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1. 发明公开

EP3155416A4 METHODS FOR ANALYSIS OF LIPIDS USING MASS SPECTROMETRY 审中-实审
公开(公告)号：EP3155416A4
公开(公告)日：2018-01-17
申请号：EP15806252
申请日：2015-06-04
申请人： DH TECH DEVELOPMENT PTE LTD
发明人： BABA TAKASHI , CAMPBELL JOHN LAWRENCE
IPC分类号： H01J49/00
CPC分类号： H01J49/0054 , H01J49/0072 , H01J49/4225
摘要： A method and apparatus for analyzing samples using mass spectrometry are disclosed. The apparatus includes a reaction device configured to dissociate sample ions into fragments by reacting the sample ions with a charged species (e.g., electrons) such as through ECD, EID, or EIEIO. The kinetic energy of the charged species is such that the fragments may be detected and produce spectra that allow for the determination of isomeric species in the sample and the location of double bonds of sample molecules. The fragments may include radical fragments and non-radical fragments. The apparatus may also include an oxygen gas source configured to react with the radical fragments to produce oxygen-radical fragments. Spectra resulting from analysis of the fragments may allow for the determination of the oxygen-radical fragments resulting from the dissociation of the sample molecules.

2. 发明授权

EP3014278B8 PROCÉDÉ DE DÉTECTION ET DE QUANTIFICATION PAR SPECTROMÉTRIE DE MASSE ET PAR ACTIVATION D'ESPÈCES MOLÉCULAIRES IONISÉES 有权转让
标题翻译：用于检测和定量以质谱和活化制作方法电离分子种类
公开(公告)号：EP3014278B8
公开(公告)日：2017-06-21
申请号：EP14750536.6
申请日：2014-06-24
申请人： Giuliani, Alexandre
发明人： Giuliani, Alexandre
IPC分类号： G01N33/68 , H01J49/00
CPC分类号： H01J49/0077 , G01N30/7266 , G01N33/6848 , H01J49/0031 , H01J49/0045 , H01J49/0054 , H01J49/0072 , H01J49/4225

3. 发明公开

EP3170006A1 METHODS FOR MASS SPECTROMETRY OF MIXTURES OF PROTEINS OF POLYPEPTIDES USING PROTON TRANSFER REACTION 审中-公开
标题翻译：方法的大运量蛋白多肽混合物由质子转移反应
公开(公告)号：EP3170006A1
公开(公告)日：2017-05-24
申请号：EP15745324.2
申请日：2015-07-17
申请人： Thermo Finnigan LLC
发明人： STEPHENSON, James L. Jr. , SYKA, John E.P. , SPECHT, August A.
IPC分类号： G01N33/68 , H01J49/00
CPC分类号： H01J49/0072 , C12Q1/04 , G01N33/6848 , H01J49/0031 , H01J49/0445
摘要： Applications of ion-ion reaction chemistry are disclosed in which proton transfer reactions (PTR) are used to (1) simplify complex mixture analysis of samples introduced into a mass spectrometer, and (2) improve resolution and sensitivity for the analysis of large proteins in excess of 50 kDa by removing charge and reducing the collisional cross section.
摘要翻译：离子 - 离子反应化学的应用是光盘被用于哪个质子转移反应（PTR）游离缺失（1）简化引入到质谱仪中样品的复杂混合物的分析，以及（2）改善大蛋白在分析分辨率和灵敏度通过去除电荷和减少碰撞截面过量为50kDa的。

4. 发明公开

EP3155416A1 METHODS FOR ANALYSIS OF LIPIDS USING MASS SPECTROMETRY 审中-实审
标题翻译： VERFAHREN ZUR ANALYZE VON LIPIDEN MITTELS MASSENSPEKTROMETRIE
公开(公告)号：EP3155416A1
公开(公告)日：2017-04-19
申请号：EP15806252.1
申请日：2015-06-04
申请人： DH Technologies Development Pte. Ltd.
发明人： BABA, Takashi , CAMPBELL, John Lawrence
IPC分类号： G01N27/62 , H01J49/26
CPC分类号： H01J49/0054 , H01J49/0072 , H01J49/4225
摘要： A method and apparatus for analyzing samples using mass spectrometry are disclosed. The apparatus includes a reaction device configured to dissociate sample ions into fragments by reacting the sample ions with a charged species (e.g., electrons) such as through ECD, EID, or EIEIO. The kinetic energy of the charged species is such that the fragments may be detected and produce spectra that allow for the determination of isomeric species in the sample and the location of double bonds of sample molecules. The fragments may include radical fragments and non-radical fragments. The apparatus may also include an oxygen gas source configured to react with the radical fragments to produce oxygen-radical fragments. Spectra resulting from analysis of the fragments may allow for the determination of the oxygen-radical fragments resulting from the dissociation of the sample molecules.
摘要翻译：公开了使用质谱分析样品的方法和装置。该装置包括反应装置，其被配置为通过使样品离子与带电物质（例如电子）例如通过ECD，EID或EIEIO反应来将样品离子分离成片段。带电物质的动能使得可以检测碎片并产生允许测定样品中异构物种和样品分子双键位置的光谱。片段可以包括自由基片段和非自由基片段。该装置还可以包括配置成与自由基片段反应以产生氧自由基碎片的氧气源。由片段分析产生的光谱可以允许测定样品分子解离产生的氧自由基片段。

5. 发明公开

EP3005399A4 INLINE ION REACTION DEVICE CELL AND METHOD OF OPERATION 有权
标题翻译： ZELLE EINER INLINE-IONENREAKTIONSVORRICHTUNG UND VERFAHREN ZUM BETRIEB
公开(公告)号：EP3005399A4
公开(公告)日：2017-02-01
申请号：EP14804693
申请日：2014-05-29
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： BABA TAKASHI
IPC分类号： H01J49/06 , H01J49/00
CPC分类号： H01J49/0054 , H01J49/0072 , H01J49/063
摘要： A method and apparatus for conducting ion to charged species reactions, more particularly reactions wherein the charged species is an electron, such as ECD. The apparatus comprises first and second pathways which are orthogonal to one another. The first pathway through which ions are introduced comprises multiple multipoles with a gap situated there between. The second pathway introduces the charged species through the gap orthogonally to the first pathway. In this way, a cross-type reaction device allows ion-charged species interactions to occur.
摘要翻译：用于将离子引入带电物种反应的方法和装置，更具体地说，其中带电物质是电子的反应，例如ECD。该装置包括彼此正交的第一和第二路径。离子引入的第一条路径包括多个多极，其间具有间隙。第二路径通过与第一路径正交的间隙引入带电物质。以这种方式，交叉型反应装置允许发生离子充电的物质相互作用。

6. 发明授权

EP2450939B1 Method of charge reduction of electron transfer dissociation product ions 有权转让
标题翻译：一种用于减少电荷电子转移解离的制作方法
公开(公告)号：EP2450939B1
公开(公告)日：2016-12-14
申请号：EP12153370.7
申请日：2009-06-05
申请人： Micromass UK Limited
发明人： Chen, Weibin , Chakraborty, Asish , Gebler, John Charles , Brown, Jeffery Mark
IPC分类号： H01J49/06 , H01J49/00
CPC分类号： H01J49/0095 , H01J49/0072 , H01J49/062 , H01J49/165 , H01J49/26 , H01J49/36

7. 发明授权

EP2388798B1 Confining positive and negative ions in a linear RF ion trap 有权转让
标题翻译：线性RF离子阱限制性正离子和负离子
公开(公告)号：EP2388798B1
公开(公告)日：2016-08-24
申请号：EP11166832.3
申请日：2011-05-20
申请人： Bruker Daltonik GmbH
发明人： Michelmann, Karsten , Berg, Christian , Kaplan, Desmond Allen
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/4295 , H01J49/0072 , H01J49/422

8. 发明公开

EP2798661A1 GENERATION OF REAGENT IONS FOR ION-ION REACTIONS 失效转让
标题翻译：生产试剂离子ION离子反应
公开(公告)号：EP2798661A1
公开(公告)日：2014-11-05
申请号：EP12862271.9
申请日：2012-12-07
申请人： DH Technologies Development Pte. Ltd.
发明人： CAMPBELL, John, L. , LEBLANC, Yves
IPC分类号： H01J49/26 , H01J49/10
CPC分类号： H01J49/0072 , H01J49/0077 , H01J49/10 , H01J49/107
摘要： An apparatus, system and method of providing that allow for the generation of reagent ions within an inner region of a mass spectrometer for use in ion-ion reactions such as PTRs and ETD using a reagent ion generator. The location where these reagent ions are generated can be as close as possible to the point of action, or the reaction zone where the reagent ion and analyte ions will interact via ion-ion reactions to cause, e.g., PTRs and/or ETD.

9. 发明公开

EP2717291A1 Instrument for analysing compounds 审中-公开
标题翻译： Gerätfürdie Analyze von Verbindungen
公开(公告)号：EP2717291A1
公开(公告)日：2014-04-09
申请号：EP12187098.4
申请日：2012-10-03
申请人： Ionicon Analytik Gesellschaft m.b.h.
发明人： Sulzer, Philipp , Jordan, Alfons , Märk, Tilmann , Märk, Lukas
IPC分类号： H01J49/00 , H01J49/14
CPC分类号： H01J49/0072 , H01J49/0031 , H01J49/145
摘要： Instrument for analysing compounds, comprising an ion source, an adjacent drift tube and a mass spectrometer including an ion detector for separation and detection of product ions, wherein instrumental parameters of the instrument can be altered by actuating elements for actuating variables of at least one of the group consisting of ion source, adjacent drift tube, mass spectrometer and ion detector, characterized by a controlling unit which is connectable to a storage device, wherein the storage device comprises a specification for certain compounds, the specification for each compound comprising a set of data comprising at least two different instrumental parameters and corresponding intensity signals for product ions detected with the ion detector, wherein the controlling unit alters the actuating elements in accordance with the specification for each compound, wherein a correspondence signal is displayed on a display unit if the detected intensity signal for the product ion corresponds with the stored intensity signals.
摘要翻译：用于分析化合物的仪器，包括离子源，相邻的漂移管和质谱仪，所述质谱仪包括用于分离和检测产物离子的离子检测器，其中所述仪器的仪器参数可以通过用于致动元件的致动元件来改变，由离子源，相邻漂移管，质谱仪和离子检测器组成的组，其特征在于可连接到存储装置的控制单元，其中存储装置包括某些化合物的规格，每种化合物的说明书包括一组数据包括用离子检测器检测到的产品离子的至少两个不同的仪器参数和相应的强度信号，其中控制单元根据每个化合物的说明书来改变致动元件，其中在显示单元上显示对应信号，如果检测产品离子对应的强度信号与存储的强度信号一起播放。

10. 发明公开

EP2539915A1 PLASMA MASS SPECTROMETRY WITH ION SUPPRESSION 审中-实审
标题翻译：等离子体质谱与离子抑制
公开(公告)号：EP2539915A1
公开(公告)日：2013-01-02
申请号：EP11748227.3
申请日：2011-02-28
申请人： PerkinElmer Health Sciences, Inc.
发明人： BADIEI, Hamid , KAHEN, Kaveh
IPC分类号： H01J27/00
CPC分类号： H01J49/061 , H01J49/00 , H01J49/0031 , H01J49/0045 , H01J49/005 , H01J49/0072 , H01J49/0077 , H01J49/10 , H01J49/105 , H01J49/24
摘要： A mass spectrometer is provided that is configurable for operation in both a Kinetic Energy Discrimination (KED) mode and a dynamic reaction cell (DRC) mode. To operate in the KED mode, a collision cell can be filled with a quantity of the inert gas, and an energy barrier can be formed between the collision cell and a downstream mass analyzer. To operate instead in the DRC mode, the collision cell can be filled with a quantity of gas that is reactive with the interferer ions.

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