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1. 发明公开

EP2152731A2 KLEBSIELLA ANTIGENS 审中-公开
标题翻译：克雷伯菌抗原
公开(公告)号：EP2152731A2
公开(公告)日：2010-02-17
申请号：EP08736618.3
申请日：2008-04-29
申请人： Intercell AG
发明人： BAKSHI, Sharmila , CIPPS, Thomas , HANNER, Markus , PIKALO, Jutta , SATKE, Christina , NAGY, Eszter , LUNDBERG, Urban , ZIERER,Dagmar , MEINKE, Andreas , NOIGES, Birgit , STIERSCHNEIDER, Ulrike , VON GABAIN, Alexander
IPC分类号： C07K14/26 , C07K16/12 , A61K39/395 , A61P31/04
CPC分类号： C07K14/26 , A61K39/00 , A61K39/0266 , A61K45/06 , A61K2039/505 , A61K2039/55505 , A61K2039/55566 , C07K16/1228 , C07K2317/21
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae.

2. 发明公开

EP2059526A2 BORRELIA ANTIGENS 审中-公开
标题翻译：疏螺旋体抗原
公开(公告)号：EP2059526A2
公开(公告)日：2009-05-20
申请号：EP07815120.6
申请日：2007-09-14
申请人： Intercell AG
发明人： LUNDBERG, Urban , MEINKE, Andreas , NAGY, Eszter , VON GABAIN, Alexander , NOIGES, Birgit , GELBMANN, Dieter , POLJAK, Albina , TRISKA, Christine
IPC分类号： C07K14/20
CPC分类号： C07K7/08 , A61K39/00 , A61K2039/53 , C07K7/06 , C07K14/20 , Y02A50/401
摘要： The present invention relates to isolated nucleic acid molecules which encode a protein, isolated nucleic acid molecules which encode a hyperimmune serum reactive antigen, a vector which comprises such nucleic acid molecule, a host cell comprising such vector, a hyperimmune reactive antigen from Borrelia species, proteins which are preferably hyperimmune serum reactive antigens, hyperimmune serum reactive antigens, antigens, a process for producing such proteins, hyperimmune serum reactive antigens or antigens, a process for producing a cell which expresses such protein, hyperimmune serum reactive antigen or antigen, an antibody binding to such protein, hyperimmune serum reactive antigen or antigen, a hybridoma cell producing such antibody, methods for producing such antibody, a pharmaceutical composition comprising such nucleic acid molecule, protein, hyperimmune serum reactive antigen, antigen or antibody, the use of such nucleic acid molecule, protein, hyperimmune serum reactive antigen, antigen or antibody for the manufacture of a medicament, methods for identifying an antagonist capable of reducing or inhibiting the interaction activity of such protein, hyperimmune serum reactive antigen or antigen, methods for diagnosing an infection and methods for the treatment of an infection. More specifically such proteins, hyperimmune serum reactive antigens or antigens are produced by or associated with bacterial pathogens causing Lyme disease or bacterial infections caused by Borrelia burgdorferi s.1.

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