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1. 发明授权

US07364703B2 Microfabricated structures for facilitating fluid introduction into microfluidic devices 有权
标题翻译：用于促进流体引入微流体装置的微型结构
公开(公告)号：US07364703B2
公开(公告)日：2008-04-29
申请号：US11493996
申请日：2006-07-27
申请人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
发明人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
IPC分类号： G01N1/10 , B01L3/02
CPC分类号： G01N27/44791 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00891 , B01J2219/00909 , B01L3/0244 , B01L3/0262 , B01L3/5025 , B01L3/50255 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502753 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/0688 , G01N27/44743 , G01N2035/00237 , G01N2035/1037 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.
摘要翻译：通过使用完全延伸通过微流体衬底的端口来促进流体引入。可以使用毛细管力将流体保持在端口内，并且可以通过单个端口引入一系列样品或其它流体，通过依次将流体通过基底吹出，并用替代流体代替去除的流体，或者通过置换流体部分附加流体。在另一方面，微流体衬底具有在横截面尺寸上变化的通道，使得毛细管作用仅在通道网络的有限部分内扩散流体。在另一方面，引入端口可以包括从端口引导到流体通道的多个非常小的通道，以便过滤除了通道和引入端口之间的连接处可能阻挡通道的颗粒或其它污染物。

2. 发明授权

US07364704B2 Microfabricated structures for facilitating fluid introduction into microfluidic devices 有权
公开(公告)号：US07364704B2
公开(公告)日：2008-04-29
申请号：US11493997
申请日：2006-07-27
申请人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
发明人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
IPC分类号： G01N1/10 , B01L3/02
CPC分类号： G01N27/44791 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00891 , B01J2219/00909 , B01L3/0244 , B01L3/0262 , B01L3/5025 , B01L3/50255 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502753 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/0688 , G01N27/44743 , G01N2035/00237 , G01N2035/1037 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

3. 发明授权

US07364706B2 Microfabricated structures for facilitating fluid introduction into microfluidic devices 有权
公开(公告)号：US07364706B2
公开(公告)日：2008-04-29
申请号：US11617799
申请日：2006-12-29
申请人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
发明人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
IPC分类号： G01N1/10 , B01L3/02
CPC分类号： G01N27/44791 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00891 , B01J2219/00909 , B01L3/0244 , B01L3/0262 , B01L3/5025 , B01L3/50255 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502753 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/0688 , G01N27/44743 , G01N2035/00237 , G01N2035/1037 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

4. 发明授权

US07316801B2 High throughput microfluidic systems and methods 有权
标题翻译：高通量微流体系统和方法
公开(公告)号：US07316801B2
公开(公告)日：2008-01-08
申请号：US10244227
申请日：2002-09-16
申请人： Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
发明人： Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
IPC分类号： G01N21/00 , B01L3/02
CPC分类号： G01N35/028 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multi-well microtiter plates or other array structures. The multi-well plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multi-well plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip. A clamshell structure having a hinged lid can releasably support the chip while providing and/or accommodating the electrical, optical, structural, and other interface connections between the microfluidic device and the surrounding system.
摘要翻译：本发明提供用于分析标准多孔微量滴定板或其它阵列结构中所含的大量样品化合物的改进的系统，装置和方法。多孔板沿着输送系统行进到具有微流体装置的测试台。在测试台处，每个板从输送机中取出，多孔板的孔依次与微流体装置的输入端对准。在每个样品的至少一部分已经被输入到微流体通道系统中之后，板返回到输送系统。可以沿输送机系统布置前后测试站，并且使用XYZ机器人臂和新的板支撑支架允许孔中的每个样品通过固定在微流体上的探针输入微流体网络芯片。具有铰接盖的蛤壳结构可以可释放地支撑芯片，同时提供和/或容纳微流体装置和周围系统之间的电，光学，结构和其它界面连接。

5. 发明授权

US6086825A Microfabricated structures for facilitating fluid introduction into microfluidic devices 有权
公开(公告)号：US6086825A
公开(公告)日：2000-07-11
申请号：US274811
申请日：1999-03-23
申请人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
发明人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
IPC分类号： B01J19/00 , B01L3/00 , B01L3/02 , G01N27/447 , G01N35/00 , G01N35/10
CPC分类号： G01N27/44791 , B01J19/0093 , B01L3/0244 , B01L3/0262 , B01L3/5025 , B01L3/50255 , B01L3/5027 , B01L3/502715 , B01L3/50273 , G01N27/44743 , B01J2219/00783 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00891 , B01J2219/00909 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/0688 , B01L3/502723 , B01L3/502753 , G01N2035/00237 , G01N2035/1037 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

6. 发明授权

US07399448B2 Microfabricated structures for facilitating fluid introduction into microfluidic devices 有权
公开(公告)号：US07399448B2
公开(公告)日：2008-07-15
申请号：US11493998
申请日：2006-07-27
申请人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
发明人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
IPC分类号： G01N1/10 , B01L3/02
CPC分类号： G01N27/44791 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00891 , B01J2219/00909 , B01L3/0244 , B01L3/0262 , B01L3/5025 , B01L3/50255 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502753 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/0688 , G01N27/44743 , G01N2035/00237 , G01N2035/1037 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

7. 发明授权

US07364915B2 Microfabricated structures for facilitating fluid introduction into microfluidic devices 有权
公开(公告)号：US07364915B2
公开(公告)日：2008-04-29
申请号：US11617804
申请日：2006-12-29
申请人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
发明人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
IPC分类号： G01N1/10 , B01L3/02
CPC分类号： G01N27/44791 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00891 , B01J2219/00909 , B01L3/0244 , B01L3/0262 , B01L3/5025 , B01L3/50255 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502753 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/0688 , G01N27/44743 , G01N2035/00237 , G01N2035/1037 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

8. 发明授权

US06709559B2 Microfabricated structures for facilitating fluid introduction into microfluidic devices 有权
标题翻译：用于促进流体引入微流体装置的微型结构
公开(公告)号：US06709559B2
公开(公告)日：2004-03-23
申请号：US10209493
申请日：2002-07-30
申请人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
发明人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
IPC分类号： G01N2726
CPC分类号： G01N27/44791 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00891 , B01J2219/00909 , B01L3/0244 , B01L3/0262 , B01L3/5025 , B01L3/50255 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502753 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/0688 , G01N27/44743 , G01N2035/00237 , G01N2035/1037 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.
摘要翻译：通过使用完全延伸通过微流体衬底的端口来促进流体引入。可以使用毛细管力将流体保持在端口内，并且可以通过单个端口引入一系列样品或其它流体，通过依次将流体通过基底吹出并用替代流体代替去除的流体，或通过置换流体部分附加流体。在另一方面，微流体衬底具有在横截面尺寸上变化的通道，使得毛细管作用仅在通道网络的有限部分内扩散流体。在另一方面，引入端口可以包括从端口引导到流体通道的多个非常小的通道，以便过滤除了通道和引入端口之间的连接处可能阻挡通道的颗粒或其它污染物。

9. 发明授权

US6132685A High throughput microfluidic systems and methods 有权
标题翻译：高通量微流体系统和方法
公开(公告)号：US6132685A
公开(公告)日：2000-10-17
申请号：US132096
申请日：1998-08-10
申请人： Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
发明人： Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
IPC分类号： G01N35/00 , G01N35/02
CPC分类号： G01N35/028 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multiwell microtiter plates or other array structures. The multiwell plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multiwell plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip. A clamshell structure having a hinged lid can releasably support the chip while providing and/or accommodating the electrical, optical, structural, and other interface connections between the microfluidic device and the surrounding system.
摘要翻译：本发明提供用于分析标准多孔微量滴定板或其它阵列结构中所含的大量样品化合物的改进的系统，装置和方法。多孔板沿传送系统行进到具有微流体装置的测试台。在试验台，每个板从输送机上取出，多孔板的孔依次与微流体装置的输入端对准。在每个样品的至少一部分已经被输入到微流体通道系统中之后，板返回到输送系统。可以沿输送机系统布置前后测试站，并且使用XYZ机器人臂和新的板支撑支架允许孔中的每个样品通过固定在微流体上的探针输入微流体网络芯片。具有铰接盖的蛤壳结构可以可释放地支撑芯片，同时提供和/或容纳微流体装置和周围系统之间的电，光学，结构和其它界面连接。

10. 发明授权

US6090251A Microfabricated structures for facilitating fluid introduction into microfluidic devices 失效
公开(公告)号：US6090251A
公开(公告)日：2000-07-18
申请号：US870944
申请日：1997-06-06
申请人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
发明人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
IPC分类号： B01J19/00 , B01L3/00 , B01L3/02 , G01N27/447 , G01N35/00 , G01N35/10 , G01N27/26
CPC分类号： G01N27/44791 , B01J19/0093 , B01L3/0244 , B01L3/0262 , B01L3/5025 , B01L3/50255 , B01L3/5027 , B01L3/502715 , B01L3/50273 , G01N27/44743 , B01J2219/00783 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00891 , B01J2219/00909 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/0688 , B01L3/502723 , B01L3/502753 , G01N2035/00237 , G01N2035/1037 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

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