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1. 发明专利

AU2002241141B2 Corona ionisation source 未知
公开(公告)号：AU2002241141B2
公开(公告)日：2005-03-17
申请号：AU2002241141
申请日：2002-03-21
申请人： THE SEC DEP FOR DEFENSE
发明人： ROSS STUART KEITH , BELL ANDREW JOHN
IPC分类号： G01N27/62 , G01N27/64 , G01N27/68 , H01J49/04 , H01J49/10 , H01J049/40
摘要： A corona discharge ionization source is disclosed in which neutral species are removed by directing a flow of oxygen containing gas in a direction substantially different to that of the ion flow. The ion profiles produced are similar in many respects to those produced by a Ni source, thus an alternative, non-radioactive, ion source is offered.

2. 发明专利

AU2001271956B2 Ion separation instrument 未知
公开(公告)号：AU2001271956B2
公开(公告)日：2005-06-23
申请号：AU2001271956
申请日：2001-07-10
申请人： UNIV INDIANA RES & TECH CORP
发明人： CLEMMER DAVID E
IPC分类号： G01N27/62 , G01N27/64 , H01J49/10 , H01J49/26 , H01J49/40 , H01J049/40

3. 发明专利

AU2001261372B2 Gridless, focusing ion extraction device for a time-of-flight mass spectrometer 未知
公开(公告)号：AU2001261372B2
公开(公告)日：2004-05-13
申请号：AU2001261372
申请日：2001-05-10
申请人： UNIV JOHNS HOPKINS
发明人： CORNISH TIMOTHY J
IPC分类号： G01N27/62 , H01J49/06 , H01J49/40 , H01J049/40
摘要： A miniature time-of-flight mass spectrometer (TOF-MS) is provided having (1) a gridless, focusing ionization extraction device allowing for the use of very high extraction energies in a maintenance-free design, (2) a miniature flexible circuit-board reflector using rolled flexible circuit-board material, and (3) a low-noise, center-hole microchannel plate detector assembly that significantly reduces the noise (or "ringing") inherent in the coaxial design. A method is also provided for increasing the collection efficiency of laser-desorbed ions in the TOF-MS. The method includes the steps of providing within the TOF-MS an ionization extraction device having an unobstructed central chamber having a first region and a second region; creating an ion acceleration/extraction field within the first region; accelerating ions within the first region; de-accelerating the ions in the second region; and drifting the ions in a drift region to cause ion dispersion.

4. 发明申请

US20040222371A1 Soft ionization device and applications thereof 失效
标题翻译：软电离装置及其应用
公开(公告)号：US20040222371A1
公开(公告)日：2004-11-11
申请号：US10456939
申请日：2003-06-06
申请人： Ionfinity LLC
发明人： Frank T. Hartley
IPC分类号： H01J049/40
CPC分类号： H01J49/168 , G01N2223/612 , H01J3/027 , H01J3/04 , H01J27/02 , H01J27/26 , H01J37/08 , H01J49/0018 , H01J49/0427 , H01J2237/061 , H01J2237/0815 , H01J2237/317
摘要： A soft ionization device is disclosed that comprises a series of electrodes having spacing less than the means free path of the molecules to be ionized. In some embodiments, the soft ionization device is used in various applications that require ion or electron sources such as biological or chemical reactors, ion milling, and numerous replacements for conventional hot cathode systems. In another embodiment, a valence spectrometer is disclosed that is configured to variably ionize molecules by their valiancy. In other embodiments, the ionization device is coupled to a spectrometer for the characterization of biological matter. Also disclosed is a preconditioner for preparing biological matter to be ionized.
摘要翻译：公开了一种软电离装置，其包括具有小于待离子化分子的平均自由程的间隔的一系列电极。在一些实施例中，软电离装置用于需要离子或电子源（例如生物或化学反应器，离子研磨）和常规热阴极系统的多种替代品的各种应用中。在另一个实施方案中，公开了一种化学光谱仪，其被配置为通过它们的缬氨酸可变地离子化分子。在其它实施方案中，将离子化装置耦合到用于表征生物物质的光谱仪。还公开了用于制备待离子化的生物物质的预处理剂。

5. 发明申请

US20040206900A1 Mass spectrometer for simulataneous detection of reflected and direct ions 有权
标题翻译：用于同时检测反射和直接离子的质谱仪
公开(公告)号：US20040206900A1
公开(公告)日：2004-10-21
申请号：US10480243
申请日：2003-12-09
发明人： Timothy J Cornish , Scott A Ecelberger
IPC分类号： H01J049/40
CPC分类号： H01J49/025 , H01J49/405
摘要： Techniques for simultaneously detecting direct and reflected ions in a time-of-flight tube (120) and a source (110) for generating an ion beam of ions of a sample and introducing the ion beam into a first portion of the flight tube. A reflector (126) reflects ions from the ion beam in a second portion of the flight tube. A plate (140) substantially perpendicular to an axis of the ion beam is located between the first portion of the flight tube and the second portion of the flight tube. The plate has a hole through which some ions in the ion beam may pass from the first portion to the second portion of the flight tube. Each of two opposite faces of the plate includes a set of one or more ion detectors (140). The technique allows rapid, reliable detection of complex agents in a small number of samples.
摘要翻译：用于同时检测飞行时间管（120）和源（110）中的直接和反射离子的技术，用于产生样品的离子离子束并将离子束引入飞行管的第一部分。反射器（126）在飞行管的第二部分中从离子束反射离子。基本上垂直于离子束的轴线的板（140）位于飞行管的第一部分和飞行管的第二部分之间。该板具有一个孔，离子束中的一些离子可以从该孔穿过飞行管的第一部分到第二部分。板的两个相对面中的每一个包括一组一个或多个离子检测器（140）。该技术允许在少量样品中快速，可靠地检测复合物。

6. 发明申请

US20040144919A1 Compact very high resolution time-of-flight mass spectrometer 有权
标题翻译：紧凑的非常高分辨率的飞行时间质谱仪
公开(公告)号：US20040144919A1
公开(公告)日：2004-07-29
申请号：US10688207
申请日：2003-10-17
申请人： Bruker Daltonik GMBH
发明人： Gerhard Weiss
IPC分类号： H01J049/40
CPC分类号： H01J49/408
摘要： The invention relates to a compact time-of-flight mass spectrometer which enables very accurate mass determinations. The invention consists of a method of producing a high resolution by means of a long flight path, where the ion beam repeatedly sweeps a figure of eight in two opposed cylindrical capacitors, each of 254.56null, and the linear ion beam paths between the cylindrical capacitors are extended virtually by a change in potential so as to cause a time focusing with respect to an initial energy spread.

7. 发明申请

US20040144917A1 MULTI-MODE SIGNAL OFFSET IN TIME-OF-FLIGHT MASS SPECTROMETRY 有权
标题翻译：飞行时间质谱中的多模式信号偏移
公开(公告)号：US20040144917A1
公开(公告)日：2004-07-29
申请号：US10349777
申请日：2003-01-23
发明人： Charles William Russ IV , William D. Frazer
IPC分类号： H01J049/40
CPC分类号： H01J49/0036
摘要： A system and method of processing signals generated at a detector of a mass spectrometer prior to signal conversion in which a pre-ADC offset is applied to the signals that is adjustable in polarity and magnitude in accordance with a user-selected mode. According to a first mode, a positive offset is applied to the signals to improve quantitation accuracy and in a second mode, a negative offset is applied to the signals to improve resolution and mass assignment.
摘要翻译：在信号转换之前处理在质谱仪的检测器处产生的信号的系统和方法，其中根据用户选择的模式将前ADC偏移施加到可在极性和幅度上调节的信号。根据第一模式，对信号施加正偏移以提高定量精度，并且在第二模式中，向信号施加负偏移以改善分辨率和质量分配。

8. 发明申请

US20040004185A9 TANDEM FAIMS/ION-TRAPPING APPARATUS AND METHOD 有权
标题翻译： TANDEM FAIMS / ION-TRAPPING设备和方法
公开(公告)号：US20040004185A9
公开(公告)日：2004-01-08
申请号：US10221624
申请日：2002-09-13
发明人： Roger Guevremont , Randy Purves , David Barnett
IPC分类号： H01J049/40
CPC分类号： H01J49/004 , G01N27/624
摘要： A method for selectively transmitting ions using a FAIMS device is disclosed. A first analyzer region is defined by a space between first and second spaced apart electrodes. A second analyser region is provided in operational communication with the first analyzer region. Ions are provided to the first analyzer region. The ions are coupled from the first analyser region to the second analyzer region. An asymmetric waveform is used to generate an electric field within the first analyser region and a compensation voltage is applied to prevent some ions from exiting the analyser region. Conditions are provided within the second analyzer region for effecting a second different separation of ions therein. Finally, the separated ions are trapped to accumulate ions within a trapping region thereof.
摘要翻译：公开了一种使用FAIMS装置选择性地传输离子的方法。第一分析器区域由第一和第二间隔开的电极之间的空间限定。提供与第一分析器区域操作通信的第二分析器区域。离子被提供给第一分析器区域。离子从第一分析器区域耦合到第二分析器区域。使用非对称波形来产生第一分析器区域内的电场，并且施加补偿电压以防止一些离子离开分析器区域。在第二分析仪区域内提供条件以实现其中的离子的第二不同分离。最后，分离的离子被捕获以在其捕获区域内积聚离子。

9. 发明申请

US20030230711A1 FAIMS apparatus having plural ion inlets and method therefore 有权
标题翻译：因此具有多个离子入口的FAIMS装置和方法
公开(公告)号：US20030230711A1
公开(公告)日：2003-12-18
申请号：US10359642
申请日：2003-02-07
发明人： Roger Guevremont , Randy Purves , David Barnett
IPC分类号： H01J049/40
CPC分类号： G01N27/624 , G01N21/03 , G01N21/35 , G01N21/3504 , G01N21/65 , Y10T436/105831 , Y10T436/24
摘要： Disclosed are an apparatus and a method for separating ions in the gas phase. An apparatus according to the instant invention includes a high field asymmetric waveform ion mobility spectrometer including an inner electrode having an outer surface and a length. The apparatus further includes an outer electrode having an inner surface and a length and surrounding the inner electrode over at least a portion of the length of the inner electrode, the inner electrode and the outer electrode defining an analyzer region therebetween and being disposed in a spaced apart arrangement for allowing ions to propagate therebetween. The outer electrode also includes an outlet from the analyzer region and at least a first ion inlet and a second distinct ion inlet into the analyzer region. The first ion inlet and the second distinct ion inlet are each for communicating with at least one ionization source. The inner electrode and the outer electrode are for providing an electric field within the analyzer region resulting from application of an asymmetric waveform voltage to at least one of the inner electrode and the outer electrode and from application of a compensation voltage to at least one of the inner electrode and outer electrode, the electric field for selectively transmitting ions within the analyzer region between at least one of the first ion inlet and the second distinct ion inlet and the outlet.
摘要翻译：公开了一种用于分离气相中的离子的装置和方法。根据本发明的装置包括具有外表面和长度的内电极的高场非对称波形离子迁移谱仪。该装置还包括具有内表面和长度的外部电极，并且在内部电极的至少一部分长度上围绕内部电极，内部电极和外部电极在其间限定分析器区域并且设置在间隔开的位置用于允许离子在其间传播的分离布置。外部电极还包括来自分析器区域的出口和至少第一离子入口和进入分析器区域的第二不同离子入口。第一离子入口和第二不同离子入口各自用于与至少一个电离源连通。内部电极和外部电极用于在分析器区域内提供电场，该电场是通过向内部电极和外部电极中的至少一个施加不对称波形电压，并且将补偿电压施加到至少一个内部电极和外部电极，用于选择性地将分析器区域内的离子传输到第一离子入口和第二不同离子入口和出口中的至少一个之间的电场。

10. 发明申请

US20030222211A1 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20030222211A1
公开(公告)日：2003-12-04
申请号：US10446079
申请日：2003-05-28
发明人： Akihiko Okumura , Izumi Waki
IPC分类号： H01J049/40
CPC分类号： H01J49/40 , H01J49/004 , H01J49/4265
摘要： In the time-of-flight mass spectrometer, after ions are accumulated in a quadrupole ion trap in a low vacuum chamber, the ions are ejected and transferred to a high vacuum chamber and are accelerated by an acceleration electrode in a direction orthogonal to the traveling direction of ions, and time of flight for the accelerated ions is measured. Total content of detected ions is calculated with a data processing unit. An ion introduction time for the next operation is determined on the basis of the obtained total ion content, the time for introduction of ions into the ion trap and a preset threshold value of the total ion content. The threshold value of total ion content is set such that the ions ejected out of the ion trap can pass through a slit formed in a partition wall for portioning the low vacuum chamber and the high vacuum chamber.
摘要翻译：在飞行时间质谱仪中，离子聚集在低真空室中的四极离子阱中后，离子被喷射并转移到高真空室，并通过加速电极在与行进方向正交的方向上加速测量离子的方向和加速离子的飞行时间。用数据处理单元计算检测离子的总含量。基于获得的总离子含量，离子进入离子阱的时间和总离子含量的预设阈值，确定下次操作的离子引入时间。总离子含量的阈值被设定为使得从离子阱中排出的离子可以通过形成在用于分配低真空室和高真空室的分隔壁中的狭缝。

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