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    • 19. 发明公开
    • PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE AMINOPHOSPHINYLBUTANOIC ACID
    • VERFAHREN ZUR HERSTELLUNG VON OPTISCH AKTIVERAMINOPHOSPHINYLBUTTERSÄURE
    • EP2060578A1
    • 2009-05-20
    • EP07806589.3
    • 2007-09-03
    • Meiji Seika Kaisha Ltd.Takasago International Corporation
    • MINOWA, NobutoNAKANISHI, NozomuMITOMI, MasaakiNARA, HidekiYOKOZAWA, Tohru
    • C07F9/30C07F9/32C07B53/00C07B61/00
    • C07B53/00C07F9/301C07F9/3211
    • The present invention is a process for producing optically active aminophosphinylbutanoic acids represented by the formula (2)

      (in the formula (2), R 1 represents an alkyl group having 1 to 4 carbon atom(s), R 2 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s), R 3 represents an alkyl group having 1 to 4 carbon atom(s), an alkoxy group having 1 to 4 carbon atom(s), an aryl group, an aryloxy group, or a benzyloxy group, and R 4 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s); and * represents an asymmetric carbon atom), wherein a compound represented by the formula (1)

      (in the formula (1), R 1 represents an alkyl group having 1 to 4 carbon atom(s), R 2 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s), R 3 represents an alkyl group having 1 to 4 carbon atom(s), an alkoxy group having 1 to 4 carbon atom(s), an aryl group, an aryloxy group, or a benzyloxy group, and R 4 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s))
      is asymmetrically hydrogenated in the presence of a ruthenium-optically active phosphine complex. With the process for the production, a compound useful in a herbicide such as L-AHPB can be produced with good efficiency and high asymmetric yield.
    • 本发明是由式(2)表示的光学活性氨基氧膦基丁酸的制造方法(式(2)中,R 1表示碳原子数1〜4的烷基,R 2表示氢原子或 具有1至4个碳原子的烷基,R 3表示具有1至4个碳原子的烷基,具有1至4个碳原子的烷氧基,芳基,芳氧基或 苄氧基,R 4表示氢原子或碳原子数1〜4的烷基,*表示不对称碳原子),式(1)表示的化合物(式(1)表示) ,R 1表示碳原子数1〜4的烷基,R 2表示氢原子或碳原子数1〜4的烷基,R 3表示碳原子数1〜4的烷基(s ),具有1〜4个碳原子的烷氧基,芳基,芳氧基或苄氧基,R 4表示氢原子或具有1个 至4个碳原子)在钌 - 光学活性膦配合物的存在下不对称氢化。 通过制备方法,可以以高效率和高不对称产率制备可用于除草剂如L-AHPB的化合物。