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11. 发明公开

EP2814506A1 RECOMBINANT POXVIRAL VECTORS EXPRESSING BOTH RABIES AND OX40 PROTEINS, AND VACCINES MADE THEREFROM 有权转让
标题翻译： BOTH以及狂犬病表达重组OX40蛋白质，POXVIRUSVEKTOREN和疫苗由其MADE
公开(公告)号：EP2814506A1
公开(公告)日：2014-12-24
申请号：EP13707085.0
申请日：2013-02-14
申请人： Merial Limited
发明人： MEBATSION, Teshome , MINKE, Jules, Maarten , DAVID, Frederic
IPC分类号： A61K39/12 , A61K39/008 , A61K39/39
CPC分类号： C12N15/86 , A61K39/008 , A61K39/12 , A61K39/205 , A61K39/39 , A61K2039/5256 , A61K2039/53 , A61K2039/552 , A61K2039/55516 , C12N15/8633 , C12N2710/24043 , C12N2760/20134
摘要： The present invention provides vectors that contain and co-express in vivo or in vitro immunogenic polypeptides or antigens together with an OX40L polypeptide, which functions as a genetic adjuvant. Together, the immunogenic polypeptide and the OX40L polypeptide elicit an immune response in animal or human, which is greater than the immune response elicited by the immunogenic polypeptide alone. In a particular example, the invention provides vectors encoding a Rabies G immunogenic polypeptide and a canine OX40L genetic adjuvant, which vectors elicit strong immune responses in canine against rabies virus.
摘要翻译：本发明提供了载体确实含有与体内或体外免疫原性多肽或抗原与OX40L多肽，如遗传佐剂发挥功能一起共表达。一起，所述免疫原性多肽和OX40L多肽引发在动物或人类中，所有这比通过单独免疫原性多肽引发的免疫应答更大的免疫反应。在特定示例中，本发明提供编码狂犬病病毒G免疫原性多肽和犬科动物OX40L遗传佐剂，其中载体引发针对狂犬病毒在犬强免疫应答的载体

12. 发明授权

EP1546206B1 Novel immunogenic lipopeptides comprising T-helper and cytotoxic T lymphocyte (CTL) epitiopes 有权
标题翻译：含有新的免疫原性的脂肽的T辅助和细胞毒性T淋巴细胞（CTL）表位的
公开(公告)号：EP1546206B1
公开(公告)日：2014-12-17
申请号：EP03783852.1
申请日：2003-08-12
申请人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
发明人： JACKSON, David , ZENG, Weiguang
IPC分类号： A61K39/385 , A61K39/39 , C07K14/005 , C07K14/195
CPC分类号： A61K39/39 , A61K39/07 , A61K39/12 , A61K39/145 , A61K39/29 , A61K39/385 , A61K2039/5158 , A61K2039/55516 , A61K2039/55544 , A61K2039/55566 , A61K2039/57 , A61K2039/6018 , A61K2039/6031 , A61K2039/6037 , A61K2039/6075 , C07K14/005 , C07K14/195 , C07K19/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/18422 , C12N2770/24222 , C12N2770/24234

13. 发明公开

EP2807184A1 INFLUENZA C VIRUS AND VACCINE 无效
标题翻译： INFLUENZA-C-VIRUS UND IMPFSTOFFE
公开(公告)号：EP2807184A1
公开(公告)日：2014-12-03
申请号：EP13704305.5
申请日：2013-01-28
申请人： Newport Laboratories, Inc.
发明人： SIMONSON, Randy, R. , COLLIN, Emily, A. , HAUSE, Benjamin, M.
IPC分类号： C07K14/11 , A61P31/16 , A61K39/145
CPC分类号： C07K14/005 , A61K2039/5252 , C12N7/00 , C12N2760/16321 , C12N2760/16322 , C12N2760/16334
摘要： A further influenza C virus with only low homology to any influenza C virus previously characterized. Challenge studies show that the virus can infect pigs and be transmitted between pigs. Additionally, influenza C is commonly thought of as a human pathogen and serological studies have been performed, looking at the incidence of antibodies against this virus in both pigs and humans. Approximately 10% of pigs and 30% of humans have antibodies to this virus. Additional experimental data show that the virus can infect and transmit in ferrets (a surrogate for human infection studies). In a third aspect, the present invention is the partial genome of this novel influenza C virus. In another aspect, the present invention is a method of detection in animals of this further influenza C virus.
摘要翻译：一种与以前特有的任何甲型流感病毒只有低同源性的新型甲型流感病毒。挑战研究表明，病毒可以感染猪，并在猪之间传播。此外，流感C通常被认为是人类病原体，并且已经进行了血清学研究，研究了猪和人中针对该病毒的抗体的发生率。大约10％的猪和30％的人对这种病毒有抗体。额外的实验数据表明病毒可以感染和传播在雪貂（人类感染研究的替代品）。在第三方面，本发明是该新型流感C病毒的部分基因组。另一方面，本发明是这种新型甲型流感病毒的动物检测方法。

14. 发明公开

EP2789340A1 LIPID METABOLISM AND/OR SUGAR METABOLISM IMPROVER CONTAINING LACTIC ACID BACTERIUM OR TREATMENT PRODUCT THEREOF 无效转让
标题翻译： US US US US US US US US US US US US US US US US US US US US US US US US US US US US US US US US US US US US US US US US US US
公开(公告)号：EP2789340A1
公开(公告)日：2014-10-15
申请号：EP12855562.0
申请日：2012-12-06
申请人： Calpis Co., Ltd.
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61K35/74 , A23L1/30 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P43/00 , C12N1/20
CPC分类号： A61K35/747 , A23L2/52 , A23L33/135 , A23V2002/00 , A23Y2220/05 , A23Y2220/37 , A61K35/745 , C12N1/20 , C12R1/225 , A23V2200/326 , A23V2200/328 , A23V2200/332
摘要： This invention provides the use of a microorganism capable of improving both lipid metabolism and sugar metabolism. Specifically, the invention relates to: a lipid metabolism and/or sugar metabolism improver comprising, as an active ingredient, a bacterial cell selected from bacteria belonging to the genus Lactobacillus and the genus Bifidobacterium, a treated product of the bacterial cell, or a mixture thereof, having dual-agonistic activities to peroxisome proliferator activated receptor (PPAR)α and peroxisome proliferator activated receptor (PPAR)γ; to a food or a beverage comprising the improver; and to a pharmaceutical composition comprising the improver.
摘要翻译：本发明提供能够改善脂质代谢和糖代谢的微生物的用途。具体而言，本发明涉及：脂质代谢和/或糖代谢改善剂，其包含选自属于乳杆菌属和双歧杆菌属的细菌的细菌细胞作为活性成分，细菌细胞的处理产物或混合物其具有过氧化物酶体增殖物激活受体（PPAR）±和过氧化物酶体增殖物激活受体（PPAR）3的双重激动活性; 包括改良剂的食品或饮料; 以及包含改良剂的药物组合物。

15. 发明公开

EP2773725A1 METHOD FOR REMOVAL OF TOXIC WASTE FROM TIMBER 审中-公开
标题翻译：过程对于有毒废物，从锯材拆除
公开(公告)号：EP2773725A1
公开(公告)日：2014-09-10
申请号：EP12844909.7
申请日：2012-11-05
申请人： SOLRAY HOLDINGS LIMITED
发明人： BATHURST, Christopher Francis
IPC分类号： C10G1/04 , B01D11/04 , B27K9/00 , B01J14/00 , D21C3/20 , D21C3/22
CPC分类号： C05B17/00 , B01D11/0242 , C10G1/065 , D21C3/20 , D21C3/22 , Y02P20/145
摘要： A continuous flow wood processing technology for extracting lignin from woody plant material and converting the delignified cellulosic residue to crude bio-oils is provided. Wood is chipped before processing starts and fed into a lignin extractor. The lignin extractor uses ethanol at high temperatures to dissolve the lignin with counter current material contactors and heat exchangers and a computer control system to control the operation. Most of the preservative chemicals are likely to precipitate out at this stage as a heavy sludge which can be removed from the process. The ethanol containing dissolved lignin is removed from the lignin extractor, the dissolved lignin recovered, the ethanol being recycled into the lignin extractor and the residual heat returned to the process. The delignified cellulosic pulp is removed from the lignin extractor and subjected to a milling operation to convert the pulp into a smooth sludge for entry to a bio-convertor by a super critical water process. The residue is prepared as a high phosphate Fertilizer. Also described is a process for the removal of toxic preservative chemicals from waste timber and conversion to useful or nontoxic forms.

16. 发明授权

EP1409527B1 NOVEL HUMAN CYTOMEGALOVIRUS (HCMV) CYTOTOXIC T CELL EPITOPES, POLYEPITOPES, COMPOSITIONS COMPRISING SAME AND DIAGNOSTIC AND PROPHYLACTIC AND THERAPEUTIC USES THEREFOR 有权
标题翻译： NEW细胞毒性T细胞表位和人巨细胞病毒（HCMV）的多表位，将含有组合物和诊断，预防和治疗其应用
公开(公告)号：EP1409527B1
公开(公告)日：2014-08-20
申请号：EP02737666.4
申请日：2002-06-26
申请人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
发明人： KHANNA, Rajiv , ELKINGTON, Rebecca, Ann , WALKER, Susan, Jennifer
IPC分类号： C07K14/045 , A61K39/12 , A61K39/295 , A61P31/12 , C12N15/00
CPC分类号： C07K14/005 , A61K2039/525 , C12N2710/16122

17. 发明授权

EP2115143B1 VARIANT BUTTIAUXELLA SP. PHYTASES HAVING ALTERED PROPERTIES 有权
标题翻译：具有改变性质的布丘氏菌植酸酶的SP变异
公开(公告)号：EP2115143B1
公开(公告)日：2014-07-16
申请号：EP08725296.1
申请日：2008-02-06
申请人： Danisco US, Inc., Genencor Division
发明人： CERVIN, Marguerite, A. , KENSCH, Oliver , KETTLING, Ulrich , KIM, Steve , LEUTHNER, Birgitta , MIASNIKOV, Andrei , PELLENGAHR, Klaus , WARD, Michael
IPC分类号： C12N15/55 , C12N9/16 , A23K1/165
CPC分类号： C12N9/16 , A23K20/189 , A23K50/10 , A23K50/30 , A23K50/75 , A23K50/80 , C12Y301/03008 , C12Y301/03026 , C13K1/06 , Y02A40/818 , Y02E50/17
摘要： The present invention relates to variant phytase enzymes having altered properties

18. 发明公开

EP2745838A1 PROPHYLACTIC AGENT AND/OR THERAPEUTIC AGENT FOR SEPSIS 有权
标题翻译： PROPHYLAKTISCHES MITTEL UND / ODER THERAPEUTISCHES MITTEL GEGEN SEPSIS
公开(公告)号：EP2745838A1
公开(公告)日：2014-06-25
申请号：EP12824258.3
申请日：2012-08-10
申请人： SBI Pharmaceuticals Co., Ltd. , Nihon University
发明人： KINOSHITA, Kosaku , TANJOH, Katsuhisa , NODA, Akihiro , SAKURAI, Atsushi , TANAKA, Tohru , TAKAHASHI, Kiwamu , NAKAJIMA, Motowo , ABE, Fuminori
IPC分类号： A61K31/197 , A61K31/28 , A61K31/295 , A61K33/06 , A61K33/26 , A61K33/30 , A61K33/34 , A61P31/04 , A61P43/00
CPC分类号： A61K33/26 , A61K31/197 , A61K31/28 , A61K31/295 , A61K45/06
摘要： The present invention provides a sepsis therapeutic drug useful for prophylaxis and treatment of sepsis. A prophylactic agent and/or a therapeutic agent for sepsis containing 5-aminolevulinic acid (5-ALA) or a derivative thereof or a pharmacologically acceptable salt of 5-ALA or the derivative as an active ingredient is prepared. The prophylactic agent and/or the therapeutic agent preferably contains a metal-containing compound such as ferrous sodium citrate in addition to the ALAs. Preferred examples of the ALAs include ALA; various esters of ALA such as methyl, ethyl, propyl, butyl, and pentyl esters; and hydrochlorides, phosphates, sulfates of ALA and the esters.
摘要翻译：本发明提供可用于预防和治疗败血症的败血症治疗药物。制备含有5-氨基乙酰丙酸（5-ALA）或其衍生物或5-ALA或其衍生物作为活性成分的药理学上可接受的盐的败血症的预防剂和/或治疗剂。除ALA之外，预防剂和/或治疗剂优选含有含金属的化合物如柠檬酸亚铁铵。 ALA的优选实例包括ALA; 各种ALA的酯如甲基，乙基，丙基，丁基和戊酯; 和盐酸盐，磷酸盐，ALA的硫酸盐和酯。

19. 发明授权

EP1592793B2 OLIGOMERIC COMPOUNDS FOR THE MODULATION OF SURVIVIN EXPRESSION 有权
标题翻译：低聚物化合物调制表达生存素的
公开(公告)号：EP1592793B2
公开(公告)日：2014-05-07
申请号：EP04709580.7
申请日：2004-02-10
申请人： Santaris Pharma A/S
发明人： HANSEN, Jens Bo Rode , THRUE, Charlotte, Albaek , PETERSEN, Kamille, Dumong , WESTERGAARD, Majken , WISSENBACH, Margit
IPC分类号： C12N15/113 , A61K31/7088 , A61P35/00
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/31 , C12N2310/315 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346

20. 发明授权

EP2019687B1 VACCINE AGAINST STREPTOCOCCI 有权
标题翻译：球菌疫苗
公开(公告)号：EP2019687B1
公开(公告)日：2014-03-19
申请号：EP07759635.1
申请日：2007-03-29
申请人： Merial Limited
发明人： AUDONNET, Jean-christophe, Francis , MINKE, Jules, Maarten
IPC分类号： A61K39/295 , C07K14/315 , A61P31/04 , G01N33/569 , A61K39/09
CPC分类号： A61K39/092 , A61K2039/543 , A61K2039/552 , A61K2039/55566 , C07K14/315 , G01N33/56944 , G01N2469/20
摘要： The invention relates to subunit immunogenic or vaccine compositions which may comprise at least one polypeptide of Streptococcus equi and methods for preparing and/or formulating such compositions. The invention also relates to the use of such subunit compositions, such as a method for eliciting an immunogenic response or a protective immune response, which may comprise administering the composition to a mammal susceptible to streptococcal infection.

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