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1. 发明公开

EP3387006A1 LIPIDATEDSTREPTOCOCCUS PNEUMONIAE 无效
公开(公告)号：EP3387006A1
公开(公告)日：2018-10-17
申请号：EP16871875.7
申请日：2016-12-09
申请人： National Research Council of Canada , National Health Research Institutes
发明人： LENG, Chih-Hsiang , CHEN, Wangxue , CHONG, Pele
IPC分类号： C07K14/315 , A61K39/09 , A61P31/04 , A61P37/04 , C07K16/12 , C07K7/08 , C12N15/31 , C12N15/63 , C12P21/02
CPC分类号： A61K39/092 , A61K2039/6018 , A61P31/04 , C07K7/08 , C07K14/315 , C07K14/3156 , C07K16/12 , C07K19/00 , C07K2319/00 , C07K2319/21 , C12N15/63 , C12N15/70 , C12P21/02
摘要： There are provided compositions and methods for prevention or treatment of Streptococcus pneumoniae (SP)-associated diseases. More specifically, there are provided recombinant lipidated fusion proteins comprising pneumococcal surface antigen A (PsaA), the recombinant lipidated fusion proteins comprising, from N-terminus to C-terminus, the N-terminal native lipid signal peptide of PsaA and the C-terminal structural gene for PsaA. Methods of inducing broad spectrum mucosal immunity against SP comprising administering a vaccine comprising recombinant lipidated fusion proteins are also described.

2. 发明授权

EP2755680B1 PARTICULATE VACCINE FORMULATIONS 有权
公开(公告)号：EP2755680B1
公开(公告)日：2018-07-04
申请号：EP12831495.2
申请日：2012-09-12
申请人： PDS Biotechnology Corporation
发明人： BEDU-ADDO, Frank , CONN, Gregory , JACOBSON, Eric , MERCER, Carol , JOHNSON, Kenya
IPC分类号： A61K39/00 , A61K45/00
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/12 , A61K2039/55511 , A61K2039/55555 , A61K2039/55566 , A61K2039/585 , A61K2039/6018 , C12N2710/20034
摘要： The present disclosure provides vaccine formulations comprising at least one peptide antigen assembly and at least one adjuvant. The disclosure also provides methods of inducing an immune response in a mammal and methods of treating a disease in a mammal utilizing the vaccine formulations.

3. 发明公开

EP3236999A1 GAS-FILLED MICROVESICLES FOR USE AS VACCINE 有权转让
标题翻译：用作疫苗的充气微透镜
公开(公告)号：EP3236999A1
公开(公告)日：2017-11-01
申请号：EP15820139.2
申请日：2015-12-21
申请人： Bracco Suisse SA
发明人： BIOLEY, Gilles , CORTHESY, Blaise , LASSUS, Anne , BUSSAT, Philippe
IPC分类号： A61K39/39
CPC分类号： A61K39/0005 , A61K39/39 , A61K47/6925 , A61K2039/55555 , A61K2039/577 , A61K2039/60 , A61K2039/6018
摘要： Gas-filled microvesicles comprising an antigen bound thereto and to aqueous suspensions containing said microvesicles, for use in immunomodulating formulations, in particular as a vaccine. The antigen is covalently bound to a component of the microvesicles envelope. The microvesicles of the invention, comprising a molar excess of fatty acids in the stabilizing envelope, are particularly effective in the uptake by antigen-presenting cells, in particular dendritic cells.
摘要翻译：包含与其结合的抗原的充气微囊泡和含有所述微囊泡的水悬浮液，用于免疫调节制剂，特别是用作疫苗。抗原共价结合到微泡包膜的成分。包含稳定化包膜中摩尔过量的脂肪酸的本发明的微泡特别有效地摄取抗原呈递细胞，特别是树突细胞。

4. 发明授权

EP2316478B1 Vaccin thérapeutique ciblé contre la P-glycoprotéine 170 pour inhiber la resistance multidrogues dans le traitement des cancers 有权
标题翻译： Vaccinthérapeutiquecontre la P-glycoprotéine170 pour inhibiter la resistance multidrogues dans le traitement des cancers
公开(公告)号：EP2316478B1
公开(公告)日：2017-04-26
申请号：EP10185331.5
申请日：2004-07-25
申请人： AC Immune S.A.
发明人： Tosi, P. F. , Madoulet, Claudie , Nicolau, Claude , Hickman, David T.
IPC分类号： A61K39/00 , A61K39/385 , A61P35/00
CPC分类号： A61K39/0011 , A61K9/127 , A61K39/00 , A61K39/0005 , A61K47/646 , A61K48/00 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018 , C07K16/30 , C12N5/06 , G01N33/574
摘要： Immunogenic composition (A) comprising a vehicle and as antigenic structure, a conjugate (I) of at least one peptide (Ia) derived from extracellular loop 1 of protein P-170, where each (Ia) is associated with several molecules (Ib) of fatty acid of chain length 12-24C is new. Immunogenic composition (A) comprising a vehicle and as antigenic structure, a conjugate (I) of at least one peptide (Ia) derived from extracellular loop 1 of protein P-170, where each (Ia) is associated with several molecules (Ib) of fatty acid of chain length 12-24C is new. (I) displays at least part of the conformation of the loop for inducing anti-P-107 antibodies (Ab) or for causing reversal of multidrug resistance in cancer patients. ACTIVITY : Cytostatic. The tetrapalmitoylated peptide Lys-Gly-Gly-Asn-Met-Thr-Asp-Ser-Phe-Thr-Lys-Ala-Glu-Ala-Ser-Ile-Leu-Pro-Ser-Ile-Thr-Asn-Gln-Gly-Pro-Asn-Ser-Thr-Leu-Ile-Ile-Ser-Asn-Ser-Ser-Leu-(Glu) 3-Gly-Lys-Lys-NH 2 was formulated in liposomes (mole ratio peptide:lipids 1:250) and administered three times to mice at intervals of 2 weeks, at doses of 0.2 ml. The animals were then inoculated (day 0) with1 million P388R chemoresistant cells and treated with 5.5 mg/kg doxorubicin (days 1, 10 and 21) and 2.5 mg/kg vinblastine (days 4 and 14). The mean survival time was 39 days; compare 22 days for animals injected with empty liposomes. MECHANISM OF ACTION : Vaccine; inhibtion of P-170 which is responsible for expulsion of chemotherapeutic agents from cells.
摘要翻译：包含载体和作为抗原结构的免疫原性组合物（A），源自蛋白质P-170的细胞外环1的至少一种肽（Ia）的缀合物（I），其中每个（Ia）与几个分子（Ib）链长12-24C的脂肪酸是新的。包含载体和作为抗原结构的免疫原性组合物（A），源自蛋白质P-170的细胞外环1的至少一种肽（Ia）的缀合物（I），其中每个（Ia）与几个分子（Ib）链长12-24C的脂肪酸是新的。（I）显示用于诱导抗P-107抗体（Ab）或用于引起癌症患者中多药物抗性逆转的环的构象的至少一部分。活动：细胞生长抑制。四棕榈酰化肽Lys-Gly-Gly-Asn-Met-Thr-Asp-Ser-Phe-Thr-Lys-Ala-Glu-Ala-Ser-Ile-Leu-Pro- Ser-Ile-Thr-Asn-Gln-Gly 在脂质体中配制Pro-Asn-Ser-Thr-Leu-Ile-Ile-Ser-Asn-Ser-Ser-Leu-（Glu）3 -Gly-Lys-Lys-NH 2（摩尔比肽：脂质1： 250），并以0.2ml的剂量以2周的间隔对小鼠施用三次。然后将动物接种（第0天）与100万P388R化学耐药细胞并用5.5mg / kg多柔比星（第1,10和21天）和2.5mg / kg长春碱（第4和14天）处理。平均生存时间为39天; 比较注射空脂质体的动物22天。作用机制：疫苗; 抑制负责将化疗剂从细胞中排出的P-170。

5. 发明公开

EP2993182A4 IMMUNITY INDUCER FOR SACCHARIDE ANTIGENS 有权
标题翻译：抗氰菌胺的免疫诱导剂
公开(公告)号：EP2993182A4
公开(公告)日：2017-01-04
申请号：EP14791926
申请日：2014-05-02
申请人： NAT INST ADVANCED IND SCIENCE & TECH
发明人： OKUDA TETSUYA , SHIMIZU HIROKI
IPC分类号： C07K16/00 , A61K31/702 , A61K39/00 , A61P37/04 , C07H15/02 , C08B37/00
CPC分类号： A61K47/48046 , A61K31/702 , A61K31/7028 , A61K39/0011 , A61K39/39 , A61K47/543 , A61K2039/55511 , A61K2039/6018 , A61K2039/627 , C07H15/06 , C07H15/10 , C07K16/18 , C07K2317/92 , C07K2317/94 , C08B37/00
摘要： The present invention provides an immunity inducer and an immunity inducing method using same. The immunity inducer has an immunopotentiation effect on any target oligosaccharide antigen, in particular oligosaccharide antigens included in mammal-derived glycoprotein N-linked sugar chains; is capable of providing a monoclonal antibody having high specificity to and affinity with target oligosaccharide antigens; and has as an effective component thereof a glycolipid including a target oligosaccharide antigen (R) and indicated by general formula (2), or a salt thereof. General formula (2): R-Z-Y-CH(NH-CO-(CH 2 ) n1 -CH 3 -(CH 2 ) n2 -CH 3 (in the formula, R indicates a straight-chain or branched oligosaccharide comprising 2-30 of at least one type of monosaccharide. Z indicates a single bond, O, S or NH, a linker bound to thiomethyl, amino methylated sugar alcohol. Y indicates -(CH 2 ) m -. n1 indicates an integer of 2-40, n2 indicates an integer of 1-27, and m indicates an integer of 1-30).
摘要翻译：本发明提供免疫诱导剂和使用其的免疫诱导方法。免疫诱导剂对任何靶寡糖抗原，特别是包含在哺乳动物衍生的糖蛋白N-连接的糖链中的寡糖抗原具有免疫增强作用; 能够提供对靶寡糖抗原具有高特异性和亲和力的单克隆抗体; 并且具有作为其有效成分的包含目标寡糖抗原（R）并由通式（2）表示的糖脂或其盐。通式（2）：RZY-CH（NH-CO-（CH 2）n1 -CH 3 - （CH 2）n2 -CH 3（式中，R表示直链或支链的寡糖，至少一种单糖，Z表示单键，O，S或NH，与硫甲基，氨基甲基化糖醇结合的接头，Y表示 - （CH 2）m - ，n1表示2-40的整数，n2 表示1-27的整数，m表示1-30的整数）。

6. 发明公开

EP2958551A4 PARTICLE FORMULATIONS FOR DELIVERY OF TLR AGONISTS AND ANTIGENS 有权
标题翻译：颗粒制剂用于递送TLR激动剂和抗原
公开(公告)号：EP2958551A4
公开(公告)日：2016-11-02
申请号：EP14754426
申请日：2014-02-24
申请人： PARTICLE SCIENCES INC
发明人： MITCHNICK MARK , LOXLEY ANDREW , GWOZDZ GARRY THOMAS
IPC分类号： A61K9/14 , A61P37/04
CPC分类号： A61K39/385 , A61K9/107 , A61K9/1075 , A61K39/39 , A61K47/186 , A61K47/44 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/6018
摘要： Compositions of one or more TLR agonists and one or more antigens adsorbed or attached to the same particles or to different particles are provided. Also provided are methods for producing and using these compositions.

7. 发明授权

EP2231196B1 INCREASE OF IMMUNE RESPONSE BY PEPTIDE ANTIGEN LINKAGE 有权转让
标题翻译：增的免疫反应肽抗原LINK
公开(公告)号：EP2231196B1
公开(公告)日：2016-05-25
申请号：EP08846406.0
申请日：2008-11-07
申请人： ABIVAX
发明人： SERRA, Vincent
IPC分类号： A61K47/48 , A61K39/385 , C07H15/06
CPC分类号： C07H15/06 , A61K39/385 , A61K47/549 , A61K47/646 , A61K2039/57 , A61K2039/6018
摘要： The present invention relates to compounds consisting of glycolipids covalently bound to an antigen or a drug via a linker. The said compounds are able to induce a stronger immune response than a composition comprising separated glycolipids and antigen. The said compounds are also able to target drug to CD1d restricted cells.

8. 发明授权

EP1651257B1 VACCIN THERAPEUTIQUE CIBLE CONTRE LA P-GLYCOPROTEINE 170 POUR INHIBER LA RESISTANCE MULTIDROGUES DANS LE TRAITEMENT DES CANCERS 有权
标题翻译：靶向治疗性疫苗针对P-糖蛋白170用于抑制MULTI产生耐药性IN癌症治疗
公开(公告)号：EP1651257B1
公开(公告)日：2016-02-17
申请号：EP04763487.8
申请日：2004-07-25
申请人： AC Immune SA
发明人： TOSI, P., F. , MADOULET, Claudine , NICOLAU, Claude , HICKMAN, David, T.
IPC分类号： A61K39/00 , A61K39/385 , A61P35/00
CPC分类号： A61K39/0011 , A61K9/127 , A61K39/00 , A61K39/0005 , A61K47/646 , A61K48/00 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018 , C07K16/30 , C12N5/06 , G01N33/574

9. 发明公开

EP2841559A4 GLYCOENGINEERED OUTER MEMBRANE VESICLES AND USE THEREOF AS VACCINES 审中-公开
标题翻译： BY糖生产外膜囊泡及其用途疫苗
公开(公告)号：EP2841559A4
公开(公告)日：2015-12-16
申请号：EP13782478
申请日：2013-04-26
申请人： UNIV ALBERTA
发明人： FELDMAN MARIO , PRICE NANCY , GARCIA-QUINTANILLA FATIMA , IELMINI MARIA VERONICA
IPC分类号： C12N1/21 , A61K39/00 , A61K39/02 , A61K39/09 , A61K39/116 , A61P31/04 , A61P37/04 , C12N15/52 , C12N15/63 , C12N15/70 , C12P19/00 , C12P19/04 , C12P21/00
CPC分类号： A61K39/092 , A61K39/0208 , A61K2039/55555 , A61K2039/6018 , C12N15/52 , C12N15/70 , C12P19/04

10. 发明公开

EP2809345A4 IMMUNOSTIMULATORY COMPOSITIONS, PARTICLES, AND USES RELATED THERETO 审中-公开
标题翻译：免疫刺激成分，颗粒整齐，用途与CONNECTION
公开(公告)号：EP2809345A4
公开(公告)日：2015-11-25
申请号：EP13743997
申请日：2013-02-01
申请人： UNIV EMORY
发明人： SELVARAJ PERIASAMY
IPC分类号： A61K39/00 , A61K39/12 , A61P31/12 , A61P35/00
CPC分类号： A61K39/385 , A61K39/0011 , A61K39/39 , A61K2039/515 , A61K2039/5152 , A61K2039/5258 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55533 , A61K2039/55538 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/62 , A61K2039/627
摘要： In some embodiments, described herein is a method of tumor treatment or tumor vaccination. The method generally comprises applying to a human being in need thereof a tumor therapeutic composition or tumor vaccine defined herein. The tumor therapeutic composition or tumor vaccine can be produced by protein transfer of glycosyl-phosphatidylinositol (GPI)-anchored immunostimulatory or costimulatory molecules.

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