专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明公开

EP1803711A1 Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy 有权
标题翻译：阿尔法里安·祖尔
公开(公告)号：EP1803711A1
公开(公告)日：2007-07-04
申请号：EP07003558.9
申请日：2002-07-10
申请人： BRACCO IMAGING S.p.A.
发明人： Giovenzana, Giovanni Battista , Palmisano, Giovanni , Sisti, Massimo , Cavallotti, Camilla , Aime, Silvio , Calabi, Luisella
IPC分类号： C07D243/08 , A61K49/08 , C07C229/16 , C07C229/76
CPC分类号： C07D243/08 , A61K49/0002 , A61K49/101
摘要： Compounds of general formula (I):
in which: R 1 is hydrogen, C 1 -C 20 alkyl, C 3 -C 10 cycloalkyl, C 4 -C 20 cycloalkylalkyl, aryl, arylalkyl, or two R 1 , taken together, form a straight or cyclic C 2 -C 10 alkylene group or an ortho disubstituted arylene; R 2 is hydrogen, C 1 -C 20 alkyl, C 3 -C 10 cycloalkyl, C 4 -C 20 cycloalkylalkyl, aryl or arylalkyl optionally substituted with functional groups which allow conjugation with a suitable molecule able to interact with physiological systems; R 3 , R 4 and R 5 are hydrogen, C 1 -C 20 alkyl, C 3 -C 10 cycloalkyl, C 4 -C 20 cycloalkylalkyl, aryl, arylalkyl; FG are carboxy, -PO 3 H 2 or -RP(O)OH groups, wherein R is hydrogen, C 1 -C 20 alkyl, C 3 -C 10 cycloalkyl, C 4 -C 20 cycloalkylalkyl, aryl, arylalkyl; and their chelates with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42, 43, 44, 49, and between 57 and 83, and radioisotopes chosen among 203 Pb, 67 Ga, 68 Ga, 72 As, 111 In, 113 In, 90 Y, 97 Ru, 62 Cu, 64 Cu, 52 Fe, 52m Mn, 140 La, 175 Yb, 153 Sm, 166 Ho, 149 Pm, 177 Lu, 142 Pr, 159 Gd, 212 Bi, 47 Sc, 149 Pm, 67 Cu, 111 Ag, 199 Au, 161 Tb and 51 Cr as well as the salts thereof with physiologically compatible bases or acids.
摘要翻译：通式（I）的化合物：其中：R 1为氢，C 1 -C 20烷基，C 3 -C 10环烷基，C 4 -C 20环烷基烷基，芳基，芳基烷基或两个R 1一起形成直链或环状C 2 -C 10亚烷基或邻二取代亚芳基; R 2是氢，C 1 -C 20烷基，C 3 -C 10环烷基，C 4 -C 20环烷基烷基，任选地被允许与能够与生理系统相互作用的合适分子缀合的官能团取代的芳基或芳烷基; R 3，R 4和R 5是氢，C 1 -C 20烷基，C 3 -C 10环烷基，C 4 -C 20环烷基烷基，芳基，芳基烷基; FG是羧基，-PO 3 H 2或-RP（O）OH基团，其中R是氢，C 1 -C 20烷基，C 3 -C 10环烷基，C 4 -C 20环烷基烷基，芳基，芳基烷基; 其螯合物与金属元素的二价离子的原子序数范围在20,31,39,42,43,44,49和57和83之间，放射性同位素选自203 Pb，67 Ga，68 Ga， 72 As，111 In，113 In，90 Y，97 Ru，62 Cu，64 Cu，52 Fe，52m Mn，140 La，175 Yb，153 Sm，166 Ho，149 Pm，177 Lu，142 Pr，159 Gd ，212 Bi，47 Sc，149 Pm，67 Cu，111 Ag，199 Au，161 Tb和51 Cr以及其与生理相容性碱或酸的盐。

12. 发明公开

EP1397372A4 WATER-SOLUBLE POLYMERIC METAL ION AFFINITY COMPOSITIONS AND METHODS FOR USING THE SAME 有权
标题翻译：水溶性聚合物的组合物随着对金属离子亲和申请流程。
公开(公告)号：EP1397372A4
公开(公告)日：2007-03-07
申请号：EP02742266
申请日：2002-06-20
申请人： CLONTECH LAB INC
发明人： TCHAGA GRIGORIY S
IPC分类号： B01J20/281 , C07K1/22 , B01J20/285 , C07C229/76 , C08B37/00 , C08B37/02 , C08B37/12 , G01N30/88
CPC分类号： C08B37/0021 , C07C229/76 , C07K1/22
摘要： Water-soluble metal ion affinity compounds and methods for using the same are provided. The subject compounds include an aspartate based metal chelating ligand bonded to a water-soluble polymeric substrate, where the ligand is complexed with a metal ion. In certain embodiments, the subject compounds further include a member of a signal producing system, e.g., a directly or an indirectly detectable label moiety. Also provided are water-insoluble supports having the subject compounds present on, e.g., immobilized on, at least one surface thereof. The subject compounds find use in a variety of different applications, including analyte detection and analyte purification applications.

13. 发明授权

EP1153029B1 AMPHIPATIC POLYCARBOXYLIC CHELATES AND COMPLEXES WITH PARAMAGNETIC METALS AS MRI CONTRAST AGENTS 有权
标题翻译：两亲性POLYCARBOXYLCHELATE和复杂与对磁性金属AS MRI造影剂
公开(公告)号：EP1153029B1
公开(公告)日：2007-01-10
申请号：EP99956261.4
申请日：1999-11-25
申请人： BRACCO International B.V.
发明人： ANELLI, Pier Lucio , LATTUADA, Luciano , UGGERI, Fulvio , LUX, Giovanna , SERLETI, Michele , GABELLINI, Milena , TOURNIER, Hervé
IPC分类号： A61K49/06 , C07C229/16 , C07C233/47 , C07C237/10 , C07C229/76 , C07C237/08 , C07C237/12 , C07J41/00
CPC分类号： C07J41/0055 , A61K49/06 , A61K49/1812 , C07C229/16 , C07C229/76 , C07C233/47 , C07C237/08 , C07C237/10 , C07C237/12 , C07F9/091 , Y10S977/896 , Y10S977/927 , Y10S977/93
摘要： Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI). The paramagnetic complexes of the polycarboxylic ligands possess advantageous tensioactive properties and are useful as MRI contrast media in formulations for investigating the blood pool.

14. 发明公开

EP1364647A4 HYPOGLYCEMIC AGENT 审中-公开
标题翻译：降糖药
公开(公告)号：EP1364647A4
公开(公告)日：2006-04-05
申请号：EP02716383
申请日：2002-01-25
申请人： JAPAN SCIENCE & TECH AGENCY
发明人： KOJIMA YOSHITANE , SAKURAI HIROMU , YOSHIKAWA YUTAKA
IPC分类号： A23L1/30 , A61K31/315 , A61K31/341 , A61K31/555 , A61K33/30 , A61K38/00 , A61P3/10 , A61P9/12 , C07C51/41 , C07C229/76 , C07D213/36 , C07D307/58 , C07D307/62 , C07F3/06 , C07K5/06 , C07K5/08 , C07K5/10 , A61K38/05 , A61K38/06 , C07C59/08 , C07C62/04 , C07D213/38 , C07K5/00 , C07K101/00
CPC分类号： C07K5/1002 , A61K31/315 , A61K31/341 , A61K31/555 , A61K38/00 , C07C51/412 , C07C229/76 , C07D307/58 , C07K5/06008 , C07K5/08 , C07K5/0802 , C07C59/08
摘要： A zinc(II) complex which is lowly toxic, has high insulin-like activity, and is effectively usable as a hypoglycemic agent for the prevention or treatment of diabetes; a hypoglycemic agent containing the complex; a medicinal preparation which contains the complex and is useful as a preventive/remedy for diabetes; and a food containing the complex, such as a health food or supplementary health food. The hypoglycemic agent contains an organic zinc(II) complex having as a ligand a compound selected among aminoalkylpyridines, bis-optically active amino acids, bisaminoalkylcarboxylic acids, oligopeptides, oligopseudopeptides, di-substituted aminocarboxylic acids, α- and β-hydroxycarboxylic acids, vitamins, glutamine derivatives, etc.

15. 发明公开

EP1325012A4 A COMPOSITION AND METHOD FOR PREPARING AMINO ACID CHELATES FREE OF INTERFERING IONS 审中-公开
标题翻译：组合物及其制备方法氨基酸螯合物，无干扰离子ARE
公开(公告)号：EP1325012A4
公开(公告)日：2005-08-10
申请号：EP01981466
申请日：2001-10-10
申请人： ALBION INT
发明人： ASHMEAD STEPHEN D , WHEELWRIGHT DAVID C , ERICSON CLAYTON , PEDERSEN MARK
IPC分类号： C07C227/16 , C07C229/76 , C07F1/08 , C07F3/02 , C07F3/06 , C07F13/00 , C07F15/02 , C07F15/06
CPC分类号： C07C227/16 , C07C229/76
摘要： The present invention relates to compositions and methods of preparing amino chelates that are free of interfering ions, and optionally, electrically neutral. In one embodiment, the compsosition is prepared by reacting in an aqueous solution a calcium oxide and/or hydroxide, an amino acid, and a soluble metal sulfate salt at a ratio sufficient to allow substantially all of the ions present in solution to react forming a metal amino acid chelate and an essentially inert calcium sulfate, and wherein the metal amino acid chelate has a ligand to metal molar ratio from 2:1 to 3:1. Alternatively, the composition can be prepared by reacting in an aqueous solution, a calcium oxide and/or hydroxide, an amino acid, and a soluble metal sulfate salt at a ratio sufficient to allow substantially all of the ions present in solution to react forming a positively charged metal amino acid chelate having a hydroxide counter-ion, and a calcium sulfate, and wherein the metal amino acid chelate has a ligand to metal molar ratio from 1:1 to 2:1.

16. 发明授权

EP1176137B1 POWDERY S,S-ETHYLENEDIAMINE-N,N'-DISUCCINIC ACID IRON COMPLEX AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：铁粉乙二胺N，N'-二琥珀酸盐和运营部门的一种方法
公开(公告)号：EP1176137B1
公开(公告)日：2004-06-30
申请号：EP00921090.7
申请日：2000-04-28
申请人： Mitsubishi Rayon Co., Ltd.
发明人： TANAKA, Shigeho, Chemicals Dev. Lab. Mitsubishi , BANBA, Hiroyasu, Chemicals Dev. Lab. Mitsubishi , NIWA, Kiyonobu, Chemicals Dev. Lab. Mitsubishi
IPC分类号： C07C229/76 , G03C7/42 , C07C227/38 , C07C227/42 , C07C229/24 , C07F15/02
CPC分类号： C07C229/76 , C07C227/38 , C07C227/42 , C07C229/24 , C07F15/025 , G03C5/44 , G03C7/42

17. 发明公开

EP1256342A4 HYPOGLYCEMICS COMPRISING ORGANIC ZINC (II) COMPLEXES 有权
标题翻译：降糖剂，有机锌复合体包括
公开(公告)号：EP1256342A4
公开(公告)日：2003-10-08
申请号：EP00974960
申请日：2000-11-13
申请人： JAPAN SCIENCE & TECH CORP
发明人： KOJIMA YOSHITANE , SAKURAI HIROMU
IPC分类号： C07D333/40 , A61K31/136 , A61K31/145 , A61K31/198 , A61K31/315 , A61K31/351 , A61K31/381 , A61K31/40 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/455 , A61K31/555 , A61K33/30 , A61P3/10 , A61P31/10 , A61P43/00 , C07C229/76 , C07C323/34 , C07C323/52 , C07D207/06 , C07D213/55 , C07D213/79 , C07D213/80 , C07D213/89 , C07D277/06 , C07D295/21 , C07D309/38 , C07D309/40 , C07F3/06
CPC分类号： A61K31/351 , A61K31/315 , A61K31/381 , A61K31/44 , A61K31/555 , A61K33/30 , C07D213/55 , C07D213/79 , A61K2300/00
摘要： Hypoglycemics having a lower toxicity than vanadium and an adequate stability and exerting an adequate fat-soluble insulin-like effect; and medicinal preparations having an insulin-like effect and being useful as preventives and remedies for diabetes. Hypoglycemics comprising organic zinc (II) complexes which contain as the ligand selected from among ligands having pyridine ring, ligands having pyrone ring, ligands having thiazolidine ring, ligands comprising amino acids, ligands comprising 2-aminothiophenols and ligands comprising pyrrolinedithiocarbamic acids; and medicinal preparations containing the above-described organic zinc (II) complexes which are useful as remedies for diabetes.

18. 发明公开

EP1176137A4 POWDERY S,S-ETHYLENEDIAMINE-N,N'-DISUCCINIC ACID IRON COMPLEX AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：铁粉乙二胺N，N'-二琥珀酸盐和运营部门的一种方法
公开(公告)号：EP1176137A4
公开(公告)日：2003-04-23
申请号：EP00921090
申请日：2000-04-28
申请人： MITSUBISHI RAYON CO
发明人： TANAKA SHIGEHO , BANBA HIROYASU , NIWA KIYONOBU
IPC分类号： C07C227/38 , C07C227/42 , C07C229/24 , C07C229/76 , C07F15/02 , G03C5/44 , G03C7/42
CPC分类号： C07C229/76 , C07C227/38 , C07C227/42 , C07C229/24 , C07F15/025 , G03C5/44 , G03C7/42
摘要： A powdery S,S-ethylenediamine-N,N'-disuccinic acid (S,S-EDDS) iron complex reduced in aggregation. The complex is crystalline and has an average particle diameter of 10 to 1,000 mu m and a water content of 7 wt.% or lower. It further has a compression strength of 1 kg/cm or lower as measured in accordance with JIS A 1108 on a sample kept under the conditions of 50 DEG C and a load of 300 g/cm for 2 months.

19. 发明公开

EP1224162A1 MIXED-METAL CHELATES AND PROCES FOR THE PREPARATION THEREOF 有权
标题翻译：混合金属螯合物及其制备方法
公开(公告)号：EP1224162A1
公开(公告)日：2002-07-24
申请号：EP00970737.3
申请日：2000-10-10
申请人： THE DOW CHEMICAL COMPANY
发明人： ST. GEORGE, George, M.
IPC分类号： C07C229/76 , C07F15/02 , C07F15/06 , C07F11/00
CPC分类号： C07F15/065 , C07F11/005 , C07F15/025
摘要： Mixed-metal chelates represented by the following general formula CaM(III)EDTA(OH)).xH2O wherein M is a trivalent transition metal and x is 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, or 8 and a process for their preparation are disclosed. The process comprises the steps of a) reacting calcium hydroxide or calcium oxide, ethylenediaminetetraacetic acid, and a transition metal-containing material in an aqueous medium, optionally in the presence of an oxidant to convert any transition metal present in a divalent form to its trivalent form; and b) separating the formed mixed-metal chelate by filtration or evaporation. These mixed-metal chelates are useful as catalyst precursors and dietary supplements.

20. 发明授权

EP0882010B1 PHARMAZEUTISCHE MITTEL ENTHALTEND PERFLUORALKYLHALTIGE METALLKOMPLEXE UND IHRE VERWENDUNG IN DER TUMORTHERAPIE UND INTERVENTIONELLEN RADIOLOGIE 失效
标题翻译：制药含肿瘤治疗和介入放射学全氟烷金属络合物使用
公开(公告)号：EP0882010B1
公开(公告)日：2001-05-02
申请号：EP97903278.6
申请日：1997-02-14
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： PLATZEK, Johannes , NIEDBALLA, Ulrich , RADÜCHEL, Bernd , SCHLECKER, Wolfgang , WEINMANN, Hanns-Joachim , FRENZEL, Thomas
IPC分类号： C07C229/06 , C07C229/76 , C07C237/12 , C07C311/00 , C07D257/02 , A61K33/00
CPC分类号： C07D295/26 , A61K31/28 , A61K31/555 , A61K33/24 , A61K45/06 , A61K49/06 , C07D257/02 , A61K2300/00

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式