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21. 发明授权

EP0510178B1 IMPROVED FLOATING BEARING PROSTHETIC KNEE 失效
标题翻译：与活动承改进的膝关节假体
公开(公告)号：EP0510178B1
公开(公告)日：1998-02-25
申请号：EP92901122.9
申请日：1991-11-14
申请人： ARCH DEVELOPMENT CORPORATION
发明人： POTTENGER, Lawrence , DRAGANICH, Louis, F.
IPC分类号： A61F2/38
CPC分类号： A61F2/3868 , A61F2/3886
摘要： A semiconstrained prosthetic knee for surgical replacement of a dysfunctional knee includes a tibial platform (22), a movable bearing element (16), and a femoral component (12). The femoral component (12) includes a polycentric convex bearing which slidably engages a movable bearing (16). The superior surface of the bearing element (16) is designed to congruently slidably engage the inferior surface of the bearing portion of the femoral component (12). The inferior surface of the femoral component (12) is generally convex with two or more offset portions of varying radii of curvature matching complementary superior surfaces of the bearing element (16). The inferior surface of the femoral component (12) may have more than one radius of curvature at different points along the convex surface. The superior surface of the tibial platform (22) is generally flat and includes at least one protrusion for controlling the movement of the bearing element (16).

22. 发明公开

EP0768895A1 CAMPTOTHECIN DRUG COMBINATIONS AND MEDICAMENTS WITH REDUCED SIDE EFFECTS 失效
标题翻译：与减少的副作用喜树碱药物合用
公开(公告)号：EP0768895A1
公开(公告)日：1997-04-23
申请号：EP95925476.0
申请日：1995-07-05
申请人： ARCH DEVELOPMENT CORPORATION
发明人： RATAIN, Mark, J. , GUPTA, Elora
IPC分类号： A61K45 , A61K31
CPC分类号： A61K31/47 , A61K45/06 , Y10S514/01 , A61K2300/00
摘要： This invention provides methods and combination formulations and kits to reduce the toxicity of camptothecin drugs, such as irinotecan (CPT-11). Disclosed are therapeutics and treatment methods employing such drugs in combination with agents that increase conjugative enzyme activity or glucuronosyltransferase activity, and agents that decrease biliary transport protein activity, such as cyclosporine A, the resultant effects of which are to decrease the significant side effects previously associated with treatment using these drugs.

23. 发明公开

EP0760624A1 AUTOMATED DETECTION OF LESIONS IN COMPUTED TOMOGRAPHY 有权
标题翻译：自动检测病变计算出
公开(公告)号：EP0760624A1
公开(公告)日：1997-03-12
申请号：EP95914166.0
申请日：1995-03-30
申请人： ARCH DEVELOPMENT CORPORATION
发明人： GIGER, Maryellen, L. , BAE, Kyongtae (Ty) , DOI, Kunio
IPC分类号： A61B6 , G06T1 , G06T7
CPC分类号： G06T7/0012 , G06T2207/10081 , G06T2207/30064 , Y10S378/901
摘要： A method and system for the automated detection of lesions in computed tomographic images, including generating image data from at least one selected portion of an object, for example, from CT images of the thorax. The image data are then analyzed in order to produce the boundary of the thorax. The image data within the thoracic boundary is then further analyzed to produce boundaries of the lung regions using predetermined criteria. Features within the lung regions are then extracted using multi-gray-level thresholding and correlation between resulting multi-level threshold images and between at least adjacent sections. Classification of the features as abnormal lesions or normal anatomic features is then performed using geometric features yielding a likelihood of being an abnormal lesion along with its location in either the 2-D image section or in the 3-D space of the object.

24. 发明公开

EP0731952A1 AUTOMATED METHOD AND SYSTEM FOR IMPROVED COMPUTERIZED DETECTION AND CLASSIFICATION OF MASSES IN MAMMOGRAMS 失效
标题翻译： FOR乳房X线照片改进计算机化的检测和分类大众的自动方法和系统
公开(公告)号：EP0731952A1
公开(公告)日：1996-09-18
申请号：EP95903554.0
申请日：1994-11-29
申请人： ARCH DEVELOPMENT CORPORATION
发明人： GIGER, Maryellen, L. , DOI, Kunio , LU, Ping , HUO, Zhimin
IPC分类号： A61B6 , G06K9 , G06T1 , G06T7
CPC分类号： G06K9/00127 , G06T7/0012
摘要： A method and system for automated detection and classification of masses in mammograms. This method and system include the performance of iterative, multi-level gray level thresholding (202), followed by lesion extraction (203) and feature extraction techniques (205) for classifying true masses from false-postive masses and malignant masses from benign masses. The method and system provide improvements in the detection of masses including multi-gray-level thresholding (202) of the processed images to increase sensitivity and accurate region growing and feature analysis to increase specificity. Novel improvements in the classification of masses include a cumulative edge gradient orientation histogram analysis relative to the radial angle of the pixels in question; i.e. either around the margin of the mass or within or around the mass in question. The classification of the mass leads to a likelihood malignancy.

25. 发明授权

EP0449942B1 METHOD FOR SEPARATING METAL IONS USING PHOSPHONIC ACIDS AS COMPLEXANTS 失效
标题翻译：用于金属离子与膦ALS COMPLEXBILDNER分离
公开(公告)号：EP0449942B1
公开(公告)日：1996-04-17
申请号：EP90901143.9
申请日：1989-10-31
申请人： ARCH DEVELOPMENT CORPORATION
发明人： Horwitz,Earl Philip , Gatrone, Ralph Carl , Nash, Kenneth LaVerne
IPC分类号： C02F1/42
CPC分类号： C07F9/3839 , B01D61/38 , C01B25/461 , C01F17/0006 , C02F1/683 , C07F11/005 , C07F15/025 , C07F15/065 , C07F19/005 , C22B3/0067 , G21F9/04 , G21F9/06 , Y02P10/234
摘要： Diphosphonic acids and their derivatives such as vinylidene-1,1-diphosphonic acid and 1,2-dihydroxyethane-1,1-diphosphonic acid complex metal ions, especially in II-VI oxidation states, to form water soluble complexes especially in strong acid media. After complexing, the metal complex is separated and then the metal is recovered by decomposition under mild conditions preferably of heat and/or oxidation to release the metal for disposal or recovery and form especially environmentally innocuous byproducts.

26. 发明公开

EP0700402A1 METHODS AND MATERIALS FOR MODULATION OF THE IMMUNOSUPPRESSIVE ACTIVITY AND TOXICITY OF MONOCLONAL ANTIBODIES 失效
标题翻译：工艺和材料来调节免疫抑制活性和Toxitätvon单克隆抗体
公开(公告)号：EP0700402A1
公开(公告)日：1996-03-13
申请号：EP94920062.0
申请日：1994-06-01
申请人： ARCH DEVELOPMENT CORPORATION
发明人： BLUESTONE, Jeffrey, A. , ZIVIN, Robert, A. , JOLLIFFE, Linda
IPC分类号： C12N15 , A61K39 , A61P37 , C07K16 , C12P21 , A61K38 , C12R1
CPC分类号： C07K16/2809 , A61K38/00 , C07K2317/34 , C07K2319/02
摘要： The binding specificity of the murine OKT3 has been transferred into a human antibody framework in order to reduce its immunogenicity. 'Humanized' anti-CD3 mAbs, such as gOKT3-5 and gOKT3-7, have been shown to retain, in vitro, all the properties of native OKT3, including T cell activation which has been correlated, in vivo, with the severe side-effects observed in transplant recipients after the first administration of the mAb. Disclosed are modified versions of humanized anti-CD3 mAbs that do not have the property of T cell activation. Further disclosed are methods of using such mAbs.

27. 发明公开

EP0682701A1 APOLIPOPROTEIN B mRNA EDITING PROTEIN COMPOSITIONS AND METHODS 失效
标题翻译：载脂蛋白B基因editaton蛋白质组分和方法。
公开(公告)号：EP0682701A1
公开(公告)日：1995-11-22
申请号：EP94908009.0
申请日：1994-02-08
申请人： ARCH DEVELOPMENT CORPORATION
发明人： TENG, Babie , DAVIDSON, Nicholas , BURANT, Charles F.
IPC分类号： C07K14 , C12N15 , A61K38
CPC分类号： C07K14/47 , A61K38/00 , C07K14/775
摘要： The present invention provides a protein that edits apo B RNA. A polynucleotide that comprises a DNA sequence that encodes an apo B RNA editing protein and an expression vector comprising such a polynucleotide are also provided. Processes for producing an apo B RNA editing protein, editing apo B RNA and altering apo B protein production are also provided.

28. 发明公开

EP0652749A1 METHODS AND COMPOSITIONS FOR INHIBITING 5$g(a)-REDUCTASE ACTIVITY 失效
标题翻译：方法和组合物5的α的抑制 - 还原酶活性。
公开(公告)号：EP0652749A1
公开(公告)日：1995-05-17
申请号：EP93910950.0
申请日：1993-04-30
申请人： ARCH DEVELOPMENT CORPORATION
发明人： LIAO, Shutsung , LIANG, Tehming
IPC分类号： G01N33 , A61K8 , A61K9 , A61K31 , A61K45 , A61K47 , A61P3 , A61P13 , A61P15 , A61P17 , A61P35 , A61Q5 , A61Q7 , A61Q19 , C07C53 , C07C57 , C07C61 , C07C69 , C07D209 , C07D225 , C07D313 , C07D317 , C07D331 , C07D337 , C12N9
CPC分类号： C07D337/00 , A61K8/361 , A61K8/37 , A61K8/4906 , A61K8/4973 , A61K8/67 , A61K31/20 , A61K31/23 , A61K31/353 , A61K31/565 , A61K45/06 , A61K2800/782 , A61Q5/00 , A61Q19/00 , C07C53/21 , C07C57/52 , C07C57/56 , C07C61/16 , C07C61/40 , C07C69/63 , C07C69/65 , C07C69/675 , C07C69/716 , C07C69/738 , C07C69/88 , C07D209/48 , C07D225/02 , C07D313/00 , A61K2300/00
摘要： Disclosed is a novel class of antiandrogenic compounds including saturated and unsaturated fatty acids, their derivatives, and synthetic analogs, their method of synthesis, and their use in treating disorders associated with androgenic activities. Also disclosed is the use of known compounds not previously known for their antiandrogenic activity in treating disorders related to androgenic activities.

29. 发明公开

EP0621874A1 SOMATOSTATIN RECEPTORS 失效
标题翻译： SOMATOSTATINREZEPTOREN。
公开(公告)号：EP0621874A1
公开(公告)日：1994-11-02
申请号：EP93902841.0
申请日：1992-12-30
申请人： ARCH DEVELOPMENT CORPORATION
发明人： BELL, Graeme, I. , YAMADA, Yuichiro , SEINO, Susumu
IPC分类号： G01N33 , A61K39 , C07K14 , C07K16 , C12N1 , C12N5 , C12N15 , C12P21 , C12R1
CPC分类号： C07K14/723
摘要： L'invention concerne d'une manière générale des compositions et des procédés permettant d'obtenir des récepteurs de somotostatine. L'invention concerne également des séquences d'ADN codant des récepteurs de somotostatine, les vecteurs de recombinaison portant ces séquences, les cellules hôtes de recombinaison comprenant soit les séquences soit les vecteurs, et des polypeptides de récepteurs de somotostatine de recombinaison. A titre d'exemple, l'invention concerne le clonage et l'expression fonctionnelle d'au moins trois récepteurs différents de somotostatine, SSTR1, SSTR2 et SSTR3 à partir de deux sources mammifères différentes. L'invention comprend également des procédés d'utilisation des polypeptides de récepteurs de recombinaison dans des dosages destinés à sélectionner et améliorer des substances capables d'avoir une interaction avec des polypeptides de récepteurs de somotostatine à des fins diagnostiques, de mise au point de médicaments et à des applications thérapeutiques.

30. 发明授权

EP0243155B1 Recombinant herpes simplex viruses, vaccines and methods 有权转让
标题翻译：重组病毒简单的病毒，疫苗和方法
公开(公告)号：EP0243155B1
公开(公告)日：1993-08-04
申请号：EP87303512.5
申请日：1987-04-22
申请人： ARCH DEVELOPMENT CORPORATION
发明人： Roizman, Bernard
IPC分类号： C12N15/86 , C12N7/00 , A61K39/245 , C07K15/00
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C12N2710/16622 , C12N2710/16643 , C12N2730/10122

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