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1. 发明公开

EP4182964A1 ELECTRON ACTIVATION DISSOCIATION REACTION DEVICE WITH ION ISOLATION FUNCTIONALITY IN MASS SPECTROMETRY 审中-实审
公开(公告)号：EP4182964A1
公开(公告)日：2023-05-24
申请号：EP21742908.3
申请日：2021-07-12
申请人： DH Technologies Development PTE. Ltd.
发明人： BABA, Takashi , GODBEHERE, Grant
IPC分类号： H01J49/00 , H01J49/42

2. 发明公开

EP3775929A1 TOP-DOWN ANALYSIS OF ANTIBODIES IN MASS SPECTROMETRY 审中-实审
公开(公告)号：EP3775929A1
公开(公告)日：2021-02-17
申请号：EP19785079.5
申请日：2019-04-09
申请人： DH Technologies Development Pte. Ltd.
发明人： BABA, Takashi , RYUMIN, Pavel , LOYD, William M.
IPC分类号： G01N33/68 , G16B40/10 , G16B30/00

3. 发明公开

EP3178106A1 BAND PASS EXTRACTION FROM AN ION TRAPPING DEVICE AND TOF MASS SPECTROMETER SENSITIVITY ENHANCEMENT 有权
标题翻译：带离子俘获装置的带通提取和飞行时间质谱分析仪灵敏度增强
公开(公告)号：EP3178106A1
公开(公告)日：2017-06-14
申请号：EP15829557.6
申请日：2015-07-24
申请人： DH Technologies Development PTE. Ltd.
发明人： BABA, Takashi
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/063 , H01J49/067 , H01J49/429
摘要： A multipole rod set of an ion guide is adapted to receive a radial RF trapping voltage and a radial dipole direct current DC voltage. A lens electrode of the ion guide is positioned at one end of the multipole rod set to extract ions from the multipole rod set and adapted to receive an axial trapping AC voltage and a DC voltage. A radial dipole DC voltage is applied to the multipole rod set and an axial trapping AC voltage is simultaneously applied to a lens electrode in order to extract a bandpass mass range of ions trapped in the multipole rod set. Alternatively, a radial RF trapping voltage amplitude is applied to the multipole rod set and an axial trapping AC voltage is simultaneously applied to the lens electrode in order to extract a bandpass mass range of ions trapped in the multipole rod set.
摘要翻译：离子导向器的多极杆组适于接收径向RF捕获电压和径向偶极子直流DC电压。离子导向器的透镜电极位于多极杆组的一端，以从多极杆组中提取离子并适于接收轴向俘获AC电压和DC电压。将径向偶极DC电压施加到多极杆组，并且将轴向俘获AC电压同时施加到透镜电极，以提取俘获在多极杆组中的带通质量范围的离子。或者，径向RF俘获电压幅值被施加到多极杆组，并且轴向俘获AC电压被同时施加到透镜电极，以提取被捕获在多极杆组中的带通质量范围的离子。

4. 发明公开

EP3155416A1 METHODS FOR ANALYSIS OF LIPIDS USING MASS SPECTROMETRY 审中-实审
标题翻译： VERFAHREN ZUR ANALYZE VON LIPIDEN MITTELS MASSENSPEKTROMETRIE
公开(公告)号：EP3155416A1
公开(公告)日：2017-04-19
申请号：EP15806252.1
申请日：2015-06-04
申请人： DH Technologies Development Pte. Ltd.
发明人： BABA, Takashi , CAMPBELL, John Lawrence
IPC分类号： G01N27/62 , H01J49/26
CPC分类号： H01J49/0054 , H01J49/0072 , H01J49/4225
摘要： A method and apparatus for analyzing samples using mass spectrometry are disclosed. The apparatus includes a reaction device configured to dissociate sample ions into fragments by reacting the sample ions with a charged species (e.g., electrons) such as through ECD, EID, or EIEIO. The kinetic energy of the charged species is such that the fragments may be detected and produce spectra that allow for the determination of isomeric species in the sample and the location of double bonds of sample molecules. The fragments may include radical fragments and non-radical fragments. The apparatus may also include an oxygen gas source configured to react with the radical fragments to produce oxygen-radical fragments. Spectra resulting from analysis of the fragments may allow for the determination of the oxygen-radical fragments resulting from the dissociation of the sample molecules.
摘要翻译：公开了使用质谱分析样品的方法和装置。该装置包括反应装置，其被配置为通过使样品离子与带电物质（例如电子）例如通过ECD，EID或EIEIO反应来将样品离子分离成片段。带电物质的动能使得可以检测碎片并产生允许测定样品中异构物种和样品分子双键位置的光谱。片段可以包括自由基片段和非自由基片段。该装置还可以包括配置成与自由基片段反应以产生氧自由基碎片的氧气源。由片段分析产生的光谱可以允许测定样品分子解离产生的氧自由基片段。

5. 发明公开

EP3090441A1 ION GUIDE FOR MASS SPECTROMETRY 审中-公开
标题翻译：离子引导FOR MASS
公开(公告)号：EP3090441A1
公开(公告)日：2016-11-09
申请号：EP14877306.2
申请日：2014-11-18
申请人： DH Technologies Development PTE. Ltd.
发明人： BABA, Takashi
IPC分类号： H01J49/26
CPC分类号： H01J49/062 , H01J49/06
摘要： Methods and systems for transmitting ions in an ion guide are provided herein. In accordance with various aspects of the applicant's teachings, the methods and systems can cause at least a portion of ions entrained in a gas flow entering an ion guide to be extracted from the gas jet and be guided downstream along one or more path of gas flow, where the gas lacking the ions can be removed from the ion guide. In some embodiments, the ions extracted from the gas stream can be guided into a focusing region in which the ions can be focused, e.g., via RF focusing, to enter into subsequence processing stages, such as a mass analyzer.

6. 发明公开

EP3058580A1 MULTIPLEXED PRECURSOR ISOLATION FOR MASS SPECTROMETRY 审中-公开
标题翻译：复用PRE-保温MASS
公开(公告)号：EP3058580A1
公开(公告)日：2016-08-24
申请号：EP14853329.2
申请日：2014-10-07
申请人： DH Technologies Development PTE. Ltd.
发明人： BABA, Takashi
IPC分类号： H01J49/26
CPC分类号： H01J49/0036 , H01J49/0031 , H01J49/004 , H01J49/04 , H01J49/067 , H01J49/4285
摘要： Systems and methods for multiplexed precursor ion selection are provided. A mass isolator includes a selection region of rods, a transmission region of rods, and a barrier electrode lens separating the selection and transmission regions. Two or more different precursor ions are selected by applying two or more different AC voltage frequencies to rods of a selection region in order to resonate the two or more different precursor ions from a continuous beam of ions. The two or more different precursor ions are transmitted by applying a DC voltage to the barrier electrode lens, creating an electric field potential barrier over which only the resonating ions are transmitted. Precursor ions of product ions from combined product ion spectra produced by multiplexed precursor ion selection are identified by grouping the target precursor ions.

7. 发明公开

EP4334967A1 REDUCING AC EFFECTS ON IONS ENTERING ION GUIDE WITH PULSING AUXILIARY AC 审中-实审
公开(公告)号：EP4334967A1
公开(公告)日：2024-03-13
申请号：EP22724131.2
申请日：2022-05-03
申请人： DH Technologies Development Pte. Ltd.
发明人： CHERNUSHEVICH, Igor , BABA, Takashi , RYUMIN, Pavel
IPC分类号： H01J49/00 , H01J49/42

8. 发明公开

EP4038657A1 ELECTRON INDUCED DISSOCIATION DEVICES AND METHODS 审中-实审
公开(公告)号：EP4038657A1
公开(公告)日：2022-08-10
申请号：EP20789273.8
申请日：2020-09-29
申请人： DH Technologies Development Pte. Ltd.
发明人： BABA, Takashi
IPC分类号： H01J49/06 , H01J49/00

9. 发明公开

EP3969915A1 BACKGROUND REDUCTION IN TOP-DOWN ANTIBODY ANALYSIS 审中-实审
公开(公告)号：EP3969915A1
公开(公告)日：2022-03-23
申请号：EP20805987.3
申请日：2020-05-13
申请人： DH Technologies Development Pte. Ltd.
发明人： BABA, Takashi , RYUMIN, Pavel
IPC分类号： G01N33/68 , G01N27/62 , H01J49/26

10. 发明公开

EP3864685A1 AN RF-ION GUIDE WITH IMPROVED TRANSMISSION OF ELECTRONS 审中-实审
公开(公告)号：EP3864685A1
公开(公告)日：2021-08-18
申请号：EP19789757.2
申请日：2019-10-08
申请人： DH Technologies Development Pte. Ltd.
发明人： RYUMIN, Pavel , BABA, Takashi
IPC分类号： H01J49/00 , H01J49/06

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