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1. 发明申请

WO2021229085A2 A POINT OF CARE DEVICE 审中-公开
公开(公告)号：WO2021229085A2
公开(公告)日：2021-11-18
申请号：PCT/EP2021/062893
申请日：2021-05-14
申请人： ABACUSLABS LTD.
发明人： ANHOLD, Heinrich , CANDON, Ruth
IPC分类号： G01N21/84 , G01N21/8483
摘要： A portable point of care device (1) for use in testing a biological sample, the device comprising: a sample collection member (4), a test cartridge (2), and a reader (220).

2. 发明申请

WO2021247721A1 QUANTITATIVE HORMONE AND CHEMICAL ANALYTE TEST RESULT SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2021247721A1
公开(公告)日：2021-12-09
申请号：PCT/US2021/035471
申请日：2021-06-02
申请人： EASY HEALTHCARE CORPORATION
发明人： LIU, Xiaolian , ZOU, Li
IPC分类号： C12Q1/24 , G01N2021/7759 , G01N21/78 , G01N21/8483 , G01N33/54373 , G01N33/743 , G01N33/76 , G06T11/206 , G06T2210/41 , G06V10/44 , G06V10/56 , G06V20/00
摘要： Systems, methods, and apparatus are disclosed for determining quantitative hormone and chemical analyte results from qualitative test results. An image is taken of an ovulation test device. The image is analyzed to identify a color intensity ratio (T/C ratio) between a color density of a test-line to a color density of a control-line. Additionally, a quantitative substance level may be determined using the T/C ratio, by identifying the type of test device and referencing a data structure that relates quantitative substance levels to T/C ratios for the identified type of test device.

3. 发明申请

WO2021228631A1 ASSAY READING METHOD 审中-公开
公开(公告)号：WO2021228631A1
公开(公告)日：2021-11-18
申请号：PCT/EP2021/061761
申请日：2021-05-04
申请人： FORSITE DIAGNOSTICS LIMITED
发明人： ADSUL, Neeraj
IPC分类号： G06T7/00 , G01N21/00 , G01N21/6428 , G01N21/8483 , G01N33/53 , G06T2207/30072 , G06T7/0012 , G06T7/97
摘要： A method for reading a test region of an assay, the method comprising: capturing a plurality of images of an assay with an imaging device; from each image of the plurality of images, extracting a region of interest comprising pixels of the image associated with a test region of the assay; from each extracted region of interest, estimating respective intensity values of at least a portion of the pixels; grouping the estimated intensity values into one or more clusters, said grouping comprising determining a total number of intensity values grouped into each cluster and a variance of each cluster; selecting the cluster having a total number of intensity values at or above a predetermined threshold and a smallest variance; calculating a mean intensity value of the selected cluster; and outputting the calculated mean intensity value as a result of the assay.

4. 发明申请

WO2021130286A1 ADJUSTMENT METHOD FOR ADJUSTING A SETUP FOR AN ANALYTICAL METHOD 审中-公开
公开(公告)号：WO2021130286A1
公开(公告)日：2021-07-01
申请号：PCT/EP2020/087727
申请日：2020-12-22
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIABETES CARE GMBH , ROCHE DIABETES CARE, INC.
发明人： BERG, Max , KETH, Ingrid , LIMBURG, Bernd , SIEFFERT, Daniel
IPC分类号： G01N21/84 , G01N21/8483
摘要： The present invention refers to an adjustment method for adjusting a setup for an analytical method of determining a concentration of an analyte in a bodily fluid based on a color formation reaction in an optical test strip mobile device for performing analytical measurements. The invention further relates to a mobile device configured for performing the adjustment method, a computer program and a computer-readable storage medium for performing the adjustment method and a kit comprising a test strip or a dummy test strip and at least one of the mobile device, the computer program and the computer-readable storage medium. The method, device, computer program, storage media and kit specifically may be used in medical diagnostics, in order to for example qualitatively or quantitatively detect one or more analytes in one or more body fluids, such as for detecting glucose in blood and/or interstitial fluid. Other fields of application of the present invention, however, are feasible.

5. 发明申请

WO2021004564A2 VORRICHTUNG ZUR AUSLESUNG EINES TEST-KITS ZUM NACHWEIS VON BIOMARKERN 审中-公开
公开(公告)号：WO2021004564A2
公开(公告)日：2021-01-14
申请号：PCT/DE2020/000150
申请日：2020-07-06
申请人： SCHEBO BIOTECH AG
发明人： SCHEEFERS, Hans
IPC分类号： G01N33/543 , G01N33/558 , G01N21/00 , G01N21/8483 , G01N33/54346
摘要： Die Erfindung betrifft eine gewerblich anwendbare Vorrichtung zur Auslesung eines Test-Kits zum Nachweis von Biomarkern, beispielsweise zum Nachweis von Biomarkern im menschlichen und/oder tierischen Stuhl. Die Vorrichtung ist dazu geeignet und bestimmt, den qualitativen und/oder quantitativen Nachweis der Biomarker zu objektivieren. Die Erfindung betrifft im Besonderen eine Vorrichtung, in die ein Teststreifen eines immunchromatografischen Nachweisverfahrens ortsfest eingelegt wird. Der Teststreifen wird durch näher definierte Beleuchtungseinrichtungen beleuchtet und das von der Oberfläche des Schnellteststreifens reflektierte Licht durch einen näher spezifizierten Sensor aufgezeichnet. Mittels eines speziellen Beleuchtungs- und Ausleseverfahrens erfolgt eine präzise Auslesung des angezeigten Testergebnisses.

6. 发明申请

WO2022104083A2 APPARATUS AND METHODS FOR ASSAYING A LIQUID SAMPLE 审中-公开
公开(公告)号：WO2022104083A2
公开(公告)日：2022-05-19
申请号：PCT/US2021/059173
申请日：2021-11-12
申请人： REDCOAT SOLUTIONS, INC.
发明人： HALL, William John , STURMAN, Andy
IPC分类号： G16H10/40 , G01N21/78 , B01L3/00 , B01L2200/025 , B01L2200/028 , B01L2300/043 , B01L2300/0825 , B01L3/5023 , G01N21/8483
摘要： Devices, systems, and kits for assaying a liquid sample include a reader and a test strip. The test strip may comprise a disposable cassette. The system may include a test strip mounting structure configured to receive the cassette in a predetermined orientation. The apparatus includes a processor and memory, together configured to conduct an assay of the liquid sample. The apparatus may include a display configured to generate a pattern encoding data related to a result of the assay.

7. 发明申请

WO2021249895A1 METHOD OF DETERMINING THE CONCENTRATION OF AN ANALYTE IN A SAMPLE OF A BODILY FLUID, MOBILE DEVICE, KIT, COMUTER PROGRAM AND COMPUTER-READABLE STORAGE MEDIUM 审中-公开
公开(公告)号：WO2021249895A1
公开(公告)日：2021-12-16
申请号：PCT/EP2021/065087
申请日：2021-06-07
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIABETES CARE GMBH , ROCHE DIABETES CARE, INC.
发明人： BERG, Max , HAILER, Fredrik , LIMBURG, Bernd , TUERCK, Volker , WINKELNKEMPER, Momme
IPC分类号： G01N21/78 , G01N21/27 , A61B5/00 , G01N21/29 , G01N21/84 , G06T7/90 , G01N21/17 , G01N21/77 , G01N2021/1776 , G01N2021/7759 , G01N2021/8488 , G01N21/274 , G01N21/293 , G01N21/8483 , G01N2201/0221
摘要： A method of determining the concentration of at least one analyte in a sample of a bodily fluid by using a mobile device (112) having at least one camera (120), the method comprising: i) capturing, by using the camera (120), at least one image of at least a part of a color reference card (118) and of at least a part of at least one reagent test field (116) of at least one optical test strip (114) having the sample applied thereto, - wherein, in the image, the test field (116) is in a defined position with respect to the color reference card (118), - wherein the color reference card (118) comprises a plurality of different gray reference fields (126) locally assigned to the test field (116), wherein the plurality of gray reference fields (126) and the test field (116) are locally assigned to each other by being placed in neighboring positions or wherein the plurality of gray reference fields (126) locally assigned to the test field (116) are arranged on the color reference card (118) such that the plurality of gray reference fields (126) surrounds the test field (116), and - wherein the color reference card (118) comprises a plurality of different color reference fields (128) having known reference color values and a plurality of different gray reference fields (126) locally assigned to the color reference fields (128), wherein the plurality of gray reference fields (126) and the color reference fields (128) are locally assigned to each other by being placed in neighboring positions or wherein the plurality of gray reference fields (126) locally assigned to the color reference fields (128) are arranged on the color reference card (118) such that the plurality of gray reference fields (126) surrounds the color reference fields (128), ii) applying at least one predetermined pixel-based mean tone map correction to the image obtained in step i), thereby obtaining at least one first intensity-corrected image, wherein the predetermined pixel-based mean tone map correction comprises an assignment of a second brightness value to a first brightness value, wherein the first brightness value is recorded by the camera (120), wherein each pixel of the recorded image is corrected individually by the predetermined A method of determining the concentration of at least one analyte in a sample of a bodily fluid by using a mobile device (112) having at least one camera (120), the method comprising: i) capturing, by using the camera (120), at least one image of at least a part of a color reference card (118) and of at least a part of at least one reagent test field (116) of at least one optical test strip (114) having the sample applied thereto, - wherein, in the image, the test field (116) is in a defined position with respect to the color reference card (118), - wherein the color reference card (118) comprises a plurality of different gray reference fields (126) locally assigned to the test field (116), wherein the plurality of gray reference fields (126) and the test field (116) are locally assigned to each other by being placed in neighboring positions or wherein the plurality of gray reference fields (126) locally assigned to the test field (116) are arranged on the color reference card (118) such that the plurality of gray reference fields (126) surrounds the test field (116), and - wherein the color reference card (118) comprises a plurality of different color reference fields (128) having known reference color values and a plurality of different gray reference fields (126) locally assigned to the color reference fields (128), wherein the plurality of gray reference fields (126) and the color reference fields (128) are locally assigned to each other by being placed in neighboring positions or wherein the plurality of gray reference fields (126) locally assigned to the color reference fields (128) are arranged on the color reference card (118) such that the plurality of gray reference fields (126) surrounds the color reference fields (128), ii) applying at least one predetermined pixel-based mean tone map correction to the image obtained in step i), thereby obtaining at least one first intensity-corrected image, wherein the predetermined pixel-based mean tone map correction comprises an assignment of a second brightness value to a first brightness value, wherein the first brightness value is recorded by the camera (120), wherein each pixel of the recorded image is corrected individually by the predetermined pixel- based mean tone map correction, wherein the mean tone map correction is derived by combining a plurality of tone map corrections for different types of mobile devices; iii) deriving, from the first intensity-corrected image, local brightness information (174) for at least some of the color reference fields (128) and for the test field (116), by using the gray reference fields (126) locally assigned to the color reference fields (128) and the test field (116), respectively, wherein the local brightness information (174) comprises a numerical indication describing the local intensity of at least one RGB color of the color reference fields (128) and the test field (116), respectively; iv) applying at least one mobile device-specific tone map correction to the first intensity-corrected image, the mobile device-specific tone map correction taking into account the local brightness information (174), thereby obtaining at least one second intensity-corrected image; and v) determining the analyte concentration based on a color formation reaction of the test field (116) by using the second intensity-corrected image.

8. 发明申请

WO2021191196A1 OPTICAL MODULE 审中-公开
公开(公告)号：WO2021191196A1
公开(公告)日：2021-09-30
申请号：PCT/EP2021/057405
申请日：2021-03-23
申请人： AMS AG
发明人： CHONG CHEAH, Boon , FREDERIX, Filip , JAN LOUS, Erik
IPC分类号： G01N21/84 , G01N21/78 , G01N21/77 , G01N2021/7759 , G01N21/8483 , G01N2201/0642
摘要： An optical module (100) for reading a test region of an assay. The optical module comprises: a first light source (101) for illuminating the test region of the assay; an optical detector (103), comprising an optical input for receiving light emitted from the test region and an electrical output; a substrate (104) for mounting the first light source (101) and the optical detector (103); and a housing (105) comprising: a first opening (106) for providing a first optical path from the first light source (101) to the test region (103); wherein the housing (105) and the substrate (104) enclose and positionally align the first source (101) and the optical detector (103) relative to the first opening (106). The housing (105) may comprise one or more legs (108), such as a flexible hook portion which secures the housing (105) to the substrate (104) with a snap-fit engagement, extending from a first and/or second outer surface of the housing (105) in a vertical direction. Beneficially, the snap-fit engagement provided by the flexible hook portion allows the housing to be aligned and secured without the need to use glue or for example a screw and thread that can be difficult to control and/or risks misalignment of the housing.

9. 发明申请

WO2022239023A1 A PORTABLE DEVICE FOR TESTING AGRO-DAIRY BASED SAMPLES 审中-公开
公开(公告)号：WO2022239023A1
公开(公告)日：2022-11-17
申请号：PCT/IN2022/050440
申请日：2022-05-06
申请人： FAUNATECH SOLUTIONS PRIVATE LIMITED
发明人： PANDYA, Rajat , JENA, Sidhant , SUBRAMANIAN, Sandhyaa , PALVALLI, Rajashekar Reddy
IPC分类号： G01N21/78 , G01N33/04 , A01J5/0132 , A01J5/0135 , C12Q1/04 , C12Q1/32 , G01N15/06 , G01N2015/0053 , G01N2015/0065 , G01N2015/0687 , G01N2015/0693 , G01N2021/7759 , G01N21/8483 , G01N2201/0221 , G01N33/54366 , G01N33/54387 , G01N33/68 , G01N33/92
摘要： The invention relates to a portable device for testing agro-dairy based samples. The said device comprises an optical detector based on micro-spectroscopy. With the aid of an adaptor, the device is amenable to holding a colorimetric test strip, a concave shaped holder for a solid or semi-solid substance and/or a cuvette. The invention also describes a system of testing agro-dairy based samples comprising the said portable device and also a method of testing agro-dairy based samples using the said system.

10. 发明申请

WO2021255268A1 METHODS FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN THE PLASMA FRACTION OF A SAMPLE OF WHOLE BLOOD 审中-公开
公开(公告)号：WO2021255268A1
公开(公告)日：2021-12-23
申请号：PCT/EP2021/066676
申请日：2021-06-18
申请人： GENTIAN AS
发明人： SUNDREHAGEN, Erling , SUNDE, Kathrin , FANT, Camilla , WAHLSTEN, Olov , HIDDEN, Clara Mathilde
IPC分类号： G01N21/64 , G01N21/84 , G16H10/40 , A61B5/145 , A61B5/1455 , G01N33/543 , B01L3/00 , G01N21/25 , G01N33/72 , A61B5/14535 , B01L2200/10 , B01L2300/0825 , B01L3/5023 , G01N21/8483 , G01N33/54388 , G01N33/721
摘要： The precision of a lateral flow assay for determining the concentration of an analyte in the plasma fraction of a sample of whole blood can be significantly improved by applying an integrated step for determining the hematocrit of the optionally diluted sample, and taking both hematocrit and dilution factor into account when calculating the concentration of the analyte. This is made possible inter alia by using a predetermined wavelength when taking an image of the sample after application to a substrate in the lateral flow assay device, and wherein said wavelength is selected based on the dilution factor used. This hematocrit measurement is advantageously integrated in lateral flow assay methods and devices for the measurement of an analyte in plasma and contributes significantly to an improved precision of such assays.

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