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11. 发明授权

EP3302802B1 SAMPLE PROCESSING DEVICES, AND METHODS OF USE THEREOF 有权转让
公开(公告)号：EP3302802B1
公开(公告)日：2019-09-04
申请号：EP16736297.9
申请日：2016-06-06
申请人： Douglas Scientific, LLC
发明人： HJELSETH, Robert , HODGSON, Cory , BRISTOW, Andrew , BAUMGARTNER, Mark , SELLNOW, David , KEPPEL, Cassie , STECKELBERG, John , NEWMAN, Paul
IPC分类号： B01L3/00 , G01N1/28 , C12M3/00 , C12M1/33

12. 发明公开

EP3302802A2 SAMPLE PROCESSING DEVICES, AND METHODS OF USE THEREOF 有权转让
标题翻译：样品处理装置及其使用方法
公开(公告)号：EP3302802A2
公开(公告)日：2018-04-11
申请号：EP16736297.9
申请日：2016-06-06
申请人： Douglas Scientific, LLC
发明人： HJELSETH, Robert , HODGSON, Cory , BRISTOW, Andrew , BAUMGARTNER, Mark , SELLNOW, David , KEPPEL, Cassie , STECKELBERG, John , NEWMAN, Paul
IPC分类号： B01L3/00 , G01N1/28 , C12M3/00 , C12M1/33
CPC分类号： B01L3/5635 , B01L3/50 , B01L3/502 , B01L3/508 , B01L3/561 , B01L2200/026 , B01L2200/0631 , B01L2300/021 , B01L2300/042 , B01L2300/044 , B01L2300/0681 , B01L2300/0832 , B01L2400/0457 , C12M45/06 , C12N15/1017
摘要： Embodiments of the invention provide a filter kit including filters for processing a biological sample. Some embodiments include a filter cap in a tube kit with a first tube containing a buffer solution and a second tube containing a lyophilized master mix. Some embodiments include a method of processing a sample using the kit including mixing a biological sample in a first tube with the buffer solution, positioning the filter cap in the first tube, positioning a second tube on the filter cap, flipping the first tube, the filter cap, and the second cap to filter the biological sample and buffer solution mixture with the filter cap as it flows from the first tube to the second tube. Some embodiments include structure enabling transfer of materials through inline flow between the tubes. Some further embodiments include integrated structure for sample pulverization with integrated buffer and lyophilized master mix.

13. 发明公开

EP3175247A4 INSTRUMENT FOR ANALYZING BIOLOGICAL SAMPLES AND REAGENTS 有权转让
公开(公告)号：EP3175247A4
公开(公告)日：2018-01-10
申请号：EP15826849
申请日：2015-07-28
申请人： DOUGLAS SCIENT LLC
发明人： COOK DARREN LYNN , JOHNSON ERIC GUY , WESTAD NATHAN LUTHER , HAUG ANDREW RICHARD , KONYNENBELT JAMES HENRY , MAASJO GRANT EDWARD , PATTERSON JARED WHITTIER , URKE BRENT CONRAD , ZITZMANN RYAN JOHN , SMITH CHAD STEVEN
IPC分类号： G01N35/02 , B01L3/00
CPC分类号： G01N35/00009 , B01L3/502 , B01L3/50851 , B01L7/52 , B01L2200/0605 , B01L2200/0689 , B01L2200/14 , B01L2300/021 , B01L2300/0627 , B01L2300/0812 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/1827 , C12Q1/686 , G01N35/00029 , G01N35/0099 , G01N35/04 , G01N35/10 , G01N35/1004 , G01N35/1065 , G01N2035/00148 , G01N2035/00346 , G01N2035/00366 , G01N2035/00376 , G01N2035/00445 , G01N2035/0405 , G01N2035/0422 , G01N2035/0425 , G01N2035/0465
摘要： An instrument for processing a biological sample includes a chassis. Connected to the chassis is a tape path along which a tape with a matrix of wells can be automatically advanced through the instrument, a dispensing assembly for dispensing the biological sample and a reagent into the matrix of wells of the tape to form a biological sample and reagent mixture, a sealing assembly for sealing the biological sample and reagent mixture in the tape, and an amplification and detection assembly for detecting a signal from the biological sample and reagent mixture in the matrix of wells in the tape.

14. 发明公开

EP2972408A4 WASH THROUGH PIPETTOR 有权转让
标题翻译： DURCHWASCHPIPETTIERVORRICHTUNG
公开(公告)号：EP2972408A4
公开(公告)日：2016-11-23
申请号：EP14762494
申请日：2014-03-14
申请人： DOUGLAS SCIENT LLC
发明人： SCHOENECK RICHARD J , WAGNER PAUL H
IPC分类号： G01N35/10 , B01L3/02 , G01N1/14
CPC分类号： B01L3/0217 , B01L3/0234 , B01L2200/0689 , B01L2200/141 , B01L2300/0829 , B01L2300/0861 , B08B3/12 , B08B9/023 , B08B9/0323 , G01N35/1004 , G01N35/1065
摘要： A pipettor includes a wash chamber between an upper plate, a lower plate, an upper seal, and a lower seal. The upper and lower seal retain each other and are located between the upper and lower plates. The pipettor includes a gasket located below the lower plate, a pipette tip retained by the gasket, and a piston with a tapered tip that passes through the plates, seals, and gasket into the pipette tip. The upper and lower seal isolate the piston from the wash chamber. The pipettor includes a channel defined by the piston, extending into the pipette tip, and an actuator that advances and retracts the piston. When the actuator retracts the piston such that the piston loses sealing contact with the lower seal and the wash chamber is supplied with wash fluid and pressurized, wash fluid passes through the groove in the upper seal and into the channel.
摘要翻译：移液器包括在上板，下板，上密封和下密封之间的洗涤室。上下密封彼此保持并位于上板和下板之间。移液器包括位于下板下方的垫圈，由垫圈保持的移液管末端，以及具有锥形尖端的活塞，其通过板，密封件和垫圈进入移液管尖端。上下密封将活塞与洗涤室隔离开。移液器包括由活塞限定的通道，延伸到移液管末端，以及促进和缩回活塞的致动器。当致动器缩回活塞，使得活塞与下部密封件密封接触，并且洗涤室被供应洗涤流体并被加压，洗涤流体通过上部密封件中的槽并进入通道。

15. 发明公开

EP2972408A1 WASH THROUGH PIPETTOR 有权转让
标题翻译：通过PIPETTOR洗涤
公开(公告)号：EP2972408A1
公开(公告)日：2016-01-20
申请号：EP14762494.4
申请日：2014-03-14
申请人： Douglas Scientific, LLC
发明人： SCHOENECK, Richard J. , WAGNER, Paul H.
IPC分类号： G01N35/10 , G01N1/14 , B01L3/02
CPC分类号： B01L3/0217 , B01L3/0234 , B01L2200/0689 , B01L2200/141 , B01L2300/0829 , B01L2300/0861 , B08B3/12 , B08B9/023 , B08B9/0323 , G01N35/1004 , G01N35/1065
摘要： A pipettor includes a wash chamber between an upper plate, a lower plate, an upper seal, and a lower seal. The upper and lower seal retain each other and are located between the upper and lower plates. The pipettor includes a gasket located below the lower plate, a pipette tip retained by the gasket, and a piston with a tapered tip that passes through the plates, seals, and gasket into the pipette tip. The upper and lower seal isolate the piston from the wash chamber. The pipettor includes a channel defined by the piston, extending into the pipette tip, and an actuator that advances and retracts the piston. When the actuator retracts the piston such that the piston loses sealing contact with the lower seal and the wash chamber is supplied with wash fluid and pressurized, wash fluid passes through the groove in the upper seal and into the channel.
摘要翻译：移液器包括上板，下板，上部密封件和下部密封件之间的洗涤室。上部和下部密封件彼此保持并位于上部和下部板之间。移液器包括位于下板下方的垫圈，由垫圈保持的移液管尖端和带有锥形尖端的活塞，其穿过板，密封件和垫圈进入移液管尖端。上部和下部密封将活塞与洗涤室隔离。移液器包括由活塞限定的通道，延伸到移液管尖端中，以及致动器，其使活塞前进和缩回。当致动器缩回活塞使得活塞失去与下密封件的密封接触并且洗涤室被供应有洗涤流体并被加压时，洗涤流体穿过上密封件中的凹槽并进入通道。

16. 发明授权

EP3709026B1 INSTRUMENT FOR ANALYZING BIOLOGICAL SAMPLES AND REAGENTS 有权
公开(公告)号：EP3709026B1
公开(公告)日：2024-07-17
申请号：EP20173320.1
申请日：2015-07-28
IPC分类号： G01N35/02 , B01L3/00 , G01N35/10 , G01N35/00
CPC分类号： G01N2035/0034620130101 , G01N35/0099 , G01N35/10 , G01N2035/042520130101 , B01L3/50851 , B01L2200/068920130101 , B01L2300/02120130101 , B01L2300/12320130101 , G01N35/00009 , G01N35/1065 , G01N2035/107620130101 , G01N35/1074 , G01N35/109 , G01N35/1072

17. 发明公开

EP4007923A1 AN ASPIRATE-DISPENSE APPARATUS AND ASSOCIATED METHODS 审中-实审转让
公开(公告)号：EP4007923A1
公开(公告)日：2022-06-08
申请号：EP20751636.0
申请日：2020-07-23
申请人： Douglas Scientific, LLC
发明人： WESTAD, Nathan Luther , HAUG, Andrew Richard
IPC分类号： G01N35/10 , G01N35/00 , B01L3/02

18. 发明授权

EP2943580B1 BIOLOGICAL SAMPLE ANALYTICAL INSTRUMENT 有权转让
公开(公告)号：EP2943580B1
公开(公告)日：2021-03-10
申请号：EP14737813.7
申请日：2014-01-13
发明人： WHALEN, Mark , GERVAIS, Charles , SANBORN, Anthony , HAUG, Andrew , COOK, Darren , RAI, Satish , MISCHE, Hans A. , JUDICE, Stephen A. , SHAFFER, Daniel J.
IPC分类号： G01N30/06 , G01N21/29 , G01N35/00 , G01N35/10 , B01J19/00 , B01L7/00

20. 发明公开

EP3175247A1 INSTRUMENT FOR ANALYZING BIOLOGICAL SAMPLES AND REAGENTS 有权转让
标题翻译：仪器仪表分析仪生物科学研究所
公开(公告)号：EP3175247A1
公开(公告)日：2017-06-07
申请号：EP15826849.0
申请日：2015-07-28
申请人： Douglas Scientific, LLC
发明人： COOK, Darren Lynn , JOHNSON, Eric Guy , WESTAD, Nathan Luther , HAUG, Andrew Richard , KONYNENBELT, James Henry , MAASJO, Grant, Edward , PATTERSON, Jared, Whittier , URKE, Brent Conrad , ZITZMANN, Ryan John , SMITH, Chad Steven
IPC分类号： G01N35/02
摘要： An instrument for processing a biological sample includes a chassis. Connected to the chassis is a tape path along which a tape with a matrix of wells can be automatically advanced through the instrument, a dispensing assembly for dispensing the biological sample and a reagent into the matrix of wells of the tape to form a biological sample and reagent mixture, a sealing assembly for sealing the biological sample and reagent mixture in the tape, and an amplification and detection assembly for detecting a signal from the biological sample and reagent mixture in the matrix of wells in the tape.
摘要翻译：用于处理生物样品的仪器包括底盘。连接到底盘的是磁带路径，带有矩阵阵列的磁带可以通过仪器自动前进，用于将生物样品和试剂分配到带的孔的基质中的分配组件以形成生物样品，试剂混合物，用于密封带中的生物样品和试剂混合物的密封组件，以及扩增和检测组件，用于检测来自带中的孔中的生物样品和试剂混合物的信号。

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