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1. 发明公开

EP2761012A4 PRODUCTION AND SECRETION OF FATTY ACIDS AND FATTY ACID DERIVATIVES 失效
标题翻译： HERSTELLUNG UND SEKRETION VONFETTSÄURENUNDFETTSÄUREDERIVATEN
公开(公告)号：EP2761012A4
公开(公告)日：2015-04-15
申请号：EP12835668
申请日：2012-09-27
申请人： SYNTHETIC GENOMICS INC
发明人： HOLTZAPPLE ERIK , BROWN ROBERT C , SESHADRI REKHA , COPPERSMITH JENNIFER , VERRUTO JOHN
IPC分类号： C12P7/64
CPC分类号： C12P7/6409 , C07K14/21 , C07K14/28 , C12N9/0008 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N15/70 , C12N15/74 , C12P5/02 , C12P7/04 , C12P7/6436 , C12Y102/0108 , C12Y203/0102 , C12Y203/01075 , C12Y203/01084 , C12Y301/0202 , C12Y401/01 , C12Y401/99005

2. 发明公开

EP3385375A1 ACYL-ACP REDUCTASE WITH IMPROVED PROPERTIES 有权转让
公开(公告)号：EP3385375A1
公开(公告)日：2018-10-10
申请号：EP18172072.3
申请日：2014-01-16
申请人： REG Life Sciences, LLC
发明人： Rude, Mathew , Trinh, Na , Schirmer, Andreas , Gano, Jacob
IPC分类号： C12N9/02 , C12N15/53 , C12P7/04
CPC分类号： C12N9/0008 , C12P7/04 , C12P7/24 , C12P7/6409 , C12Y102/0108
摘要： The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.

3. 发明公开

EP2753701A1 ACYL-ACP WAX ESTER SYNTHASES 有权
标题翻译： ACYL-ACP蜡酯合成
公开(公告)号：EP2753701A1
公开(公告)日：2014-07-16
申请号：EP12835320.8
申请日：2012-03-06
申请人： ExxonMobil Research and Engineering Company
发明人： HOLTZAPPLE, Erik , VERRUTO, John, H.
IPC分类号： C12P7/64 , C12N1/21
CPC分类号： C12P7/6409 , C07K14/21 , C07K14/28 , C12N9/0008 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N15/70 , C12N15/74 , C12P5/02 , C12P7/04 , C12P7/6436 , C12Y102/0108 , C12Y203/0102 , C12Y203/01075 , C12Y203/01084 , C12Y301/0202 , C12Y401/01 , C12Y401/99005
摘要： The invention relates to acyl-CoA-independent methods of producing a wax ester in recombinant host cells engineered to express an acyl-ACP wax ester synthase, and an alcohol- forming acyl-ACP reductase. The methods of the invention may take place in photo synthetic microorganisms, and particularly in cyanobacteria. Isolated nucleotide molecules and vectors expressing an acyl-ACP wax ester synthase and/or an alcohol-forming acyl-ACP reductase, recombinant host cells expressing an acyl-ACP wax ester synthase and optionally an alcohol- forming acyl-ACP reductase, and systems for producing a wax ester via an acyl-CoA- independent pathway, are also provided.
摘要翻译：本发明涉及在工程化表达酰基-ACP蜡酯合酶和形成醇的酰基-ACP还原酶的重组宿主细胞中产生蜡酯的不依赖酰基辅酶A的方法。本发明的方法可以发生在光合成微生物中，特别是在蓝细菌中。表达酰基-ACP蜡酯合酶和/或形成醇的酰基-ACP还原酶的分离的核苷酸分子和载体，表达酰基-ACP蜡酯合酶和任选地形成醇的酰基-ACP还原酶的重组宿主细胞和用于还提供了经由酰基-CoA非依赖性途径产生蜡酯的方法。

4. 发明公开

EP2283121A2 METHODS AND COMPOSITIONS FOR PRODUCING HYDROCARBONS 有权转让
标题翻译：方法和组合物用于烃的生产
公开(公告)号：EP2283121A2
公开(公告)日：2011-02-16
申请号：EP09747777.2
申请日：2009-05-18
申请人： LS9, Inc.
发明人： SCHIRMER, Andreas , RUDE, Mathew , BRUBAKER, Shane
IPC分类号： C12N9/04 , C12P7/24 , C12N15/53 , C12P7/04
CPC分类号： C12P7/64 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C12N9/0004 , C12N9/0008 , C12N9/88 , C12P5/02 , C12P5/026 , C12P7/04 , C12P7/24 , C12P7/6409 , C12P7/6436 , C12P7/649 , C12Y102/0108 , C12Y401/99005 , Y02E50/13 , Y02P20/52 , Y02T50/678
摘要： Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels.

5. 发明授权

EP2927315B1 METHODS AND COMPOSITIONS FOR PRODUCING FATTY ACIDS AND FATTY ALCOHOLS 有权转让
公开(公告)号：EP2927315B1
公开(公告)日：2018-09-19
申请号：EP15153942.6
申请日：2009-05-18
申请人： REG Life Sciences, LLC
发明人： Schirmer, Andreas , Rude, Mathew , Brubaker, Shane
IPC分类号： C12N9/02 , C12N9/88 , C12P7/64 , C10L1/02 , C12P5/02 , C12P7/04 , C12P7/24
CPC分类号： C12P7/64 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C12N9/0004 , C12N9/0008 , C12N9/88 , C12P5/02 , C12P5/026 , C12P7/04 , C12P7/24 , C12P7/6409 , C12P7/6436 , C12P7/649 , C12Y102/0108 , C12Y401/99005 , Y02E50/13 , Y02P20/52 , Y02T50/678
摘要： Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels.

6. 发明授权

EP3103867B1 ACYL-ACP REDUCTASE WITH IMPROVED PROPERTIES 有权转让
标题翻译：具有改进性质的ACYL-ACP还原酶
公开(公告)号：EP3103867B1
公开(公告)日：2018-05-16
申请号：EP16181205.2
申请日：2014-01-16
申请人： REG Life Sciences, LLC
发明人： RUDE, Mathew , TRINH, Na , SCHIRMER, Andreas , GANO, Jacob
IPC分类号： C12N9/02 , C12N15/53 , C12P7/04
CPC分类号： C12N9/0008 , C12P7/04 , C12P7/24 , C12P7/6409 , C12Y102/0108
摘要： The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.

7. 发明授权

EP2288694B1 METHODS AND COMPOSITIONS FOR PRODUCING HYDROCARBONS 有权转让
公开(公告)号：EP2288694B1
公开(公告)日：2018-03-07
申请号：EP09747776.4
申请日：2009-05-18
申请人： REG Life Sciences, LLC
发明人： SCHIRMER, Andreas , RUDE, Mathew , BRUBAKER, Shane
IPC分类号： C12N9/02 , C12N9/88 , C12P7/64 , C10L1/02 , C12P7/04 , C12P7/24 , C12P5/02
CPC分类号： C12P7/64 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C12N9/0004 , C12N9/0008 , C12N9/88 , C12P5/02 , C12P5/026 , C12P7/04 , C12P7/24 , C12P7/6409 , C12P7/6436 , C12P7/649 , C12Y102/0108 , C12Y401/99005 , Y02E50/13 , Y02P20/52 , Y02T50/678
摘要： Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels.

8. 发明授权

EP2761012B1 PRODUCTION AND SECRETION OF FATTY ACIDS AND FATTY ACID DERIVATIVES 失效
标题翻译：脂肪酸和脂肪酸衍生物的生产和分配
公开(公告)号：EP2761012B1
公开(公告)日：2017-08-09
申请号：EP12835668.0
申请日：2012-09-27
申请人： Synthetic Genomics, Inc.
发明人： HOLTZAPPLE, Erik , BROWN, Robert, C. , SESHADRI, Rekha , COPPERSMITH, Jennifer , VERRUTO, John
IPC分类号： C12P7/64
CPC分类号： C12P7/6409 , C07K14/21 , C07K14/28 , C12N9/0008 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N15/70 , C12N15/74 , C12P5/02 , C12P7/04 , C12P7/6436 , C12Y102/0108 , C12Y203/0102 , C12Y203/01075 , C12Y203/01084 , C12Y301/0202 , C12Y401/01 , C12Y401/99005

9. 发明公开

EP2927315A1 Methods and compositions for producing fatty acids and fatty alcohols 有权转让
标题翻译：方法和组合物用于制备脂肪醇和脂肪醛的
公开(公告)号：EP2927315A1
公开(公告)日：2015-10-07
申请号：EP15153942.6
申请日：2009-05-18
申请人： REG Life Sciences, LLC
发明人： Schirmer, Andreas , Rude, Mathew , Brubaker, Shane
IPC分类号： C12N9/02 , C12N9/88 , C12P7/64 , C10L1/02
CPC分类号： C12P7/64 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C12N9/0004 , C12N9/0008 , C12N9/88 , C12P5/02 , C12P5/026 , C12P7/04 , C12P7/24 , C12P7/6409 , C12P7/6436 , C12P7/649 , C12Y102/0108 , C12Y401/99005 , Y02E50/13 , Y02P20/52 , Y02T50/678
摘要： Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels.
摘要翻译：组合物和生产碳氢化合物的方法：如醛，烷烃，烯烃和描述。某些碳氢化合物可在生物燃料的使用。

10. 发明公开

EP2655605A1 MODIFIED PHOTOSYNTHETIC MICROORGANISMS FOR PRODUCING LIPIDS 无效
标题翻译：生物脂质体修饰的光合微生物
公开(公告)号：EP2655605A1
公开(公告)日：2013-10-30
申请号：EP11804899.0
申请日：2011-12-19
申请人： Matrix Genetics, LLC
发明人： ROBERTS, James , CROSS, Fred , KAISER, Brett K.
IPC分类号： C12N9/02 , C12P7/64
CPC分类号： C12P7/6436 , C12N9/0008 , C12N15/74 , C12N15/8242 , C12N15/8247 , C12P7/6409 , C12Y102/0108
摘要： This disclosure describes genetically modified photosynthetic microorganisms,
e.g ., Cyanobacteria, that overexpress an acyl-acyl carrier protein reductase (acyl-ACP reductase). These microorganisms may optionally overexpress one or more fatty acid synthesis proteins such as ACP and ACCase, and/or one or more polypeptides associated with glycogen breakdown. Also included are photosynthetic microorganisms comprising mutations or deletions in a glycogen biosynthesis or storage pathway, which accumulate a reduced amount of glycogen under reduced nitrogen conditions as compared to a wild type photosynthetic microorganism. The modified photosynthetic microorganisms provided herein are capable of producing increased amounts of lipids such as fatty acids or wax esters and/or synthesizing triglycerides.
摘要翻译：本公开描述了过表达酰基 - 酰基载体蛋白还原酶（酰基-ACP还原酶）的基因修饰的光合微生物，例如蓝细菌。这些微生物可以任选地过表达一种或多种脂肪酸合成蛋白，例如ACP和ACCase，和/或一种或多种与糖原分解相关的多肽。还包括光合微生物，其包含糖原生物合成或储存途径中的突变或缺失，与野生型光合微生物相比，其在减少的氮条件下积累减少量的糖原。本文提供的修饰的光合微生物能够产生增加量的脂质，例如脂肪酸或蜡酯和/或合成甘油三酯。

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