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31. 发明授权

EP2464722B1 MICROBIAL PRODUCTION OF FATTY ALCOHOLS 有权
标题翻译：微生物生产脂肪醇
公开(公告)号：EP2464722B1
公开(公告)日：2017-10-04
申请号：EP10808723.0
申请日：2010-08-11
申请人： Synthetic Genomics, Inc.
发明人： ROESSLER, Paul, G. , WATTS, Kevin , LIU, Bo
IPC分类号： C12N1/13 , C12N1/21 , C12P7/64
CPC分类号： C12P7/04 , C12N9/0008 , C12N9/001

32. 发明公开

EP3138088A1 TAMPER-RESISTANT ASSEMBLY FOR SECURING VALUABLE MATERIAL 审中-公开
标题翻译：操作简单的三角形ZUM SICHERN VON WERTSTOFFEN
公开(公告)号：EP3138088A1
公开(公告)日：2017-03-08
申请号：EP15786364.8
申请日：2015-05-01
申请人： Synthetic Genomics, Inc.
发明人： WARDEN, Laurence , NEWMAN-LEHMAN, Tei , GIBSON, Daniel
IPC分类号： G08B13/00 , G08B13/02 , G08B13/14
CPC分类号： B65D61/00 , B01L3/50851 , B01L9/523 , B01L2200/026 , B01L2200/028 , B01L2200/0689 , B01L2200/141 , B01L2300/0829 , B01L2300/0887 , B65B5/04 , B65B7/28 , B65C1/04 , B65D25/108 , B65D25/205 , B65D43/0235 , B65D2101/0007 , B65D2101/0092 , G01N21/6428 , G01N21/6486 , G01N21/77 , G01N2021/6439
摘要： The invention provides a tamper resistant assembly that that securely contains a valuable material. The assembly has a container for holding the valuable material, an optional carrier that contains the container, one or more cover components that enclose the valuable material in the container, and one or more labels having a plurality of devices that reveal tampering by distortion of at least one of the plurality of devices. The label(s) are positioned so that dislodging a cover component causes a detectable distortion in at least one of the plurality of devices, thereby revealing tampering with the assembly. In one embodiment the label can be affixed partially to a surface of a cover component and partially to a surface of the container or the optional carrier. Also disclosed are methods of detecting tampering and method of manufacturing a temper-resistant assembly. Because the assembly allows a remote validator to validate the assembly prior to providing essential instructions or authorization for conducting procedures on valuable material contained by the assembly, the manufacturer is assured that its procedures are being provided only to authorized persons.
摘要翻译：本发明提供一种安全地包含有价值材料的防篡改组件。组件具有用于容纳有价值材料的容器，容纳容器的可选载体，将容器中的有价值材料包围的一个或多个盖部件以及一个或多个标签，其具有多个通过在多个装置中的至少一个。定位标签使得移除覆盖部件在多个装置中的至少一个装置中引起可检测的变形，从而显示对组件的篡改。在一个实施例中，标签可以部分地固定到盖部件的表面并且部分地固定到容器的表面或可选的载体上。还公开了检测篡改的方法和制造耐回火组件的方法。由于组件允许远程验证器在组装之前提供必要的指令或授权进行有价值的材料的程序验证组件，所以制造商保证其程序仅提供给授权的人员。

33. 发明公开

EP3119899A2 COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF 审中-公开
标题翻译：组合物和方法对化学品及其衍生物的生产
公开(公告)号：EP3119899A2
公开(公告)日：2017-01-25
申请号：EP15764217.4
申请日：2015-03-20
申请人： Synthetic Genomics, Inc.
发明人： KAMBOURAKIS, Spiros , GRIFFIN, Benjamin, M. , MARTIN, Kevin, V.
IPC分类号： C12P7/58 , C12P7/42 , C12P17/04 , C12N9/04
CPC分类号： C12P7/58 , C12P7/44 , C12P17/06
摘要： The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into D-glucarate (Step 7); an enzymatic conversion of 5-ketogluconate (5-KGA) into L-Iduronic acid (Step 15); an enzymatic conversion of L-Iduronic acid into Idaric acid Step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-DDH) (Step 16). In some embodiments the methods of the invention produce 2,5-furandicarboxylic acid (FDCA) as a product. The methods include both enzymatic and chemical conversions as steps. Various pathways are also provided for converting glucose into 5-dehdyro-4-deoxy-glucarate (DDG), and for converting glucose into 2,5-furandicarboxylic acid (FDCA). The methods also involve the use of engineered enzymes that perform reactions with high specificity and efficiency. Additional products that can be produce include metabolic products such as, but not limited to, guluronic acid, L-iduronic acid, idaric acid, glucaric acid. Any of the products can be produced using glucose as a substrate or using any intermediate in any of the methods or pathways of the invention.

34. 发明公开

EP3064599A1 METHODS FOR IN VITRO JOINING AND COMBINATORIAL ASSEMBLY OF NUCLEIC ACID MOLECULES 有权
标题翻译： VERFAHREN ZUR IN-VITRINDUNG UND ZUR KOMBINATORISCHEN ANORDNUNG VONNUKLEINSÄUREMOLEKÜLEN
公开(公告)号：EP3064599A1
公开(公告)日：2016-09-07
申请号：EP16165528.7
申请日：2009-02-13
申请人： Synthetic Genomics, Inc.
发明人： VENTER, Craig , GIBSON, Daniel , SMITH, Hamilton , HUTCHISON, Clyde , YOUNG, Lei
IPC分类号： C12Q1/68 , C12P19/34 , C12N15/10
CPC分类号： C12P19/34 , C12N15/10 , C12N15/1027 , C12N15/64 , C12N15/66
摘要： The present invention relates to methods of joining two or more double-stranded (ds) or single-stranded (ss) DNA molecules of interest in vitro, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule of each pair share a region of sequence identity. The method allows the joining of a large number of DNA fragments, in a predetermined order and orientation, without the use of restriction enzymes. It can be used, e.g. to join synthetically produced sub-fragments of a gene or genome of interest. Kits for performing the method are also disclosed. The methods of joining DNA molecules may be used to generate combinatorial libraries useful to generate, for example, optimal protein expression through codon optimization, gene optimization, and pathway optimization.
摘要翻译：本发明涉及在体外连接两个或多个目的双链（ds）或单链（ss）DNA分子的方法，其中第一DNA分子的远端区域和第二DNA分子的近端区域每对共享序列同一性的区域。该方法允许以预定顺序和取向连接大量DNA片段，而不使用限制酶。它可以使用，例如加入合成的基因或感兴趣的基因组的亚片段。还公开了用于执行该方法的套件。连接DNA分子的方法可用于产生组合文库，其可用于产生例如通过密码子优化，基因优化和途径优化的最佳蛋白质表达。

35. 发明公开

EP2929029A2 ALGAL MUTANTS HAVING A LOCKED-IN HIGH LIGHT ACCLIMATED PHENOTYPE 有权
标题翻译：具有固定HOCHLICHTAKKLIMATISIERTEN表型突变体藻类
公开(公告)号：EP2929029A2
公开(公告)日：2015-10-14
申请号：EP13860017.6
申请日：2013-12-06
申请人： Synthetic Genomics, Inc.
发明人： BAILEY, Shaun , MCCARREN, Jay , LIEBERMAN, Soyan, Leung , MEUSER, Jonathan, E. , ROMANO, Anna, E. , YEE, Daniel , SORIAGA, Leah , BROWN, Robert, C. , WEISSMAN, Joseph, C. , PRINCE, Roger, C. , NIELSEN, Robert, D. , SCHWARTZ, Ariel, S.
IPC分类号： C12N15/11 , C12N15/82 , C12N15/87 , A01G7/00 , A01G17/14
CPC分类号： C12N15/825 , C07K14/405 , C07K14/415 , C12N1/12 , C12N1/36 , C12N15/01 , C12N15/8269
摘要： Mutant photosynthetic microorganisms having reduced chlorophyll and increased photosynthetic efficiency are provided. The mutants have a locked in high light-acclimated phenotype, in which many of the photosynthetic parameters characteristic of high light acclimated wild type cells are found in the LIHLA mutants when acclimated to low light, such as reduced chlorophyll, reduced NPQ, higher qP, higher Ek, higher Pmax per unit chlorophyll with little to no reduction in Pmax per cell, and higher rates of electron transport through photosystem II over a wide range of light intensities. Provided herein are constructs for attenuating or disrupting genes are provided for generating mutants having the LIHLA phenotype. Also provided are methods of culturing LIHLA mutants for the production of biomass or other products.

36. 发明公开

EP2761012A1 PRODUCTION AND SECRETION OF FATTY ACIDS AND FATTY ACID DERIVATIVES 失效
标题翻译：生产和脂肪酸和氨基酸衍生物分泌
公开(公告)号：EP2761012A1
公开(公告)日：2014-08-06
申请号：EP12835668.0
申请日：2012-09-27
申请人： Synthetic Genomics, Inc.
发明人： HOLTZAPPLE, Erik , BROWN, Robert, C. , SESHADRI, Rekha , COPPERSMITH, Jennifer , VERRUTO, John
IPC分类号： C12P7/64
CPC分类号： C12P7/6409 , C07K14/21 , C07K14/28 , C12N9/0008 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N15/70 , C12N15/74 , C12P5/02 , C12P7/04 , C12P7/6436 , C12Y102/0108 , C12Y203/0102 , C12Y203/01075 , C12Y203/01084 , C12Y301/0202 , C12Y401/01 , C12Y401/99005
摘要： The invention relates to acyl-CoA-independent methods of producing fatty alcohols in recombinant host cells engineered to express an alcohol-forming acyl-ACP reductase. The recombinant host cells may be photosynthetic microorganisms, such as cyanobacteria. Isolated nucleic acid molecules, vectors, and recombinant host cells expressing an alcohol-forming acyl-ACP reductase, and systems for producing fatty alcohols via an acyl-CoA-independent pathway, are also provided. Also provided are microorganisms engineered for the secretion of fatty acids and fatty acid derivatives, including fatty alcohols, and methods of producing fatty acid derivatives using such engineering microorganisms.

37. 发明授权

EP1963525B1 SYNTHESIS OF ERROR-MINIMIZED NUCLEIC ACID MOLECULES 有权转让
标题翻译：以最小的错误数量的核酸分子的合成
公开(公告)号：EP1963525B1
公开(公告)日：2013-11-20
申请号：EP06844856.2
申请日：2006-12-04
申请人： Synthetic Genomics, Inc.
发明人： YOUNG, Lei
IPC分类号： C12N15/10
CPC分类号： C12N15/1093 , C12N15/1027
摘要： A method is provided for synthesis of error-minimized nucleic acid molecules. Oligonucleotides intended to have fragments of a desired, full-length nucleotide sequence, and optionally containing other desired nucleotides, such as nucleotides for binding the oligonucleotides to a substrate, are obtained. Oligonucleotides for both strands of the desired, full-length sequence may be obtained. The oligonucleotides are amplified and assembled into a first set of molecules intended to have the desired, full-length nucleotide sequence. The first set of molecules is denatured and annealed to form a second set of molecules intended to have the desired, full-length nucleotide sequence. The second set of molecules is cut into smaller segments, for example, by mixing the molecules with endonucleases that form blunt cuts in the second set of molecules where there are sequence errors, as well as randomly along the molecules. The smaller segments are assembled into a set of molecules intended to have the desired, full-length nucleotide sequence. By promoting cutting of the molecules in this manner near the end of the nucleic acid molecule synthesis process, a set of full-length molecules can be obtained with fewer nucleotide sequence errors than can be achieved with other methods.

38. 发明公开

EP2576763A4 METHODS TO STIMULATE BIOGENIC METHANE PRODUCTION FROM HYDROCARBON-BEARING FORMATIONS 审中-公开
标题翻译：用于从碳 - 碳化配方刺激生产生物甲烷生产的方法
公开(公告)号：EP2576763A4
公开(公告)日：2013-11-13
申请号：EP11790489
申请日：2011-06-03
申请人： SYNTHETIC GENOMICS INC
发明人： CLEMENT BRIAN G , FERRY JAMES G , UNDERWOOD STUART
IPC分类号： C12N1/20 , C12P5/02 , E21B43/00
CPC分类号： C12N1/26 , C09K8/582 , C09K8/70 , C12N1/20 , C12P5/023 , Y02E50/343

39. 发明公开

EP2576763A2 METHODS TO STIMULATE BIOGENIC METHANE PRODUCTION FROM HYDROCARBON-BEARING FORMATIONS 审中-公开
标题翻译：方法刺激生物成因气产量从含烃地层
公开(公告)号：EP2576763A2
公开(公告)日：2013-04-10
申请号：EP11790489.6
申请日：2011-06-03
申请人： Synthetic Genomics, Inc.
发明人： CLEMENT, Brian, G. , FERRY, James, G. , UNDERWOOD, Stuart
IPC分类号： C12N1/20
CPC分类号： C12N1/26 , C09K8/582 , C09K8/70 , C12N1/20 , C12P5/023 , Y02E50/343
摘要： The present invention describes methods of stimulating the biogenic production of methane in hydrocarbon-bearing formations. The present application provides various stimulants which, when contacted with a hydrocarbon deposit
in situ or
ex situ , induce or enhance coalbed methane production.

40. 发明公开

EP2448955A4 ACYL-ACP THIOESTERASE GENES AND USES THEREFOR 有权
标题翻译：酰基ACP THIOESTERASEGENE及其用途
公开(公告)号：EP2448955A4
公开(公告)日：2013-03-06
申请号：EP10800309
申请日：2010-06-29
申请人： SYNTHETIC GENOMICS INC
发明人： ROESSLER PAUL GORDON , ROY GENA
IPC分类号： C07H21/04 , C12N9/16 , C12N15/82 , C12P7/64
CPC分类号： C12P7/6409 , C12N9/16 , C12N15/8247 , C12P7/6436 , C12P7/6463 , C12Y301/02014
摘要： The present invention provides novel genes encoding Class II acyl-ACP thioesterases and variants thereof that are active on C8, C10, C12, C14, C16, and C18 acyl-ACP substrates. The thioesterases can be introduced into transgenic organisms, including microorganisms and photosynthetic organisms, for producing fatty acids and fatty acid products.

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