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111. 发明公开

EP2354253A3 Method for non-invasive prenatal diagnosis 审中-公开
标题翻译：无创性产前诊断方法
公开(公告)号：EP2354253A3
公开(公告)日：2011-11-16
申请号：EP10189690.0
申请日：2004-09-07
申请人： Trustees of Boston University , The Chinese University Of Hong Kong
发明人： Cantor, Charles R. , Ding, Chunming , Lo, Yuk Ming Dennis , Chiu, Rossa Wai-Kwun
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6872 , C12Q2600/156 , C12Q2600/172 , C12Q2535/125
摘要： The present invention is directed to methods of detecting nucleic acids in a biological sample. The method is based on a novel combination of a base extension reaction, which provides excellent analytical specificity, and a mass spectrometric analysis, which provides excellent specificity. The method can be used, for example, for diagnostic, prognostic and treatment purposes. The method can be used, for example, for diagnostic, prognostic and treatment purposes. The method allows accurate detection of nucleic acids that are present in very small amounts in a biological sample. For example, the method of the present invention is preferably used to detect fetal nucleic acid in maternal blood sample; circulating tumor-specific nucleic acids in a blood, urine or stool sample; and donor-specific acids in transplant recipients. In another embodiment, one can detect viral, bacterial, fungal, or other foreign nucleic acids in biological sample.
摘要翻译：本发明涉及检测生物样品中的核酸的方法。该方法基于提供优异分析特异性的碱基延伸反应和提供优异特异性的质谱分析的新型组合。该方法可以用于例如诊断，预后和治疗目的。该方法可以用于例如诊断，预后和治疗目的。该方法允许准确检测生物样品中存在的非常少量的核酸。例如，本发明的方法优选用于检测母体血液样品中的胎儿核酸; 在血液，尿液或粪便样品中循环肿瘤特异性核酸; 和移植受体中的供体特异性酸。在另一个实施方案中，可以检测生物样品中的病毒，细菌，真菌或其他外源核酸。

112. 发明公开

EP2313149A1 METHOD AND DEVICE FOR PREVENTING ANKLE SPRAIN INJURIES 审中-公开
标题翻译：预防踝关节扭伤的方法和装置
公开(公告)号：EP2313149A1
公开(公告)日：2011-04-27
申请号：EP09806372.0
申请日：2009-08-12
申请人： The Chinese University Of Hong Kong
发明人： CHAN, Kai-Ming , FONG, Tik Pui Daniel , YUNG, Shu Hang Patrick
IPC分类号： A61N1/18 , A61B5/11
CPC分类号： A61N1/36003 , A61B5/1071 , A61B5/112 , A61B5/6807 , A61B5/6828 , A61B2562/0215
摘要： Devices and methods for preventing ankle sprain injuries. To protect the ankle joint from acute ankle supination or inversion sprain injuries, the device comprises a sensing part configured to sense data of an ankle motion; an analyzing part configured to analyze the data to judge whether the motion is a sprain motion; and a stimulating part configured to stimulate one or more lower limb muscles against the motion in light of a result of the analyzing. The method also involves sensing data of an ankle motion; analyzing the data to judge whether the motion is a sprain motion; and stimulating one or more lower limb muscles against the motion if the motion is a sprain motion.
摘要翻译：防止脚踝扭伤的装置和方法。为了保护脚踝关节免受急性脚踝外翻或倒置扭伤的伤害，该装置包括配置为感测脚踝运动数据的感测部分; 分析部分，配置为分析数据以判断运动是否是扭伤运动; 以及刺激部分，其被配置为根据分析结果刺激一个或多个下肢肌肉抵抗运动。该方法还涉及感测脚踝运动的数据; 分析数据以判断运动是否是扭伤运动; 并且如果运动是扭转运动，则针对该运动刺激一个或多个下肢肌肉。

113. 发明公开

EP2231137A4 METHOD OF MODULATING MEMBRANE POTENTIAL OF A CELL 有权转让
标题翻译：方法用于调制的细胞膜潜力
公开(公告)号：EP2231137A4
公开(公告)日：2011-04-06
申请号：EP08871016
申请日：2008-12-18
申请人： YANG DAN , LI XIANG , SHEN BING , YAO XIAO-QIANG , THE CHINESE UNIVERSITY OF HONG KONG , VERSITECH LTD
发明人： YANG DAN , LI XIANG , SHEN BING , YAO XIAO-QIANG
IPC分类号： A61K31/16 , A61K31/215 , A61K31/4412 , A61P9/12 , A61P13/12 , A61P19/08 , A61P25/00 , A61P25/08 , A61P25/14 , A61P27/00 , C07C217/46 , C07C217/48 , C07C225/08 , C07C225/14 , C07C225/16 , C07C237/42 , C07C239/14 , C07C239/20 , C07D213/63 , C07D213/79 , C07D213/81
CPC分类号： A61K31/166
摘要： Provided herein are methods of modulating membrane potential of a cell membrane using self-assembling compounds. Also provided herein are methods of regulating a natural voltage-dependent ion channel in a cell membrane using the self-assembling compounds disclosed herein. Further provided herein are methods of treating, preventing and/or managing a disease that is related to the abnormal membrane potential responses by using the self-assembling compounds disclosed herein.

114. 发明公开

EP2161347A3 Markers for prenatal diagnosis and monitoring 有权
标题翻译：标记用于产前诊断和产前监测
公开(公告)号：EP2161347A3
公开(公告)日：2010-06-16
申请号：EP09011318.4
申请日：2006-03-17
申请人： The Chinese University Of Hong Kong
发明人： Lo, Yuk-Ming, Dennis , Chiu, Rossa Wai Kwun , Chim, Stephen, Siu Chung , Tsui, Nancy Bo Yin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more RNA species derived from a set of genetic loci and comparing the amount of the RNA species with a standard control.

115. 发明公开

EP2191622A1 LOAD BALANCING AND ADMISSION SCHEDULING IN PULL-BASED PARALLEL VIDEO SERVERS 审中-公开
标题翻译：负载均衡和录取调度并行视频服务器TO PULL BASE
公开(公告)号：EP2191622A1
公开(公告)日：2010-06-02
申请号：EP08800621.8
申请日：2008-09-19
申请人： The Chinese University Of Hong Kong
发明人： LEE, Yiu Bun
IPC分类号： H04L12/56
CPC分类号： H04N21/6375 , H04N7/17336 , H04N21/23103 , H04N21/2318 , H04N21/2396
摘要： A pull-based parallel video server system and method of implementation useful in an on-demand video system includes a plurality of slave admission schedulers operating in parallel with a master admission scheduler to back up the master admission scheduler that controls access to an array of pull-based video servers according to a protocol that accounts for jitter and loss of packets, as well as network delays. A transport protocol is provided that improves video data throughput under such conditions. To determine the architecture and functional requirements of the redundant admission schedulers, an analytical tool in the form of a performance model has been developed that incorporates network delays, delay jitters and packet losses on the communication links between the clients, schedulers and servers.

116. 发明公开

EP1977220A1 SURFACE PLASMON RESONANCE SENSORS AND METHODS FOR DETECTING SAMPLES USING THE SAME 审中-公开
标题翻译： FOR其检测使用的样品表面等离子体共振传感器和方法
公开(公告)号：EP1977220A1
公开(公告)日：2008-10-08
申请号：EP07702114.5
申请日：2007-01-18
申请人： THE CHINESE UNIVERSITY OF HONG KONG
发明人： HO, Ho Pui , WU, Shu Yuen , LIN, Chinlon , KONG, Siu Kai
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , Y10S435/808 , Y10S436/805
摘要： Disclosed is an optical sensing device including a source unit providing a beam of light with continuously modulated phase retardation between p- and s-polarization components of the light by employing a LCM; a reference unit receiving a first part of the light to provide a reference signal; a SPR sensing unit receiving a second part of the light to induce a phase retardation change between the p- and s-polarization components due to SPR associated with a sample; a probe unit receiving the light after SPR to provide a probe signal; and a detection unit connected to the reference unit and the probe unit to detect characteristics of the sample by comparing the reference signal with the probe signal. By using active phase modulation technologies and differential phase measurement, it is possible to fulfill chemical and biological detection.

117. 发明公开

EP1927208A1 METHOD AND SYSTEM FOR QUANTUM KEY DISTRIBUTION OVER MULTI-USER WDM NETWORK WITH WAVELENGTH ROUTING 有权
标题翻译：方法和系统量子密钥分配上更为用户WDM网络，波长路由
公开(公告)号：EP1927208A1
公开(公告)日：2008-06-04
申请号：EP06761549.2
申请日：2006-07-24
申请人： THE CHINESE UNIVERSITY OF HONG KONG
发明人： LUO, Yuhui , CHAN, Kam, Tai
IPC分类号： H04J14/02
CPC分类号： H04J14/0246 , H04B10/70 , H04J14/0227 , H04J14/0282 , H04L9/0852
摘要： A system and a method for quantum key distribution over a multi-user wavelength division multiplexing (WDM) network are disclosed. The system comprises a tunable or multi-wavelength transmitter; a plurality of receivers, each assigned a receiving-wavelength; and a multi-user WDM network linking the transmitter to the receivers. The transmitter can select a receiver among the receivers to be communicated therewith and transmit quantum signals to the selected receiver over the WDM network. The quantum signals are at a wavelength equal to a receiving-wavelength of the receiver. Therefore the WDM network allows quantum signals to be communicated between the transmitter and the receivers by wavelength routing.

118. 发明授权

EP1390027B1 COMPOSITION COMPRISING DEMETHYLCANTHARIDIN IN COMBINATION WITH PLATINUM-CONTAINING ANTICANCER AGENTS AND USE THEREOF 有权
标题翻译：组成DEMETHYLCANTHARIDIN铂类含有抗癌症剂及其使用综合
公开(公告)号：EP1390027B1
公开(公告)日：2008-04-02
申请号：EP01951327.4
申请日：2001-05-31
申请人： THE CHINESE UNIVERSITY OF HONG KONG
发明人： AU-YEUNG, Steve C.F. , TO, Kenneth K.W. , HO, Yee-Ping
IPC分类号： A61K31/365 , A61K31/343 , A61K31/555 , A61P35/00
CPC分类号： A61K31/343 , A61K31/555 , A61K33/24 , A61K2300/00
摘要： The invention provides a pharmaceutical composition for inhibiting cisplatin, carboplatin or oxaliplatin-sensitive and resistant tumorous cells comprising a combination of demethycantharidin with a platinum-containing anticancer agent and a use thereof. The invention also discloses synergistic effect of demethycantharidin or pharmaceutically acceptable derivative thereof in combination with platinum-containing anticancer agents in inhibiting cisplatin, carboplatin or oxaliplatin-sensitive and resistant tumorous cells.

119. 发明公开

EP1859051A1 MARKERS FOR PRENATAL DIAGNOSIS AND MONITORING 审中-公开
标题翻译： MARKER进行产前诊断和监测
公开(公告)号：EP1859051A1
公开(公告)日：2007-11-28
申请号：EP06722066.5
申请日：2006-03-17
申请人： THE CHINESE UNIVERSITY OF HONG KONG
发明人： LO, YuK-Ming Dennis , CHIU, Rossa Wai Kwun, Flat 1a, Block 1 , CHIM, Stephen Siu Chung , TSUI, Nancy Bo Yin, Rm 1501, Blk 10
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more RNA species derived from a set of genetic loci and comparing the amount of the RNA species with a standard control.

120. 发明公开

EP1749831A1 DEMETHYL-CANTHARIDIN PLATINUM COMPLEX ISOMERS AND THEIR USE 审中-公开
标题翻译：二甲基 - 甲硫氨酸铂络合物异构体及其用途
公开(公告)号：EP1749831A1
公开(公告)日：2007-02-07
申请号：EP05741689.3
申请日：2005-04-08
申请人： THE CHINESE UNIVERSITY OF HONG KONG
发明人： HO, Yee-Ping , AU-YEUNG, Steve, C., F. , TO, Kin Wah , WANG, Xinning
IPC分类号： C07F15/00 , A61K31/282 , A61P35/00
CPC分类号： C07F15/0093
摘要： The present invention provides a stereo-isomer of the demethylcantharidin platinum complex of formula I and use thereof. The stereo-isomer inhibits the growth of cisplatin, carboplatin or oxaliplatin-sensitive and -resistant tumorous cells. The invention also describes a pharmaceutical composition comprising the stereo-isomer of the demethylcantharidin platinum complex and use thereof.
摘要翻译：本发明提供式I的去甲基斑rid素铂络合物的立体异构体及其用途。立体异构体抑制顺铂，卡铂或奥沙利铂敏感和耐药的肿瘤细胞的生长。本发明还描述了包含去甲基斑rid素铂络合物的立体异构体的药物组合物及其用途。

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