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21. 发明公开

EP2752121A1 CHEWING-ENHANCED FOOD 审中-公开
标题翻译：口味增强的食物
公开(公告)号：EP2752121A1
公开(公告)日：2014-07-09
申请号：EP12827477.6
申请日：2012-08-23
申请人： Meiji Co., Ltd. , Showa University
发明人： NAKAMURA Yoshitaka , KANNO Takahiro , IGAWA Megumu , TAKAHASHI Takeshi , MUKAI Yoshiharu , UTSUMI Akemi
IPC分类号： A23L1/30 , A23G3/50
CPC分类号： A23L1/1041 , A23G3/50 , A23L7/198 , A23L29/212 , A23L29/225 , A23L33/10 , A23L33/22
摘要： The object of the present invention is to provide a food product for enhancing chewing ability having hardness, viscosity and so on suitable for the mouth of a small child from the age of one year to five years and eleven months, in particular a young child in the age of approximately one and one-half years who can utilize teeth for chewing after weaning. The food product for enhancing chewing ability of the present invention contains at least one type of main raw material selected from the flour group consisting of wheat flour, rice flour and starchy flour, and at least one type of secondary raw material selected from the group consisting of sorbitol and glycerol. This food product for enhancing chewing ability preferably has a breaking stress, breaking strain, brittleness stress and cohesiveness within predetermined ranges.
摘要翻译：本发明的目的是提供一种用于提高咀嚼能力的食品，其具有适合于1岁至5岁和11月龄的小孩的口腔的硬度，粘度等特别是幼儿断奶后可以利用牙齿咀嚼的大约一岁半的年龄。本发明的用于提高咀嚼能力的食品包含选自由小麦粉，米粉和淀粉粉组成的面粉组中的至少一种主要原材料和至少一种选自以下的二次原料：山梨糖醇和甘油。这种用于提高咀嚼能力的食品优选具有预定范围内的断裂应力，断裂应变，脆性应力和内聚性。

22. 发明公开

EP2452679A1 CYTOPROTECTIVE AGENT 有权转让
标题翻译：三苯乙酮ZELLSCHUTZMITTEL
公开(公告)号：EP2452679A1
公开(公告)日：2012-05-16
申请号：EP10796931.3
申请日：2010-02-05
申请人： National University Corporation Tokyo University Of Agriculture and Technology , Showa University , TMS Co., Ltd.
发明人： HONDA, Kazuo , HASHIMOTO, Terumasa , SHIBATA, Keita , HASEGAWA, Keiko , HASUMI, Keiji
IPC分类号： A61K31/407 , A61P7/02 , A61P9/10
CPC分类号： A61K31/407 , C07D491/04
摘要： Disclosed is a cytoprotective agent for use with respect to ischemic damage, including as an active ingredient a triprenyl phenol compound represented by the following general formula (I), wherein X is -CHY-C(CH 3 ) 2 Z, Y and Z are each independently -H or -OH, or jointly form a single bond, and R represents a hydrogen atom or a substituent with a molecular weight of 1000 or less.
摘要翻译：公开了一种关于缺血性损伤使用的细胞保护剂，其包括作为活性成分的由以下通式（I）表示的三苯甲基酚化合物，其中X为-CHY-C（CH 3）2 Z，Y和Z为各自独立地为-H或-OH，或共同形成单键，R表示氢原子或分子量为1000以下的取代基。

23. 发明公开

EP2340841A1 OSTEOGENESIS PROMOTER COMPRISING [4-(METHYLTHIO)PHENYLTHIO]METHANEBISPHOSPHONIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT 有权转让
标题翻译：氨基葡萄糖胺[4-（甲基硫代）苯基]甲烷二磷酸酯药物制剂阿拉伯树胶SALZ DARAUS ALS WIRKSTOFF
公开(公告)号：EP2340841A1
公开(公告)日：2011-07-06
申请号：EP09811231.1
申请日：2009-08-05
申请人： Tohoku University , Showa University
发明人： SHINODA, Hisashi , IGARASHI, Kaoru , MURAKAMI, shinobu , SUZUKI, Keiko
IPC分类号： A61K31/663 , A61K9/08 , A61K47/02 , A61P1/02 , A61P19/08 , A61P43/00
CPC分类号： A61K31/663
摘要： Disclosed are: a compound which can be produced through a chemical synthesis at low cost, has an excellent osteogenesis-promoting activity, has high affinity for a bone, and can be applied without the need of any special DDS; and a method for promoting osteogenesis by administering the compound and applying the promotion of osteogenesis to the formation or regeneration of a bone. Specifically disclosed are: an osteogenesis promoter or a pharmaceutical composition comprising [4-(methylthio)phenylthio]methanebisphosphonic acid, which is one of bisphosphonic acids, or a pharmaceutically acceptable salt thereof as an active ingredient; and a method for promoting osteogenesis, which comprises administering the osteogenesis promoter or the pharmaceutical composition to a subject to be treated.
摘要翻译：本发明公开了以低成本化学合成制造的化合物，具有优异的成骨促进活性，对骨骼具有高亲和力，可以无需特殊的DDS而应用; 以及通过施用化合物和促进成骨来促进骨形成或再生的方法。具体公开的是：成骨促进剂或包含作为双膦酸之一的[4-（甲硫基）苯硫基]甲烷二膦酸或其药学上可接受的盐作为活性成分的药物组合物; 以及促进成骨的方法，其包括将成骨促进剂或药物组合物施用于待治疗的对象。

24. 发明公开

EP3939659A1 DRUG AND METHOD FOR TREATING OR PREVENTING COMPLICATIONS FROM DIABETES, USING SAID DRUG 无效转让
公开(公告)号：EP3939659A1
公开(公告)日：2022-01-19
申请号：EP20771088.0
申请日：2020-03-12
申请人： Showa University , TMS Co., Ltd.
发明人： SHIBATA, Keita , SHINOUCHI, Ryosuke , HASHIMOTO, Terumasa , NOBE, Koji
IPC分类号： A61P9/10 , A61P13/12 , A61P25/00 , A61P25/02 , A61P27/02 , A61K31/407 , A61K31/502
摘要： A drug containing a compound represented by formula (I) as an active ingredient, used for complications from diabetes.

25. 发明公开

EP3878400A1 INTRAORAL SENSING APPARATUS AND MANUFACTURING METHOD THEREOF 有权转让
公开(公告)号：EP3878400A1
公开(公告)日：2021-09-15
申请号：EP21161634.7
申请日：2021-03-09
申请人： Seiko Holdings Kabushiki Kaisha , Showa University
发明人： YOSHIDA, Yoshifumi , ISOGAI, Ryosuke , MAKI, Kotaro , SHIOTSU, Rumi
IPC分类号： A61C7/08 , A61B5/00 , A61C8/00 , A61C13/00
摘要： The present intraoral sensing apparatus is configured to be installed in an oral cavity, and is provided with: an electronic device equipped with electronic components mounted on a circuit board; a first dental resin material which completely covers the electronic device; a second dental resin material which completely covers the first dental resin material; and an intraoral instrument having a first recess in which the electronic device covered with the first dental resin material and the second dental resin material is accommodated.

26. 发明公开

EP3705892A1 DETECTION METHOD AND DETECTION DEVICE OF CIRCULATING TUMOR CELL 审中-公开
公开(公告)号：EP3705892A1
公开(公告)日：2020-09-09
申请号：EP20161512.7
申请日：2020-03-06
申请人： Showa University
发明人： NAOE, Michio , OGAWA, Yoshio , ISHII, Hikaru
IPC分类号： G01N33/543 , G01N33/574
摘要： A detection method of detecting CTCs as target cells contained in a test sample, the method includes a concentration step of concentrating the target cells contained in the test sample, a labeling step of labeling the target cells and other components by bringing the concentrated test sample into contact with first labeling antibodies in which antibodies specifically binding to antigens, which exclude antigens expressing in epithelial cells and specifically express in the target cells, are labeled by a first labeling substance, and into contact with second labeling antibodies in which antibodies binding to antigens expressing in the other components excluding the target cells are labeled by a second labeling substance, and a detection step of detecting, from the test sample, cells that are labeled by the first labeling antibodies and are not labeled by the second labeling antibodies as the target cells.

27. 发明授权

EP2340841B1 OSTEOGENESIS PROMOTER COMPRISING [4-(METHYLTHIO)PHENYLTHIO]METHANEBISPHOSPHONIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT 有权转让
标题翻译： WITH [4-（甲硫基）苯硫基]METHANBISPHOSPHONSÄURE或药学上可接受的盐作为活性成分OSTEOGENESEPROMOTER THEREOF
公开(公告)号：EP2340841B1
公开(公告)日：2016-11-09
申请号：EP09811231.1
申请日：2009-08-05
申请人： Tohoku University , Showa University
发明人： SHINODA, Hisashi , IGARASHI, Kaoru , MURAKAMI, shinobu , SUZUKI, Keiko
IPC分类号： A61K31/663 , A61K9/08 , A61K47/02 , A61P1/02 , A61P19/08 , A61P43/00
CPC分类号： A61K31/663

28. 发明公开

EP2479738A1 EXERCISE MODEL FOR SMALL INTESTINE ENDOSCOPE 审中-公开
标题翻译： TRAININGSMODELLFÜREIN KLEINES DARMENDOSKOP
公开(公告)号：EP2479738A1
公开(公告)日：2012-07-25
申请号：EP10813585.6
申请日：2010-07-27
申请人： Showa University , Koken Co., Ltd.
发明人： ENDO, Yutaka , UNO, Hiroshi
IPC分类号： G09B23/28 , A61B1/00
CPC分类号： G09B23/285 , A61B1/00057
摘要： It is possible to provide a small intestine endoscope training simulator (11) which allows to obtain a feeling similar to that of inserting an endoscope (38) into the small intestine (34) of the living body (30) and learn the actual operation of the endoscope (38). This training simulator (11) includes a plurality of longitudinal elastic members (32) for applying an elastic force to each of a plurality of portions of a simulated small intestine (13). One end portion sides of the plurality of longitudinal elastic members (32) are respectively attached to the first attachment portions (27) on the simulated small intestine (13) side. The other end portion sides of the plurality of longitudinal elastic members (32) are respectively attached to the second attachment portions (33, 57) on the case (12) side.
摘要翻译：可以提供一种小肠内窥镜训练模拟器（11），其能够获得与将内窥镜（38）插入到生物体（30）的小肠（34）中的感觉相似的感觉，并且学习实际操作内窥镜（38）。该训练模拟器（11）包括多个用于向模拟小肠（13）的多个部分中的每一个施加弹性力的纵向弹性构件（32）。多个纵向弹性构件（32）的一个端部侧分别安装在模拟的小肠（13）侧上的第一附接部分（27）上。多个纵向弹性构件（32）的另一个端部侧分别安装在壳体（12）侧上的第二安装部分（33,57）上。

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