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11. 发明公开

EP1804819A4 USE OF AROMATASE INHIBITORS FOR ENDOMETRIAL THINNING IN PREPARATION FOR SURGICAL PROCEDURES ON THE ENDOMETRIAL CAVITY AND UTERUS 审中-公开
标题翻译：芳香化酶抑制剂在子宫内膜THINNER使用外科手术对子宫内膜及子宫研制
公开(公告)号：EP1804819A4
公开(公告)日：2007-12-12
申请号：EP05802604
申请日：2005-10-04
申请人： UNIV WAYNE STATE , MOUNT SINAI HOSPITAL CORP
发明人： MITWALLY MOHAMED F M , DIAMOND MICHAEL P , CASPER ROBERT F
IPC分类号： A61K45/00 , A61K45/06 , A61P15/12
CPC分类号： A61K31/56 , A61K31/4196 , A61K31/5685 , A61K45/06 , A61K2300/00

12. 发明公开

EP1539944A4 METHODS AND COMPOSITIONS FOR THE IDENTIFICATION OF ANTIBIOTICS THAT ARE NOT SUSCEPTIBLE TO ANTIBIOTIC RESISTANCE 审中-公开
标题翻译：方法和组合物用于识别耐药性侵害不敏感的抗生素
公开(公告)号：EP1539944A4
公开(公告)日：2005-12-28
申请号：EP03762329
申请日：2003-07-01
申请人： UNIV WAYNE STATE
发明人： CUNNINGHAM PHILLIP R
IPC分类号： G01N33/50 , A61K39/002 , A61K39/02 , C07H21/02 , C07H21/04 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/10 , C12N15/11 , C12N15/63 , C12N15/70 , C12N15/74 , C12P21/00 , C12Q1/02 , C12Q1/68 , G01N20060101 , G01N33/15
CPC分类号： C12N15/70 , C12N15/1058 , C12N15/1086

13. 发明公开

EP1165560A4 2-HYDROXY METHYLCYCLOPRO PYLIDENEMETHYL PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS 有权
标题翻译： 2-羟基METHYLCYCLOPROPYLIDENMETHYL嘌呤和嘧啶，其病毒物质
公开(公告)号：EP1165560A4
公开(公告)日：2002-04-17
申请号：EP00913872
申请日：2000-03-10
申请人： UNIV MICHIGAN , UNIV WAYNE STATE
发明人： ZEMLICKA JIRI , QIU YAO-LING , DRACH JOHN C , PTAK ROGER G
IPC分类号： C07D473/16 , A61K31/52 , A61K31/522 , A61K31/7072 , A61K31/708 , A61P31/12 , A61P31/18 , A61P31/20 , A61P31/22 , C07D239/46 , C07D239/54 , C07D473/00 , C07D473/18 , C07F9/6506 , C07F9/6561
CPC分类号： C07D239/47 , C07D239/54 , C07D473/00 , C07D473/16 , C07D473/18 , C07D473/34 , C07F9/65061 , C07F9/65616

14. 发明公开

EP3194623A4 SYSTEMS AND METHODS TO DETECT STEM CELL STRESS AND USES THEREOF 有权
公开(公告)号：EP3194623A4
公开(公告)日：2018-03-14
申请号：EP15831338
申请日：2015-08-11
申请人： UNIV WAYNE STATE
发明人： PUSCHECK ELIZABETH , RAPPOLEE DANIEL A
IPC分类号： C12Q1/68 , C12N5/00 , C12N5/073 , C12N5/0735 , C12Q1/6897
CPC分类号： C12N5/0606 , C12N5/0605 , C12N2500/02 , C12N2500/60 , C12N2501/119 , C12N2503/02 , C12Q1/6897
摘要： Systems and methods (S/M) to detect stress in stem cells are described. The S/M, including modified stem cells, assays and high throughput screens, can be used to identify compounds or other potential stressors that can negatively affect development potential.

15. 发明公开

EP2974143A4 PRK-BASED SCHEDULING FOR PREDICTABLE LINK RELIABILITY 有权
标题翻译： PRK-BASIERTE TERMINPLANUNGFÜRVORHERSEHBAREVERKNÜPFUNGSZUVERLÄSSIGKEIT
公开(公告)号：EP2974143A4
公开(公告)日：2016-08-03
申请号：EP14768253
申请日：2014-03-14
申请人： UNIV WAYNE STATE
发明人： ZHANG HONGWEI , LIU XIAOHUI , LI CHUAN
IPC分类号： H04L12/26 , H04L12/24 , H04L12/851 , H04L12/863
CPC分类号： H04W40/16 , H04L47/626 , H04W40/20 , H04W72/1231 , H04W72/1242 , Y02D70/00 , Y02D70/144 , Y02D70/34 , Y02D70/38
摘要： A Distributed sensing and control network includes multiple sensing/control nodes, each of which includes a controller. Each sensing/control node determines signal transmission/receipt scheduling based on a physical-ratio-k-scheduling (PRKS) protocol stored within the controller.
摘要翻译：分布式感测和控制网络包括多个感测/控制节点，每个节点包括一个控制器。每个感测/控制节点基于存储在控制器内的物理比k调度（PRKS）协议来确定信号发送/接收调度。

16. 发明公开

EP2831390A4 COMBUSTION MODIFICATION AND EMISSIONS REDUCTION UTILIZING AN ELECTRICALLY INSULATED ENGINE MEMBER IN INTERNAL COMBUSTION ENGINES 审中-公开
标题翻译：燃烧改性或隔离电动元件减少排放内燃机中
公开(公告)号：EP2831390A4
公开(公告)日：2016-05-11
申请号：EP13768462
申请日：2013-03-28
申请人： UNIV WAYNE STATE
发明人： ESTEFANOUS FADI A , HENEIN NAEIM A
IPC分类号： F02B51/04 , F02D35/02 , F02P5/04 , F02P9/00
CPC分类号： F02P9/002 , F02B51/04 , F02D35/021 , F02P5/045 , F02P9/007 , Y02T10/126

17. 发明公开

EP2909315A4 IDENTIFICATION AND ANALYSIS OF FETAL TROPHOBLAST CELLS IN CERVICAL MUCUS FOR PRENATAL DIAGNOSIS 有权
标题翻译： ERKENNUNG UNDANALYZE VONFÖTALENTROPHOBLASTENZELLEN IN DERGEBÄRMUTTERHALSSCHLEIMHAUTZURPRÄNATALENDIAGNOSE
公开(公告)号：EP2909315A4
公开(公告)日：2016-04-20
申请号：EP13847056
申请日：2013-10-18
申请人： UNIV WAYNE STATE
发明人： ARMANT D RANDALL , DIAMOND MICHAEL P
IPC分类号： C12N5/073 , C12Q1/24 , C12Q1/68 , G01N33/569
CPC分类号： C12Q1/24 , C12N5/0605 , C12N2503/00 , C12Q1/6888 , C12Q2600/156 , G01N33/56966 , G01N2333/70539 , G01N2800/368
摘要： A method of retrieving fetal cells from an endocervical sample by removing the mucus from the endocervical sample by disassociating fetal cells and maternal cells in the endocervical sample; and isolating disassociated fetal cells from other cells in the endocervical sample. Also provided is a method of retrieving fetal cells from an endocervical sample, by obtaining a mixture of disassociated cells prepared by the above method, treating the cells with a fetal-specific antibody, identifying cells that have bound to the fetal-specific antibody, and isolating the identified cells. The disassociated cell prepared by the above method can be analyzed and used for a variety of purposes including, but not limited to, the identification of fetal cells among cervical cells, determination of fetal cell density to predict high risk pregnancy, genetic analysis of fetal cells, and determination of growth factor or other biomarker expression to predict obstetrical disorders.
摘要翻译：一种通过从胎儿宫颈样品中分离胎儿细胞和母体细胞而从子宫颈内样品中去除粘液来从子宫颈样品中检索胎儿细胞的方法; 并从子宫颈样品中的其他细胞分离脱离的胎儿细胞。还提供了通过获得通过上述方法制备的解离细胞的混合物，用胎儿特异性抗体处理细胞，鉴定与胎儿特异性抗体结合的细胞的方法，从子宫颈样品中检索胎儿细胞，以及分离鉴定的细胞。通过上述方法制备的分离细胞可以分析并用于各种目的，包括但不限于宫颈细胞中胎儿细胞的鉴定，胎儿细胞密度的测定，预测高危妊娠，胎儿细胞的遗传分析，以及生长因子或其他生物标志物表达的测定以预测产科障碍。

18. 发明公开

EP2836833A4 PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 审中-公开
标题翻译： PRISNATALES TESTVERFAHREN AUF DAS DOWN-SYNDROM UND TRISOMIE 18
公开(公告)号：EP2836833A4
公开(公告)日：2015-10-14
申请号：EP13775727
申请日：2013-04-12
申请人： UNIV WAYNE STATE , NICOLAIDES KYPROS
发明人： NICOLAIDES KYPROS , BAHADO-SINGH RAY
IPC分类号： G01N33/68 , G06F19/00
CPC分类号： G01N33/70 , G01N33/492 , G01N33/50 , G01N33/6806 , G01N33/6812 , G01N2570/00 , G01N2800/387 , G16H50/30 , Y10T436/147777 , Y10T436/173845 , Y10T436/201666 , Y10T436/203332
摘要： The present invention is directed to methods for predicting a pregnant woman's risk of carrying a fetus with Down syndrome (Trisomy 21) or Trisomy 18. The methods are based on measuring one or more metabolites obtained from a pregnant woman's bodily fluid, such as blood or urine, and found to be predictive of Trisomy 21 or Trisomy 18.
摘要翻译：本发明涉及用于预测怀孕妇女携带唐氏综合症（三体积21）或三体层析器18的胎儿的风险的方法。该方法基于测量从孕妇身体液体获得的一种或多种代谢物，例如血液或尿，并发现可预测三体21或三体18。

19. 发明公开

EP2552458A4 INJECTABLE DENDRIMER HYDROGEL NANOPARTICLES 审中-公开
标题翻译：可注射树枝状聚合物 - 水凝胶的纳米颗粒
公开(公告)号：EP2552458A4
公开(公告)日：2014-08-27
申请号：EP11763407
申请日：2011-03-31
申请人： UNIV WAYNE STATE , NAT INST HEALTH
发明人： KANNAN RANGARAMANUJAM M , KANNAN SUJATHA , ROMERO ROBERTO , NAVATH RAGHAVENDRA , MENJOGE ANUPA
IPC分类号： A61K47/48 , A61P25/28 , A61P31/00 , C08G73/02 , C08L79/02
CPC分类号： A61K47/48207 , A61K9/0019 , A61K9/0051 , A61K31/43 , A61K47/595 , A61K47/6903 , C08G73/028 , C08L79/02
摘要： The invention discloses injectable hydrogels which are in the form of crosslinked nano beads or particle in the size range 5 nm to 10 μm, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents and their methods of preparation. The said gel is formed by reaction of the PAMAM dendrimer with asymmetrical end groups with other polymer wherein the other polymer is selected from the group of linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms. The gel disclosed in the present invention is formed as small crosslinked particles in the size range 25 nm to 10 μm and is suitable for injectable delivery of hydrogel to any of the body orifices, tissues by intramuscular or subcutaneous route and ocular delivery for the purpose of therapeutic treatment and imaging.

20. 发明公开

EP2627332A4 SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME 审中-公开
标题翻译： PROTON耦合式选择性FOLATTRANSPORTER和叶酸受体抑制剂的化合物GARFTASE和/或其他FOLATMETABOLISIERUNGSENZYMEN及其使用方法
公开(公告)号：EP2627332A4
公开(公告)日：2014-08-20
申请号：EP11833198
申请日：2011-10-10
申请人： UNIV HOLY GHOST DUQUESNE , UNIV WAYNE STATE
发明人： GANGJEE ALEEM , MATHERLY LARRY H
IPC分类号： A61K31/519 , A61P35/00 , A61P37/06 , C07D487/04 , C07D491/048 , C12N5/09 , C12N9/99
CPC分类号： C07D487/04 , A61K31/519 , C07D491/048 , C12N9/99

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