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31. 发明公开

EP2277854A1 Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol 有权
标题翻译：在1-甲氧基-2-丙醇和水，或甲醇碘克沙醇的合成
公开(公告)号：EP2277854A1
公开(公告)日：2011-01-26
申请号：EP09178844.8
申请日：2009-12-11
申请人： GE Healthcare AS
发明人： Homestad, Ole Magne
IPC分类号： C07C231/12 , C07C237/46
CPC分类号： C07C231/12 , C07C237/46
摘要： This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with a solvent mixture comprising 1-methoxy-2-propanol and water or methanol.
摘要翻译：本发明涉及碘克沙醇（1,3-双（乙酰胺基）-N，N'-双[3,5-双（2,3-二dihydroxypropylaminocarbonyl）-2,4,6-三碘苯基〕-2-羟基丙烷的合成），更具体地涉及的二聚化5-乙酰氨基-N，N'-双（2,3-二羟丙基）-2,4,6-三碘间苯二甲酰胺与溶剂混合物含有1-甲氧基-2-丙醇和水或甲醇。

32. 发明公开

EP2277852A1 Synthesis of iodixanol in water 有权
标题翻译：在Wasser中合成von Iodixanol
公开(公告)号：EP2277852A1
公开(公告)日：2011-01-26
申请号：EP09178838.0
申请日：2009-12-11
申请人： GE Healthcare AS
发明人： Brekke, Geir , Rogne, Otto , Kjernli, Trond , Svendsen, Terje
IPC分类号： C07C231/12 , C07C237/46
CPC分类号： C07C231/12 , C07C237/46
摘要： This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with water as solvent.
摘要翻译：本发明涉及碘克沙醇（1,3-双（乙酰氨基）-N，N'-双[3,5-双（2,3-二羟基丙基氨基羰基）-2,4,6-三碘苯基] -2-羟基丙烷），更具体地涉及5-乙酰氨基-N，N'-双（2,3-二羟丙基）-2,4,6-三碘 - 间苯二酰胺与水作为溶剂的二聚。

33. 发明公开

EP2277851A1 Acetylation using reduced volume of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents 审中-公开
标题翻译：乙酸酐的乙酰化减少的体积生产的非离子X-射线造影介质的
公开(公告)号：EP2277851A1
公开(公告)日：2011-01-26
申请号：EP09178833.1
申请日：2009-12-11
申请人： GE Healthcare AS
发明人： Cervenka, Jan , Holmaas, Lars Terje , Larsen, Leif
IPC分类号： C07C231/02 , C07C237/46
CPC分类号： C07C231/02 , C07C237/46
摘要： This invention relates to an improved method for the synthesis of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide ("Compound A"), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to acetylation of 5-amino-N, N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide ("Compound B") using a reagent and solvent mixture containing between about 1.5 and about 3.0 liter of acetic anhydride and acetic acid per kilogram of Compound B. Preferably, following the acetylation reaction, the reagent and solvent mixture is distilled for re-use.
摘要翻译：本发明涉及到用于合成改进方法5-乙酰氨基-N，N'-双（2,3-二羟基丙基）-2,4,6-三triiodoisophthalamide（“化合物A”），以在中间工业制备的非离子X-射线造影剂。特别是，它涉及的乙酰化5-氨基-N，N'-双（2,3-二羟丙基）-2,4,6-三碘-1,3-苯二甲酰胺（“化合物B”），使用的试剂和溶剂约1.5至约3.0升醋酸酐和每化合物B的千克优选乙酸，继乙酰化反应之间含有混合物，使用的试剂和溶剂混合物蒸馏以供再使用。

34. 发明公开

EP2277846A1 Obtaining free iodine in preparation of aqueous iodine chloride by adding potassium iodide 审中-公开
标题翻译： Erhalt freien Iods bei der Herstellung vonwässrigemIodchlorid durch Zugabe von Iodid
公开(公告)号：EP2277846A1
公开(公告)日：2011-01-26
申请号：EP09176509.9
申请日：2009-11-19
申请人： GE Healthcare AS
发明人： Ingvoldstad, Odd Einar
IPC分类号： C07C17/156
CPC分类号： C01B7/14 , C01B7/24
摘要： This invention relates generally to the preparation of non-ionic X-ray contrast agents, iohexol, ioversol, and iodixanol. It further relates to an improved method for the iodination reaction, a key step in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a method for producing free iodine in an aqueous solution of iodine chloride by adding minor amounts of potassium iodide.
摘要翻译：本发明一般涉及非离子X射线造影剂碘海醇，碘奥昔莫和碘克沙醇的制备。它还涉及一种改进的碘化反应方法，这是非离子X射线造影剂的工业制备中的关键步骤。特别涉及通过加入少量碘化钾在碘化氯水溶液中产生游离碘的方法。

35. 发明授权

EP1805126B1 METHOD FOR PRODUCING PYRUVIC ACID 有权
标题翻译：用于生产丙酮酸
公开(公告)号：EP1805126B1
公开(公告)日：2010-11-24
申请号：EP05797104.6
申请日：2005-09-30
申请人： GE HEALTHCARE AS
发明人： ROLANDSGAARD, Marit , SANDOSHAM, Jessie , THOMASSEN, Terje , GRACE, David
IPC分类号： C07C51/02 , C07C59/19
CPC分类号： C07C51/44 , C07B2200/05 , C07C51/02 , C07C51/48 , C07C59/19
摘要： The invention relates to a method for the production of pyruvic acid.

36. 发明公开

EP2247313A2 ESTER IMAGING AGENTS 审中-公开
标题翻译：酯映射剂
公开(公告)号：EP2247313A2
公开(公告)日：2010-11-10
申请号：EP09717640.8
申请日：2009-03-03
申请人： GE Healthcare AS
发明人： DANIKAS, Antonios , ERIKSEN, Morten
IPC分类号： A61K49/00
CPC分类号： A61M31/005 , A61B5/0071 , A61B5/0084 , A61B5/4842 , A61B5/6853 , A61K49/0017 , A61K49/0021
摘要： The present invention relates to contrast agents for optical imaging of oesophageal cancer and Barrett's oesophagus in patients. The contrast agents are esters of 5- aminolevulinic acid (5-ALA). They are useful in the diagnosis of oesophageal cancer and Barrett's oesophagus, for follow up of progress in disease development, and for follow up of treatment of oesophageal cancer and Barrett's oesophagus. The contrast agents are delivered by particular routes of administration.
摘要翻译：本发明涉及食管癌和Barrett食管在患者中光学成像的造影剂。造影剂是5-氨基乙酰丙酸（5-ALA）的酯。它们可用于食管癌和Barrett食管的诊断，用于随访疾病发展的进展，以及用于随访食道癌和Barrett食管的治疗。造影剂通过特定的给药途径递送。

37. 发明公开

EP2245003A2 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：EP2245003A2
公开(公告)日：2010-11-03
申请号：EP09715655.8
申请日：2009-02-26
申请人： GE Healthcare AS , Priebe, Hanno
发明人： PRIEBE, Hanno
IPC分类号： C07C235/66 , C07C235/84 , C07D309/10 , C07C233/09 , A61K49/04
CPC分类号： A61K49/04 , A61K49/0438 , B22D11/1287 , B23K9/048 , B23K35/02 , B23K35/0261 , B23K35/30 , B23K35/3086 , B23K2201/04 , B23K2203/04 , C07C235/66 , C07C235/84 , C07D309/10 , C22C38/18 , C22C38/26
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R-N(CO-CH
3 ) — X— N(CO-CH
3 )- R and salts or optical active isomers thereof, wherein X denotes a divalent linking moiety with 5 to 10 bridge elements of carbon, oxygen, sulphur and nitrogen separating the acetylated nitrogen atoms, and which may be further substituted by hydroxyl groups, by C
1 to C
4 alkyl moieties optionally substituted by hydroxyl groups, by C
1 to C
4 alkoxy groups, by amino groups and by C
1 to C
4 alkylamino groups, and wherein 2 or 3 carbon bridge elements together with alkyl or alkoxy groups form a cyclopentane, cyclohexane, pentahydropyran or tetrahydrofuran entity which may be alkyl- or hydroxyalkyl- substituted and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有两个通式为RN（CO-CH 3）-X-N（CO-CH 3）-R的连接碘化苯基的化合物及其盐或光学活性异构体，其中X表示二价连接部分与碳原子，氧原子，硫原子和氮原子的5至10个桥联元素分隔乙酰化的氮原子，并且可以被羟基进一步取代，被C 1至C 4烷基部分任选地被羟基取代，被C 1 至C 4烷氧基，氨基和C 1至C 4烷基氨基，并且其中2或3个碳桥基与烷基或烷氧基一起形成环戊烷，环己烷，五氢吡喃或四氢呋喃实体，其可以是烷基或羟烷基 - 取代的并且每个R表示进一步被亲水部分取代的三碘代苯基残基。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这种化合物的造影剂。

38. 发明公开

EP2129664A1 TRISUBSTITUTED TRIAZAMACROCYCLI C COMPOUNDS AND THEIR USE AS CONTRAST AGENTS 审中-公开
标题翻译：三取代TRIAZAMAKROZYKLENç化合物及其作为造影剂
公开(公告)号：EP2129664A1
公开(公告)日：2009-12-09
申请号：EP08741718.4
申请日：2008-04-03
申请人： GE HEALTHCARE AS
发明人： MORISSON-IVESON, Véronique
IPC分类号： C07D239/04 , C07D255/00 , A61K49/04
CPC分类号： C07D239/04 , A61K49/04 , C07D255/00
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a saturated triaza cyclic central moiety containing carbonyl functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.

39. 发明公开

EP2119457A1 Method of magnetic resonance investigation with hyperpolarised contrast agents 有权
标题翻译： Verfahren zur Herstellung eines hyperpolarisierten Kontrastmittels
公开(公告)号：EP2119457A1
公开(公告)日：2009-11-18
申请号：EP09009608.2
申请日：1998-12-23
申请人： GE Healthcare AS
发明人： Ardenkjaer-Larsen, Jan Henrik , Axelsson, Oskar , Golman, Klaes , Hansson, Georg , Leunbach, Ib , Petersson, Stefan , Wistrand, Lars-Göran
IPC分类号： A61K49/06 , A61K49/08 , G01R33/28 , G01R33/62
CPC分类号： G01R33/5601 , A61K49/08 , A61K49/10 , A61K49/18 , A61K49/1815 , G01R33/282 , G01R33/62
摘要： This invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising:
(i) producing a hyperpolarised solution of a high T 1 agent by dissolving in a physiologically tolerable solvent a hyperpolarised solid sample of said high T 1 agent;
(ii) where the hyperpolarisation of the solid sample of said high T 1 agent in step (i) is effected by means of a polarising agent, optionally separating the whole, substantially the whole, or a portion of said polarising agent from said high T 1 agent;
(iii) administering said hyperpolarised solution to said sample;
(iv) exposing said sample to a second radiation of a frequency selected to excite nuclear spin transitions in selected nuclei eg the MR imaging nuclei of the high T 1 agent;
(v) detecting magnetic resonance signals from said sample; and
(vi) optionally, generating an image, dynamic flow data, diffusion data, perfusion data, physiological data (eg. pH, pO 2 , pCO 2 , temperature or ionic concentrations) or metabolic data from said detected signals,

wherein said high T 1 agent in said hyperpolarised solution has a T 1 value (at a field strength in the range 0.01-5T and a temperature in the range 20-40°C) of at least 5 seconds.
摘要翻译：本发明提供了一种样品，优选人或非人动物体的磁共振研究方法，所述方法包括：（i）通过将高T 1试剂溶解在生理上可耐受的溶剂中制成超极化溶液所述高T 1试剂的固体样品; （ii）其中步骤（i）中所述高T 1试剂的固体样品的超极化是通过偏振剂进行的，任选地从所述高T分离整个，基本上全部或部分所述偏振剂 1代理; （iii）将所述超极化溶液施用于所述样品; （iv）将所述样品暴露于所选频率的第二辐射，以激发所选择的核中的核自旋跃迁，例如高T 1试剂的MR成像核; （v）检测来自所述样品的磁共振信号; 和（vi）可选地，从所述检测到的信号生成图像，动态流动数据，扩散数据，灌注数据，生理数据（例如pH，pO 2，pCO 2，温度或离子浓度）或代谢数据，其中所述高T 所述超极化溶液中的一种试剂具有至少5秒的T 1值（在0.011-5T的范围内的场强和20-40℃的温度）。

40. 发明公开

EP2114464A2 RADIOFLUORINATION METHODS 审中-公开
标题翻译： RADIOFLUORINATIONSVERFAHREN
公开(公告)号：EP2114464A2
公开(公告)日：2009-11-11
申请号：EP07869939.4
申请日：2007-12-27
申请人： GE HEALTHCARE AS
发明人： CUTHBERTSON, Alan , SOLBAKKEN, Magne , KARLSEN, Hege
IPC分类号： A61K51/08
CPC分类号： A61K51/08 , A61K51/088 , C07B59/001
摘要： The invention relates to conjugates of formula (V) or (VI), their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.

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