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91. 发明公开

EP2212339A1 BIDENTATE CHIRAL LIGANDS FOR USE IN CATALYTIC ASYMMETRIC ADDITION REACTIONS 有权转让
标题翻译： ZWEIZÄHNIGECHIRALE LIGANDENFÜRKATALYTISCHE不对称添加剂
公开(公告)号：EP2212339A1
公开(公告)日：2010-08-04
申请号：EP08851059.9
申请日：2008-11-14
申请人： Solvias AG
发明人： PUGIN, Benoît , LOTZ, Matthias , LANDERT, Heidi , WYSS, Adrian , AARDOOM, Raphael , GSCHWEND, Björn , PFALTZ, Andreas , SPINDLER, Felix
IPC分类号： C07F9/46 , C07F9/50 , C07F9/655 , C07F9/6553 , B01J31/12 , C07B35/02 , C07B53/00 , C07C67/303 , C07C213/02 , C07C231/12 , C07C231/18 , C07F15/00 , C07F17/02
CPC分类号： C07F13/005 , B01J31/1875 , B01J31/2291 , B01J31/2495 , B01J2231/643 , B01J2231/645 , B01J2531/0238 , B01J2531/822 , B01J2531/827 , C07B53/00 , C07B2200/07 , C07C67/303 , C07C67/31 , C07C231/12 , C07C231/18 , C07F9/46 , C07F9/5004 , C07F9/5018 , C07F9/5022 , C07F9/5027 , C07F9/65515 , C07F9/65517 , C07F9/65522 , C07F9/655354 , C07F17/02 , C07C69/34 , C07C69/732 , C07C69/675 , C07C233/47
摘要： Compounds of the formula (I), in the form of mixtures comprising predominantly one diastereomer or in the form of pure diastereomers, Z1-Q-P*R0R1 (I) in which Z1 is a C-bonded, secondary phosphine group -P(R)2; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals, or Z1 is the -P*R0R1 group; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton.
摘要翻译：主要为一种非对映体或纯非对映异构体形式的混合物形式的式（I）化合物，其中Z 1为C键，仲膦基-P（R）的Z1-QP * R0R1（I） 2; 其中R各自独立地为烃基或杂烃基，或Z1为-P * R0R1基团; Q是二价，非手性芳族碱基骨架，二价，非手性二茂铁碱骨架，任选取代的二价环烷烃或杂环烷骨架，或C 1 -C 4亚烷基骨架。

92. 发明公开

EP1840116A4 PROCESS FOR PRODUCING OPTICALLY ACTIVE BETA-HYDROXY-ALPHA-AMINOCARBOXYLIC ACID DERIVATIVE 有权
标题翻译：工艺生产光学活性的β-羟基-α--AMINOCARBOXYLSÄUREDERIVATES
公开(公告)号：EP1840116A4
公开(公告)日：2010-08-04
申请号：EP06711598
申请日：2006-01-12
申请人： NISSAN CHEMICAL IND LTD
发明人： HAMADA YASUMASA , MAKINO KAZUISHI
IPC分类号： C07C227/16 , B01J31/24 , C07B53/00 , C07B61/00 , C07C229/36 , C07C269/04 , C07C271/22 , C07D307/54 , C07D317/60 , C07D333/16
CPC分类号： C07C227/32 , B01J31/2409 , B01J2231/643 , B01J2531/0266 , B01J2531/822 , C07D307/54 , C07D317/60 , C07D333/16 , C07C229/36

93. 发明公开

EP2186812A1 PRODUCTION PROCESS OF OPTICALLY ACTIVE 3-QUINUCLIDINOL DERIVATIVE 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG EINES OPTISCH AKTIVEN 3-CHINUCLIDINOL-DERIVATS
公开(公告)号：EP2186812A1
公开(公告)日：2010-05-19
申请号：EP08829356.8
申请日：2008-09-02
申请人： National University Corporation Hokkaido University , Nippon Soda Co., Ltd.
发明人： OHKUMA, Takeshi , ARAI, Noriyoshi , AKASHI, Masaya , OOOKA, Hirohito , INOUE, Tsutomu
IPC分类号： C07D453/02 , B01J31/24 , C07B53/00 , C07B61/00
CPC分类号： C07D453/02 , B01J31/1805 , B01J31/2409 , B01J2231/643 , B01J2531/0266 , B01J2531/821 , C07B53/00
摘要： A process is provided for efficiently producing an optically active 3-quinuclidinol derivative of high optical purity using a readily available ruthenium compound as an asymmetric reduction catalyst. This process is a process for producing an optically active 3-quinuclidinol derivative represented by the following formula (III) comprising asymmetrically hydrogenating a 3-quinuclidinone derivative represented by the following formula (I) in the presence of a ruthenium compound (II) represented by formula (II): Ru(X) (Y) (Px) n [R 1 R 2 C * (NR 3 R 4 )-A-R 5 R 6 C * (NR 7 R 8 )] (in the formulas, R represents a hydrogen atom or C7 to C18 aralkyl group and the like, X and Y represent hydrogen atoms or halogen atoms and the like, Px represents a phosphine ligand, n represents 1 or 2, R1 to R8 represent hydrogen atoms or C1 to C20 alkyl groups and the like, * represents an optically active carbon atom and A represents an ethylene group and the like).
摘要翻译：提供了使用容易获得的钌化合物作为不对称还原催化剂有效地制备高光学纯度的光学活性3-奎宁环醇衍生物的方法。该方法是制备由下式（III）表示的光学活性3-奎宁环醇衍生物的方法，包括在下述式（I）表示的钌化合物（II）的存在下不对称地氢化下式（I）表示的3-奎宁环酮衍生物：式（II）：Ru（X）（Y）（Px）n [R 1 R 2 C *（NR 3 R 4）-AR 5 R 6 C *（NR 7 R 8）]（式中，R表示氢原子或C 7〜C 18芳烷基等，X和Y表示氢原子或卤素原子等，P x表示膦配体，n表示1或2，R 1至R 8表示氢原子或C 1至C 20烷基等，*表示光学活性碳原子，A表示亚乙基等）。

94. 发明公开

EP2172443A1 METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG EINES OPTISCH AKTIVEN AMINS
公开(公告)号：EP2172443A1
公开(公告)日：2010-04-07
申请号：EP08790722.6
申请日：2008-06-30
申请人： Hamari Chemicals, Ltd.
发明人： MAEDA, Sadayuki
IPC分类号： C07C213/02 , C07C217/70 , C07C303/40 , C07C311/37 , C07D405/04 , C07B53/00
CPC分类号： C07C213/02 , C07B53/00 , C07B2200/07 , C07C303/40 , C07D405/04 , C07C311/37 , C07C217/70
摘要： The present invention provides a method for producing chiral amines, comprising asymmetric transfer hydrogenation of imine compounds in the presence of a hydrogen donor compound and an iridium(III) complex having a chiral prolinamide compound as a ligand. The present invention is useful for production of chiral amines in an efficient manner in terms of their optical and chemical yields.
摘要翻译：本发明提供了一种制备手性胺的方法，包括在氢供体化合物和具有手性脯氨酰胺化合物作为配体的铱（III）络合物的存在下，亚胺化合物的不对称转移氢化。本发明在其光学和化学产率方面以有效的方式生产手性胺是有用的。

95. 发明授权

EP1686114B1 PROCESS FOR PRODUCING OPTICALLY ACTIVE 2-ALKYLCYSTEINE, DERIVATIVE THEREOF, AND PROCESSES FOR PRODUCTION 有权
标题翻译：工艺生产光学有源2 ALKYLCYSTEIN，其衍生物和过程
公开(公告)号：EP1686114B1
公开(公告)日：2009-10-07
申请号：EP04818942.7
申请日：2004-11-18
申请人： MITSUBISHI GAS CHEMICAL COMPANY, INC.
发明人： HIGUCHI, Yasushi; c/o Japan Hydrazine Co,Inc. , TANAKA, Akinori; c/o Mitsubishi Gas Chemical Co., , HASEMI, Ryuji; c/o Mitsubishi Gas Chemical Co., In , SUGITA, Masaki;2c/o Mitsubishi Gas Chemical Co., I
IPC分类号： C07C319/02 , C07C323/58 , C07D277/06 , C07B53/00 , C07B57/00 , C12P13/12 , C12P41/00
CPC分类号： C12P13/12 , C07B2200/07 , C07C319/02 , C07D277/06 , C07D277/60 , C07C323/58
摘要： A process for producing an optically active 2-alkylcysteine or a salt thereof, characterized by comprising causing cells of a microorganism or a product of treatment of the cells, the microorganism having the ability to stereoselectively hydrolyze the amide bond of a 2-alkyl-L-cysteinamide or a salt thereof, to act on a mixture of the D and L isomers of either a 2-alkylcysteinamide or a salt thereof and then reacting the resultant 2-alkyl-L-cysteine and 2-alkyl-D-cysteinamide with an aldehyde, a ketone, or an acetal or ketal of either to yield a 4-alkylthiazolidine-4-carboxylic acid or salt thereof and a 4-alkylthiazolidine-4-carboxamide or salt thereof and thereby efficiently isolate either of the 2-alkyl-L-cysteine or salt thereof and the 2-alkyl-D-cysteine or salt thereof. Also provided is a process for producing a 4-alkylthiazolidine-4-carboxylic acid or salt thereof from a 2-alkylcysteine or salt thereof.

96. 发明公开

EP2088144A1 METHOD OF PRODUCING S-(-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID AND PRODUCT OBTAINED BY THE METHOD 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON S - （ - ） - 6-羟基-2,5,7,8-四甲基嘧啶-2-碳
公开(公告)号：EP2088144A1
公开(公告)日：2009-08-12
申请号：EP07830535.6
申请日：2007-10-25
申请人： Mitsubishi Gas Chemical Company, Inc.
发明人： IIDA, Akifumi , KYUUKO, Youichi , HIDAKA, Toshio
IPC分类号： C07D311/66 , C07B53/00
CPC分类号： C07D311/66 , C07B53/00
摘要： The present invention provides an industrially available method for efficiently producing high-purit y S-(-)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid excellent in solid-liquid separability from an S-(-)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid ester, and also provides products obtained by the method.
Under a temperature condition of 50-80°C in an aqueous solvent, (A) an S-(-)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid ester represented by the general formula (1) is hydrolyzed under a basic condition for 1-3 hours; then (B) the insoluble matters contained in the reaction solution resulting from the hydrolysis are removed; and (C) an acid is added to the resulting solution to effect crystallization; provided that R in the general formula (1) represents an alkyl or aryl group.
摘要翻译：本发明提供了一种工业上可行的方法，用于有效地生产具有优异的固液分离性的高纯度的S - （ - ） - 6-羟基-2,5,7,8-四氢苯并二氢吡喃-2-羧酸， - ） - 6-羟基-2,5,7,8-四氢苯并二氢吡喃-2-羧酸酯，还提供通过该方法得到的产物。在水性溶剂中在50-80℃的温度条件下，（A）由通式（（A）表示的S - （ - ） - 6-羟基-2,5,7,8-四氢苯并二氢吡喃-2-羧酸酯 1）在碱性条件下水解1-3小时; 然后（B）除去由水解产生的反应溶液中所含的不溶物; 和（C）向所得溶液中加入酸以进行结晶; 条件是通式（1）中的R表示烷基或芳基。

97. 发明公开

EP2088136A1 PROCESS FOR PRODUCTION OF HYDROXYADAMANTANEAMINE 审中-公开
标题翻译：生产羟基金刚烷胺的方法
公开(公告)号：EP2088136A1
公开(公告)日：2009-08-12
申请号：EP07828703.4
申请日：2007-09-28
申请人： Shionogi Co., Ltd.
发明人： WATANABE, Hideaki
IPC分类号： C07C213/02 , C07B53/00 , C07B57/00 , C07C213/10 , C07C215/44 , C07C217/58 , C07D231/20 , C07B61/00
CPC分类号： C07B53/00 , C07B57/00 , C07C213/08 , C07C213/10 , C07C215/44 , C07C2603/74 , C07D231/20
摘要： Disclosed is a process for producing 1-hydroxy-4-aminoadamantane.
摘要翻译：公开了一种生产1-羟基-4-氨基金刚烷的方法。

98. 发明授权

EP1380342B1 COMPLEX CATALYST, PROCESS FOR PRODUCING THE COMPLEX CATALYST, AND PROCESS FOR PRODUCING ALCOHOL DERIVATIVE WITH THE COMPLEX CATALYST 有权
标题翻译： “配位化合物催化剂制造方法配合物催化剂和方法用于生产具有复杂CATALYST醇衍生物”
公开(公告)号：EP1380342B1
公开(公告)日：2009-07-01
申请号：EP02720443.7
申请日：2002-04-17
申请人： Sumitomo Chemical Company, Limited
发明人： SASAKI, Kazuaki
IPC分类号： B01J31/22 , C07B53/00 , C07C41/03 , C07C43/23 , C07D213/64 , B01J27/20
CPC分类号： B01J31/2243 , B01J2231/48 , B01J2531/0252 , B01J2531/60 , B01J2531/72 , B01J2531/845 , C07D213/64
摘要： An (asymmetric) complex catalyst comprising a Lewis acid and a metal complex represented by the formula (1): (wherein R?1, R2, R3, R4, R5, R6, R7, and R8¿ are the same or different and each represents hydrogen, halogeno, alkyl, etc.; one of R?9 and R10¿ represents hydrogen and the other represents C¿1-4? alkyl, etc.; Q represents a single bond, C1-4 alkylene, etc.; M represents a metal ion; and A represents a counter ion or ligand for balancing); a process for producing an (optically active) alcohol derivative, characterized by reacting a cyclic ether compound with a phenol derivative in the presence of the complex catalyst; and a process for producing an (optically active) nitrogenous heterocyclic compound which comprises reacting the alcohol derivative with a halogenated nitrogenous heterocyclic compound in the presence of a base.

99. 发明公开

EP1731522A4 PROCESS FOR PRODUCING FLAVONE C GLYCOSIDE DERIVATIVES 审中-公开
标题翻译：用于生产黄酮-C-糖苷衍生物
公开(公告)号：EP1731522A4
公开(公告)日：2009-05-27
申请号：EP05721621
申请日：2005-03-28
申请人： SUNTORY LTD
发明人： TSUJI KUNIRO , NUKAYA HARUO
IPC分类号： C07D493/14 , A61K31/35 , A61P17/00 , A61P37/08 , A61P43/00 , C07B53/00 , C07B61/00
CPC分类号： C07D493/14
摘要： It is intended to provide a process for efficiently producing a flavone C glycoside derivative represented by the formula (1) which is an antiallergic substance or its salt, or a flavone C glycoside derivative represented by the formula (4) or its salt. According to this process, the flavone C glycoside derivative represented by the formula (1) or its salt and the flavone C glycoside derivative represented by the formula (4) can be easily and efficiently synthesized by using isovitexine and vitexine contained in herbs and so on as the starting materials.

100. 发明公开

EP2041047A2 FATTY ACID BLENDS AND USES THEREFOR 无效转让
标题翻译： FETTSÄUREMISCHUNGENUND IHRE VERWENDUNG
公开(公告)号：EP2041047A2
公开(公告)日：2009-04-01
申请号：EP07809993.4
申请日：2007-06-27
申请人： Cibus, LLC
发明人： KNUTH, Mark, E. , BEETHAM, Peter, R. , WALKER, Keith, A. , GOCAL, Gregory, Francis William
IPC分类号： C07B53/00 , C07C53/00
CPC分类号： C10L1/026 , A23D9/00 , C10L2200/0476 , C11C1/08 , C11C3/003 , C12N9/0083 , C12N15/8247 , Y02E50/13
摘要： Provided herein are blends of oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a biodiesel. Also provided are genetically altered or modified plants, modified such that the amount of medium chain fatty acids generated by the plants are increased.
摘要翻译：本文提供包含大于50％的中链脂肪酸或其脂肪酸烷基酯并且具有低熔点的油或脂肪酸的共混物。这种共混物可用作燃料或用作生产例如生物柴油的原料。还提供了遗传改变或修饰的植物，被修饰，使得由植物产生的中链脂肪酸的量增加。

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