNPs. It also concerns a process for the preparation of these multimeric RNPs or recombinant yeasts or yeast lysates. In particular, the present invention relates to their use as active ingredient for the in vitro production of an immunogenic composition or in eliciting a protective prophylactic or a therapeutic immune response against said heterologous polypeptide in a host in need thereof. Recombinant yeasts or yeast lysates of the invention can also be used as expression and vector systems for delivery to a host.
摘要翻译：本发明涉及一种亚单位疫苗平台基于多聚核糖核蛋白（RNP），其包含非节段负海滩核糖核酸（RNA）病毒作为异源多肽的载体的核蛋白。因此，本发明涉及一种多聚体RNP从至少200融合蛋白与细胞RNA的组装得到的，或与表达论文多聚RNP重组酵母或酵母裂解物。因此，它涉及一种用于合成多聚体RNP或重组酵母或酵母裂解物的制备方法。特别地，本发明涉及它们作为用于免疫原性组合物的体外生产或在引发保护性预防或抵抗在需要其的宿主所述异源多肽的治疗性免疫应答的活性成分使用。重组酵母或本发明的酵母溶胞产物可以因此被用作表达和载体系统用于输送到主机。

50. 发明授权

EP2268816B1 POLYNUCLÉOTIDES ET POLYPEPTIDES CHIMÉRIQUES PERMETTANT LA SÉCRÉTION D'UN POLYPEPTIDE D'INTÉRÊT EN ASSOCIATION AVEC DES EXOSOMES ET LEUR UTILISATION POUR LA PRODUCTION DE COMPOSITIONS IMMUNOGÈNES 有权转让
标题翻译：多核苷酸和POLYPEPTIDCHIMÄRENFOR RELEASE感兴趣结合多肽与其用于免疫原性组合物的制备外来体
公开(公告)号：EP2268816B1
公开(公告)日：2015-05-06
申请号：EP09721663.4
申请日：2009-03-18
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS- , UNIVERSITE MONTPELLIER II SCIENCES ET TECHNIQUES DU LANGUEDOC
发明人： MAMOUN, Robert, Zaine El Abiddine , TRENTIN, Bernadette, Nadine , VIDAL, Michel
IPC分类号： C12N15/62
CPC分类号： C12N15/625 , C07K2319/01 , C12N5/0634

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