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1. 发明公开

EP1966594A1 VORRICHTUNG UND VERFAHREN ZUM NACHWEIS VON MYKOTOXINEN 有权
标题翻译：设备和检测方法的霉菌毒素
公开(公告)号：EP1966594A1
公开(公告)日：2008-09-10
申请号：EP06829574.0
申请日：2006-12-13
申请人： Bayer Technology Services GmbH , Bayer CropScience Aktiengesellschaft
发明人： BURMEISTER, Jens , DORN, Ingmar , RABE, Uwe , HÄUSER-HAHN, Isolde
IPC分类号： G01N21/77 , G01N33/543 , G01N33/569
CPC分类号： G01N21/7703 , G01N21/6428 , G01N21/648 , G01N33/54373 , G01N2021/7786 , G01N2333/37
摘要： The invention relates to a device and a method for identifying mycotoxins and to kits which are suitable for carrying out said method.

2. 发明授权

EP1966594B1 VORRICHTUNG UND VERFAHREN ZUM NACHWEIS VON MYKOTOXINEN 有权
标题翻译：设备和检测方法的霉菌毒素
公开(公告)号：EP1966594B1
公开(公告)日：2013-01-23
申请号：EP06829574.0
申请日：2006-12-13
申请人： Bayer Intellectual Property GmbH , Bayer CropScience Aktiengesellschaft
发明人： BURMEISTER, Jens , DORN, Ingmar , RABE, Uwe , HÄUSER-HAHN, Isolde
IPC分类号： G01N21/64 , G01N21/77 , G01N33/543 , G01N33/569
CPC分类号： G01N21/7703 , G01N21/6428 , G01N21/648 , G01N33/54373 , G01N2021/7786 , G01N2333/37

3. 发明公开

EP1682929A1 SCHICHTSTRUKTUR UND OPTISCHER WELLENLEITER-SENSOR BASIEREND AUF PHOTOADRESSIERBAREN POLYMEREN 审中-公开
标题翻译：基于光寻址聚合物层结构和光纤传感器
公开(公告)号：EP1682929A1
公开(公告)日：2006-07-26
申请号：EP04765981.8
申请日：2004-10-16
申请人： Bayer Technology Services GmbH
发明人： DORN, Ingmar , BIERINGER, Thomas , HAGEN, Rainer , KOSTROMINE, Serguei , KUNZ, Rino, E.
IPC分类号： G02B1/04 , G01N21/77 , G01N33/543
CPC分类号： G01N21/7703 , G01N21/648 , G02B1/045
摘要： The invention relates to an optical lamellar structure comprising at least two layers and a sensor based on this lamellar structure. The lamellar structure comprises at least one substrate layer, at least one (optical) wave-guiding layer and a launching element for launching the optical radiation, whereby the layer adjacent to the wave-guiding layer has a lower refractive index than the wave-guiding layer, and at least one layer is made of a photoaddressable polymer.

4. 发明公开

EP1563089A2 SOLID PHASE BASED NUCLEIC ACID ASSAYS COMBINING HIGH AFFINITY AND HIGH SPECIFICITY 审中-公开
标题翻译：固相基于核酸分析具有高亲和力和特异性
公开(公告)号：EP1563089A2
公开(公告)日：2005-08-17
申请号：EP03749248.5
申请日：2003-08-29
申请人： Bayer Healthcare LLC , Bayer Technology Services GmbH
发明人： WARNER, Brian , QUINN, Jack , BURMEISTER, Jens , DORN, Ingmar , DIESSEL, Edgar
IPC分类号： C12Q1/68 , C12P19/34 , C12M1/34 , C07H21/02 , C07H21/04 , C07H19/00
CPC分类号： C12Q1/6837 , C12Q1/6827 , C12Q1/6834 , C12Q2565/543 , C12Q2561/125 , C12Q2537/143 , C12Q2535/125 , C12Q2565/537 , C12Q2565/519 , C12Q2535/131 , C12Q2525/186
摘要： The invention relates to methods for detection of nucleic acids on a solid phase, combining high affinity and high specificity. More particularly, the invention relates to methods combining high-affinity hybridization with highly specific enzymatic discrimination in solid phase based nucleic acid assays. This invention further relates to kits containing the reagents necessary for carrying out the disclosed assays.

5. 发明授权

EP1444517B1 ASSAY BASIEREND AUF DOTIERTEN NANOTEILCHEN 有权
标题翻译：测定法基于掺杂纳米
公开(公告)号：EP1444517B1
公开(公告)日：2007-06-27
申请号：EP02787546.7
申请日：2002-11-04
申请人： Bayer Technology Services GmbH
发明人： BOHMANN, Kerstin , HOHEISEL, Werner , KÖHLER, Burkhard , DORN, Ingmar
IPC分类号： G01N33/542 , G01N33/58 , C12Q1/68 , C12Q1/34 , C12Q1/37 , C12Q1/42 , C12Q1/48
CPC分类号： B82Y30/00 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00722 , B01J2219/00725 , C12Q1/6818 , C40B40/06 , C40B40/10 , G01N33/542 , C12Q2563/155 , C12Q2545/101
摘要： The invention relates to an assay based on resonance energy transfer (RET), comprising a first molecule group A, which is marked with at least one energy donor, and at least one second molecule group B which is marked with at least one energy acceptor, the donor comprising a molecule or particle which can be energetically excited by an external radiation source and which is fluorescence enabled and the acceptor comprising a molecule or particle which can be excited by energy transfer via the donor with partial or complete quenching of the donor fluorescence, and the donor and/or acceptor comprise luminescing inorganic doped nanoparticles having an expansion of ≤ 50 nanometers, emitting electromagnetic radiation with stokes or anti-stokes scattering after energetic excitation.

6. 发明公开

EP2416881A1 EINWEG-MIKROFLUIDIK-TESTKASSETTE ZUR BIOASSAY VON ANALYTEN 审中-公开
公开(公告)号：EP2416881A1
公开(公告)日：2012-02-15
申请号：EP10711021.5
申请日：2010-03-27
申请人： Bayer Technology Services GmbH
发明人： DORN, Ingmar , SCHADE, Andreas
IPC分类号： B01L3/00 , C12Q1/68
CPC分类号： B01L3/502 , B01L2200/16 , B01L2300/0816
摘要： The invention relates to a single-use test cartridge for the qualitative and/or quantitative analysis of analytes, comprising a structured body into which cavities that are connected to each other by channels are introduced, wherein the test cartridge comprises at least one inlet for introducing a test fluid containing the analyte, at least one reagent chamber in which one or more reagents for reacting with the analytes or for mixing with the sample fluid are accommodated, and at least one detection chamber in which a signal for proving or for the quantitative analysis of the analyte is detected, characterized in that the bottom or the top of the detection chamber comprises a signal converter or a window for detecting a signal, the channels are designed such that the fluid cannot be drawn into the reagent chamber or to the opening by capillary forces, and the reagents are accommodated in the reagent chamber and optionally further reactants are accommodated in the detection chamber in dry form. The invention further relates to a device for the bioassay of analytes by means of bio and/or chemo sensors, comprising the test cartridge according to the invention, at least one coupling point for positioning the test cartridge, at least one means for delivering the test fluids into the test cartridge, and at least one temperature control unit, and to a method for operating said device. The test cartridge, device and method according to the invention can be used in the field of environmental analytics, the food industry, human and veterinary diagnostics and plant protection in order to qualitatively and/or quantitatively determine analytes.
摘要翻译：一种一次性测试盒，用于对分析物进行定性和/或定量分析，其具有通过通道彼此连接的引入空腔的结构化体，用于引入含有分析物的样品流体的至少一个入口，至少一个试剂室，存储更多的试剂，并且至少一个检测室，其中检测到用于分析物的检测或定量分析的信号，其中检测室的底板或天花板是用于检测信号的信号转换器或窗口，流体不能通过毛细管拉入试剂室或开口，并且至少试剂室中的试剂以干燥形式储存。还公开了一种用于生物分析包括测试盒的分析物的装置，以及用于操作该装置的方法。

7. 发明公开

EP2411530A2 SOLID PHASE BASED NUCLEIC ACID ASSAYS COMBINING HIGH AFFINITY CAPTURING AND DETECTION BY SPECIFIC HYBRIDIZATION 审中-公开
标题翻译：核酸测试程序上捕捉高亲和力的结合和证明特异性杂交固相BASE
公开(公告)号：EP2411530A2
公开(公告)日：2012-02-01
申请号：EP07759429.9
申请日：2007-03-27
申请人： Bayer Technology Services GmbH
发明人： BURMEISTER, Jens , DORN, Ingmar , WARNER, Brian
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6827 , C12Q2539/101 , C12Q2537/161 , C12Q2535/131
摘要： This invention relates to methods for detection of nucleic acids on a solid phase with high affinity and high specificity. More particularly, the invention relates to methods combining high-affinity hybridization-based capturing with highly specific hybridization-based discrimination in solid phase based nucleic acid assays. This invention further relates to kits containing the reagents necessary for carrying out the disclosed assays. The detection of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) is of importance in human or veterinary diagnostics, food control, environmental analysis, crop protection, biochemical/pharmacological research, or forensic medicine.

8. 发明公开

EP2335078A1 APPARATUS FOR AUTOMATICALLY PERFORMING ANALYSES 有权
标题翻译： VORRICHTUNG ZUR AUTOMATISCHENDURCHFÜHRUNGVON ANALYSEN
公开(公告)号：EP2335078A1
公开(公告)日：2011-06-22
申请号：EP09778690.9
申请日：2009-09-24
申请人： Bayer Technology Services GmbH
发明人： DIESSEL, Edgar , DORN, Ingmar , HABIG, Michael , KÜSTER, Mike , OCHMANN, Klaus
IPC分类号： G01N35/02
CPC分类号： G01N35/028 , G01N2035/00306 , G01N2035/00326 , G01N2035/1051 , Y10T436/11
摘要： The present invention relates to an apparatus and a method for automatically performing chemical, biochemical and biological analyses.
摘要翻译：本发明涉及一种用于自动执行化学，生化和生物分析的装置和方法。该装置包括用于对微量滴定板上的样品执行不同操作的子系统，用于传送板和用于保持板的机械系统，例如。一个抽屉

9. 发明公开

EP1722839A1 VERBESSERTES VERFAHREN ZUR ZEITLICHEN DOSIERUNG VON ARZNEISTOFFEN 有权转让
标题翻译：设备对于原料药的剂量TIME
公开(公告)号：EP1722839A1
公开(公告)日：2006-11-22
申请号：EP05715413.0
申请日：2005-02-19
申请人： Bayer Technology Services GmbH
发明人： WILLMANN, Stefan , SCHMITT, Walter , LIPPERT, Jörg , DORN, Ingmar
IPC分类号： A61M5/00 , A61M15/00
CPC分类号： A61M5/1723 , A61M15/00 , A61M15/0083 , A61M16/01 , A61M2005/14208 , G06F19/00 , G06F19/12 , G06F19/26 , G06F19/3468 , G16H50/50 , G16H50/70

10. 发明公开

EP1671250A2 VERFAHREN ZUR BESTIMMUNG EINER WIRKSTOFFDOSIERUNG 审中-公开
标题翻译：方法确定活性剂量
公开(公告)号：EP1671250A2
公开(公告)日：2006-06-21
申请号：EP04765437.1
申请日：2004-09-21
申请人： Bayer Technology Services GmbH
发明人： SCHMITT, Walter , WILLMANN, Stefan , DIEßEL, Edgar , DORN, Ingmar , BURMEISTER, Jens
IPC分类号： G06F19/00
CPC分类号： G06F19/18 , G06Q50/24
摘要： The invention relates to a method for determining the dosage of at least one active ingredient based on a genetic analysis. The method comprises the following steps: a) analysis (101) of specific genetic sequences, using a genetic sequence-specific analysis device, in particular a sequence-specific sensor, or determination of the expression of proteins, either by RNA transcription using quantitative RNA-specific identification methods or by the direct measurement of the protein expression by a protein analysis device; b) assignment of the genetic sequences to physiological functions of the human or animal body, in particular to those physiological functions that influence the decomposition, absorption, release or distribution behaviour of the active ingredient in the body; c) transmission of the genetic and assignment data to a physiology-based pharmacokinetic model (PBPK model) (108); d) input of active ingredient-specific data into the PBPK model (108); e) input of characteristic patient data, optionally from direct measurements on the body; f) calculation of physiological influence parameters that are required for the PBPK model from the patient data, using information contained in the knowledge database and transmission of said parameters to the PBPK model (108); g) calculation of the individual dose from the data in steps c), d) and f), using the PBPK model (108).

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