专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

EP2917372B1 NUCLEIC ACID SEQUENCING USING TAGS 有权转让
公开(公告)号：EP2917372B1
公开(公告)日：2020-04-08
申请号：EP13853114.0
申请日：2013-11-07
申请人： Genia Technologies, Inc.
发明人： DAVIS, Randall W. , CHEN, Roger , BIBILLO, Arkadiusz , KORENBLUM, Daniel , DORWART, Michael
IPC分类号： C12Q1/6869 , G01N27/447 , G01N33/487

32. 发明授权

EP3212810B1 ALPHA-HEMOLYSIN VARIANTS WITH ALTERED CHARACTERISTICS 有权转让
公开(公告)号：EP3212810B1
公开(公告)日：2020-01-01
申请号：EP15855632.4
申请日：2015-10-28
申请人： Genia Technologies, Inc.
发明人： DORWART, Michael , KORENBLUM, Daniel
IPC分类号： C12Q1/68 , C07K14/31 , C12Q1/6869

33. 发明公开

EP3436602A1 NANOPORE PROTEIN CONJUGATES AND USES THEREOF 有权
公开(公告)号：EP3436602A1
公开(公告)日：2019-02-06
申请号：EP17715423.4
申请日：2017-03-29
申请人： Genia Technologies, Inc.
发明人： CRAIG, Timothy , HARRIS, Corissa , DIPETRO, Matt , AMBROSO, Mark , ZOU, Yaozhong , PORTER, Marshall , DELKANINIA, Issa , NOBLE, Alexxa , FAIRMAN, James , WU, Wiseley , BAJAJ, Kapil , BELLESIA, Giovanni , SHIN, Seong-Ho
IPC分类号： C12Q1/68

34. 发明公开

EP3423576A1 POLYMERASE VARIANTS 有权转让
公开(公告)号：EP3423576A1
公开(公告)日：2019-01-09
申请号：EP17708201.3
申请日：2017-02-27
申请人： Genia Technologies, Inc.
发明人： AYER, Aruna , DALAL, Dhruti , SARVABHOWMAN, Preethi
IPC分类号： C12N9/12

35. 发明公开

EP3344993A1 SMALL APERTURE LARGE ELECTRODE NANOPORE CELL AND METHOD OF MANUFACTURE 有权转让
公开(公告)号：EP3344993A1
公开(公告)日：2018-07-11
申请号：EP16766235.2
申请日：2016-08-26
申请人： Genia Technologies, Inc. , Roche Diagnostics GmbH
发明人： FOSTER, John , MAGER, Morgan
IPC分类号： G01N33/487
CPC分类号： G01N33/48721 , G01N27/44791 , H01L29/401
摘要： A nanopore cell includes a conductive layer and a working electrode disposed above the conductive layer and at the bottom of a well into which an electrolyte may be contained, such that at least a portion of a top base surface area of the working electrode is exposed to the electrolyte. The nanopore cell further includes a first insulating wall disposed above the working electrode and surrounding a lower section of a well, and a second insulating wall disposed above the first insulating wall and surrounding an upper section of the well, forming an overhang above the lower section of the well. The upper section of the well includes an opening that a membrane may span across, and wherein a base surface area of the opening is smaller than the at least a portion of the top base surface area of the working electrode that is exposed to the electrolyte.

36. 发明公开

EP3122759A1 CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES 无效转让
标题翻译： CHEMISCHE VERFAHREN ZUR HERSTELLUNG VON MARKIERTEN NUKLEOTIDEN
公开(公告)号：EP3122759A1
公开(公告)日：2017-02-01
申请号：EP15768383.0
申请日：2015-03-23
申请人： The Trustees of Columbia University in the City of New York , Genia Technologies, Inc.
发明人： FULLER, Carl, W. , KUMAR, Shiv , JU, Jingyue , DAVIS, Randall , CHEN, Roger
IPC分类号： C07H19/04
CPC分类号： C12Q1/6874 , C07H17/02 , C07H19/10 , C07H19/20 , C12Q1/6806
摘要： This disclosure provides systems and methods for attaching nano pore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disdosed tagged nudeotides. Provided herein are nudeotides with attached tags and methods for attaching tags to nudeotides. The tags can be attached by chemical reactions, such as "dick chemistry". In an aspect, the present disdosure provides a tagged nudeotide, comprising: (a) a poly-phosphate moiety having a terminal phosphate; and (b) a tag covalently coupled to the terminal phosphate of the nudeotide by a triazole, a 1,2-diazine, a disulfide, a secondary amine, a hydrazone, a thio-acetamide, or a maleimide-thioadduct.
摘要翻译：本公开提供了将纳米孔可检测标签附着于核苷酸的系统和方法。本公开还提供了使用公开的标记核苷酸对核酸进行测序的方法。

37. 发明公开

EP2861768A4 CHIP SET-UP AND HIGH-ACCURACY NUCLEIC ACID SEQUENCING 审中-公开
标题翻译： CHIP设置及高精度核酸测序
公开(公告)号：EP2861768A4
公开(公告)日：2016-03-02
申请号：EP13804403
申请日：2013-06-14
申请人： GENIA TECHNOLOGIES INC
发明人： DAVIS RANDALL W , CHEN ROGER , BIBILLO ARKADIUSZ , DEIERLING KEVIN
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/53
CPC分类号： G01N27/44791 , C12Q1/6869 , G01N33/48721 , C12Q2565/631

38. 发明公开

EP2807476A1 NANOPORE BASED MOLECULAR DETECTION AND SEQUENCING 审中-公开
标题翻译：鉴定及测序分子对纳米多孔质基体
公开(公告)号：EP2807476A1
公开(公告)日：2014-12-03
申请号：EP13738391.5
申请日：2013-01-18
申请人： Genia Technologies, Inc.
发明人： DAVIS, Randall , CHEN, Roger
IPC分类号： G01N27/26 , C12Q1/68 , G01N27/414
CPC分类号： C12Q1/6869 , C12Q1/6874 , G01N33/48721 , C12Q2521/101 , C12Q2565/607
摘要： This disclosure provides systems and methods for molecular identification and polymer (e.g., nucleic acid) sequencing using nanopores. The polymer may be passed through or in proximity to the nanopore and various subunits of the polymer may affect the current flowing through the nanopore. The various subunits may be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. In some cases, the polymerization of tagged nucleotides presents tag molecules to the nanopore that can be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. Also provided herein are systems and methods for sequencing both the sense and anti-sense strand of a double stranded nucleic acid molecule with a nanopore and methods for using ribonucleic acid (RNA) speed bump molecules to slow the passage of a nucleic acid molecule through or in proximity to a nanopore.

39. 发明公开

EP2534284A1 SYSTEMS AND METHODS FOR MANIPULATING A MOLECULE IN A NANOPORE 有权转让
标题翻译：系统在VERFAHREN ZUR操作系列EINESMOLEKÜLSIN EINER NANOPORE
公开(公告)号：EP2534284A1
公开(公告)日：2012-12-19
申请号：EP11740145.5
申请日：2011-02-04
申请人： Genia Technologies Inc.
发明人： CHEN, Roger , DAVIS, Randy
IPC分类号： C40B30/00 , C40B40/04
CPC分类号： G01N33/48721 , C12Q1/6869 , C12Q2523/305 , C12Q2563/116 , C12Q2565/631
摘要： Techniques for manipulating a molecule in a nanopore embedded in a lipid bilayer are described. In one example, an acquiring electrical stimulus level is applied across a lipid bilayer wherein a region of the lipid bilayer containing the nanopore is characterized by a resistance and wherein the acquiring electrical stimulus level tends to draw the molecule from a surrounding fluid into the nanopore, a change in the resistance of the lipid bilayer resulting from the acquisition of at least a portion of a molecule into the nanopore is detected, the acquiring electrical stimulus level is changed to a holding electrical stimulus level wherein the portion of the molecule remains in the nanopore upon the changing of the acquiring electrical stimulus level to the holding electrical stimulus level.
摘要翻译：描述了在嵌入脂质双层中的纳米孔中操纵分子的技术。在一个实例中，获得电刺激水平跨越脂质双层施加，其中包含纳米孔的脂质双层的区域的特征在于阻力，并且其中获取电刺激水平倾向于将分子从周围流体吸引到纳米孔中，检测到从将至少一部分分子获得到纳米孔中获得的脂质双层的电阻的变化，将获得的电刺激水平改变为保持电刺激水平，其中分子的部分保留在纳米孔中将获取的电刺激水平改变为保持电刺激水平。

40. 发明公开

EP4194566A1 SENSOR CIRCUIT FOR CONTROLLING, DETECTING, AND MEASURING A MOLECULAR COMPLEX 审中-实审转让
公开(公告)号：EP4194566A1
公开(公告)日：2023-06-14
申请号：EP23154993.2
申请日：2013-02-27
申请人： Genia Technologies, Inc.
发明人： DEIERLING, Kevin , CHEN, Roger J A , FULLAGAR, David J
IPC分类号： C12Q1/6869 , G01N33/487
摘要： A device for controlling, detecting, and measuring a molecular complex is disclosed. The device comprises a common electrode. The device further comprises a plurality of measurement cells. Each measurement cell includes a cell electrode and an integrator electronically coupled to the cell electrode. The integrator measures the current flowing between the common electrode and the cell electrode. The device further comprises a plurality of analog-to-digital converters, wherein an integrator from the plurality of measurement cells is electrically coupled to one analog-to-digital converter of the plurality of analog-to-digital converters.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式