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21. 发明公开

EP1080209A2 METHODS OF TREATMENT OF TYPE 2 DIABETES 审中-公开
标题翻译： METHODS FOR 2型糖尿病的治疗
公开(公告)号：EP1080209A2
公开(公告)日：2001-03-07
申请号：EP99970689.8
申请日：1999-10-21
申请人： Arch Development Corporation , Board of Regents,The University of Texas System
发明人： POLONSKY, Kenneth, S. , HORIKAWA, Yukio , ODA, Naohisa , SREENAN, Seamus , ZHOU, Yun-Ping , OTANI, Kenichi , HANIS, Craig, L. , BELL, Graeme, Ian , COX, Nancy, J.,University of Chicago
IPC分类号： C12N15/63 , C12N9/64 , C12Q1/68 , A61K38/55
CPC分类号： C12N9/6472 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates generally to the field of diabetes. More particularly, it concerns the identification of genes responsible for NIDDM1 for use in diagnostic and therapeutic applications. The present invention demonstrates that the NIDDM1 locus is, in fact, the calpain 10 gene. The invention further relates to the discovery that analysis of mutations in calpain genes and gene products can be diagnostic for type 2 diabetes. The invention also contemplates methods of treating diabetes in view of the fact that calpain mutations can cause diabetes. Further, the invention relates to novel polynucleotides of the NIDDM1 locus and polypeptides encoded by such polynucleotides.

22. 发明公开

EP1054890A1 OLIGODEOXYRIBONUCLEOTIDES COMPRISING O6-BENZYLGUANINE AND THEIR USE 有权
标题翻译： O6苄基鸟嘌呤寡脱氧核糖核苷酸含及其用途
公开(公告)号：EP1054890A1
公开(公告)日：2000-11-29
申请号：EP99906925.5
申请日：1999-02-12
申请人： THE UNITED STATES OF AMERICA,as represented by THE SECRETARY, Department of Health and Human Services , ARCH DEVELOPMENT CORPORATION , THE PENN STATE RESEARCH FOUNDATION
发明人： MOSCHEL, Robert, C. , PAULY, Gary, T. , PEGG, Anthony, E. , DOLAN, M., Eileen
IPC分类号： C07H21/00 , C07H21/04 , A61K31/70
CPC分类号： C07H21/00
摘要： The present invention provides a single-stranded oligodeoxyribonucleotide, which (i) comprises from about 5 to 11 bases, at least one of which is a substituted or an unsubstituted O6-benzylguanine, and (ii) inactivates human AGT. The present invention also provides a single-stranded oligodeoxyribonucleotide, which can inactivate a mutant human AGT, which either is not inactivated by O6-benzylguanine or is less inactivated by O6-benzylguanine than by said single-stranded oligodeoxyribonucleotide. A phosphate of the single-stranded oligodeoxyribonucleotide can be replaced by a methylphosphonate or a phosphorothioate. The present invention also provides a composition comprising such an oligodeoxyribonucleotide. In addition, the present invention provides a method of enhancing the effect of an antineoplastic alkylating agent, which alkylates the O6 position of guanine residues in DNA, in the chemotherapeutic treatment of cancer in a mammal, which method comprises the co-administration to the mammal of a cancer-treatment effective amount of an antineoplastic alkylating agent and a chemotherapeutic treatment-enhancing amount of a present inventive oligodeoxyribonucleotide or composition thereof.

23. 发明公开

EP1053492A1 APPARATUS FOR APPLYING OPTICAL GRADIENT FORCES 有权
标题翻译：装置生产光学梯度力
公开(公告)号：EP1053492A1
公开(公告)日：2000-11-22
申请号：EP99904575.0
申请日：1999-02-03
申请人： Arch Development Corporation
发明人： GRIER, David, G. , DUFRESNE, Eric, R.
IPC分类号： G02B5/18 , G02B5/32 , G02B27/44 , H05H3/04
CPC分类号： H05H3/04 , G02B5/18 , G02B21/32 , G02B27/1086 , G02B27/1093 , Y10S359/90
摘要： An apparatus and method for manipulating small dielectric particles. The apparatus and method involves use of a diffractive optical element (40) which receives a laser beam and forms a plurality of light beams. These light beams are operated on by a telescope lens system (34) and then an objective lens element (20) to create an array of optical traps (50) for manipulating small dielectric particles.

24. 发明公开

EP1025535A1 COMPUTERIZED DETECTION OF LUNG NODULES USING ENERGY-SUBTRACTED SOFT-TISSUE AND STANDARD CHEST IMAGES 审中-公开
标题翻译： LUNGENNODULEN计算机化检测中减去软组织和乳腺标准
公开(公告)号：EP1025535A1
公开(公告)日：2000-08-09
申请号：EP99933560.7
申请日：1999-07-21
申请人： Arch Development Corporation
发明人： XU, Xin-Wei , DOI, Kunio , MACMAHON, Heber
IPC分类号： G06K9/00
CPC分类号： G06T7/0012
摘要： A method, system and computer readable medium configured for computerized detection of lung abnormalities, including obtaining a standard digital chest image (10) and a soft-tissue digital chest image; generating a first difference image from the standard digital chest image (20) and a second difference image from the soft-tissue digital chest image; identifying candidate abnormalities in the first and second difference images; extracting from the standard digital chest image and the first difference image predetermined first features of each of the candidate abnormalities identified in the first difference image; extracting from the soft-tissue digital chest image and the second difference images predetermined second features of each of the candidate abnormalities identified in the second difference image; analyzing the extracted first features and the extracted second features to identify and eliminate false positive candidate abnormalities respectively corresponding thereto; applying extracted features from remaining candidate abnormalities derived respectively from the first and second difference images and remaining after the elimination of the false positive candidate abnormalities to respective artificial neural networks to eliminate further false positive candidate abnormalities by performing a logical OR operation of the candidate abnormalities derived respectively from the first and second difference images.

25. 发明公开

EP1019524A2 METHOD FOR IDENTIFYING INDUCERS AND INHIBITORS OF PROGRAMMED CELL DEATH 失效
标题翻译：一种用于识别电感和程序性细胞死亡的抑制剂
公开(公告)号：EP1019524A2
公开(公告)日：2000-07-19
申请号：EP98903847.6
申请日：1998-01-30
申请人： ARCH DEVELOPMENT CORPORATION
发明人： ROIZMAN, Bernard , BIN, He
IPC分类号： C12Q1/00
CPC分类号： C12Q1/42 , G01N2333/912 , G01N2333/916
摘要： Methods for identifying inducers and inhibitors of programmed cell death in a cell-free system are described. The methods exploit the finding that programmed cell death is accompanied by shutdown of cellular protein synthesis and by phosphorylation of eIF-2α and that the dephosphorylation of eIF-2α prevents the shutdown of protein synthesis.

26. 发明公开

EP0993269A2 METHODS FOR IMPROVING THE ACCURACY IN DIFFERENTIAL DIAGNOSIS ON RADIOLOGIC EXAMINATIONS 失效
标题翻译：方法以提高在放射性检查鉴别诊断准确性
公开(公告)号：EP0993269A2
公开(公告)日：2000-04-19
申请号：EP98936974.9
申请日：1998-07-24
申请人： Arch Development Corporation
发明人： NISHIKAWA, Robert, M. , JIANG, Yulei , ASHIZAWA, Kazuto , DOI, Kunio
IPC分类号： A61B5/05
CPC分类号： G06T7/0012 , G06F19/00 , Y10S128/925
摘要： A computer-aided method for detecting, classifying, and displaying candidate abnormalities, such as microcalcifications and interstitial lung disease in digitized medical images, such as mammograms and chest radiographs, a computer programmed to implement the method, and a data structure for storing required parameters, wherein in the classifying method candidate abnormalities in a digitized medical image are located, regions are generated around one or more of the located candidate abnormalities, features are extracted from at least one of the located candidate abnormalities within the region and from the region itself, the extracted features are applied to a classification technique, such as an artificial neural network (ANN) to produce a classification result (i.e., probability of malignancy in the form of a number and a bar graph), and the classification result is displayed along with the digitized medical image annotated with the region and the candidate abnormalities within the region. In the detecting method candidate abnormalities in each of a plurality of digitized medical images are located, regions around one or more of the located candidate abnormalities in each of a plurality of digitized medical images are generated, the plurality of digitized medical images annotated with respective regions and candidate abnormalities within the regions are displayed, and a first indicator (e.g., blue arrow) is superimposed over candidate abnormalities comprising of clusters and a second indicator (e.g., red arrow) is superimposed over candidate abnormalities comprising of masses. In a user modification mode, during classification, a user modifies the located candidate abnormalities, the determined regions, and/or the extracted features, so as to modify the extracted features applied to the classification technique and the displayed results, and, during detection, a user modifies the located candidate abnormalities, the determined regions, and the extracted features, so as to modify the displayed results.

27. 发明公开

EP0979513A1 PROCESS AND APPARATUS FOR THE PRODUCTION OF Bi-212 AND A USE THEREOF 失效
标题翻译：方法和装置碧-212及其使用EREUGUNG
公开(公告)号：EP0979513A1
公开(公告)日：2000-02-16
申请号：EP97940622.0
申请日：1997-08-26
申请人： ARCH DEVELOPMENT CORPORATION
发明人： ROTMENSCH, Jacob , WHITLOCK, Jenny, L. , HINES, John, J. , HARPER, Paul, V.
IPC分类号： G21G1/00 , B01D59/00
CPC分类号： G21G1/001 , A61K51/1282 , G21G1/0005 , G21G2001/0084
摘要： A process for producing substantially radio-impurity-free Bi-212 is disclosed. An acidic feed solution containing Pb-212 is contacted with an extraction medium to bind the Pb-212 thereto. The extraction medium is rinsed with a second acid solution to remove impurities therefrom, leaving a substantially impurity-free Pb-212-laden extraction medium. The Pb-212 grows on the extraction medium to form Bi-212 by radioactive decay. The Bi-212 is then eluted from the extraction medium with an acid solution to form a substantially radio-impurity-free Bi-212 acid solution. An apparatus for carrying out this process and a process for the therapeutic use thereof are also disclosed.

28. 发明授权

EP0746855B1 SYSTEM FOR MONITORING AN INDUSTRIAL PROCESS AND DETERMINING SENSOR STATUS 失效
标题翻译：监测系统的传感器态的一种工业法确定
公开(公告)号：EP0746855B1
公开(公告)日：1999-06-23
申请号：EP94918170.5
申请日：1994-05-27
申请人： ARCH DEVELOPMENT CORPORATION
发明人： GROSS, Kenneth, C. , HOYER, Kristin, K. , HUMENIK, Keith, E.
IPC分类号： G21C7/36 , G06G7/19
CPC分类号： G21C17/00 , G05B9/03 , Y10S706/914

29. 发明公开

EP0917577A2 HERPES SIMPLEX VIRUS ICP4 IS AN INHIBITOR OF APOPTOSIS 失效
标题翻译：单纯疱疹病毒作为凋亡抑制ICP4
公开(公告)号：EP0917577A2
公开(公告)日：1999-05-26
申请号：EP97935080.0
申请日：1997-07-23
申请人： ARCH DEVELOPMENT CORPORATION
发明人： LEOPARDI, Rosario , ROIZMAN, Bernard
IPC分类号： C12N15 , A61K38 , A61K39 , A61K45 , A61P43 , C07K14 , C12N5 , C12P21 , A61K48
CPC分类号： C07K14/005 , A61K38/00 , A61K48/00 , C12N2710/16622
摘要： The ICP4 protein of herpes simplex virus plays an important role in the transactivation of viral genes. The present invention discloses that ICP4 also has the ability to inhibit apoptosis. This function appears to reside in functional domain distinct from the transactivating function, as indicated by studies using temperature sensitive mutants of ICP4 that transactivating function at elevated temperatures. Also disclosed are methods for inhibition of apoptosis using ICP4 or an ICP4 encoding gene, such as an α4 gene, methods of inhibiting ICP4's apoptosis-inhibiting function, and methods for the production of recombinant proteins and treatment of HSV infections.

30. 发明公开

EP0871908A1 DESIGN OF NONIMAGING OPTICAL CONCENTRATORS AND ILLUMINATORS 失效
标题翻译：形象设计没有结束收集和照明光学系统
公开(公告)号：EP0871908A1
公开(公告)日：1998-10-21
申请号：EP96924348.0
申请日：1996-07-03
申请人： ARCH DEVELOPMENT CORPORATION
发明人： WINSTON, Roland , JENKINS, David, Gerard
IPC分类号： F21S11 , F24J2 , G02B5 , G02B17 , G03B27
CPC分类号： G02B5/10 , F24S23/00 , F24S23/80 , F24S2023/838 , Y02E10/44
摘要： A nonimaging concentrator (or illuminator) of light. The concentrator (or illuminator) has a shape defined by dR/d phi =Rtan alpha where R is a radius vetor from an origin to a point of reflection of a light edge ray from a reflector surface and phi is an angle between the R vector and an exit aperture external point of the concentrator (illuminator) and coordinates (R, phi ) represent a point on a reflector curve and alpha is an angle the light edge ray from an origin point makes with a normal to the reflector curve. The reflector surface allows the light edge ray on the reflector curve to vary as a function of position. In the concentrator an absorber has a shape variable which varies with position along the absorber surface.

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