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21. 发明公开

EP3037107A1 POLYMER NANOPARTICLE COMPOSITE AND COMPOSITION FOR MRI IMAGING INCLUDING SAME 有权
标题翻译：聚合物纳米颗粒复合物和组合物用于MRI成像为了
公开(公告)号：EP3037107A1
公开(公告)日：2016-06-29
申请号：EP14837292.3
申请日：2014-08-22
申请人： The University of Tokyo
发明人： KATAOKA, Kazunori , NISHIYAMA, Nobuhiro , CABRAL, Horacio , MI, Peng , KISHIMURA, Akihiro , MIURA, Yutaka , AOKI, Ichio , KOKURYO, Daisuke , SAGA, Tsuneo
IPC分类号： A61K49/00
CPC分类号： A61K49/1872 , A61K9/14 , A61K9/143 , A61K49/128 , A61K49/1818 , A61K49/1824 , A61K49/1851 , A61K49/1866 , C08K3/32
摘要： The present invention provides a safe polymer nanoparticle composite with few side effects, and an MRI contrast agent incorporating said polymer nanoparticle composite. The polymer nanoparticle composite is capable of specifically accumulating on a tumor tissue to selectively extract the tissue, exhibiting high contrast even when used in small amounts, and enabling imaging over prolonged periods of time. This polymer nanoparticle composite is characterized by containing a block copolymer that includes a non-charged hydrophilic polymer chain segment and an anionic polymer chain segment, and MnCaP.

22. 发明公开

EP3009512A1 TARGETING APTAMER FOR ATHEROSCLEROSIS AND PREPARATION METHOD AND APPLICATION THEREOF 有权
标题翻译：有针对性的适体动脉粥样硬化方法及用途
公开(公告)号：EP3009512A1
公开(公告)日：2016-04-20
申请号：EP13886916.9
申请日：2013-10-14
申请人： Guangzhou Tongpeng Zhongxu Pharmaceutical Co., Ltd.
发明人： Guangzhou Tongpeng Zhongxu Pharmaceutical Co., Ltd.
IPC分类号： C12N15/115 , C12Q1/68 , A61K49/12 , G01N24/08
CPC分类号： A61K49/1848 , A61K49/085 , A61K49/1851 , A61K49/1857 , C12N15/115 , C12N2310/16 , G01R33/5601
摘要： Disclosed are a targeting aptamer for atherosclerosis and a preparation method and application thereof. The targeting aptamer is a targeting aptamer fragment for atherosclerosis obtained through screening of macrophage-derived foam cells together with reverse screening of smooth muscle cells, endothelial cells, and THP-1 cells using a SELEX method; and the use of the targeting aptamer in preparation of an MRI targeting nano-contrast agent for atherosclerosis allows the specific binding of the MRI targeting nano-contrast agent for atherosclerosis only with the macrophage-derived foam cells, and allows high specific binding thereof with vascular tissues with AS lesion, thus improving targeting effect of the MRI targeting nano-contrast agent for atherosclerosis and realizing early specific diagnosis of arterial sclerosis.

23. 发明公开

EP2755692A4 NANOCONJUGATES ABLE TO CROSS THE BLOOD-BRAIN BARRIER 有权转让
标题翻译：纳米缀FOR通过血 - 脑屏障
公开(公告)号：EP2755692A4
公开(公告)日：2015-05-27
申请号：EP12831067
申请日：2012-09-14
申请人： UNIV NORTH WESTERN
发明人： MIRKIN CHAD A , KO CAROLINE H , STEGH ALEXANDER , GILJOHANN DAVID A , LUCIANO JANINA , JENSEN SAM
IPC分类号： A61K47/48 , A61K49/18 , A61P25/00 , A61P35/00 , C12N15/113
CPC分类号： A61K47/48861 , A61K47/6923 , A61K47/6929 , A61K49/1851 , C12N15/113 , C12N2310/14 , C12N2320/32 , C12N2320/35
摘要： The present disclosure is directed to nanoconjugates that cross the blood-brain barrier and methods of their therapeutic use.

24. 发明公开

EP2671570A4 MAGNETIC NANOPARTICLE, HAVING A CURIE TEMPERATURE WHICH IS WITHIN BIOCOMPATIBLE TEMPERATURE RANGE, AND METHOD FOR PREPARING SAME 有权转让
标题翻译：为具有居里温度内的生物相容性温度范围及其制造方法的磁性纳米粒子
公开(公告)号：EP2671570A4
公开(公告)日：2015-05-27
申请号：EP12741665
申请日：2012-01-31
申请人： UNIV KOREA RES & BUS FOUND
发明人： KIM YOUNG KEUN , WU JUN HUA , MIN JI HYUN , LEE JI-SUNG , JUNG JAE-HO
IPC分类号： A61K9/16 , A61K47/02 , A61K47/48 , A61K49/08
CPC分类号： G01N27/72 , A61K49/1827 , A61K49/1851 , A61K49/1866 , A61K49/1875 , C01G45/12 , C01P2002/72 , C01P2002/85 , C01P2004/04 , C01P2004/62 , C01P2004/64 , C01P2006/42 , G01N33/587
摘要： The present invention relates to a magnetic nanoparticle having a Curie temperature which is within a biocompatible temperature range, a method for preparing same, and a nanocomposite and a target substance detection composition comprising the magnetic nanoparticle. As the magnetic nanoparticle of the present invention has a Curie temperature within the temperature range of 0 degrees centigrade to 41 degrees centigrade, the ferromagnetic and paramagnetic properties of the magnetic nanoparticle may be controlled within a biocompatible temperature range at a temperature at which a biological control agent is not destroyed, and the temperature of the magnetic nanoparticle is adjusted to control the magnetic properties thereof such that the properties of the magnetic nanoparticle may be used only when ferromagnetic properties are required, such as in the case of signal amplification in detecting, separating, and delivering biological control agents. Accordingly, the magnetic nanoparticle of the present invention can minimize adverse effects of ferromagnetic properties thereof, and can be used in the effective detection and separation of biological control agents.
摘要翻译：本发明涉及一种具有一个居里温度所有这些是生物相容的温度范围内，其制备方法，以及纳米复合材料和目标物质的检测组合物，包含磁性纳米粒子的磁性纳米颗粒。作为本发明的磁性纳米颗粒具有的温度范围为0摄氏度至41摄氏度范围内的居里温度时，磁性纳米颗粒的铁磁和顺磁性质可以生物相容性的温度范围内的温度下控制在哪一种生物控制剂不被破坏，和磁性纳米颗粒的温度被调整，以控制磁特性及其检查没有磁性纳米粒子的性质可以仅当铁磁性质是必需的，：如在检测信号放大的情况下被使用，分离，并提供生物控制剂。因此，本发明的磁性纳米粒子可以最小化铁磁性能的不利影响，以及它们的可生物控制剂的有效检测和分离中使用。

25. 发明公开

EP2755692A1 NANOCONJUGATES ABLE TO CROSS THE BLOOD-BRAIN BARRIER 有权转让
标题翻译：纳米缀FOR通过血 - 脑屏障
公开(公告)号：EP2755692A1
公开(公告)日：2014-07-23
申请号：EP12831067.9
申请日：2012-09-14
申请人： North Western University
发明人： MIRKIN, Chad, A. , KO, Caroline, H. , STEGH, Alexander , GILJOHANN, David, A. , LUCIANO, Janina , JENSEN, Sam
IPC分类号： A61K47/48
CPC分类号： A61K47/6923 , A61K47/6929 , A61K49/1851 , C12N15/113 , C12N2310/14 , C12N2320/32 , C12N2320/35
摘要： The present disclosure is directed to nanoconjugates that cross the blood-brain barrier and methods of their therapeutic use.

26. 发明公开

EP2671570A2 MAGNETIC NANOPARTICLE, HAVING A CURIE TEMPERATURE WHICH IS WITHIN BIOCOMPATIBLE TEMPERATURE RANGE, AND METHOD FOR PREPARING SAME 有权转让
标题翻译：为具有居里温度内的生物相容性温度范围及其制造方法的磁性纳米粒子
公开(公告)号：EP2671570A2
公开(公告)日：2013-12-11
申请号：EP12741665.9
申请日：2012-01-31
申请人： Korea University Research and Business Foundation
发明人： KIM, Young Keun , WU, Jun Hua , MIN, Ji Hyun , LEE, Ji-Sung , JUNG, Jae-Ho
IPC分类号： A61K9/16 , A61K47/48 , A61K47/02 , A61K49/08
CPC分类号： G01N27/72 , A61K49/1827 , A61K49/1851 , A61K49/1866 , A61K49/1875 , C01G45/12 , C01P2002/72 , C01P2002/85 , C01P2004/04 , C01P2004/62 , C01P2004/64 , C01P2006/42 , G01N33/587
摘要： The present invention relates to a magnetic nanoparticle having a Curie temperature which is within a biocompatible temperature range, a method for preparing same, and a nanocomposite and a target substance detection composition comprising the magnetic nanoparticle. As the magnetic nanoparticle of the present invention has a Curie temperature within the temperature range of 0 degrees centigrade to 41 degrees centigrade, the ferromagnetic and paramagnetic properties of the magnetic nanoparticle may be controlled within a biocompatible temperature range at a temperature at which a biological control agent is not destroyed, and the temperature of the magnetic nanoparticle is adjusted to control the magnetic properties thereof such that the properties of the magnetic nanoparticle may be used only when ferromagnetic properties are required, such as in the case of signal amplification in detecting, separating, and delivering biological control agents. Accordingly, the magnetic nanoparticle of the present invention can minimize adverse effects of ferromagnetic properties thereof, and can be used in the effective detection and separation of biological control agents.

27. 发明公开

EP2621852A2 IRON OXIDE NANOCAPSULE, METHOD OF MANUFACTURING THE SAME, AND MRI CONTRAST AGENT USING THE SAME 审中-公开
标题翻译：氧化铁纳米胶囊，方法以生产和MRI造影剂
公开(公告)号：EP2621852A2
公开(公告)日：2013-08-07
申请号：EP11822141.5
申请日：2011-08-31
申请人： Hanwha Chemical Corporation
发明人： KWON, Eun Byul , JEON, Bong-Sik , KIM, Eung Gyu , PARK, Ju Young , MYEONG, Wan Jae
IPC分类号： B82B3/00 , A61K49/06
CPC分类号： A61K49/1863 , A61K49/12 , A61K49/126 , A61K49/128 , A61K49/1818 , A61K49/1827 , A61K49/1851 , B01J13/06 , B82Y5/00
摘要： Provided is an iron oxide nanocapsule which has extremely excellent water dispersibility, which is very stable in the body and which has very excellent MR I contrast ability, a method of manufacturing the same, and an MRI contrast agent using the same. The method of manufacturing the iron oxide nanocapsule includes the steps of: thermally decomposing an iron complex to prepare hydrophobic ligand-bonded iron oxide nanoparticles; and encapsulating the hydrophobic ligand-bonded iron oxide nanoparticles by a carboxymethyldextrandodecylamine conjugate encapsulation material or a dextran-linoleic acid conjugate encapsulation material to form an iron oxide nanocapsule.

28. 发明授权

EP2184262B1 PROCESS FOR PRODUCTION OF SURFACE-COATED INORGANIC PARTICLES 有权
标题翻译：用于生产表面被覆无机颗粒
公开(公告)号：EP2184262B1
公开(公告)日：2012-12-26
申请号：EP08791605.2
申请日：2008-07-25
申请人： Tokyo Institute of Technology
发明人： HANDA, Hiroshi , HATAKEYAMA, Mamoru , ABE, Masanori , SAKAMOTO, Satoshi , MASAIKE, Yuka , NISHIO, Kosuke , KITA, Yoshinori , KISHI, Hiroshi
IPC分类号： C01G49/00 , A61K49/00 , B22F1/02 , H01F1/20 , H01F1/34 , H01F1/36
CPC分类号： H01F1/0045 , A61K41/0052 , A61K49/183 , A61K49/1833 , A61K49/1836 , A61K49/1851 , A61K49/1854 , B22F1/0022 , B22F1/0062 , B82Y25/00 , B82Y30/00 , C01G49/00 , C01P2006/42 , C09C1/24 , C09C3/08 , C09C3/10 , C09C3/12 , G01N33/53 , G01N33/54393 , H01F1/0054

29. 发明公开

EP2184262A4 PROCESS FOR PRODUCTION OF SURFACE-COATED INORGANIC PARTICLES 有权
标题翻译：用于生产表面被覆无机颗粒
公开(公告)号：EP2184262A4
公开(公告)日：2011-12-14
申请号：EP08791605
申请日：2008-07-25
申请人： TOKYO INST TECH
发明人： HANDA HIROSHI , HATAKEYAMA MAMORU , ABE MASANORI , SAKAMOTO SATOSHI , MASAIKE YUKA , NISHIO KOSUKE , KITA YOSHINORI , KISHI HIROSHI
IPC分类号： C01G49/00 , A61K49/00 , B22F1/02 , H01F1/20 , H01F1/34 , H01F1/36
CPC分类号： H01F1/0045 , A61K41/0052 , A61K49/183 , A61K49/1833 , A61K49/1836 , A61K49/1851 , A61K49/1854 , B22F1/0022 , B22F1/0062 , B82Y25/00 , B82Y30/00 , C01G49/00 , C01P2006/42 , C09C1/24 , C09C3/08 , C09C3/10 , C09C3/12 , G01N33/53 , G01N33/54393 , H01F1/0054

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