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31. 发明公开

EP3460036A1 STERILE PROBE SAMPLING FOR A SINGLE-USE VESSEL 有权
公开(公告)号：EP3460036A1
公开(公告)日：2019-03-27
申请号：EP17290122.5
申请日：2017-09-22
申请人： Sartorius Stedim Biotech GmbH
发明人： Reinert, Inga , Gay, Isabelle , Meadows, Charles , Zumbrum, Michael
IPC分类号： C12M1/00 , C12M1/26 , B01L3/00
CPC分类号： C12M23/28 , B01L3/50 , B01L3/563 , B01L2200/026 , B01L2200/141 , C12M23/40 , C12M33/00
摘要： A system and method for transferring chemical, pharmaceutical, and/or biological material into or out of a container are provided. Further, a use of a transfer interface for accessing the interior of a disposable container is provided. The system comprises a disposable container having at least one port for accessing the interior of the container. The system further comprises a transfer interface connectable to the at least one port. The transfer interface comprises a plurality of extendable transfer elements for collecting samples from the disposable container in a sterile manner. The transfer elements may also be referred to as sampling elements, extractors, or probes. Each of the transfer elements has a corresponding biasing element for retracting the transfer element. The biasing element may be implemented as a spring or as another device capable of applying a biasing force.

32. 发明公开

EP3305885A1 CULTURING DEVICE 有权
标题翻译：培养设备
公开(公告)号：EP3305885A1
公开(公告)日：2018-04-11
申请号：EP16800017.2
申请日：2016-05-24
申请人： Nipro Corporation
发明人： TAKEUCHI, Masakatsu , TAGUCHI, Atsushi
IPC分类号： C12M3/00 , C12M1/10
CPC分类号： C12M3/043 , B01L3/50 , B01L3/563 , B01L2200/025 , B01L2200/026 , B01L2300/046 , C12M1/007 , C12M1/065 , C12M1/10 , C12M1/38 , C12M3/02 , C12M23/14 , C12M23/34 , C12M23/42 , C12M23/44 , C12M23/50 , C12M29/00 , C12M41/48
摘要： [Object] To provide a compact culture device 10 capable of performing large-scale culture in an aseptic state.
[Solution] The culture device 10 has a culture bag 70 which has ports 73 and 74 through which a liquid flows and enables cell culture, a bag holding portion 31 having holding plates 42 and 43 holding the culture bag 70 and rotating shafts 48 and 49, a rotation mechanism 34 supporting and rotating the rotating shaft 48, a liquid supply/discharge mechanism 37 supplying and discharging a liquid to/from the culture bag 70, and a rotation control portion 20 controlling the rotation of the rotation mechanism 34. The rotation control portion 20 brings the bag holding portion 31 into a first position in parallel with the approximately horizontal direction according to a first information, brings the bag holding portion 31 into a second position when a culture medium in the culture bag 70 is caused to flow out of the port 74 according to a second information, and brings the bag holding portion 31 into a third position in parallel with the approximately vertical direction at least when a cell suspension in the culture bag 70 is caused to flow out of the port 74 according to a third information.
摘要翻译：本发明的目的是提供一种能够在无菌状态下进行大规模培养的小型培养装置10。培养装置10具有培养袋70，该培养袋70具有供液体流动并能够进行细胞培养的端口73,74;袋保持部31，其具有保持培养袋70的保持板42,43;以及旋转轴48,49 ，支承旋转轴48并使其旋转的旋转机构34，向培养袋70供给液体并从培养袋70排出液体的液体供给排出机构37，以及控制旋转机构34的旋转的旋转控制部20。控制部20根据第一信息使袋保持部31进入与大致水平方向平行的第一位置，当使培养袋70中的培养基流出时使袋保持部31进入第二位置根据第二信息，将袋保持部31置于与大致垂直方向平行的第三位置，至少在单元su 根据第三信息使培养袋70中的张力从端口74流出。

33. 发明公开

EP3143120A4 MANUFACTURING ARTICLE 无效
公开(公告)号：EP3143120A4
公开(公告)日：2018-02-28
申请号：EP15792577
申请日：2015-05-15
申请人： SAINT-GOBAIN PERFORMANCE PLASTICS CORP
发明人： SNYDER MITCHELL L , ZOELLNER CLEMENS E , NIXON THOMAS R
IPC分类号： C12M3/02 , B01J19/00 , B01L3/00 , B01L3/02 , B01L9/00 , B01L9/06 , C12M1/00 , C12M1/12 , C12M3/00
CPC分类号： C12M23/04 , B01L3/0289 , B01L3/527 , B01L3/563 , B01L9/00 , B01L9/06 , C12M23/40 , C12M23/54 , C12M29/00
摘要： A manufacturing article adapted for use in the production of pharmaceuticals comprising a tray comprising a base having a top surface; and a manifold extending from the top surface of the base, the manifold comprising a sidewall and an upper surface, the upper surface further comprising a channel, wherein, when viewed from the top surface, the base has an area, AB, the upper surface of the manifold has an area AM, and AB>AM, and wherein the base is adapted to support a plurality of vessels each adapted to contain a fluid.

34. 发明公开

EP3157678A1 SEQUENCING DEVICE 有权
标题翻译：测序装置
公开(公告)号：EP3157678A1
公开(公告)日：2017-04-26
申请号：EP15733595.1
申请日：2015-06-17
申请人： Life Technologies Corporation
发明人： SCHULTZ, Jonathan , ROSWECH, Todd , HOSHIZAKI, Jon , CARRILLO, Albert , BALL, James
IPC分类号： B01L3/00 , G01N35/10
CPC分类号： C12Q1/6869 , B01F1/0027 , B01F5/0683 , B01F11/0048 , B01F11/0071 , B01L3/502 , B01L3/505 , B01L3/527 , B01L3/563 , B01L2200/04 , B01L2200/16 , B01L2300/022 , B01L2300/0681 , B01L2300/0861 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0683 , C12Q1/6806 , G01N27/4145 , G01N35/1002 , G01N35/1095 , Y10T436/11 , Y10T436/143333
摘要： A method of preparing reagents includes inserting a cartridge into an instrument. The cartridge includes a plurality of reagent enclosures disposed in a cavity of the cartridge and exposing a port to an exterior of the cartridge. Each reagent enclosure includes a reagent container including a reagent and an internal cavity defining a compressible volume, an opening defined through the reagent container to the internal cavity. The method further includes connecting a plurality of fluid ports to the openings of the plurality of reagent enclosures; applying a solution through the fluid ports to at least partially fill the plurality of reagent enclosures; and cycling a pressure of the cavity, whereby for each of the reagent enclosures, during increasing pressure, the solution enters the internal cavity of the reagent container, combines with the reagent, and compresses the compressible volume, and during decreasing pressure, the compressible volume decreases and the reagent is ejected through the opening.
摘要翻译：制备试剂的方法包括将药筒插入器械中。盒包括多个试剂外壳，所述试剂外壳设置在盒的空腔中并且将端口暴露于盒的外部。每个试剂外壳包括试剂容器，该试剂容器包括试剂和限定可压缩容积的内腔，开口通过试剂容器限定到内腔。该方法还包括将多个流体端口连接到多个试剂外壳的开口; 通过所述流体端口施加溶液以至少部分地填充所述多个试剂外壳; 并且循环腔的压力，由此对于每个试剂腔，在增加压力期间，溶液进入试剂容器的内腔，与试剂结合并压缩可压缩容积，并且在减压过程中，可压缩容积减少并且试剂通过开口喷射。

35. 发明公开

EP2971031A4 METHOD AND APPARATUS FOR RAPIDLY AND CYCLICALLY HEATING AND COOLING A FLUID SAMPLE DURING PCR TESTING 有权
标题翻译：方法和设备快速循环加热和液体样本中冷却过程中的PCR试验
公开(公告)号：EP2971031A4
公开(公告)日：2016-10-26
申请号：EP14764417
申请日：2014-03-15
申请人： DRUMMOND SCIENT CO
发明人： DRUMMOND DAVID , STROHSAHL CHRISTOPHER
IPC分类号： C12P19/34
CPC分类号： C12Q1/686 , B01L3/563 , B01L7/525 , B01L2200/026 , B01L2200/0673 , B01L2200/143 , B01L2300/0838 , B01L2400/0487
摘要： Methods and apparatuses rapidly and cyclically heating and cooling a fluid sample during PCT testing to reduce the duration for full amplification of target DNA using most PCR procedures. Instead of heating and cooling static target solution in a reaction tube, the target solution reciprocates (alternately flows) back and forth within an elongate, thick-walled, small-bore tube. Sections of the tube are maintained at different temperatures so that an ascending/descending temperature gradient is maintained along the length of the tube. As the target solution flows within and along the tube from section to section, it rapidly achieves thermal equilibrium with the tube at each section, thereby rapidly thermally cycling the target solution.
摘要翻译：方法和装置快速且循环地加热和PCT测试期间冷却流体样品，以减少用于使用PCR程序大多数靶DNA的完全放大的持续时间。代替加热和冷却静态目标溶液中的反应管的，目标溶液往复运动（可替换地流）来回内伸长，厚壁，小口径管。管的部分被维持在不同温度以升序所以没有/下降温度梯度沿管的长度保持不变。作为目标溶液内并沿着从部分到部分的管流动时，它很快就达到热平衡与所述管在每个部分中，从而快速热循环的目标的解决方案。

36. 发明授权

EP1691924B1 A MODULAR BIOCHIP ASSEMBLY 有权
标题翻译： MODULARE BIOCHIP ANORDNUNG
公开(公告)号：EP1691924B1
公开(公告)日：2016-09-14
申请号：EP03768079.0
申请日：2003-12-10
申请人： The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin
发明人： VIVIENNE, Williams , IGOR, Schvets , DMITRI, Kashanin , DERMOT, Kelleher , SIOBHAN, Mitchell
IPC分类号： B01L3/00 , F16L39/00 , F15C5/00
CPC分类号： B01L3/502715 , B01J2219/0081 , B01L3/563 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2300/0887 , B01L2400/0478 , B01L2400/0487 , G01N35/1065 , G01N2035/00326 , G01N2035/1034

37. 发明公开

EP2708886A3 Fluidic interface valve assembly with elastomeric ferrule device 有权
标题翻译：具有弹性套筒装置液体界面阀组件
公开(公告)号：EP2708886A3
公开(公告)日：2016-06-22
申请号：EP13184349.2
申请日：2013-09-13
申请人： Idex Health&Science LLC
发明人： Servin, Carl
IPC分类号： G01N30/20 , B01L3/00
CPC分类号： F16L47/00 , B01L3/563 , B01L2200/0689 , F16K3/085 , F16K5/0278 , F16K99/0013 , F16K2099/0084 , F16K2099/0086 , G01N30/20 , G01N2030/202 , Y10T137/9247
摘要： A tubing interface (20) having an elongated tube (21), an elastomeric ferrule (24) and a support ring device (30) disposed around the ferrule (24). The ferrule (24) includes a bore (28) which is sized for receipt of the tube (21). The tubing interface (20) further includes a cap member (31) having an exterior surface (32), an opposed interior surface (33), and a tube receiving passage (35) extending therethrough. The receiving passage (35) is formed and dimensioned for axial sliding receipt of the tube member therethrough. The cap member (31) further includes a cup-shaped receiving recess (36) extending proximally from the interior surface (33), and is formed and dimensioned for axial receipt of the proximal end of the ferrule body member (25) and the support ring (30). When the cap member (31) is mounted to a valve apparatus (29), the support ring (30) and the elastomeric ferrule device (24) compressively cooperate with the cup-shaped recess (36) to form a fluid-tight seal between the tube port (22) and a communication port (45) of the valve apparatus (29).

38. 发明公开

EP2892496A4 SYSTEMS, DEVICES, AND METHODS FOR BODILY FLUID SAMPLE COLLECTION 有权转让
标题翻译：用于去除身体流体样本的系统，装置和方法
公开(公告)号：EP2892496A4
公开(公告)日：2016-04-13
申请号：EP13834412
申请日：2013-09-06
申请人： THERANOS INC
发明人： HOLMES ELIZABETH , CHEN MICHAEL , KO PEY-JIUN , BURD TAMMY , LATH ADRIT , MCHALE PATRICIA
IPC分类号： A61J1/05 , A61B5/15 , A61B5/151 , A61B5/154 , A61B10/00 , B01L3/00
CPC分类号： A61B5/150251 , A61B5/150022 , A61B5/15016 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/150572 , A61B5/150732 , A61B5/150755 , A61B5/150793 , A61B5/150824 , A61B5/150954 , A61B5/15109 , A61B5/15111 , A61B5/15113 , A61B5/15117 , A61B5/15142 , A61B5/154 , A61B5/157 , A61B10/0045 , A61B2010/008 , B01L3/502 , B01L3/563 , B01L2300/0672 , B01L2400/0406 , B01L2400/049
摘要： Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.

39. 发明公开

EP2971031A1 METHOD AND APPARATUS FOR RAPIDLY AND CYCLICALLY HEATING AND COOLING A FLUID SAMPLE DURING PCR TESTING 有权
标题翻译：方法和设备快速循环加热和液体样本中冷却过程中的PCR试验
公开(公告)号：EP2971031A1
公开(公告)日：2016-01-20
申请号：EP14764417.3
申请日：2014-03-15
申请人： Drummond Scientific Company
发明人： DRUMMOND, David , STROHSAHL, Christopher
IPC分类号： C12P19/34
CPC分类号： C12Q1/686 , B01L3/563 , B01L7/525 , B01L2200/026 , B01L2200/0673 , B01L2200/143 , B01L2300/0838 , B01L2400/0487
摘要： Methods and apparatuses rapidly and cyclically heating and cooling a fluid sample during PCT testing to reduce the duration for full amplification of target DNA using most PCR procedures. Instead of heating and cooling static target solution in a reaction tube, the target solution reciprocates (alternately flows) back and forth within an elongate, thick-walled, small-bore tube. Sections of the tube are maintained at different temperatures so that an ascending/descending temperature gradient is maintained along the length of the tube. As the target solution flows within and along the tube from section to section, it rapidly achieves thermal equilibrium with the tube at each section, thereby rapidly thermally cycling the target solution.

40. 发明公开

EP2892496A1 SYSTEMS, DEVICES, AND METHODS FOR BODILY FLUID SAMPLE COLLECTION 有权转让
标题翻译： VORRICHTUNGEN ZUR ENTNAHME VONKÖRPERFLÜSSIGKEITSPROBEN
公开(公告)号：EP2892496A1
公开(公告)日：2015-07-15
申请号：EP13834412.2
申请日：2013-09-06
申请人： Theranos, Inc.
发明人： HOLMES, Elizabeth , CHEN, Michael , KO, Pey-Jiun , BURD, Tammy , LATH, Adrit , MCHALE, Patricia
IPC分类号： A61J1/05
CPC分类号： A61B5/150251 , A61B5/150022 , A61B5/15016 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/150572 , A61B5/150732 , A61B5/150755 , A61B5/150793 , A61B5/150824 , A61B5/150954 , A61B5/15109 , A61B5/15111 , A61B5/15113 , A61B5/15117 , A61B5/15142 , A61B5/154 , A61B5/157 , A61B10/0045 , A61B2010/008 , B01L3/502 , B01L3/563 , B01L2300/0672 , B01L2400/0406 , B01L2400/049
摘要： Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.
摘要翻译：提供了体液样品收集系统，装置和方法。该装置可以包括第一部分，该第一部分至少包括样品收集通道，其被配置成经由第一类型的动力将流体样品吸入样品收集通道。样品收集装置可以包括第二部分，其包括用于接收收集在样品收集通道中的体液样品的样品容器，所述样品容器可操作地可接合地与收集通道流体连通，于是当建立流体连通时，容器提供不同于第一动力的第二动力，以将大部分体液样品从通道移动到容器中。

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