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1. 发明公开

EP3244918A2 PROTEINS AND NUCLEIC ACIDS USEFUL IN VACCINES TARGETING KLEBSIELLA PNEUMONIAE 审中-公开
标题翻译：针对肺炎球菌疫苗的蛋白质和核酸
公开(公告)号：EP3244918A2
公开(公告)日：2017-11-22
申请号：EP16700429.0
申请日：2016-01-12
申请人： Evaxion Biotech ApS
发明人： IVERSEN MØLLER, Niels , HOLM MATTSSON, Andreas
IPC分类号： A61K39/108 , C07K14/26 , G01N33/569
CPC分类号： C07K14/26 , A61K39/0266 , G01N33/56916 , G01N2333/26 , G01N2469/20
摘要： The present invention relates to proteins and nucleic acids derived from Klebsiella pneumoniae as well as therapeutic and diagnostic uses of the proteins and nucleic acids.

2. 发明授权

EP2336364B1 Candida parapsilosis nucleic acid sequences for detection and identification in clincal specimen 失效
标题翻译：近平滑念珠菌的临床样品中的鉴定和检测核酸序列
公开(公告)号：EP2336364B1
公开(公告)日：2015-04-08
申请号：EP10181610.6
申请日：1997-11-04
申请人： Geneohm Sciences Canada, Inc.
发明人： Bergeron, Michel G. , Picard, Francois , Ouellette, Marc , Roy, Paul H.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C07K14/195 , C07K14/21 , C07K14/212 , C07K14/245 , C07K14/26 , C07K14/285 , C07K14/31 , C07K14/315 , C07K14/3156 , C12Q1/6895 , C12Q2600/156

3. 发明公开

EP2495328A4 NOVEL METHOD FOR PRODUCING 3-HYDROXYPROPIONIC ACID FROM GLYCEROL 失效转让
标题翻译：新方法由甘油制备3-羟基酸
公开(公告)号：EP2495328A4
公开(公告)日：2013-09-11
申请号：EP09850890
申请日：2009-10-29
申请人： KOREA RES INST OF BIOSCIENCE
发明人： KIM CHUL-HO , SEO JEONG-WOO , LUO LIANHUA , OH BAEK ROCK , SEO PIL-SOO , HEO SUN-YEON
IPC分类号： C12P7/18 , C12N1/21 , C12N15/53
CPC分类号： C12P7/42 , C07K14/26 , C12N9/0006 , C12N9/0008 , C12P7/18 , C12P7/52

4. 发明授权

EP1138786B1 Specific and universal amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories 失效
标题翻译：具体的和普遍的探针和扩增引物用于快速确定和常见的细菌病原体和临床样品中的抗生素抗性基因在微生物实验室常规诊断标识
公开(公告)号：EP1138786B1
公开(公告)日：2013-09-11
申请号：EP01110039.3
申请日：1995-09-12
申请人： Geneohm Sciences Canada, Inc.
发明人： Bergeron, Michel G. , Ouellette, Marc , Roy, Paul H.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C07K14/195 , C07K14/21 , C07K14/212 , C07K14/245 , C07K14/26 , C07K14/285 , C07K14/31 , C07K14/315 , C07K14/3156 , C12N15/65 , C12Q2600/16

5. 发明公开

EP2336366A1 Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories 失效
标题翻译：热带假丝酵母Nukleinsäuresequenzzur Erkennung und Identifikation in klinischen Proben
公开(公告)号：EP2336366A1
公开(公告)日：2011-06-22
申请号：EP10184075.9
申请日：1997-11-04
申请人： Geneohm Sciences Canada, Inc.
发明人： Bergeron, Michel G. , Picard, François , Ouellette, Marc , Roy, Paul H.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C07K14/195 , C07K14/21 , C07K14/212 , C07K14/245 , C07K14/26 , C07K14/285 , C07K14/31 , C07K14/315 , C07K14/3156 , C12Q1/6895 , C12Q2600/156
摘要： DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida are disclosed. DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample antibiotic resistance genes selected from the group consisting of bla tem , bla rob , bla shv , bla oxa , blaZ, aadB, aacC1, aacC2, aacC3, aacA4, aac6'-IIa, ermA, ermB, ermC, mecA, vanA, vanB, vanC, satA, aac(6)-aph(2'), aad(6'), vat, vga, msrA, sul and int are also disclosed. The above microbial species, genera and resistance genes are all clinically relevant and commonly encountered in a variety of clinical specimens. These DNA-based assays are rapid, accurate and can be used in clinical microbiology laboratories for routine diagnosis. These novel diagnostic tools should be useful to improve the speed and accuracy of diagnosis of microbial infections, thereby allowing more effective treatments. Diagnostic kits for (i) the universal detection and quantification of bacteria, and/or (ii) the detection, identification and quantification of the above-mentioned bacterial and fungal species and/or genera, and/or (iii) the detection, identification and quantification of the above-mentioned antibiotic resistance genes are also claimed.
摘要翻译：基于DNA的方法，使用扩增引物或探针来检测，鉴定和定量来自（i）任何细菌的测试样品DNA，（ii）无乳链球菌，腐生葡萄球菌，屎肠球菌，脑膜炎奈瑟氏球菌，单核细胞增生利斯特氏菌和白色念珠菌，和（iii）任何种属的链球菌属，葡萄球菌属，肠球菌属，奈瑟球菌属和假丝酵母属。基于DNA的方法，使用扩增引物或探针来检测，鉴定和定量测试样品抗生素抗性基因，其选自bla tem，bla rob，bla shv，bla oxa，blaZ，aadB，aacC1，aacC2，aacC3 ，aacA4，aac6'-IIa，ermA，ermB，ermC，mecA，vanA，vanB，vanC，satA，aac（6）-aph（2'），aad（6'），vat，vga，msrA，sul和int 也被披露。上述微生物物种，属和抗性基因在临床上都是临床相关的，常见于各种临床标本。这些基于DNA的测定是快速，准确的，可用于临床微生物实验室进行常规诊断。这些新型诊断工具应该有助于提高微生物感染诊断的速度和准确性，从而可以进行更有效的治疗。诊断试剂盒，用于（i）细菌的普遍检测和定量，和/或（ii）上述细菌和真菌物种和/或属的检测，鉴定和定量，和/或（iii）检测，鉴定还要求对上述抗生素抗性基因的定量。

6. 发明公开

EP2336364A1 Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories 失效
标题翻译：假丝酵母假丝酵母菌Nukleinsäuresequenzzur Identifizierung und Erkennung in klinischen Proben
公开(公告)号：EP2336364A1
公开(公告)日：2011-06-22
申请号：EP10181610.6
申请日：1997-11-04
申请人： Geneohm Sciences Canada, Inc.
发明人： Bergeron, Michel G. , Picard, Francois , Ouellette, Marc , Roy, Paul H.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C07K14/195 , C07K14/21 , C07K14/212 , C07K14/245 , C07K14/26 , C07K14/285 , C07K14/31 , C07K14/315 , C07K14/3156 , C12Q1/6895 , C12Q2600/156
摘要： DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida are disclosed. DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample antibiotic resistance genes selected from the group consisting of bla tem , bla rob , bla shv , bla oxa , blaZ, aadB, aacC1, aacC2 , aacC3 , aacA4, aac6'-lla , ermA, ermB, ermC, mecA, vanA, vanB, vanC, satA, aac(6)-aph(2"), aad(6' ), vat, vga, msrA, sul and int are also disclosed. The above microbial species, genera and resistance genes arc all clinically relevant and commonly encountered in a variety of clinical specimens. These DNA-based assays are rapid, accurate and can be used in clinical microbiology laboratories for routine diagnosis. These novel diagnostic tools should be useful to improve the speed and accuracy of diagnosis of microbial infections, thereby allowing more effective treatments. Diagnostic kits for (i) the universal detection and quantification of bacteria, and/or (ii) the detection, identification and quantification of the above-mentioned bacterial and fungal species and/or genera, and/or (iii) the detection, identification and quantification of the above-mentioned antibiotic resistance genes arc also claimed.
摘要翻译：基于DNA的方法，使用扩增引物或探针来检测，鉴定和定量来自（i）任何细菌的测试样品DNA，（ii）无乳链球菌，腐生葡萄球菌，屎肠球菌，脑膜炎奈瑟氏球菌，单核细胞增生利斯特氏菌和白色念珠菌，和（iii）任何种属的链球菌属，葡萄球菌属，肠球菌属，奈瑟球菌属和假丝酵母属。基于DNA的方法，使用扩增引物或探针来检测，鉴定和定量测试样品抗生素抗性基因，其选自bla tem，bla rob，bla shv，bla oxa，blaZ，aadB，aacC1，aacC2，aacC3 ，aacA4，aac6'-11a，ermA，ermB，ermC，mecA，vanA，vanB，vanC，satA，aac（6）-aph（2“），aad（6'），vat，vga，msrA，sul和int 上述微生物物种，属和抗性基因全部临床相关，常见于各种临床标本，这些基于DNA的检测方法快速，准确，可用于临床微生物实验室进行常规诊断。诊断工具应有助于提高微生物感染诊断的速度和准确性，从而允许更有效的治疗。诊断试剂盒用于（i）细菌的普遍检测和定量，和/或（ii）检测，鉴定和定量上面提到的细菌和/或（iii）上述抗生素抗性基因的检测，鉴定和定量也被要求保护。

7. 发明公开

EP2327715A1 Replikin peptides and uses thereof 审中-公开
公开(公告)号：EP2327715A1
公开(公告)日：2011-06-01
申请号：EP10012947.7
申请日：2002-03-26
申请人： Bogoch, Samuel , Bogoch, Elenore S.
发明人： Bogoch, Samuel , Bogoch, Elenore S.
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16122 , Y02A50/412 , Y02A50/478
摘要： Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus. Isolated peptides of the Bacillus anthracis anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.

8. 发明授权

EP1305422B1 2,5-DKG PERMEASES 有权
标题翻译： 2,5-DKG通透
公开(公告)号：EP1305422B1
公开(公告)日：2011-05-18
申请号：EP01959520.6
申请日：2001-08-03
申请人： Microgenomics, Inc. , Danisco US Inc.
发明人： DARTOIS, Veronique, A. , HOCH, James, A. , VALLE, Fernando , KUMAR, Manoj
IPC分类号： C12N15/31 , C07K14/24 , C07K14/26 , C12P7/60
CPC分类号： C12P7/60 , C07K14/24 , C07K14/26
摘要： The invention provides isolated nucleic acid molecules encoding polypeptides having 2,5-DKG permease activity, and oligonucleotides therefrom. The isolated nucleic acid molecules can be expressed in appropriate bacterial cells to enhance the production of 2-KLG, which can subsequently be converted to ascorbic acid. Further provided are isolated polypeptides having 2,5-DKG permease acitivity, immunogenic peptides therefrom, and antibodies specific therefor. The invention also provides methods of identifying novel 2,5-DKG permeases.

9. 发明公开

EP2152731A2 KLEBSIELLA ANTIGENS 审中-公开
标题翻译：克雷伯菌抗原
公开(公告)号：EP2152731A2
公开(公告)日：2010-02-17
申请号：EP08736618.3
申请日：2008-04-29
申请人： Intercell AG
发明人： BAKSHI, Sharmila , CIPPS, Thomas , HANNER, Markus , PIKALO, Jutta , SATKE, Christina , NAGY, Eszter , LUNDBERG, Urban , ZIERER,Dagmar , MEINKE, Andreas , NOIGES, Birgit , STIERSCHNEIDER, Ulrike , VON GABAIN, Alexander
IPC分类号： C07K14/26 , C07K16/12 , A61K39/395 , A61P31/04
CPC分类号： C07K14/26 , A61K39/00 , A61K39/0266 , A61K45/06 , A61K2039/505 , A61K2039/55505 , A61K2039/55566 , C07K16/1228 , C07K2317/21
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae.

10. 发明授权

EP0754231B1 FRAGMENT PEPTIDIQUE DE LA PROTEINE G DU VIRUS RESPIRATOIRE SYNCYTIAL, AGENT IMMUNOGENE, COMPOSITION PHARMACEUTIQUE LE CONTENANT ET PROCEDE DE PREPARATION 失效
标题翻译：肽片段G蛋白呼吸道合胞病毒，免疫原性连接和药物组合物，可以包含和方法的
公开(公告)号：EP0754231B1
公开(公告)日：2006-06-21
申请号：EP95916721.4
申请日：1995-04-06
申请人： PIERRE FABRE MEDICAMENT
发明人： BINZ, Hans , N'GUYEN, Ngoc, Thien , BAUSSANT, Thierry , TRUDEL, Michel
IPC分类号： C12N15/45 , C12N15/31 , C07K14/135 , C07K14/26 , C07K14/765 , A61K39/155 , A61K47/48
CPC分类号： A61K39/155 , A61K38/00 , A61K39/12 , A61K47/646 , A61K2039/55505 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/6081 , C07K14/005 , C07K14/26 , C07K14/765 , C07K2319/00 , C07K2319/40 , C12N2760/18522 , C12N2760/18534
摘要： A polypeptide useful as an immunogen element and characterised in that it is carried on the peptide sequence between amino acid residues 130-230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine respiratory syncytial virus, or on a sequence at least 80 % homologous thereto. An immunogenic agent or pharmaceutical composition containing said polypeptide, and a method for preparing same, are also disclosed.

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