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1. 发明公开

EP1754041A4 METHOD AND DEVICE FOR RAPID DETECTION AND QUANTITATION OF MACRO AND MICRO MATRICES 审中-公开
标题翻译：方法和设备的快速检测和快速宏观量化和MIKROMATRIZES
公开(公告)号：EP1754041A4
公开(公告)日：2008-06-25
申请号：EP05755029
申请日：2005-06-01
申请人： SQI DIAGNOSTICS SYSTEMS INC
发明人： LEA PETER , DING SHI-FA
IPC分类号： G01N33/543 , C12M1/34 , C12Q1/04 , C12Q1/06 , C12Q1/70 , G01N1/28 , G01N1/40 , G01N15/10 , G01N21/00 , G01N21/64 , G01N33/02 , G01N33/53 , G01N33/554 , G01N33/558 , G01N33/569
CPC分类号： G01N33/5302 , G01N33/569
摘要： The present invention provides a method and device for rapidly detecting the presence of analytes in a sample. Quantitative and qualitative measurements of analyte concentration in a sample may be rapidly obtained. A sample including the analyte and analyte metabolites produced by the analyte are introduced into a vessel that contains a reagent or reagents that have a detectable marker and rapidly bind to the analyte and to the metabolite. The sample is then introduced to an assay device that has a loading area, a separation and a reading area. The sample is introduced into the loading area of the assay device and moves to the reading area preferably by capillary action. The methodology permits for the detection of analytes and metabolites using means for the detecting the detectable marker. The sample may be subjected to a force application means for the controlled progressive fragmentation of any analyte, which is preferably a pathogen present in the sample, into a plurality of fragments. The sample is then introduced into a vessel that contains reagents having a detectable marker that rapidly bind to the fragments of the analyte(s) to which the assay is directed. The sample is then introduced to the assay device for detection of analyte fragments. An assay device having a test dot is printed on the reading portion. The test dot includes a bound reagent that is adapted to bind to analyte fragments of the analyte for which the assay is directed. Once the fragments are bound to the test dot, the presence of the analyte fragments in the test dot can be determined by methods known in the art. The test dot may alternatively include a bound reagent that is adapted to bind to analyte or other metabolites that are produced by an analyte which is a bacterium or other pathogen to which the test is directed. The reading portion may also have a section for gathering analyte labeled with detectable markers for visual detection. Background interference caused by laser diffraction is removed.

2. 发明公开

EP2350653A4 ARRAY FLUORESCENCE EQUALIZATION METHOD 失效
标题翻译：方法补偿阵列荧光
公开(公告)号：EP2350653A4
公开(公告)日：2012-09-05
申请号：EP09818715
申请日：2009-10-07
申请人： SQI DIAGNOSTICS SYSTEMS INC
发明人： LEA PETER
IPC分类号： G01N33/543 , G01N1/34
CPC分类号： G01N1/34 , G01N21/64 , G01N33/54366

3. 发明公开

EP2510355A4 ANALYTE QUANTIFICATION MULTIPLEX MICROARRAYS COMBINING INTERNAL AND EXTERNAL CALIBRATION 失效
标题翻译： MULTIPLEX-MIKROARRAYS ZURANALYTQUANTIFIZIERUNG MIT INTERNER UND EXERNER KALIBRIERUNG
公开(公告)号：EP2510355A4
公开(公告)日：2013-05-22
申请号：EP10825894
申请日：2010-10-29
申请人： SQI DIAGNOSTICS SYSTEMS INC
发明人： LEA PETER , HANSEN JENNIFER , SMITH KATE
IPC分类号： G01N33/68
CPC分类号： G01N33/6845 , G01N2440/18 , G01N2800/101 , G01N2800/52
摘要： The present invention relates to multiplex microarrays and methods for the quantification of analytes. In particular, the invention relates to improved methods which standardize a target analyte concentration in a test sample against a reference standardization curve derived from validated, approved and recognized reference standards for the target analyte of known concentrations. The present invention also relates to methods and checks for simultaneous measurement of confidence confirming normalization standards and controls.
摘要翻译：本发明涉及多重微阵列和用于定量分析物的方法。特别地，本发明涉及一种改进的方法，其将标准化测试样品中的目标分析物浓度相对于来自已知浓度的目标分析物的已验证的，已批准和公认的参考标准的参考标准化曲线。本发明还涉及同时测量确定归一化标准和控制的置信度的方法和检查。

4. 发明公开

EP2329247A4 METHOD AND DEVICE TO REMOVE FLUID AND VAPOR 有权
标题翻译：方法和装置去除液体和蒸气
公开(公告)号：EP2329247A4
公开(公告)日：2013-03-20
申请号：EP09815538
申请日：2009-09-29
申请人： SQI DIAGNOSTICS SYSTEMS INC
发明人： LEA PETER
IPC分类号： G01N1/28 , B01D53/26 , C12M3/00 , C40B60/00 , F26B5/04 , F26B5/12
CPC分类号： F26B5/12 , B01J2219/00315 , B01J2219/00414 , B01J2219/00605 , B01L2200/025 , B01L2400/049 , F26B5/04 , G01N35/1074

5. 发明公开

EP2382468A4 METHODS FOR MULTIPLEX ANALYTE DETECTION AND QUANTIFICATION 审中-公开
标题翻译：方法进行多重分析物的数量化
公开(公告)号：EP2382468A4
公开(公告)日：2012-07-11
申请号：EP09835936
申请日：2009-12-29
申请人： SQI DIAGNOSTICS SYSTEMS INC
发明人： LEA PETER
IPC分类号： G01N33/543 , G01N33/564 , G01N33/58
CPC分类号： G01N33/564 , B01L3/5085 , G01N33/543

6. 发明公开

EP2229402A4 SYNTHETIC PEPTIDES IMMUNO-REACTIVE WITH RHEUMATOID ARTHRITIS AUTO-ANTIBODIES 失效
标题翻译：类风湿性关节炎相关的自身抗体的免疫反应性塑料肽
公开(公告)号：EP2229402A4
公开(公告)日：2012-01-11
申请号：EP08857631
申请日：2008-12-03
申请人： SQI DIAGNOSTICS SYSTEMS INC
发明人： LEA PETER , LING MINGFU
IPC分类号： C07K7/08 , C07K7/50 , C07K7/64 , C40B40/10 , G01N33/543 , G01N33/564
CPC分类号： C07K7/08 , G01N33/564 , G01N2800/102

7. 发明公开

EP1789789A4 METHOD AND DEVICE TO OPTIMIZE ANALYTE AND ANTIBODY SUBSTRATE BINDING BY LEAST ENERGY ADSORPTION 失效转让
标题翻译：方法和设备优化分析物和抗体结合底采用微ENERGY吸附
公开(公告)号：EP1789789A4
公开(公告)日：2008-06-11
申请号：EP05768273
申请日：2005-07-20
申请人： SQI DIAGNOSTICS SYSTEMS INC
发明人： LEA PETER , EWART THOMAS G , CARMICHAEL STUART X , RICKS CLAUDE
IPC分类号： G01N33/543 , G01N33/53 , G01N33/545 , G01N37/00
CPC分类号： G01N33/54353 , G01N33/54366
摘要： The present invention provides a method of making an assay device for conducting an assay to detect a concentration of an analyte in a sample fluid. The assay devices would typically have a substantially planar surface having a series of site specific immobilized calibration spot arrays containing pre-determined quantities of the analyte printed thereon. In addition, a series of site specific immobilized test spot arrays, including capture antibody for binding the analyte protein is printed on the assay device. The method involves first modifying the planar surface to provide hydrophobic binding sites, hydrophilic linking and covalent bonding sites. Then the method requires printing the series of site specific immobilized test spot arrays and the series of site specific immobilized calibration spot arrays on the substantially planar surface. Applying the sample fluid to the assay device is the next step followed by testing a sensitivity of the assay and modulating ratios of the hydrophobic, hydrophilic and covalent binding sites in order to optimize the sensitivity of the assay.

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