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1. 发明公开

EP2534284A1 SYSTEMS AND METHODS FOR MANIPULATING A MOLECULE IN A NANOPORE 有权转让
标题翻译：系统在VERFAHREN ZUR操作系列EINESMOLEKÜLSIN EINER NANOPORE
公开(公告)号：EP2534284A1
公开(公告)日：2012-12-19
申请号：EP11740145.5
申请日：2011-02-04
申请人： Genia Technologies Inc.
发明人： CHEN, Roger , DAVIS, Randy
IPC分类号： C40B30/00 , C40B40/04
CPC分类号： G01N33/48721 , C12Q1/6869 , C12Q2523/305 , C12Q2563/116 , C12Q2565/631
摘要： Techniques for manipulating a molecule in a nanopore embedded in a lipid bilayer are described. In one example, an acquiring electrical stimulus level is applied across a lipid bilayer wherein a region of the lipid bilayer containing the nanopore is characterized by a resistance and wherein the acquiring electrical stimulus level tends to draw the molecule from a surrounding fluid into the nanopore, a change in the resistance of the lipid bilayer resulting from the acquisition of at least a portion of a molecule into the nanopore is detected, the acquiring electrical stimulus level is changed to a holding electrical stimulus level wherein the portion of the molecule remains in the nanopore upon the changing of the acquiring electrical stimulus level to the holding electrical stimulus level.
摘要翻译：描述了在嵌入脂质双层中的纳米孔中操纵分子的技术。在一个实例中，获得电刺激水平跨越脂质双层施加，其中包含纳米孔的脂质双层的区域的特征在于阻力，并且其中获取电刺激水平倾向于将分子从周围流体吸引到纳米孔中，检测到从将至少一部分分子获得到纳米孔中获得的脂质双层的电阻的变化，将获得的电刺激水平改变为保持电刺激水平，其中分子的部分保留在纳米孔中将获取的电刺激水平改变为保持电刺激水平。

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