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21. 发明公开

EP0161112A3 Novel substituted aromatic hydrocarbons, processes for production thereof, and use thereof 失效
标题翻译：新型取代的芳香烃，其生产方法及其用途
公开(公告)号：EP0161112A3
公开(公告)日：1986-07-30
申请号：EP85303229
申请日：1985-05-07
申请人： MITSUI PETROCHEMICAL INDUSTRIES, LTD.
发明人： Mizui, Kinya , Takeda, Masami , Ozaki, Yoshimi , Tomita, Ryosuke
IPC分类号： C07C13/61 , C07C13/68 , C07C02/66
CPC分类号： C07C13/68 , C07C2/66 , C07C13/61 , C07C2603/68 , C07C2603/86
摘要： An aromatic hydrocarbon in which at least one hydrogen atom on the ring is substituted by a group selected from the class consisting of unsubstituted or lower alkyl-substituted tricyclo [5.2.1.0 1,6 ]dec-3-yl, tricyclo [5.2.1.0 2,6 ]dec-4-yl, tetracyclo [6.2.1.1 3,6 .0 2.7 ]dodec-4-yl and tetracyclo [6.2.1.1 3,6 .0 2,7 ]dodec-5-yl groups, or its hydrogenation product. The compound is prepared by reacting an aromatic hydrocarbon having at least one hydrogen atom on the ring with a compound selected from the group consisting of unsubstituted or lower alkyl-substituted tricyclo-[5.2.1.0 2,6 ]dec-3-ene and tetracyclo [6.2.1.1 3,6 .0 2,7 ]-dodec-4-ene in the presence of a Friedel-Crafts catalyst, or hydrogenating the thus- obtained compound in the presence of a hydrogenation catalyst. The compound is useful as an additive for adhesives.

22. 发明公开

EP0112603A1 Aphidicolane derivatives, their preparation and pharmaceutical compositions comprising them 失效
标题翻译： Aphidicolanderivate，ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen。
公开(公告)号：EP0112603A1
公开(公告)日：1984-07-04
申请号：EP83304118.9
申请日：1983-07-15
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC
发明人： Ratcliffe, Arnold Harry
IPC分类号： C07C35/44 , C07C47/36 , C07C49/513 , C07C247/00 , C07C309/63 , C07C69/96 , C07C229/00 , C07C271/06 , C07D303/14 , C07D211/46 , C07D295/14
CPC分类号： C07D317/72 , C07C229/08 , C07C271/22 , C07C2603/86 , C07D211/46 , C07D295/15 , C07D303/14 , C07D493/08 , C07F7/1856
摘要： Aphidicolane derivatives of the formula:
wherein R 1 stands for hydrogen or a hydroxy radical, R 2 stands for a hydroxy or methyl radical, or the group CR 1 R 2 stands for a keto group; R 3 stands for a formyl or hydroxymethyl radical, or for the group -CH 2 0.CO.OR 6 , wherein R 6 stands for a defined radical or R 2 and R 3 are joined together to form the group -O.CO.OCH 2 -; R 4 stands for a hydroxy radical; R 5 stands for a formyl radical, a hydroxyalkyl radical -(CH 2 ) 1-3 OH, a radical -CHR 7 OH, wherein R 7 stands for a defined radical, or R 5 stands for an azidomethyl or pyrrolidinylcarbonyloxymethyl radical, or for the group -CH 2 0.CO.OR 8 , wherein R 8 stands for a defined radical, or R 5 stands for the group -CH 2 O.CO.(CH 2 )m.CR 11 R 12 .(CH 2 ) n .NR 9 R 10 . wherein m, n, R 9, R 10 , R 11 and R 12 have defined values, or R 5 stands for the group -CH 2 O.SO 2 .R 13 , wherein R 13 stands for a defined radical; or R 4 and R 5 are joined together to form the group -O.CH 2 - or -O.CO.OCH 2 -; and, where appropriate, pharmaceutically acceptable salts thereof. Processes for the preparation of said aphidicolane derivatives. Pharmaceutical compositions comprising one of thecompounds and a pharmaceutical diluent or carrier. The compounds exhibit inhibitory activity against DNA-containing viruses and they inhibit the growth of some tumours.
摘要翻译：其中R1代表氢或羟基，R2代表羟基或甲基，或基团CR1R2代表酮基; R3代表甲酰基或羟甲基或基团-CH2O.CO.OR6，其中R6表示定义的基团，或R2和R3连接在一起形成基团-O.CO.OCH 2 - ; R4代表羟基; R5代表甲酰基，羟基烷基 - （CH2）1-3OH，基团-CHR7OH，其中R7代表定义的基团，或R5代表叠氮基甲基或吡咯烷基羰基氧基甲基或基团-CH2O.CO. OR 8，其中R8代表定义的基团，或R5代表基团-CH2O.CO.（CH2）m.CR11R12。（CH2）n.NR9R10，其中m，n，R9，R10，R11和R12具有定义的值或R5代表基团-CH 2 O.SO 2 R 13，其中R 13表示定义的基团; 或R 4和R 5连接在一起形成基团-O.CH 2 - 或-O.CO.OCH 2 - ; 及其适当的药学上可接受的盐。制备所述蚜虫烷衍生物的方法。包含化合物之一和药物稀释剂或载体的药物组合物。该化合物对含DNA病毒表现出抑制活性，并抑制某些肿瘤的生长。

23. 发明公开

EP0002896A1 Antiviral tetracyclononane derivatives, processes for their manufacture and pharmaceutical compositions containing them 失效
标题翻译：抗病毒药Tetracyclononanderivate，涉及它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0002896A1
公开(公告)日：1979-07-11
申请号：EP78300756.0
申请日：1978-12-06
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC
发明人： Swallow, Douglas Lintin
IPC分类号： C07C87/40 , A61K31/13
CPC分类号： C07C217/84 , C07C211/19 , C07C211/48 , C07C211/52 , C07C2601/14 , C07C2603/86
摘要： The invention relates to a pharmaceutical composition comprising a tetracyclononane derivative of the formula:
wherein R 1 , R 2 and R 3 are hydrogen atoms or alkyl radicals and A is CH 2 CH 2 or CH-R 4 in which R4- is a hydrogen atom or an alkyl, cyclohexyl, phenylalkyl or optionally-substituted phenyl radical, or a salt thereof. The majority of compounds of the formula II are novel and they are included within the scope of the invention, as are processes for their manufacture. Typical of the compounds disclosed is 8-(1-aminoethyl)tetracyclo-[4,3,0,0 2,4 ,0 3,7 ]nonane.
摘要翻译：本发明涉及包含下式的tetracyclononane衍生物的药物组合物： II worin R1，R2和R3是氢原子或烷基基团，A为CH 2 CH 2或CH-R4其中R4是氢原子或烷基，环己基，苯基烷基或苯基任意取代，或它们的盐。大部分式Ⅱ的化合物是新的，并包括它们的本发明的范围之内，如同它们的制造工艺。游离缺失典型化合物的光盘为8-（1-氨基 - 乙基）四环[4,3,0,02,4,03,7]壬烷。

24. 发明授权

EP2655323B1 INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES 有权
标题翻译：吲哚-3-酰化物III和炔醇-3-氨基甲酸酯
公开(公告)号：EP2655323B1
公开(公告)日：2017-12-20
申请号：EP11808566.1
申请日：2011-12-22
申请人： LEO LABORATORIES LIMITED
发明人： GRUE-SØRENSEN, Gunnar , LIANG, Xifu , HÖGBERG, Thomas , MÅNSSON, Kristoffer , VEDSØ, Per , VIFIAN, Thomas
IPC分类号： C07C271/34 , C07C249/06 , C07D261/18 , C07D277/32 , C07D309/08 , C07D333/38 , C07D401/04 , C07D295/21 , A61K31/27 , A61K31/215 , A61P35/00 , A61K31/381 , A61K31/4192 , A61K31/42 , A61K31/426
CPC分类号： C07D261/18 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4192 , A61K31/42 , A61K31/472 , A61K31/502 , A61K31/5375 , A61K31/538 , C07C271/34 , C07C271/36 , C07C271/38 , C07C2603/86 , C07D209/08 , C07D209/42 , C07D213/79 , C07D215/50 , C07D217/26 , C07D231/14 , C07D231/56 , C07D233/90 , C07D237/28 , C07D239/28 , C07D249/04 , C07D249/06 , C07D261/20 , C07D263/34 , C07D265/36 , C07D271/08 , C07D277/32 , C07D277/56 , C07D277/587 , C07D295/182 , C07D295/205 , C07D295/21 , C07D307/00 , C07D307/68 , C07D307/94 , C07D309/08 , C07D333/38 , C07D333/40 , C07D401/04 , C07D405/06 , C07D471/04 , C07D493/08 , C07D495/04 , C07D513/04
摘要： The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is —NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.

26. 发明公开

EP2974744A1 Strain-promoted oxidation controlled cycloaddition with high reaction rate 审中-公开
标题翻译： Durchstammgeförderte氧化活性环加成酶Reaktionsgeschwindigkeit
公开(公告)号：EP2974744A1
公开(公告)日：2016-01-20
申请号：EP14177230.1
申请日：2014-07-16
申请人： Stichting Katholieke Universiteit
发明人： van Delft, Floris Louis , Fatunsin, Olumide Foluso , Borrmann, Annika , van Hest, Jan Cornelis Maria , Löwik, Dennis Wilhelmus Petrus Maria , Jonker, Anika Maartje
IPC分类号： A61K47/48 , A61K47/32 , C07D225/08
CPC分类号： C07D225/08 , A61K47/54 , A61K47/555 , C07C45/69 , C07C49/727 , C07C2603/86 , C07D225/04 , C07K1/13 , C09B11/24
摘要： The invention provides a the use of a (hetero)cycloalkyne and an oxo-group containing (hetero)1,3-diene for coupling a first system (A) of interest to a second system (A') of interest, wherein a (hetero)cycloalkyne is created in one of the first system (A) of interest and the second system (A') of interest, and wherein an oxo-group containing (hetero)1,3-diene is created in the other system of interest, and allowing the (hetero)cycloalkyne and the oxo-group containing (hetero)1,3-diene to react to form an A-A' conjugate.
摘要翻译：本发明提供了（异）环炔和含氧基的（杂）1,3-二烯用于将感兴趣的第一系统（A）与感兴趣的第二系统（A'）偶联的用途，其中（异构）环炔在所关心的第一系统（A）和感兴趣的第二体系（A'）中的一个中产生，并且其中在另一个感兴趣的系统中产生含氧基的（杂）1,3-二烯，并允许（杂）环炔和含氧基的（杂）1,3-二烯反应形成AA'缀合物。

27. 发明公开

EP2655312A1 3-ACYL-INGENOLS II 审中-公开
公开(公告)号：EP2655312A1
公开(公告)日：2013-10-30
申请号：EP11808567.9
申请日：2011-12-22
申请人： LEO LABORATORIES LIMITED
发明人： GRUE-SØRENSEN, Gunnar , LIANG, Xifu , HÖGBERG, Thomas , MÅNSSON, Kristoffer , VEDSØ, Per
IPC分类号： C07C69/74 , C07C69/75 , C07C69/753 , C07C229/56 , C07C255/46 , A61K31/215 , A61K31/245 , A61K31/277 , A61P35/00 , A61K31/216
CPC分类号： C07C69/74 , A61K31/215 , A61K31/235 , A61K31/245 , A61K31/277 , A61K45/06 , C07C69/013 , C07C69/75 , C07C69/753 , C07C69/76 , C07C69/78 , C07C69/92 , C07C229/56 , C07C229/58 , C07C229/64 , C07C233/54 , C07C255/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/86
摘要： The invention relates to compounds of general formula I, (I), wherein R is wherein R is aryl substituted by R3; or R is (C3-Ci3)-cycloalkyl, (C3-Ci3)- cycloalkenyl or (C7-Ci3)-cycloalkynyl optionally substituted by R4; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use -alone or in combination with one or more other pharmaceutically active compounds- in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1是其中R 3是被R 3取代的芳基; 或R 3是任选被R 4取代的（C 3 -C 13） - 环烷基，（C 3 -C 13） - 环烯基或（C 7 -C 13） - 环炔基; 及其药学上可接受的盐，水合物或溶剂合物单独或与一种或多种其它药物活性化合物组合用于治疗，用于预防，治疗或改善响应刺激嗜中性粒细胞氧化爆发的疾病或病症，响应于刺激的角质形成细胞IL-8释放或对诱导坏死有反应。

28. 发明公开

EP2655311A1 INGENOL-3-ACYLATES I 审中-公开
标题翻译：硝基-3-乙酸酯
公开(公告)号：EP2655311A1
公开(公告)日：2013-10-30
申请号：EP11805841.1
申请日：2011-12-22
申请人： LEO LABORATORIES LIMITED
发明人： GRUE-SØRENSEN, Gunnar , LIANG, Xifu , HÖGBERG, Thomas
IPC分类号： C07C69/54 , C07C235/16 , C07C251/48 , C07C255/23 , A61K31/215 , A61K31/216 , A61K31/277 , A61P35/00
CPC分类号： C07C255/41 , C07C69/013 , C07C69/24 , C07C69/533 , C07C69/54 , C07C69/60 , C07C69/608 , C07C69/614 , C07C69/616 , C07C69/618 , C07C233/56 , C07C251/44 , C07C251/48 , C07C255/23 , C07C2601/14 , C07C2603/86
摘要： The invention relates to compounds of general formula (I) wherein R is (C
1 -C
7 )alkyl, (C
2 -C
7 )alkenyl or (C
2 -C
7 )alkynyl; wherein R is substituted with R1; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use -alone or in combination with one or more other pharmaceutically active compounds- in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
摘要翻译：本发明涉及通式（I）的化合物，其中R是（C 1 -C 7）烷基，（C 2 -C 7）烯基或（C 2 -C 7）炔基; 其中R被R1取代; 和其药学上可接受的盐，水合物或溶剂化物，其用于治疗中，单独使用或与一种或多种其它药学活性化合物组合用于预防，治疗或改善对刺激中性粒细胞氧化性突发的响应刺激的疾病或病症的角质形成细胞IL-8释放或响应于坏死的诱导。

29. 发明公开

EP2622410A1 NORBORNANE-BASED PAC BALLAST AND POSITIVE-TONE PHOTOSENSITIVE RESIN COMPOSITION ENCOMPASSING THE PAC 有权
标题翻译：含降冰片连接芳醇要相片活动连接，并正感光树脂组合物这张照片活动连接
公开(公告)号：EP2622410A1
公开(公告)日：2013-08-07
申请号：EP11773589.4
申请日：2011-09-28
申请人： Promerus, LLC , Sumitomo Bakelite Company Limited
发明人： BELL, Andrew , SETO, Keitaro , MAKABE, Hiroaki
IPC分类号： G03F7/023 , C07C39/17 , C07C309/71 , G03F7/40
CPC分类号： G03F7/022 , C07C39/17 , C07C43/1782 , C07C43/1783 , C07C43/1788 , C07C245/12 , C07C309/71 , C07C2601/16 , C07C2602/10 , C07C2602/24 , C07C2603/86 , G03F7/023 , G03F7/0233 , G03F7/40
摘要： Embodiments in accordance with the present invention provide for norbornane-type ballast materials, norbornane-type photoactive compounds derived from such ballast materials and alkali-soluble positive-tone polymer compositions that encompass such norbornane-type photoactive compounds and one of a PBO or PNB resin.

30. 发明公开

EP2218706A4 BENZOPHENANTHRENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE EMPLOYING THE SAME 有权
标题翻译： BENZOPHENANTHRENDERIVAT与SO有机电致发光
公开(公告)号：EP2218706A4
公开(公告)日：2011-11-30
申请号：EP08854332
申请日：2008-11-25
申请人： IDEMITSU KOSAN CO
发明人： KAWAMURA MASAHIRO
IPC分类号： C07C15/38 , C09K11/06 , H01L51/50
CPC分类号： H01L51/0058 , C07C15/38 , C07C2603/86 , C09B1/00 , C09B57/00 , C09B57/001 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1088 , C09K2211/1092 , H01L51/0054 , H01L51/5012 , H05B33/14

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