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91. 发明公开

EP1499706A4 MICROFLUIDIC PARTICLE-ANALYSIS SYSTEMS 审中-公开
标题翻译：微流体粒子分析系统
公开(公告)号：EP1499706A4
公开(公告)日：2010-11-03
申请号：EP03721509
申请日：2003-04-01
申请人： FLUIDIGM CORP
发明人： CHOU HOU-PU , DARIDON ANTOINE , FARRELL KEVIN , FOWLER BRIAN , HAO CUNSHENG CASEY , JAVADI SHERVIN , LIAU YISH-HANN , MANGER IAN D , NASSEF HANY RAMEZ , NORTON PIERCE , THRONDSET WILLIAM
IPC分类号： G01N37/00 , B01L3/00 , C12M1/00 , C12M1/34 , C12M3/00 , C12N1/00 , C12Q1/02 , G01N15/02 , G01N15/14
CPC分类号： C12M1/34 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0636 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/06 , B01L2300/0636 , B01L2300/0645 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/087 , B01L2300/088 , B01L2300/0887 , B01L2300/0893 , B01L2300/123 , B01L2400/0409 , B01L2400/0415 , B01L2400/0481 , B01L2400/0622 , B01L2400/0655 , C12M21/06 , C12M23/16 , G01N15/1484 , G01N33/4833 , G01N2015/008 , G01N2015/0288 , G01N2015/149 , G01N2015/1493 , G02B21/32
摘要： The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.

92. 发明公开

EP2179261A1 FLUIDIC CONFIGURATION FOR FLOW INJECTION ANALYSIS SYSTEM 有权转让
标题翻译：流体结构流动注射分析系统
公开(公告)号：EP2179261A1
公开(公告)日：2010-04-28
申请号：EP08724522.1
申请日：2008-01-16
申请人： Nomadics, Inc.
发明人： QUINN, John, Gerard
IPC分类号： G01N1/10
CPC分类号： G01N35/1095 , B01L3/502761 , B01L2300/0636 , B01L2300/0816 , B01L2300/0851 , B01L2400/0622 , G01N2035/00158 , Y10T436/11
摘要： A fluidic configuration, both structural and methodological, for the injection of sample greatly reduces dead volume allowing rapid transition to 100% sample in a flow cell. For a continuous flow injection analysis system the structure and method provide counter flows to remove in one direction the dispersed region of the sample to waste before injecting non-dispersed sample into the flow cell by reversing the effective flow direction. The injection point itself is directly adjacent to the flow cell where all channels are microfluidic channels. Therefore, only the flow cell volume needs to be displaced during injection of sample in order to achieve 100% transition to sample within the flow cell. This greatly accelerates the rise and fall times thereby extending the kinetic range of the real-time interaction analysis instrument. In addition such rapid transition to sample improves overall data quality thereby improving kinetic model fitting.

93. 发明公开

EP2081211A1 Improving abrasion resistance of surfaces 审中-公开
标题翻译： Erhöhungder Abriebfestigkeit vonOberflächen
公开(公告)号：EP2081211A1
公开(公告)日：2009-07-22
申请号：EP08100490.5
申请日：2008-01-15
申请人： Agilent Technologies, Inc.
发明人： Baeuerle, Martin
IPC分类号： H01J37/32
CPC分类号： F16K99/0011 , B01L3/502707 , B01L2300/0816 , B01L2300/16 , B01L2400/0475 , B01L2400/0622 , B01L2400/0644 , C23C14/48 , F16K99/0001 , F16K99/0013 , H01J37/32412
摘要： A method for increasing abrasion resistance of a microfluidic device is described. The microfluidic device comprises a surface that is exposed to wear of friction. The method comprises hardening the surface by implanting ions into the surface.
摘要翻译：描述了用于增加微流体装置的耐磨性的方法。微流体装置包括暴露于摩擦磨损的表面。该方法包括通过将离子注入表面来硬化表面。

94. 发明公开

EP2032255A1 ASSEMBLY OF A MICROFLUIDIC DEVICE FOR ANALYSIS OF BIOLOGICAL MATERIAL 有权
标题翻译：微流体装置的生物材料的分析装置
公开(公告)号：EP2032255A1
公开(公告)日：2009-03-11
申请号：EP06780577.0
申请日：2006-06-23
申请人： STMicroelectronics S.r.l.
发明人： MAGNI, Pierangelo , BRIOSCHI, Roberto
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L2200/027 , B01L2200/10 , B01L2300/043 , B01L2300/0609 , B01L2300/0867 , B01L2300/123 , B01L2300/1805 , B01L2400/0481 , B01L2400/0622 , B01L2400/0638 , B01L2400/0644 , Y10T436/25 , Y10T436/2575
摘要： In a microfluidic assembly (20), a microfluidic device (1') is provided with a body (4) in which at least a first inlet (7) for loading a fluid to analyse and a buried area (8) in fluidic communication with the first inlet (7) are defined. An analysis chamber (10') is in fluidic communication with the buried area (8) and an interface cover (23) is coupled in a fluid-tight manner above the microfluidic device (1'). The interface cover (23) is provided with a sealing portion (35) in correspondence to the analysis chamber (10'), adapted to assume a first configuration, at rest, in which it leaves the analysis chamber (10') open, and a second configuration, as a consequence of a stress, in which it closes in a fluid-tight manner the same analysis chamber.

95. 发明授权

EP1273919B1 CATALYTIC TEST DEVICE AND METHOD FOR THE USE THEREOF IN MATERIAL TESTS 有权
标题翻译：催化试验的设备和方法在使用物料试验
公开(公告)号：EP1273919B1
公开(公告)日：2008-07-23
申请号：EP01903797.7
申请日：2001-02-08
申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS , UNIVERSIDAD POLITECNICA DE VALENCIA
发明人： CORMA CANOS, Avelino, I. de Tec. Quimica, Consejo , HERNANDEZ FENOLLOSA, Juan, Inst.de Tec. Quimica , SERRA ALFARO, Jose Manuel, Inst. de Tec. Quimica
IPC分类号： G01N35/02
CPC分类号： B01L3/502 , B01J19/0046 , B01J2219/00286 , B01J2219/00313 , B01J2219/00389 , B01J2219/00477 , B01J2219/00495 , B01J2219/00585 , B01J2219/00601 , B01J2219/00686 , B01J2219/00698 , B01J2219/00704 , B01J2219/00716 , B01J2219/00745 , B01J2219/00747 , B01L7/00 , B01L2400/0487 , B01L2400/0622 , C40B30/08 , C40B40/18 , G01N31/10 , G01N35/08 , Y10T436/117497 , Y10T436/21 , Y10T436/214 , Y10T436/216 , Y10T436/24
摘要： The invention concerns a catalytic test device comprising the following: a reaction block consisting of a set of reaction chambers, each chamber having a fluid inlet and a fluid outlet and being connected to an outgoing fluid conduit that is connected to analysis means; fluid supply means capable of independently regulating the dosing of fluid flows to the required pressure in each of the reaction chambers; automatic and dynamic pressure control means capable of regulating pressure in each reaction chamber, said means comprising a non-return valve in the outgoing fluid conduit between the outflows of the reaction chambers, in addition to a common compensation reservoir receiving the outgoing fluid from the chambers and a pressure sensor disposed in a first outgoing conduit and an automatic needle valve disposed in a second outlet conduit of the reservoir.

96. 发明公开

EP1714698A2 Vorrichtung und Verfahren zur Manipulation einer Flüssigkeit 有权
标题翻译： Vorrichtung und Verfahren zur Manipulation einerFlüssigkeit
公开(公告)号：EP1714698A2
公开(公告)日：2006-10-25
申请号：EP06007697.3
申请日：2006-04-12
申请人： Boehringer Ingelheim microParts GmbH
发明人： Willms, Thomas , Blankenstein, Gert, Dr.
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2300/0825 , B01L2300/0887 , B01L2300/089 , B01L2400/0406 , B01L2400/0421 , B01L2400/0424 , B01L2400/0622 , B01L2400/0633 , B01L2400/0644 , B01L2400/065 , B01L2400/0688
摘要： Es werden eine Vorrichtung und ein Verfahren zur Manipulation einer Flüssigkeit vorgeschlagen, wobei die Flüssigkeit von einem ersten Kanalabschnitt in einen zweiten Kanalabschnitt strömen kann und mittels eines Kapillarstops vor einem Übertritt vom ersten Kanalabschnitt in den zweiten Kanalabschnitt temporär angehalten wird. Eine zeitlich genaue Steuerung wird auf einfache Weise dadurch ermöglicht, daß die beiden Kanalabschnitte zur Überbrückung oder Aufhebung des Kapillarstops relativ zueinander bewegt, insbesondere in Anlage gebracht werden.
摘要翻译：具有两个通道部分的装置（1），其中液体（2）从第一（3）部分通道流到第二（4）部分，并且借助于毛细管塞（9），液体可以在接合之前暂时保持第二节。设备的设计使得两个通道部分可以相对于彼此移动以绕过或提升腋下停止。两个通道部分可以彼此接触。它们具有平坦和/或矩形横截面。通道部分的主要延伸部位于同一平面上。

97. 发明公开

EP1019694A4 CAPILLARY VALVE, CONNECTOR, AND ROUTER 有权
标题翻译：毛细管阀连接器和FLU方向管辖毛细管元
公开(公告)号：EP1019694A4
公开(公告)日：2006-09-13
申请号：EP98943553
申请日：1998-09-08
申请人： GE HEALTHCARE BIO SCIENCES
发明人： JOVANOVICH STEVAN B , RONAN GREGORY J , ROACH DAVID J , JOHNSTON RICHARD F
IPC分类号： G01N27/447 , B01L3/00 , F16L29/00 , F16L39/00 , G01N30/20 , G01N30/24 , G01N30/60 , G01N30/88 , G02B6/35 , G02B6/38 , G01N1/00
CPC分类号： G01N35/1097 , B01L3/5025 , B01L3/561 , B01L3/565 , B01L2200/026 , B01L2300/0838 , B01L2400/0406 , B01L2400/0622 , B01L2400/0644 , G01N30/20 , G01N30/24 , G01N30/6039 , G01N30/6078 , G01N2030/8827 , G02B6/3504 , G02B6/3558 , G02B6/381 , G02B6/3818 , G02B6/3825 , G02B6/3851 , G02B6/3854 , G02B6/3869 , G02B6/3877 , G02B6/3878 , G02B6/3887 , G02B6/3894 , G02B6/403 , Y10T137/86549 , Y10T436/143333 , Y10T436/2575
摘要： A capillary valve, connector and router where one or more cylindrical fibers, which may be capillaries, plugged capillaries, optical fibers, or the like, including at least one capillary tube (12a) are contained in a first cylindrical bundle of fibers that terminates at a first face (18a). A second cylindrical bundle of fibers also containing one or more fibers including at least one capillary tube (12b) terminates in a second face (18b) abutting the first face.

98. 发明公开

EP1670715A1 LIQUID ROUTER 有权
标题翻译： FLÜSSIGKEITSLEITVORRICHTUNG
公开(公告)号：EP1670715A1
公开(公告)日：2006-06-21
申请号：EP04775514.5
申请日：2004-10-04
申请人： GYROS PATENT AB
发明人： EKSTRAND, Gunnar , THORSEN, Gunnar
IPC分类号： B81B1/00 , G01N21/07
CPC分类号： B01L3/5027 , B01F13/00 , B01L3/5025 , B01L3/502723 , B01L3/50273 , B01L2200/0621 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2400/0409 , B01L2400/0622 , B01L2400/0688
摘要： A liquid router that comprises an inlet microconduit that branches into two exit microconduits (microconduit I and II) and is present in a microchannel structure of a microfluidic device which is using centrifugal force created by spinning the device about a spin axis for transporting liquid. The router is characterized in comprising a microcavity in which there are: a lower part comprising two exit openings (exits I and II), and an upper part comprising an inlet opening to which the inlet microconduit (3) is connected, and microconduits I and II which are connected to exits I and II, respectively, and stretch from a shorter radial position to a larger radial position relative to the spin axis. Microconduit II has a reduced hydrophilicity (=reduced apparent wettability) compared to microconduit I.
摘要翻译：液体路由器，其包括分支到两个出口微管（微管I和II）中的入口微管，并且存在于微流体装置的微通道结构中，微流体装置使用通过围绕旋转轴旋转装置而产生的离心力用于输送液体。该路由器的特征在于包括一个微腔，其中有：一个下部，包括两个出口（出口I和II），上部包括入口微管（3）连接到的入口，微通道I和 II分别连接到出口I和II，并且相对于旋转轴线从较短的径向位置延伸到较大的径向位置。与microconduit I相比，Microconduit II具有降低的亲水性（=降低的表观润湿性）。

99. 发明授权

EP0933132B1 Nucleic Acid Extraction Apparatus 有权
标题翻译：设备用于核酸提取
公开(公告)号：EP0933132B1
公开(公告)日：2005-12-28
申请号：EP99101602.3
申请日：1999-02-02
申请人： Toyo Boseki Kabushiki Kaisha
发明人： Shigeru, Komai Laboratory of toyo Boseki K.K , Katsuya Daimon Laboratory of toyo Boseki K.K , Yutaka, Takarada Laboratory of toyo Boseki K.K
IPC分类号： B01L3/00 , G01N35/00 , G01N1/40
CPC分类号： B01L3/502 , B01L3/5082 , B01L2200/026 , B01L2300/042 , B01L2300/046 , B01L2300/049 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12N15/1013 , G01N1/405 , G01N35/0098 , G01N2035/0436 , Y10S435/82

100. 发明公开

EP1531937A1 PIPETIEREINRICHTUNG UND VERFAHREN ZUM BETREIBEN EINER PIPETIEREINRICHTUNG 审中-公开
标题翻译：吸液和一种用于操作移液
公开(公告)号：EP1531937A1
公开(公告)日：2005-05-25
申请号：EP03792160.8
申请日：2003-06-17
申请人： Fraunhofer-Gesellschaft zurFörderung der angewandten Forschung e.V. , Hirschmann Laborgeräte GmbH & Co. KG
发明人： RICHTER, Martin , WACKERLE, Martin , BIGUS, Hans-Jürgen , DEBUSMANN, Ralph
IPC分类号： B01L3/02 , F04B43/04
CPC分类号： F04B43/046 , B01L3/02 , B01L2300/0681 , B01L2400/0439 , B01L2400/0622 , B01L2400/0638
摘要： Disclosed is a pipetting device comprising a micropump (200) which is provided with a pump chamber (216) having a first port (222) and a second port (224). Said micropump is also provided with a device (246, 250) for modifying the volume of the pump chamber (216). A first active valve (226) is provided for opening and closing the first port (222) while a second active valve (236) is used for opening and closing the second port (224). The inventive pipetting device further comprises a pipette tip (258) which is connected to the first (222) or second (224) port via a pipette duct.

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