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21. 发明授权

EP1087695B1 ELECTRODE FOR MEASURING ELECTROPHYSIOLOGICAL SIGNALS USING LIQUID ELECTROLYTIC GEL WITH A HIGH SALT CONCENTRATION 有权
标题翻译：电极用于测量使用电解质天使电生理信号具有高盐浓度
公开(公告)号：EP1087695B1
公开(公告)日：2005-02-09
申请号：EP99928804.6
申请日：1999-06-18
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： CORDERO, Rafael, M. , DEVLIN, Philip, H.
IPC分类号： A61B5/0408
CPC分类号： A61B5/04085 , A61B5/04087 , A61B5/0416 , A61B2562/0215
摘要： An electrophysiological electrode includes multiple layers of materials to isolate liquid electrolytic gels (39) from the conductive inks (13) on the flexible circuit (15) of the electrode substrate (14). Such an electrode has a much longer shelf life under normal storage conditions than other electrodes of such construction with high salt content liquid electrolytic gel, and is able to maintain acceptable impedance upon its eventual use.

22. 发明公开

EP1489964A1 SYSTEM AND METHOD OF ASSESSMENT OF AROUSAL, PAIN AND STRESS DURING ANESTHESIA AND SEDATION 审中-公开
标题翻译：方法蜡条件，疼痛和压力水平在麻醉过程中评估
公开(公告)号：EP1489964A1
公开(公告)日：2004-12-29
申请号：EP03746093.8
申请日：2003-04-01
申请人： Aspect Medical Systems, Inc.
发明人： DAHAN, Albert , GREENWALD, Scott, D.
IPC分类号： A61B5/0285
CPC分类号： A61B5/4821 , A61B5/02125 , A61B5/02416 , A61B5/0285 , A61B5/0452 , A61B5/0456 , A61B5/1106
摘要： A PTT (Pulse Transit Time) monitoring system for measuring arousal and responses to stress or pain during sedation or anesthesia includes ECG electrodes and a PPG (photo plethysmography) probe connected to a computer via signal conditioning and digitizing hardware. The ECG and PPG waveforms are continuously analyzed to update and display a current estimate of the subject's PPT from heart to hand. For each cardiac cycle, fiducial points are identified to indicate the pulse onset time (via QRS detection in the ECG) and pulse arrival time (via the point of steepest ascent in the PPG). Finally, the current PTT estimate is displayed numerically and the trend of PTT is updated every second. Clinicians may interpret the instantaneous PTT value directly or in context of its recent trend. If there is a rapid decrease in PTT much less than the predetermined baseline value when the patient should be unconscious and free of stress and pain, then supplemental analgesics are administered to bring PTT greater than or equal to such baseline value.

23. 发明公开

EP1087695A1 ELECTRODE FOR MEASURING ELECTROPHYSIOLOGICAL SIGNALS USING LIQUID ELECTROLYTIC GEL WITH A HIGH SALT CONCENTRATION 有权
标题翻译：电极用于测量使用电解质天使电生理信号具有高盐浓度
公开(公告)号：EP1087695A1
公开(公告)日：2001-04-04
申请号：EP99928804.6
申请日：1999-06-18
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： CORDERO, Rafael, M. , DEVLIN, Philip, H.
IPC分类号： A61B5/0408
CPC分类号： A61B5/04085 , A61B5/04087 , A61B5/0416 , A61B2562/0215
摘要： An electrophysiological electrode includes multiple layers of materials to isolate liquid electrolytic gels (39) from the conductive inks (13) on the flexible circuit (15) of the electrode substrate (14). Such an electrode has a much longer shelf life under normal storage conditions than other electrodes of such construction with high salt content liquid electrolytic gel, and is able to maintain acceptable impedance upon its eventual use.

24. 发明公开

EP0971628A1 SYSTEM AND METHOD FOR ENHANCING AND SEPARATING BIOPOTENTIAL SIGNALS 有权
标题翻译：系统和方法加强和生物电位信号的分离
公开(公告)号：EP0971628A1
公开(公告)日：2000-01-19
申请号：EP99903375.6
申请日：1999-01-25
申请人： Aspect Medical Systems, Inc.
发明人： GREENWALD, Scott, D. , DEVLIN, Philip, H. , SMITH, Charles, P.
IPC分类号： A61B5/0496 , A61B5/0478
CPC分类号： A61B5/0496 , A61B5/0478 , A61B5/7257
摘要： Disclosed is an electrode array (i.e., 'sensor') and a method for separating near and far-field signals. In one embodiment a horizontal array is used, and in an alternate embodiment a vertical array is used. The electrode array consists of two well-separated pairs of closely spaced electrodes (and a separate ground element). In a typical application of collecting a channel of EEG, 'sensing' electrodes are placed in standard locations (e.g., R and Ctr) with a ground electrode placed elsewhere on the head. The voltage measured between the well-separated sensing electrodes is the far-field dominant (i.e., EEG-dominant) channel. Additional electrodes are placed near each of the two sensing electrodes. (The additional electrodes are immediately lateral to the existing electrodes in the horizontal array, and are immediately above the existing electrodes in the vertical array.) The voltages measured between the pairs of closely spaced electrodes are near-field dominant (i.e., EMG/EOG-dominant) channels. The EEG, EMG and EOG signals can be enhanced by uncoupling them by combining information from all channels. The sensor is connected to a monitor via a patient interface cable (PIC). The sensor contains additional circuitry at the connection site that is used by the monitor to identify the presence and type of sensor, and to configure the monitor to invoke the appropriate software that will apply the method of the current invention to collect and uncouple the EEG, EMG and EOG.

25. 发明授权

EP1460933B1 SYSTEM AND METHOD OF ASSESSMENT OF MOOD DISORDERS USING EEG 有权
标题翻译：系统和方法符合条件的精神障碍脑电图使用
公开(公告)号：EP1460933B1
公开(公告)日：2008-12-17
申请号：EP03703709.0
申请日：2003-01-06
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： GREENWALD, Scott, D. , SMITH, Charles, P. , SIGL, Jeffrey, C. , DEVLIN, Philip, H.
IPC分类号： A61B5/048
CPC分类号： A61B5/4839 , A61B5/048 , A61B5/16 , A61B5/4088 , G06K9/00523
摘要： The present invention is a system and method that produces features and indices that indicate the presence or absence of a disease or condition, or of the progression of a disease or condition. The system and method of the present invention also produce features and indices that predict responsiveness to medication from a premedication baseline. The system and method of the present invention further incorporates a testing methodology to improve the performance characteristics of the features or indices. To obtain such features and indices, time domain, power spectrum, bispectrum and higher order spectrum values are derived from biopotential signals taken from the subject being tested.

26. 发明授权

EP1182965B1 A SMART ELECTROPHYSIOLOGICAL SENSOR SYSTEM WITH AUTOMATIC AUTHENTICATION AND VALIDATION 有权
标题翻译：具有真实性和验证智能ELECTRO生理传感器系统
公开(公告)号：EP1182965B1
公开(公告)日：2008-04-02
申请号：EP00970431.3
申请日：2000-06-09
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： CORDERO, Rafael, M. , DEVLIN, Philip, H. , CHAMOUN, Nassib, G. , SHAMBROOM, John, R. , MERRICK, Edwin, B. , MELO, Joao
IPC分类号： A61B5/0408 , A61B5/0428
CPC分类号： A61B5/04085 , A61B5/04286 , A61B2560/028 , A61B2562/08 , G06F19/00
摘要： A sensor system which includes a biopotential signal monitor, a smart sensor and the accompanying hardware and software interface which authenticates the source and validity of the smart sensor and also verifies that the smart sensor meets various criteria for use.

27. 发明公开

EP0957761A1 SYSTEM FOR THE EXTRACTION OF CARDIAC ARTIFACTS FROM EEG SIGNALS 失效
标题翻译：设备技术分离干扰心脏脑电信号
公开(公告)号：EP0957761A1
公开(公告)日：1999-11-24
申请号：EP97952570.0
申请日：1997-12-19
申请人： Aspect Medical Systems, Inc.
发明人： GREENWALD, Scott, D. , SMITH, Charles, P.
IPC分类号： A61B5
CPC分类号： A61B5/0476 , A61B5/7217
摘要： The disclosed filter (120) removes cardiac artifacts (310) from signals representative of a patient's cerebral activity. The filter preferably replaces portions of the signal including artifacts with temporally adjacent artifact free portions.

28. 发明公开

EP0898234A1 Method and system for generating a diagnostic index 失效
标题翻译： Verfahren und System zur Generierung eines diagnisechen Indexes
公开(公告)号：EP0898234A1
公开(公告)日：1999-02-24
申请号：EP98118100.1
申请日：1992-10-23
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： Chamoun, Nassib G. , Mead, Peter A. , Chiang Hsing-Hsing , Saini, Vikas
IPC分类号： G06F17/00
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/16 , A61B5/725 , A61B5/7253 , A61B5/7257 , G06F19/00 , G16H15/00
摘要： A method of generating a diagnostic index for quantifying the presence or absence of a phenomena which is represented by spectral values generated from acquired electrical signals of the phenomena, comprises the steps of:

sorting said spectral values into predetermined bins of ranges of spectral values;
summing all of the spectral values in each bin;
multiplying the sum of spectral values in each bin by a predetermined coefficient to obtain a bin product;
summing said bin products to obtain a diagnostic index which represents a degree of presence or absence of said phenomena.
摘要翻译：产生用于量化由所获取的现象的电信号产生的光谱值表示的现象的存在或不存在的诊断索引的方法包括以下步骤：将所述光谱值分类为光谱值范围的预定的分区; 求和每个仓中的所有光谱值; 将每个仓中的频谱值的总和乘以预定系数以获得仓积; 对所述仓库产品进行总结以获得代表所述现象的存在或不存在程度的诊断指标。

29. 发明授权

EP0489010B1 CARDIAC BIOPOTENTIAL ANALYSIS SYSTEM AND METHOD 失效
标题翻译：心脏生物分析系统与方法
公开(公告)号：EP0489010B1
公开(公告)日：1998-11-18
申请号：EP90905061.9
申请日：1990-03-13
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： CHAMOUN, Nassib, G.
IPC分类号： G06F17/18
CPC分类号： A61B5/044 , A61B5/0452 , A61B5/04525 , A61B5/0464 , A61B5/413 , A61B5/7257 , A61B5/7275 , G06F19/00
摘要： Disclosed is a cardiac biopotential analysis system and method for detecting and quantifying in a noninvasive manner nonlinear dynamic patterns of depolarization and repolarization on a beat to beat basis in real time using bispectral analysis. A suitable body surface electrode acquires the signal from a region of interest. The signal is then amplified, digitized, and transmitted to a host microcomputer where an arrhythmia-free QRST complex is chosen interactively. Using standard cross-correlation methods a suitable number of complexes are extracted from the record. The extracted complexes are used to compute bispectral parameters using a frequency domain or a parametric based approach. A reference clinical database is used to identify frequency pairs most sensitive to particular interventions or diagnostic states of interest. The values at these frequency pairs are then extracted from the patient's bispectral arrays. The ensemble of values for the particular diagnostic determination under consideration is used to compute a single value index which serves as the diagnostic criterion by which the patient's state is judged. In this way the quantification of nonlinear dynamic properties of the frequency structure of the QRST yields information about the presence and extent of coronary artery disease (CAD), myocardial ischemia, cardiac electrical stability, risk of malignant ventricular arrhydthmia, site(s) of origin of malignant arrhythmias, extent of malignancy of arrhythmias, degree of antiarrhythmic drug efficacy, neural and humoral inputs to the heart, pump function/ejection fraction, and ongoing organ rejection in cardiac transplant patients.

30. 发明公开

EP0738496A1 Monitor and method for acquiring and processing electrical signals to bodily functions 失效
标题翻译：活体的装置和用于获得方法和处理信号
公开(公告)号：EP0738496A1
公开(公告)日：1996-10-23
申请号：EP96110142.5
申请日：1993-10-13
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： Shambroom, John R.
IPC分类号： A61B5/00 , A61B5/0424 , A61B5/048
CPC分类号： A61B5/6843 , A61B5/0006 , A61B5/0476 , A61B5/7217 , G06F19/00 , G16H40/63 , Y10S128/901 , Y10S128/902
摘要： An EEG monitor utilizes a portable acquisition module (14) and a substantially stationary processing module (12). The EEG signals are acquired and converted to an oversampled stream of digital signals by a sigma-delta modulator (64) located in the data acquisition module. The signals are then filtered by a decimation filter (62) located in the processing module. Additional means are also provided to monitor the electrode leads to detect when the leads become unplugged. The monitor provides all power to the data acquisition module over a single twisted line (82) which transmits data as well.
摘要翻译：的EEG监测器模块利用便携式采集（14）和一个固定的基本处理模块（12）。的EEG信号被采集并且通过位于数据采集模块中的Σ-Δ调制器（64）在数字信号的过采样流转换为。该信号然后由位于在处理模块中的抽取滤波器（62）进行过滤。因此，提供附加的装置来监测电极引线以检测当引线成为拔出。显示器提供通过一根双绞线线（82）透射数据以及所有电源给数据采集模块。

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