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21. 发明授权

EP2092936B1 Tamper-resistant oral opioid agonist formulations 有权
标题翻译： Missbrauchsichere orale Opioidagonisten-Formulierungen
公开(公告)号：EP2092936B1
公开(公告)日：2013-03-20
申请号：EP09006024.5
申请日：2001-02-08
申请人： EURO-CELTIQUE S.A.
发明人： Oshlack, Benjamin , Wright, Curtis , Haddox, J. David
IPC分类号： A61K31/485 , A61K9/28 , A61K9/16 , A61K9/50 , A61K9/20 , A61P25/04 , A61P25/36
CPC分类号： A61K9/5084 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K9/02 , A61K9/14 , A61K9/1617 , A61K9/1635 , A61K9/1647 , A61K9/1676 , A61K9/1694 , A61K9/2077 , A61K9/2081 , A61K9/2866 , A61K9/4808 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5078 , A61K9/51 , A61K9/7053 , A61K9/7061 , A61K31/485
摘要： Disclosed is an opioid antagonist composition and an oral dosage form comprising an opioid antagonist particle in a coating which is insoluble in the gastrointestinal system or an opioid antagonist dispersed in a matrix that renders the antagonist substantially non-releasable or an opioid antagonist dispersed in a melt-extruded matrix.
摘要翻译：公开了一种阿片样物质拮抗剂组合物和口服剂型，其包含不溶于胃肠系统的涂层中的阿片样物质拮抗剂颗粒或分散在基质中的阿片样物质拮抗剂，其使拮抗剂基本上不可释放，或阿片样物质拮抗剂分散在熔体中 - 挤压矩阵。

22. 发明授权

EP2040684B1 MULTIPLE UNIT TABLETS 有权
标题翻译：多辆片剂
公开(公告)号：EP2040684B1
公开(公告)日：2013-01-23
申请号：EP07765142.0
申请日：2007-07-09
申请人： LEK Pharmaceuticals d.d.
发明人： STANIC LJUBIN, Tijana , KOCEVAR, Klemen
IPC分类号： A61K9/20
CPC分类号： A61K9/5078 , A61K9/2018 , A61K9/2054 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5084 , A61K47/34

23. 发明公开

EP2545776A2 Method for preparing particles comprising metal oxide coating and particles with metal oxide coating 审中-公开
标题翻译：一种用于生产颗粒与具有金属氧化物和金属氧化物颗粒的方法
公开(公告)号：EP2545776A2
公开(公告)日：2013-01-16
申请号：EP12181820.7
申请日：2008-02-03
申请人： Sol-Gel Technologies Ltd.
发明人： Toledano, Ofer , Bar- Simantov, Haim , Bilman, Nissim , Shapiro, Leora , Abu-Reziq, Raed , Sriadibhatla, Srikanth , Sommer, William T. , Sertchook, Hanan
IPC分类号： A01N25/26 , A61K8/11 , A61K9/16 , A61K9/50 , A61Q19/00 , B01J13/02 , B01J13/22 , C09C3/06
CPC分类号： A61K9/5073 , A01N25/26 , A01N53/00 , A61K8/11 , A61K8/25 , A61K8/38 , A61K8/671 , A61K9/501 , A61K9/5021 , A61K9/5026 , A61K2800/412 , A61Q19/00 , B01J13/02 , B01J13/22 , C09C3/063 , Y10T428/2991 , A01N2300/00
摘要： The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.
摘要翻译：本发明涉及一种用于涂覆固体，水不溶性颗粒物，用金属氧化物，其包括：（a）用在离子添加剂和在wässrige介质接触的固体，水不溶性颗粒物质，以获得所述颗粒的分散体物具有在其表面上正电荷; （B）使所述颗粒物质的涂层过程，其包括沉淀的金属氧化物盐走上的颗粒物的表面，以在其上形成金属氧化物层，从而获得由金属氧化物涂层涂覆颗粒物质; （C）重复步骤（b）至少4次以上; 和（d）老化所述涂层。本发明还涉及一种包括由一个金属氧化物层涂覆的，涉及一种使用用于局部给药的颗粒的颗粒物质的颗粒，并用于预防，减少，或消除害虫在一个轨迹，使用该颗粒的方法。

24. 发明公开

EP2491386A1 NESTED CELL ENCAPSULATION 有权
标题翻译： VERSCHACHTELTE ZELLEINKAPSELUNG
公开(公告)号：EP2491386A1
公开(公告)日：2012-08-29
申请号：EP10770733.3
申请日：2010-10-22
申请人： Plasticell Ltd
发明人： CHOO, Yen , JOHNSON, Christopher, James , ODENWÄLDER, Patrick, Klaus , JAYASINGHE, Suwan, Nalin
IPC分类号： G01N33/50 , A61K9/16 , A61K9/50
CPC分类号： G01N33/5005 , A61K9/501 , A61K9/5036 , A61K9/5073 , A61K9/5089 , C12M25/16
摘要： The invention relates to a method for encapsulating living cells and labels, as well as encapsulated labelled cells and kits for performing such encapsulation. The encapsulated cells may be useful in multiple parallel tissue culture experiments, where the labels in each microcapsule may be used to decipher a cells path through a series of culturing steps.
摘要翻译：本发明涉及一种用于包封活细胞和标签的方法，以及用于进行这种包封的封装的标记细胞和试剂盒。包封的细胞可用于多个平行组织培养实验，其中每个微胶囊中的标记可用于通过一系列培养步骤来破译细胞路径。

25. 发明公开

EP2275426A4 METALLO-ORGANIC SYSTEM FOR THE ENCAPSULATION AND RELEASE OF COMPOUNDS OF INTEREST, METHOD FOR OBTAINING SAME AND USES THEREOF 审中-公开
标题翻译：封装和某些化合物工程剥离金属有机系统获得和使用
公开(公告)号：EP2275426A4
公开(公告)日：2012-07-11
申请号：EP09738266
申请日：2009-04-29
申请人： CONSEJO SUPERIOR INVESTIGACION , INST CATALA DE NANOTECNOLOGIA
发明人： RUIZ MOLINA DANIEL , MASPOCH COMAMALA DANIEL , IMAZ GABILONDO INHAR
IPC分类号： C07F3/06 , A61K9/51 , A61K47/24 , A61K47/34 , C07F19/00
CPC分类号： C07F3/003 , A61K9/501 , A61K9/5015 , A61K49/0041 , A61K49/0043 , A61K49/0091 , A61K49/0093 , A61K49/1887

26. 发明授权

EP1944029B1 PHARMACEUTICAL PREPARATION HAVING EXCELLENT PHOTOSTABILITY 有权
标题翻译：具有出色的光稳定性配药设备
公开(公告)号：EP1944029B1
公开(公告)日：2011-12-21
申请号：EP06822589.5
申请日：2006-10-30
申请人： Kowa Company, Ltd. , Nissan Chemical Industries, Ltd.
发明人： KOZAKI, Masato , TANIZAWA, Yoshio , KAWASHIMA, Hiroyuki
IPC分类号： A61K31/47 , A61K9/16 , A61K9/28 , A61K47/02 , A61K47/20 , A61P3/06 , A61K9/20 , A61K9/50
CPC分类号： A61K9/2813 , A61K9/2072 , A61K9/2081 , A61K9/2866 , A61K9/501 , A61K9/5021 , A61K9/5073 , A61K31/47
摘要： Disclosed is a pharmaceutical preparation having excellent photostability, which comprises a pitavastatin (which is an HMG-CoA reductase inhibitor) or a salt or ester thereof. The pharmaceutical preparation comprises a pitavastatin, titanium oxide and a coloring agent having a wavelength of maximum absorption falling within the range from 400 to 500 nm.

27. 发明公开

EP2349212A1 MINERAL-COATED MICROSPHERES 有权转让
标题翻译：矿物质复盖的微球体
公开(公告)号：EP2349212A1
公开(公告)日：2011-08-03
申请号：EP09816920.4
申请日：2009-09-25
申请人： Tissue Regeneration Systems, Inc.
发明人： MURPHY, William, L. , JONGPAIBOONKIT, Leenaporn
IPC分类号： A61K9/14 , A61K35/00
CPC分类号： A61K9/501 , A61K9/5031 , A61K31/19 , A61K35/02 , A61K38/00 , C12N15/87
摘要： Provided is a microsphere comprising a bead coated with a first calcium-containing mineral. Also provided is a method of producing a microsphere. Additionally, a method of administering a compound to a vertebrate is provided.

28. 发明公开

EP2298279A3 Pharmaceutical compositions for inhalation 有权
标题翻译：用于吸入的药物组合物
公开(公告)号：EP2298279A3
公开(公告)日：2011-08-03
申请号：EP10182218.7
申请日：2001-11-30
申请人： Vectura Limited
发明人： Staniforth, John Nicholas , Harris, Haggis , Morton, David Alexander Vodden , Bannister, Robin
IPC分类号： A61K9/00 , A61K47/28
CPC分类号： A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
摘要： The invention provides microparticles for use in a pharmaceutical composition for pulmomary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.
摘要翻译：本发明提供用于用于肺部给药的药物组合物的微粒，每个微粒包含活性物质颗粒，所述活性物质颗粒在其表面上具有适于延迟活性物质溶解的疏水材料颗粒。本发明还提供了制造微粒的方法。

29. 发明公开

EP2315584A1 MICROENCAPSULATE AND PROCESS FOR THE MANUFACTURE THEREOF 有权
标题翻译： MIKROKAPSULAT UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2315584A1
公开(公告)日：2011-05-04
申请号：EP09788261.7
申请日：2009-07-31
申请人： Feyecon B.V. , Friesland Brands B.V.
发明人： Poortinga, Albert Thijs , Trambitas, Daniela Oana , Hofland, Gerard Willem
IPC分类号： A61K9/50 , B01J13/02
CPC分类号： A61K9/5089 , A61K9/501 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5052 , B01J13/043
摘要： The present invention relates to a microencapsulate comprising microcapsules having a diameter of 0.1 mum to 25 mum, said microcapsules comprising: -a core particle having a diameter of 90 nm to 23 mum and containing at least 3% of the active component by weight of said core particle; and-a coating that fully envelops the core particle and containing at least 20 wt. % of a hydrophobic polymer selected from cellulosic ethers, cellulosic esters, zein, shellac, gluten, polylactide, hydrophobic starch derivatives, polyvinyl acetate polymers, polymers or copolymers derived from an acrylic acid ester and/or a methacrylic acid ester and combinations thereof; wherein the core particle contains a release trigger component and/or the coating contains a release trigger component, said release trigger component being selected from: -a water-swellable polymer having a water-uptake capacity at 37° C. and pH 7.0 of less than 20 wt. % and a water-uptake capacity at 37° C. and pH 2.0 of at least 50 wt. %; and-an edible salt having a water solubility at 37° C. and a pH of 7.0 of less than 1 mg/ml and a water solubility at 37° C. and a pH of 2.0 of at least 5 mg/ml; The microencapsulate of the present invention does not release the encapsulated active component when incorporated in water-containing foodstuffs, beverages, nutritional compositions or pharmaceutical compositions. Following ingestion, however, the active component is released rapidly.
摘要翻译：本发明涉及一种包含直径为0.1〜25μm的微胶囊的微胶囊，所述微胶囊包含： - 直径为90nm〜23μm的核心颗粒，其含有至少3重量％的活性组分核心颗粒; 和 - 完全包封核心颗粒并含有至少20wt。选自纤维素醚，纤维素酯，玉米醇溶蛋白，虫胶，麸质，聚丙交酯，疏水性淀粉衍生物，聚乙酸乙烯酯聚合物，衍生自丙烯酸酯和/或甲基丙烯酸酯的聚合物或共聚物的疏水性聚合物的％和其组合; 其中所述核心颗粒包含释放触发组分和/或所述涂层含有释放触发组分，所述释放触发组分选自： - 具有37℃的吸水能力和pH7.0以下的水溶胀性聚合物超过20wt。％，在37℃和pH 2.0下的吸水能力至少为50wt。％; 和 - 在37℃下具有水溶性，pH7.0小于1mg / ml，水溶性在37℃，pH为2.0的至少5mg / ml的食用盐; 当掺入含水食品，饮料，营养组合物或药物组合物中时，本发明的微胶囊剂不会释放包封的活性成分。然而，摄入后，活性成分迅速释放。

30. 发明公开

EP2298285A2 Method of making particles for use in a pharmaceutical composition 审中-公开
标题翻译： HerstellungsverfahrenfürPartikel zur Verwendung in einer Arzneizusammensetzung
公开(公告)号：EP2298285A2
公开(公告)日：2011-03-23
申请号：EP10183504.9
申请日：2001-11-30
申请人： Vectura Limited
发明人： Staniforth, John Nicholas , Harris, Haggis , Morton, David Alexander Vodden , Bannister, Robin
IPC分类号： A61K9/14 , A61K9/72 , A61K9/00
CPC分类号： A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
摘要： The invention provides microparticles for use in a pharmaceutical composition for pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.
摘要翻译：本发明提供了用于肺部给药的药物组合物中的微粒，每个微粒包含活性物质的颗粒，其表面上具有适于延迟活性物质溶解的疏水性材料的颗粒。本发明还提供了制备微粒的方法。

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