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21. 发明公开

EP3856958A2 STORAGE OF INFORMATION USING MIXTURES OF MOLECULES 无效
公开(公告)号：EP3856958A2
公开(公告)日：2021-08-04
申请号：EP19874780.0
申请日：2019-09-27
申请人： President and Fellows of Harvard College , Northwestern University
发明人： WHITESIDES, George, M. , CAFFERTY, Brian, J. , TEN, Alexei, S. , FINK, Michael, J. , PRESTON, Daniel, J. , MRKSICH, Milan, M. , NAGARKAR, Amit Arun
IPC分类号： C40B60/00 , G06F16/00

22. 发明公开

EP3172362A1 SYSTEMS, DEVICES AND METHODS FOR CONSTRUCTING AND USING A BIOMARKER 审中-公开
标题翻译：系统，设备和方法生产和使用生物标记物
公开(公告)号：EP3172362A1
公开(公告)日：2017-05-31
申请号：EP15824751.0
申请日：2015-07-23
申请人： Ontario Institute for Cancer Research
发明人： BARTLETT, John , BOUTROS, Paul , SABINE, Victoria , HAIDER, Syed , STARMANS, Maud H.W. , YAO, Cindy Qianli , WANG, Jianxin
IPC分类号： C40B40/06 , C12M1/34 , C12Q1/68 , C40B30/04 , C40B60/00 , G01N33/48 , G06F19/12 , G06F19/20
CPC分类号： C12Q1/6886 , A61K31/138 , A61K31/5685 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/166 , G06F19/00 , G06F19/12 , G06F19/20 , G16H50/30 , Y02A90/26
摘要： Methods, systems, devices and computer implemented methods of prognosing or classifying patients using a biomarker comprising a plurality of subnetwork modules are disclosed. In some embodiments, the method comprises determining an activity of a plurality of genes in a test sample of a patient, wherein the plurality of genes are associated with the plurality of subnetwork modules. An expression profile is constructed using the activity of the plurality of genes. The dysregulation of each of the plurality of subnetwork modules is determined by calculating a score proportional to a degree of dysregulation in each of the plurality of subnetwork modules from the expression profile. The patient is prognosed or classified by inputting each dysregulation score into a model for predicting patient outcomes for patients having a disease, and inputting a clinical indicator of the patient into the model, to obtain a risk associated with the disease.
摘要翻译：方法，系统，装置和预后或分类使用的生物标志物的患者，其包括子网模块的多个计算机impemented方法是游离缺失盘。在一些实施方案中，该方法包括确定开采的患者的测试样品中的基因的多个活动，worin基因的多元性与子网的模块相关联的多个。表达谱是利用基因的多个活性构成。每个子网络模块，所述多个的失调被确定通过计算正比于每一子网络模块从表达谱的多个A度失调的得分开采。患者被prognosed或通过输入每个失调得分成模型预测患者结果对具有患者的疾病，并且输入所述患者的临床指标到模型中，以获得与所述疾病相关的风险分类。

23. 发明授权

EP2803988B1 Nanostructured microelectrodes and biosensing devices incorporating the same 有权
标题翻译： Nanostrukturierte Mikroelektroden und Bioerfassungsvorrichtungen damit
公开(公告)号：EP2803988B1
公开(公告)日：2017-04-12
申请号：EP14176968.7
申请日：2009-09-01
申请人： The Governing Council of the University of Toronto
发明人： Soleymani, Leyla , Fang, Zhichao , Kelley, Shana , Sargent, Edward , Taft, Bradford
IPC分类号： G01N27/327 , G01N27/30 , G01N27/403 , G01N27/416 , G01N33/53 , C12Q1/68 , C12Q1/00 , C40B60/00 , G01N33/543
CPC分类号： G01N27/3272 , G01N27/30 , G01N27/3275 , G01N27/3278 , G01N33/5438 , Y10S977/754 , Y10S977/925

24. 发明公开

EP2782866A1 DEVICES AND METHODS FOR PRODUCING PLANAR POLYMERIC MATERIALS USING MICROFLUIDICS 审中-公开
标题翻译：器件及其制造方法平面高分子材料由Microfluidics
公开(公告)号：EP2782866A1
公开(公告)日：2014-10-01
申请号：EP12851166.4
申请日：2012-11-23
申请人： The Governing Council of the University of Toronto
发明人： GUENTHER, Axel , LENG, Lian , WOLLARD, Andrew , MCALLISTER, Arianna , RADISIC, Milica , ZHANG, Boyang
IPC分类号： B81B1/00 , A23G3/00 , C08J5/18 , C12M1/34 , C12M3/00 , C12N11/02 , C40B60/00 , A61K8/72 , A61K35/12
CPC分类号： B29C47/0021 , A23G3/0002 , B01L3/5027 , C12M23/16
摘要： Methods and devices are disclosed for providing the controlled formation of planar homogeneous or heterogeneous materials using microfluidic devices. In one embodiment, a planar array of microfluidic channels is employed to produce a flowing liquid sheet having heterogeneous structure by spatially and temporally controlling dispensing of polymer liquid from selected microchannels. The resulting liquid sheet is solidified to produce a planar heterogeneous material that may be continuously drawn and/or fed from the plurality of microfluidic channels. The polymer liquid may include a payload that may be selectively incorporated into the heterogeneous structure. In some embodiments, the local material composition is controllable, thereby allowing control over local and bulk material properties, such as the permeability and the elasticity, and of creating materials with directionally dependent properties.

25. 发明公开

EP2329247A4 METHOD AND DEVICE TO REMOVE FLUID AND VAPOR 有权
标题翻译：方法和装置去除液体和蒸气
公开(公告)号：EP2329247A4
公开(公告)日：2013-03-20
申请号：EP09815538
申请日：2009-09-29
申请人： SQI DIAGNOSTICS SYSTEMS INC
发明人： LEA PETER
IPC分类号： G01N1/28 , B01D53/26 , C12M3/00 , C40B60/00 , F26B5/04 , F26B5/12
CPC分类号： F26B5/12 , B01J2219/00315 , B01J2219/00414 , B01J2219/00605 , B01L2200/025 , B01L2400/049 , F26B5/04 , G01N35/1074

26. 发明公开

EP2446966A1 LID ARRAY AND MICROTUBE ARRAY SET INCLUDING SAME 有权
标题翻译：德克萨斯州，德黑兰，达赖喇嘛
公开(公告)号：EP2446966A1
公开(公告)日：2012-05-02
申请号：EP09846545.3
申请日：2009-06-25
申请人： Kakuda, Shinichiro , Nakahana, Yoko
发明人： Kakuda, Shinichiro , Nakahana, Yoko
IPC分类号： B01L3/00 , B65B7/28 , C12M1/00 , C40B40/00 , C40B60/00 , G01N35/02
CPC分类号： B01L3/50825 , B01L3/50853 , B01L2200/023 , B01L2200/0689 , B01L2300/042 , B01L2300/0829 , B01L2300/0887 , B65B7/2821 , B65B7/2878 , C40B60/00 , Y10T428/24
摘要： Provide a lid element array and a micro tube array set for sealing the opening of each micro tube array quickly at cost. A lid element array 100 comprises a lid element sheet 120 comprising a plurality of lid element 121 arrayed corresponding to the number and the arrangement of a plurality of said micro tubes 210; a release sheet 140; a first adhesive 110 applied to said each lid element in said lid element sheet 120; a second adhesive 130 applied between said lid element sheet 120 and said release sheet 140 ; wherein, said each lid element in said lid element sheet is supported by said release sheet where a cut-line cut around the edge of each said lid element for separation from said lid element sheet, said each lid element moves to corresponding said opening of each said micro tube and seals the same by pressing said lid element to the surface of said micro tube array for facing the surface applied said first adhesive and the surface of said micro tube array. A convex object is installed on the surface of the lid element 121, said convex object works as a positioning guide for the lid element array 100.
摘要翻译：提供一个盖元件阵列和一个微管阵列，用于快速地密封每个微管阵列的开口。盖元件阵列100包括盖元件片120，其包括对应于多个所述微管210的数量和布置排列的多个盖元件121; 剥离片140; 施加到所述盖元件片120中的每个盖元件的第一粘合剂110; 施加在所述盖元件片120和所述剥离片140之间的第二粘合剂130; 其特征在于，所述盖元件片中的所述每个盖元件由所述剥离片支撑，切割线围绕每个所述盖元件的边缘切割，以与所述盖元件片分离，所述每个盖元件移动到每个所述盖元件的相应的所述开口所述微管并且通过将所述盖元件按压到所述微管阵列的表面以面对施加所述第一粘合剂和所述微管阵列的表面的表面来密封所述微管。凸形物体安装在盖元件121的表面上，所述凸起物体用作盖元件阵列100的定位引导件。

27. 发明公开

EP2331950A4 NANOSTRUCTURED MICROELECTRODES AND BIOSENSING DEVICES INCORPORATING THE SAME 有权
标题翻译：纳米结构的微电极和SO BIOERFASSUNGSVORRICHTUNGEN
公开(公告)号：EP2331950A4
公开(公告)日：2012-02-08
申请号：EP09810953
申请日：2009-09-01
申请人： UNIV TORONTO
发明人： SOLEYMANI LEYLA , FANG ZHICHAO , KELLEY SHANA , SARGENT EDWARD , TAFT BRADFORD
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/68 , C40B60/00 , G01N27/30 , G01N27/403 , G01N27/416 , G01N33/53 , G01N33/543
CPC分类号： G01N27/3272 , G01N27/30 , G01N27/3275 , G01N27/3278 , G01N33/5438 , Y10S977/754 , Y10S977/925

28. 发明公开

EP2398939A1 MICROARRAY WITH MICROCHANNELS 有权
标题翻译：与微流道微阵列
公开(公告)号：EP2398939A1
公开(公告)日：2011-12-28
申请号：EP10744357.4
申请日：2010-02-19
申请人： Massachusetts Institute of Technology
发明人： LOVE, Christopher, J. , STORY, Craig, M. , PAPA, Eliseo
IPC分类号： C40B60/00
CPC分类号： C12M23/16 , B01L3/5085 , B01L9/50 , B01L2300/0854 , C12M23/12
摘要： A microarray formed in a planar surface of a moldable slab, the microarray including a plurality of microwell sets comprising a plurality of micro wells formed in the planar surface of the moldable slab, each microwell being sized to contain at least a single cell, and a plurality of microchannels formed in the planar surface of the moldable slab, the plurality of microchannels being configured to permit liquid from a first region of the microarray to transit to a second region of the microarray.

29. 发明公开

EP2212437A4 MICROFLUIDIC DEVICE AND METHOD OF USING SAME 审中-公开
标题翻译：微流体装置和使用方法
公开(公告)号：EP2212437A4
公开(公告)日：2011-09-28
申请号：EP08846830
申请日：2008-11-07
申请人： UNIV BRITISH COLUMBIA
发明人： HANSEN CARL LARS GENGHIS , TROPINI CAROLINA
IPC分类号： C12Q1/68 , B01L7/00 , C12M1/00 , C12M1/36 , C12M1/40 , C12P19/34 , C40B30/00 , C40B60/00 , G01N35/00 , B01L11/00
CPC分类号： B01L3/5027 , B01J2219/00317 , B01J2219/00396 , B01J2219/00398 , B01J2219/00495 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , B01L3/5025 , B01L3/502723 , B01L3/50273 , B01L3/50851 , B01L7/52 , B01L2200/0605 , B01L2200/0621 , B01L2200/0642 , B01L2200/0689 , B01L2200/16 , B01L2300/0819 , B01L2300/0829 , B01L2300/0864 , B01L2300/123 , B01L2300/1805 , B01L2400/0487
摘要： A microfluidic device comprising a plurality of reaction chambers in fluid communication with a flow channel formed in an elastomeric substrate, a vapor barrier for preventing evaporation from the plurality of reaction chambers, and a continuous phase fluid for isolation of each of the plurality of reaction chambers.

30. 发明公开

EP2122333A1 SYSTEM AND METHOD FOR SURFACE PLASMON RESONANCE BASED DETECTION OF MOLECULES 审中-公开
标题翻译：系统和方法分子在表面等离子体共振基于视觉的检测
公开(公告)号：EP2122333A1
公开(公告)日：2009-11-25
申请号：EP08714664.3
申请日：2008-02-21
申请人： The Royal Institution for the Advancement of Learning/McGill University , NATIONAL RESEARCH COUNCIL CANADA
发明人： MALIC, Lidija , TABRIZIAN, Maryam , VERES, Teodor , CUI, Bo , NORMANDIN, François
IPC分类号： G01N21/75 , C40B20/00 , C40B30/00 , C40B50/00 , C40B60/00 , G01N21/01 , G01N21/78 , C12Q1/68
CPC分类号： G01N21/554 , B01J2219/00619 , B01J2219/00653 , B01J2219/00659 , B01L3/502792 , B01L2300/0636 , B01L2300/0819 , B01L2300/089 , B01L2300/0896 , B01L2300/161 , B01L2400/0427 , B01L2400/086 , B82Y30/00 , C40B20/08 , C40B30/04 , C40B40/08 , C40B60/02 , Y10T436/2575
摘要： A system and method for molecule detection uses a surface plasmon resonance (SPR) system with detection spots having fixed nanostructures. An SPR assembly may be combined with a digital microfluidic control system such as an electrowetting-on-dielectric (EWOD) chip. The microfluidic system individually directs sample droplets to different detection spots of the SPR assembly, thus allowing the SPR examination of different samples or sample reactions on the same surface. The nanostructures at the detection spots enhance the sensitivity of the SPR signals.

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