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111. 发明公开

EP3522946A1 NEGATIVE PRESSURE ENHANCED CELLULAR INFILTRATION 审中-公开
公开(公告)号：EP3522946A1
公开(公告)日：2019-08-14
申请号：EP17859162.4
申请日：2017-10-05
申请人： Temple University - Of The Commonwealth System of Higher Education
发明人： GERSTENHABER, Jonathan A. , HAR-EL, Yah-El H. , LELKES, Peter I. , TIMNAK, Azadeh
IPC分类号： A61M1/00

112. 发明公开

EP3442433A1 INFUSION CATHETER AND METHOD OF USE 有权转让
公开(公告)号：EP3442433A1
公开(公告)日：2019-02-20
申请号：EP17783344.9
申请日：2017-04-15
申请人： Temple University Of The Commonwealth System Of Higher Education
发明人： BASHIR, Riyaz , GREEN, Nicholas, A.
IPC分类号： A61B17/00 , A61B17/22 , A61B17/221 , A61B18/00 , A61F2/82

113. 发明授权

EP2810071B1 METHOD FOR DETECTING POLYOMAVIRUS REACTIVATION 有权转让
公开(公告)号：EP2810071B1
公开(公告)日：2018-10-10
申请号：EP13744099.6
申请日：2013-01-29
申请人： Temple University - Of The Commonwealth System of Higher Education
发明人： KHALILI, Kamel , SARIYER, Ilker, K.
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , G01N2333/025 , G01N2469/10 , G01N2469/20 , G01N2800/50 , G01N2800/56
摘要： The invention provides methods of detection and monitoring of polyomavirus reactivation and active polyomavirus infections using a biological fluid sample. Also provided are methods of risk assessment and risk monitoring of developing a polyomavirus-associated disease.

114. 发明公开

EP3337518A2 BAG3 COMPOSITIONS AND METHODS 审中-实审
公开(公告)号：EP3337518A2
公开(公告)日：2018-06-27
申请号：EP16837738.0
申请日：2016-08-17
申请人： Temple University Of The Commonwealth System Of Higher Education
发明人： FELDMAN, Arthur, M. , CHEUNG, Joseph, Y.
IPC分类号： A61K48/00
CPC分类号： A61K48/0066 , A61K48/0075 , A61K48/0083 , A61P9/10 , C07K14/4747 , C07K19/00 , C12N15/113 , C12N15/85 , C12N2710/10343 , C12N2310/14 , C12N2310/531
摘要： The present invention features methods and compositions for treatment of heart failure. The compositions can include an isolated nucleic acid encoding a BAG3 polypeptide or fragment thereof.

115. 发明公开

EP3324962A1 NOVEL AMINOTHIAZOLE COMPOUNDS AND METHODS USING SAME 审中-实审
公开(公告)号：EP3324962A1
公开(公告)日：2018-05-30
申请号：EP16828552.6
申请日：2016-07-21
申请人： Temple University Of The Commonwealth System Of Higher Education
发明人： ISSA, Jean-Pierre, J. , ZHANG, Hanghang , ABU-GHARBIA, Magid , CHILDERS, Wayne, E. , MORTON, George, C.
IPC分类号： A61K31/427 , C07D417/02 , A61K31/36
CPC分类号： C07D417/14 , A61K31/427 , A61K31/706 , A61K45/06 , A61K2300/00 , A61P35/00 , C07D417/06
摘要： The present invention includes novel aminothiazole compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.

117. 发明公开

EP3130021A1 SOFT-SOLID CRYSTALLINE ELECTROLYTE COMPOSITIONS 有权
标题翻译： KRISTALLINE WEICH-FESTE ELEKTROLYTZUSAMMENSETZUNGEN
公开(公告)号：EP3130021A1
公开(公告)日：2017-02-15
申请号：EP15769204.7
申请日：2015-03-20
申请人： Temple University Of The Commonwealth System Of Higher Education
发明人： ZDILLA, Michael J. , WUNDER, Stephanie L. , CHINNAM, Parameswara Rao
IPC分类号： H01M4/02 , H01M6/14 , H01M6/16 , H01M6/36
CPC分类号： H01M10/0565 , H01M4/02 , H01M6/14 , H01M6/16 , H01M6/36 , H01M10/052 , H01M10/056 , H01M2300/0017 , H01M2300/0085
摘要： The present invention relates to compositions comprising ionic compounds surrounded by organic matrices, and methods for producing such compositions. In various embodiments, the compositions of the present invention are co-crystals of an organic compound and a salt. The organic compound forms matrices with channel structures, wherein the organic matrices interact relatively poorly with the salt, thus allowing for excellent ion mobility through the channel structures. In one embodiment, the compositions are soft-solid electrolytes, comprising ions such as lithium or sodium, which can be used in batteries or other electrochemical devices. The electrolyte compositions of the present invention exhibit relatively high ionic conductivities with a negligible activation barrier for ion migration, i.e., the compositions exhibit barrierless ion conduction. In addition, the compositions exhibit good conductivities at very low temperatures, making them useful in a variety of low temperature applications. In one embodiment, the present invention further relates to free-standing films comprising the co-crystals of the present invention, and methods for preparing such films.
摘要翻译：本发明涉及包含有机基质包围的离子化合物的组合物，以及用于制备这种组合物的方法。在各种实施方案中，本发明的组合物是有机化合物和盐的共晶体。有机化合物形成具有通道结构的基质，其中有机基质与盐相互作用相对较差，从而允许通过通道结构优异的离子迁移率。在一个实施方案中，组合物是软固体电解质，其包含可用于电池或其它电化学装置中的诸如锂或钠的离子。本发明的电解质组合物显示出相对较高的离子电导率，具有可忽略的离子迁移活化屏障，即组合物表现出无障碍离子传导。此外，组合物在非常低的温度下表现出良好的电导率，使得它们可用于各种低温应用。在一个实施方案中，本发明还涉及包含本发明的共晶的自立膜以及制备这种膜的方法。

118. 发明公开

EP3065547A1 BISCATIONIC AND TRISCATIONIC AMPHILES AS ANTIMICROBIAL AGENTS 审中-公开
标题翻译： BISKATIONISCHE UND TRISKATIONISCHE AMPHILE ALS ANTIMIKROBIELLE WIRKSTOFFE
公开(公告)号：EP3065547A1
公开(公告)日：2016-09-14
申请号：EP14860208.9
申请日：2014-11-05
申请人： Temple University Of The Commonwealth System Of Higher Education , Villanova University
发明人： WUEST, William , MINBIOLE, Kevin, Patrick
IPC分类号： A01N33/02
CPC分类号： A01N33/12 , A61K31/132
摘要： The present disclosure provides an antimicrobial composition including a compound which is a biscationic or triscationic amphiphile, and the method of making such an antimicrobial composition, and the method of using such a compound or composition for antimicrobial use. The antimicrobial composition can include a compound having the formula (I) wherein R is a methylene group unsubstituted or optionally substituted, s is an integer in the range from 1 to 6, R
1 , R
2 , R
3 or R
4 is H or a C
1-4 alkyl unsubstituted or optionally substituted, X is a halogen, m and n are integers in the range from 5 to 25, and m is not equal to n. Alternatively, the antimicrobial composition can comprise a compound having the formula (III) or (IV) wherein R
1 , R
2 , R
3 , R
4 R
5 , or R
6 is H or a C
1-4 alkyl unsubstituted or optionally substituted, X or Y is a halogen, and m and n are integers in the range from 5 to 25.
摘要翻译：本公开内容提供了包含作为双阳离子或三阳离子两亲物的化合物的抗微生物组合物，以及制备这种抗微生物组合物的方法，以及使用这种化合物或组合物用于抗微生物剂的方法。抗微生物组合物可以包括具有式（I）的化合物，其中R是未取代或任选取代的亚甲基，s是1至6的整数，R 1，R 2，R 3或R 4是H或C 1- 4个未取代或任选取代的烷基，X为卤素，m和n为5至25的整数，m不等于n。或者，抗微生物组合物可以包含具有式（III）或（IV）的化合物，其中R 1，R 2，R 3，R 4，R 5或R 6是H或未取代或任选取代的C 1-4烷基，X或Y是卤素，m和n为5〜25的整数。

119. 发明公开

EP3055289A1 FUNCTIONALIZED FURAN-2-SULFONAMIDES EXHIBITING ENDOTHELIAL LIPASE INHIBITION 审中-公开
标题翻译： FUNKTIONALISIERTE FURAN-2-SULFONAMIDE MIT ENDOTHELLIPASE-HEMMUNG
公开(公告)号：EP3055289A1
公开(公告)日：2016-08-17
申请号：EP14851805.3
申请日：2014-10-06
申请人： Temple University Of The Commonwealth System Of Higher Education , Shifa Biomedical Corporation
发明人： ABOU-GHARBIA, Magid , CHILDERS, Wayne E. , MARTINEZ, Rogelio L. , GHIDU, Victor P. , ELSHOURBAGY, Nabil , MEYERS, Harold , MOUSA, Shaker A.
IPC分类号： C07D231/38
CPC分类号： C07D405/12 , C07D307/66 , C07D471/08 , C07D487/08
摘要： The present invention relates to pharmaceutical compositions comprising furan-2-sulfonamide derivatives. The present invention further relates to methods of treatment of diseases or conditions associated with endothelial lipase activity, including coronary artery disease and low HDL-C.
摘要翻译：本发明涉及包含呋喃-2-磺酰胺衍生物的药物组合物。本发明还涉及治疗与内皮脂肪酶活性相关的疾病或病症的方法，包括冠状动脉疾病和低HDL-C。

120. 发明公开

EP2978841A1 ENTEROCOCCUS FAECALIS BACTERIOPHAGE AND USES THEREOF 审中-公开
标题翻译： Enterococcus FAECALIS菌种及其用途
公开(公告)号：EP2978841A1
公开(公告)日：2016-02-03
申请号：EP14773841.3
申请日：2014-03-25
申请人： Temple University - Of The Commonwealth System of Higher Education , J. Craig Venter Institute, Inc.
发明人： STEVENS, Roy, H. , FOUTS, Derrick, E. , ZHANG, Hongming , DEPEW, Jessica
IPC分类号： C12N7/00 , A01N63/00
CPC分类号： A61K35/76 , A01N63/00 , A61K9/0014 , A61L26/0057 , A61L26/0066 , A61L2300/404 , C12N7/00 , C12N2795/00021 , C12N2795/00032 , C12N2795/10121 , C12N2795/10122 , C12N2795/10321 , C12N2795/10322
摘要： Bacteriophages are provided that infect strains of Enterococcus faecalis, an opportunistic bacterial pathogen that causes human disease. Also provided are methods of treating Enterococcus faecalis by therapeutic administration of such bacteriophages.
摘要翻译：提供的噬菌体感染粪肠球菌（一种导致人类疾病的机会性细菌病原体）的菌株。还提供了通过治疗施用这种噬菌体来治疗粪肠球菌的方法。

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