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31. 发明公开

EP2851083A1 RADIATION-STERILIZATION-RESISTANT PROTEIN COMPOSITION 有权转让
标题翻译：辐照灭菌耐药蛋白组成
公开(公告)号：EP2851083A1
公开(公告)日：2015-03-25
申请号：EP13790434.8
申请日：2013-05-13
申请人： Teijin Limited , Teijin Pharma Limited , The Chemo-Sero-Therapeutic Research Institute
发明人： KAGEYAMA, Yukako , FUJINAGA, Kentaro , YAMAGUCHI, Ayuko , AKIYAMA, Yusuke , KATOU, Souichirou , KIMURA, Yukiko , HONDA, Susumu , SATAKE, Makoto , KANEKO, Hiroaki , ISHIWARI, Ayumi , HIRASHIMA, Masaki
IPC分类号： A61K38/00 , A61K9/70 , A61K38/48 , A61K47/38 , A61L15/44 , A61P7/04
CPC分类号： A61K47/38 , A61K9/7007 , A61K38/1709 , A61K38/465 , A61K38/47 , A61K38/4833 , A61L15/225 , A61L17/10 , A61L27/26 , A61L27/505 , A61L28/0026 , A61L29/049 , A61L31/041 , A61L31/143 , C12Y302/01021 , C08L1/00 , C08L89/00
摘要： A protein composition which comprises a mixture of glycine, phenylalanine and histidine and/or a cellulose ether derivative as an additive and has resistance to radiation sterilization.

32. 发明授权

EP2277560B1 Ultra high molecular weight polyethylene articles and methods od forming ultra high molecular weight polyethylene articles 无效
标题翻译：超高分子量聚乙烯的产品和工艺，用于生产超高分子量聚乙烯的产品
公开(公告)号：EP2277560B1
公开(公告)日：2013-10-09
申请号：EP10012579.8
申请日：2005-08-18
申请人： Zimmer GmbH
发明人： Abt, Niels A. , Schneider-Storrer, Werner
IPC分类号： A61L27/16 , C08L23/06 , A61K31/355
CPC分类号： C08J3/28 , A61K31/355 , A61L27/16 , A61L27/44 , A61L27/505 , C08J3/24 , C08J7/123 , C08J2323/06 , C08K5/005 , C08K5/1545 , C08L23/04 , C08L23/06 , C08L2205/02 , C08L2207/068 , C08L2312/06 , C08L2314/02 , Y10T428/269
摘要： The present invention generally provides implantable articles and methods of forming implantable articles from a crosslinked ultrahigh molecular weight polyethylene ("UHMWPE") blend stabilized with Vitamin E. The crosslinked UHMWPE blend may be prepared by combining the UHMWPB material and vitamin E prior to irradiating the UHMWPE blend with electron beam radiation at a sufficient radiation dose rate to induce crosslinking. The crosslinked UHMWPE blend may be incorporated into a variety of implants, and in particular, into endoprosthetic joint replacements

33. 发明公开

EP2582411A2 METHODS FOR STABILIZING A BIOPROSTHETIC TISSUE BY CHEMICAL MODIFICATION OF ANTIGENIC CARBOHYDRATES 有权
标题翻译：方法用于稳定BIOPROTHESENGEWEBES通过改性碳水化合物抗原
公开(公告)号：EP2582411A2
公开(公告)日：2013-04-24
申请号：EP11796556.6
申请日：2011-06-17
申请人： Edwards Lifesciences Corporation
发明人： DOVE, Jeffrey, S. , TOD, Tara
IPC分类号： A61L27/50 , A61L27/54 , A61L2/16 , A61F2/02
CPC分类号： A61L27/505 , A61L27/3625 , A61L27/3687 , A61L2300/40 , A61L2400/02 , A61L2430/20
摘要： Methods are provided herein for modifying antigenic carbohydrate epitopes within a xenographic bioprosthetic tissue by oxidation of vicinal diols to form aldehydes or acids and subsequence reductive animation of aldehydes to form stable secondary amines, or amidation or esterification of acids to form stable amides or esters. Advantageously, methods provided herein mitigate the antigenicity of the bioprosthetic tissue while leaving the overall tissue structure substantially undisturbed, and thereby enhance the durability, safety and performance of the bioprosthetic implant.

34. 发明公开

EP2427225A2 SYNERGISTIC EFFECTS OF BLENDING MULTIPLE ADDITIVES IN UHMWPE 有权
标题翻译：混合多种添加剂在UHMWPE中的协同效应
公开(公告)号：EP2427225A2
公开(公告)日：2012-03-14
申请号：EP10772673.9
申请日：2010-05-04
申请人： Smith&Nephew, Inc.
发明人： MORRISON, Mark, L. , PAWAR, Vivek, D. , BRUNNER, Lorenz , JANI, Shilesh, C.
IPC分类号： A61L27/14 , C08F10/02 , A61F2/30 , A61F2/32 , A61F2/38
CPC分类号： G03G9/097 , A61F2/30767 , A61F2/38 , A61L27/16 , A61L27/18 , A61L27/505 , C08F8/00 , C08J3/24 , C08J3/28 , C08J2323/06 , C08K5/005 , C08K5/053 , C08K5/06 , C08K5/132 , C08K5/1545 , C08F110/02 , C08L23/06
摘要： Oxidation resistant crosslinked ultrahigh molecular weight polyethylene (UHMWPE) is described, wherein at least two different additives in the manufacture synergistically increase the oxidation resistance of crosslinked UHMWPE. This allows the manufacture of oxidation resistant crosslinked UHMWPE using lower levels of additives and/or lower levels of crosslinking irradiation or chemicals. The lower levels of additives and/or crosslinking produce crosslinked UHMWPE having desired physical properties not possible without the synergistic interaction of the additives. This crosslinked UHMWPE may be used in medical prostheses such as in bearing components having desired physical properties such as wear resistance and oxidation resistance not possible without the synergistic interaction of the additives.
摘要翻译：描述了抗氧化交联的超高分子量聚乙烯（UHMWPE），其中制造中的至少两种不同添加剂协同增加交联UHMWPE的抗氧化性。这允许使用较低水平的添加剂和/或较低水平的交联照射或化学品来制造抗氧化交联的UHMWPE。如果没有添加剂的协同相互作用，较低水平的添加剂和/或交联产生具有所需物理性质的交联UHMWPE是不可能的。这种交联的UHMWPE可以用于医学假体中，例如具有期望的物理性质如耐磨性和抗氧化性的轴承部件中，而没有添加剂的协同相互作用是不可能的。

35. 发明公开

EP2008673A3 Method of irradiation using process of adding vitamin c 审中-公开
标题翻译：使用添加维生素C的方法，辐射方法
公开(公告)号：EP2008673A3
公开(公告)日：2009-03-25
申请号：EP07017062.6
申请日：2007-09-18
申请人： Korea Atomic Energy Research Institute
发明人： Byun, Myung-Woo , Lee, Ju-Woon , Choi, Jong-II , Kim, Jae-Hun , Song, Beom-Seok
IPC分类号： A61L27/36 , A61L27/50 , A61L2/08
CPC分类号： A61L27/3608 , A61L2/0035 , A61L2/0041 , A61L2/007 , A61L27/3683 , A61L27/505 , A61L2430/02
摘要： Disclosed is an irradiation method which includes addition of vitamin C during sterilization of bone restorative demineralized bone matrix (DBM) with irradiation, so as to inhibit reduction of physical properties of a carrier containing DBM caused by irradiation and protect DBM formable bone morphogenetic protein (BMP) from irradiation. The method according to the present invention can provide bone restorative materials with more excellent stability and effectively controlled modification of physical properties by employing a sterilization process accompanied with addition of vitamin C during irradiation.

36. 发明公开

EP2035054A1 BIOMATERIAL CONTAINING DEGRADATION STABILIZED POLYMER 审中-公开
标题翻译：同时除去稳定的聚合物生物材料
公开(公告)号：EP2035054A1
公开(公告)日：2009-03-18
申请号：EP07764929.1
申请日：2007-06-28
申请人： Scil Technology GmbH
发明人： FRIESS, Wolfgang , HELLERBRAND, Klaus , HERBERG, Samuel , POMPE, Cornelius , SCHUETZ, Andreas , SIEDLER, Michael
IPC分类号： A61L27/58 , A61L27/50
CPC分类号： C08L67/04 , A61L27/505 , A61L27/58
摘要： The present invention relates to a polymer based material comprising a water binding agent, whereas the water binding agent is present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. It also relates to a polymer based material which comprises a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. Furthermore it relates to a method for manufacturing the polymer comprising material and use of the material for the preparation of a pharmaceutical composition to be used for treatment of bone, cartilage and/or periodontal defects. The invention also encompasses a kit using the polymeric material. Further, the present invention encompasses the use of a water binding agent for inhibiting water induced degradation of a polymer comprising material, for inducing blood clot stabilization in a polymer comprising material and for increasing storage stability in a polymer comprising material, wherein the water binding agent is not removed prior to application of the material.

37. 发明公开

EP1872807A1 Biomaterial containing degradation stabilized polymer 审中-公开
标题翻译： Durch Polymere gegen Abbau stableisiertes Biomaterial
公开(公告)号：EP1872807A1
公开(公告)日：2008-01-02
申请号：EP06013646.2
申请日：2006-06-30
申请人： Scil Technology GmbH
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61L27/58 , A61L27/50
CPC分类号： C08L67/04 , A61L27/505 , A61L27/58
摘要： The present invention relates to a polymer based material comprising a water binding agent, whereas the water binding agent is present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. It also relates to a polymer based material which comprises a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. Furthermore it relates to a method for manufacturing the polymer comprising material and use of the material for the preparation of a pharmaceutical composition to be used for treatment of bone, cartilage and/or periodontal defects. The invention also encompasses a kit using the polymeric material. Further, the present invention encompasses the use of a water binding agent for inhibiting water induced degradation of a polymer comprising material, for inducing blood clot stabilisation in a polymer comprising material and for increasing storage stability in a polymer comprising material, wherein the water binding agent is not removed prior to application of the material.
摘要翻译：本发明涉及包含水结合剂的聚合物基材料，而水结合剂以足以化学和/或物理吸收和/或吸附水的量存在以防止聚合物降解。它还涉及包含增塑剂或有机溶剂的聚合物基材料以及包含包含第二聚合物和/或活性剂的材料的多组分材料或复合材料。此外，本发明涉及制备包含材料的聚合物的方法和用于制备用于治疗骨，软骨和/或牙周缺陷的药物组合物的材料的用途。本发明还包括使用聚合物材料的试剂盒。此外，本发明包括水粘合剂用于抑制水分诱导的包含材料的聚合物的降解的用途，用于在包含聚合物的材料中引起血块稳定并增加包含材料的聚合物的储存稳定性，其中水结合剂在施加材料之前不被去除。

38. 发明公开

EP1531878A1 ENHANCED PHOSPHOLIPID REDUCTION AND CALCIFICATION MITIGATION OF BIOLOGICAL MATERIALS 审中-公开
标题翻译：改进的磷脂还原和生物材料钙化的减少
公开(公告)号：EP1531878A1
公开(公告)日：2005-05-25
申请号：EP03764694.0
申请日：2003-07-16
申请人： Edwards Lifesciences Corporation
发明人： CUNANAN, Crystal , DINH, Than, T. , RUBALCABA, Sophia
IPC分类号： A61L31/14 , A61L31/00 , A61L27/50 , A61L27/36
CPC分类号： A61L27/3687 , A61L27/18 , A61L27/505 , A61L31/005 , A61L31/143 , A61L2400/02
摘要： There is a need in the tissue treatment arts of methods for effectively mitigating calcification, reducing calcification and reducing phospholipid content of implanted bioprosthetic tissues. The invention provides an effective protocol for preparing biological tissue for incorporation as a bioprosthetic device. Disclosed herein is the discovery that calcification of biological tissue is mitigated and phospholipid content is reduced by including a step in the pre-implantation protocol whereby the biological tissue is treated with a surfactant and cross linking agent in the absence of a denaturant. Furthermore, the biological tissues prepared under this protocol are well suited for use in bioprosthetic devices.

39. 发明公开

EP0523555A1 Pharmaceutical composition useful in inhibiting biological degradation of polymeric implantation material 失效
标题翻译：用于聚合物植入材料和含抑制剂的聚合物植入材料的生物降解的抑制的药物组合物。
公开(公告)号：EP0523555A1
公开(公告)日：1993-01-20
申请号：EP92111737.0
申请日：1992-07-10
申请人： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA
发明人： Matsumoto, Hiroshi , Kondo, Kensuke , Inoue, Kazuhiko , Tani, Nobutaka
IPC分类号： A61L27/00 , A61L29/00 , A61L33/00 , A61K31/505
CPC分类号： A61L27/505 , A61K31/505 , A61L17/005 , A61L29/143 , A61L33/0041 , A61L2300/204 , A61L2300/42 , Y10S623/92
摘要： The invention relates to the preparation of a pharmaceutical composition useful in inhibiting decomposition and/or degradation of a polymeric implantation material in the living body, which comprises dipyridamole and/or a salt or a derivative thereof as an active component and a polymeric implantation material which contains dipyridamole and/or a salt or a derivative thereof as an active component.
摘要翻译：本发明涉及的药物组合物的制备可用于抑制在活体的聚合物植入材料，其中其包含双嘧达莫和/或盐或衍生物作为活性组分和聚合物植入材料的分解和/或降解哪包含双嘧达莫和/或其盐或它们的衍生物作为活性组分。

40. 发明授权

EP1434608B1 IMPROVED BONE GRAFT 有权转让
公开(公告)号：EP1434608B1
公开(公告)日：2018-08-22
申请号：EP02773762.6
申请日：2002-10-15
申请人： Warsaw Orthopedic, Inc.
发明人： KNAACK, David , TRAIANEDES, Kathy , DIEGMAN, Michele , FORSYTH, Nanette , WINTERBOTTOM, John
IPC分类号： A61L27/44 , A61L27/50 , A61L27/54 , A61L27/58
CPC分类号： A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61L27/227 , A61L27/3608 , A61L27/3633 , A61L27/365 , A61L27/505 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/434 , A61L2300/602 , A61L2300/802 , A61L2430/02 , B33Y80/00
摘要： The invention provides an osteoinductive composition for implantation at a bone defect site which comprises osteoinductive demineralized bone matrix in a carrier of hydrated polysaccharide, the type and quantity of polysaccharide present in the carrier being sufficient, upon hydration, of importing flowability to the composition and providing an osteoinductive activity of at least 1 as measured by the athymic rat model assay. The polysaccharide may be selected from the group consisting of starch and cellulose.

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