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1. 发明公开

EP2944699A1 METHOD OF SELECTIVELY DETERMINING GLYCATED HEMOGLOBIN 有权
标题翻译： VERFAHREN ZUR SELEKTIVEN BESTIMMUNG VON GLYKIERTEMHÄMOGLOBIN
公开(公告)号：EP2944699A1
公开(公告)日：2015-11-18
申请号：EP15174619.5
申请日：2001-07-12
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi
IPC分类号： C12Q1/26 , G01N33/72
CPC分类号： C12Q1/26 , C12Q1/37 , G01N33/723 , G01N33/725
摘要： A method of determining glycated hemoglobin is provided, by which a ratio of the glycated hemoglobin in a sample can be determined accurately and easily. The ratio of glycated hemoglobin can be determined by hemolyzing whole blood using a non-ionic surfactant; degrading glycated hemoglobin in the hemolyzed whole blood selectively with a protease to give a glycated hemoglobin degradation product; causing a redox reaction between a glycation site of the glycated hemoglobin degradation product and a fructosyl amino acid oxidoreductase; and determining the redox reaction to determine an amount of the glycated hemoglobin; wherein the protease is a metalloproteinase capable of selectively degrading the glycated hemoglobin.
摘要翻译：提供了测定糖化血红蛋白的方法，通过该方法可以准确且容易地测定样品中糖化血红蛋白的比例。糖化血红蛋白的比例可以通过使用非离子表面活性剂溶血全血来测定; 用蛋白酶选择性地降解溶血全血中的糖化血红蛋白，得到糖化血红蛋白降解产物; 引起糖化血红蛋白降解产物的糖化位点与果糖基氨基酸氧化还原酶之间的氧化还原反应; 并测定氧化还原反应以确定糖化血红蛋白的量; 其中所述蛋白酶是能够选择性降解糖化血红蛋白的金属蛋白酶。

2. 发明授权

EP2144055B1 METHOD OF ANALYZING HEMOGLOBIN BY CAPILLARY ELECTROPHORESIS AND ADDITIVE TO BE USED THEREIN 有权
标题翻译：血红蛋白分析方法毛细管以及它在SANTANDER添加剂
公开(公告)号：EP2144055B1
公开(公告)日：2014-03-12
申请号：EP08751963.3
申请日：2008-04-23
申请人： ARKRAY, Inc.
发明人： NAKAYAMA, Yusuke , YONEHARA, Satoshi
IPC分类号： G01N27/447
CPC分类号： G01N27/44747

3. 发明授权

EP2116611B1 MEASUREMENT METHOD FOR HBA1C 有权
标题翻译：法测量的A1C
公开(公告)号：EP2116611B1
公开(公告)日：2013-08-14
申请号：EP08704157.0
申请日：2008-01-30
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi , INAMURA, Norio
IPC分类号： C12Q1/26 , C12Q1/37 , G01N33/72
CPC分类号： C12Q1/26 , C12Q1/37 , G01N33/721 , G01N2333/805 , Y10T436/19 , Y10T436/25

4. 发明公开

EP2148193A1 ELECTROPHORESIS CHIP, ELECTROPHORESIS DEVICE, AND SAMPLE ANALYZING METHOD BY CAPILLARY ELECTROPHORESIS METHOD 审中-公开
标题翻译： ELEKTROPHORESE-CHIP，ELEKTROPHORESEVORRICHTUNG SOWIE VERFAHREN ZUR ANALYZE VON PROBEN DURCH KAPILLARELEKTROPHORESE
公开(公告)号：EP2148193A1
公开(公告)日：2010-01-27
申请号：EP08752216.5
申请日：2008-04-28
申请人： National Institute of Advanced Industrial Science and Technology , Arkray, Inc.
发明人： TANAKA, Yoshide , NAKAYAMA, Yusuke , YONEHARA, Satoshi
IPC分类号： G01N27/447 , G01N37/00
CPC分类号： G01N27/44791 , G01N27/44743
摘要： An electrophoresis chip that can be small and simple and that can analyze a sample with high accuracy is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, an introduction reservoir 2a, a recovery reservoir 2b and a capillary channel for sample analysis 3x.
The introduction reservoir 2a and the recovery reservoir 2b are formed in the lower substrate 1. The introduction reservoir 2a and the recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x. The introduction reservoir 2a receives a sample to be measured.
The sample is electrophoretically introduced directly into the capillary channel for sample analysis 3x by creating a potential difference between the introduction reservoir 2a and the recovery reservoir 2b, and is also analyzed in the capillary channel for sample analysis 3x during the separation of the sample while the sample is being continuously supplied.
摘要翻译：提供可以小而简单并且可以高精度地分析样品的电泳芯片。电泳芯片包括上基板4，下基板1，导入槽2a，回收槽2b和用于样品分析的毛细通道3x。引入储存器2a和回收储存器2b形成在下基板1中。引入储存器2a和回收储存器2b经由用于样本分析3x的毛细通道彼此连通。引入容器2a接收要测量的样品。通过在引入容器2a和回收容器2b之间产生电位差，将样品电泳引入毛细通道3x进行样品分析，并在样品分离过程中在毛细管通道中进行样品分析3x分析，同时样品不断供应。

5. 发明公开

EP2144056A1 ELECTROPHORESIS CHIP AND ELECTROPHORESIS APPARATUS 审中-公开
标题翻译： ELEKTROPHORESE-CHIP UND ELEKTROPHORESEVORRICHTUNG
公开(公告)号：EP2144056A1
公开(公告)日：2010-01-13
申请号：EP08751964.1
申请日：2008-04-23
申请人： Arkray, Inc.
发明人： SUGIYAMA, Koji , YONEHARA, Satoshi , NAKAYAMA, Yusuke
IPC分类号： G01N27/447 , G01N37/00
CPC分类号： G01N27/44791 , B01L3/50273 , B01L2300/0867 , B01L2300/0887 , B01L2300/16 , B01L2400/0421 , C07K1/26
摘要： An electrophoresis chip that enables an apparatus to be small, analysis time to be short and glycosylated hemoglobin to be analyzed highly accurately is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, a first introduction reservoir 2a, a first recovery reservoir 2b and a capillary channel for sample analysis 3x; the first introduction reservoir 2a and the first recovery reservoir 2b are formed in the lower substrate 1; and the first introduction reservoir 2a and the first recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x.
摘要翻译：提供能够使装置小型，分析时间短，要高精度地分析糖基化血红蛋白的电泳芯片。电泳芯片包括上基板4，下基板1，第一引入槽2a，第一回收槽2b和用于样品分析的毛细通道3x; 第一引入槽2a和第一回收槽2b形成在下基板1中; 并且第一引入槽2a和第一回收槽2b经由用于样品分析3x的毛细通道彼此连通。

6. 发明授权

EP2944699B1 METHOD OF SELECTIVELY DETERMINING GLYCATED HEMOGLOBIN 有权
标题翻译：选择性测定糖化血红蛋白的方法
公开(公告)号：EP2944699B1
公开(公告)日：2017-10-18
申请号：EP15174619.5
申请日：2001-07-12
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi
IPC分类号： C12Q1/37 , C12Q1/26 , G01N33/72
CPC分类号： C12Q1/26 , C12Q1/37 , G01N33/723 , G01N33/725

7. 发明公开

EP3001190A1 METHOD FOR DETECTING PHENOTHIAZINE-DERIVATIVE COLOR AND COLOR-DEVELOPER REAGENT USED THEREIN 有权
标题翻译：用于检测表没食子儿茶素衍生物的显色剂和显色剂的方法
公开(公告)号：EP3001190A1
公开(公告)日：2016-03-30
申请号：EP15191515.4
申请日：2008-01-30
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi , INAMURA, Norio
IPC分类号： G01N31/00 , G01N21/78 , G01N31/22 , C09B11/08 , C09B21/00 , C09B29/15 , C09B29/50 , C09B67/22 , C09B67/46 , G01N21/77
CPC分类号： G01N31/22 , C09B11/08 , C09B21/00 , C09B29/103 , C09B29/366 , C09B67/0033 , C09B67/0041 , C09B67/0089 , G01N21/78 , G01N2021/7783 , Y10T436/141111 , Y10T436/145555
摘要： The present invention provides a phenothiazine-derivative color-measuring method that can detect a phenothiazine-derivative color even at a wavelength longer than the wavelength that exhibits maximum absorption. A phenothiazine-derivative color is detected, by adding a 5-hydroxy-1-(4-sulfophenyl)-4-(4-sulfophenylazo)pyrazole-3-carboxylic acid salt, 6-hydroxy-5-(4-sulfophenylazo)-2-naphthalenesulfonic acid salt, 3-hydroxy-4-(4-sulfonaphthylazo)-2,7-naphthalenedisulfonic acid salt, or 7-hydroxy-8-(4-sulfonaphthylazo)-1,3-naphthalenedisulfonic acid salt to the reaction system containing a phenothiazine-derivative color, and then measuring the light absorbance at a wavelength of 610 to 730 nm.
摘要翻译：本发明提供即使在比显示最大吸收的波长更长的波长下也能够检测吩噻嗪衍生物颜色的吩噻嗪衍生物颜色测定方法。通过加入5-羟基-1-（4-磺基苯基）-4-（4-磺基苯基偶氮）吡唑-3-羧酸盐，6-羟基-5-（4-磺基苯偶氮基） - 2-萘磺酸盐，3-羟基-4-（4-磺基萘基偶氮）-2,7-萘二磺酸盐或7-羟基-8-（4-磺基萘基偶氮）-1,3-萘二磺酸盐加入反应体系含有吩噻嗪衍生物颜色，然后测量在610-730nm波长处的吸光度。

8. 发明授权

EP2249163B1 Method of pretreating sample for measurement of glycated amine 有权
标题翻译：一种用于预处理样品糖化胺的测定方法
公开(公告)号：EP2249163B1
公开(公告)日：2012-06-27
申请号：EP10008376.5
申请日：2002-10-09
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi , KOMORI, Tsuguki
IPC分类号： C12Q1/26 , C12Q1/37 , C12Q1/28 , G01N33/48 , G01N33/50 , G01N33/72
CPC分类号： C12Q1/26 , C12Q1/37 , G01N33/723 , G01N2333/906

9. 发明授权

EP1950309B1 ALBUMIN-DENATURING AGENT 有权
标题翻译：白蛋白变性
公开(公告)号：EP1950309B1
公开(公告)日：2011-08-17
申请号：EP06822508.5
申请日：2006-10-27
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi , INAMURA, Norio
IPC分类号： C12Q1/00 , G01N33/48 , G01N33/66 , G01N33/68
CPC分类号： C12Q1/37 , G01N33/68 , G01N2333/76 , G01N2400/00
摘要： Disclosed is an albumin-denaturing agent which is helpful for achieving a high-efficiency decomposition of albumin with a protease. The albumin-denaturing agent comprises a tertiary ammonium having a hydrocarbon group harboring 12 to more carbon atoms or a salt thereof. Albumin in a sample is decomposed with a protease in the presence of the albumin-denaturing agent, a glycosylated part in the resulting albumin decomposition product is reacted with FAOD, and the oxidation/reduction reaction between the glycosylated part and FAOD is then determined, whereby the ratio of the amount of glycosylated albumin to that of albumin (GA (%)) can be determined.

10. 发明授权

EP3001190B1 METHOD FOR DETECTING PHENOTHIAZINE-DERIVATIVE COLOR AND METHOD FOR DETECTING A TARGET COMPONENT 有权
公开(公告)号：EP3001190B1
公开(公告)日：2019-04-10
申请号：EP15191515.4
申请日：2008-01-30
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi , INAMURA, Norio
IPC分类号： G01N31/00 , G01N21/78 , G01N31/22 , C09B11/08 , C09B21/00 , C09B29/15 , C09B29/50 , C09B67/22 , C09B67/46 , G01N21/77

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