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1. 发明申请

WO2021255268A1 METHODS FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN THE PLASMA FRACTION OF A SAMPLE OF WHOLE BLOOD 审中-公开
公开(公告)号：WO2021255268A1
公开(公告)日：2021-12-23
申请号：PCT/EP2021/066676
申请日：2021-06-18
申请人： GENTIAN AS
发明人： SUNDREHAGEN, Erling , SUNDE, Kathrin , FANT, Camilla , WAHLSTEN, Olov , HIDDEN, Clara Mathilde
IPC分类号： G01N21/64 , G01N21/84 , G16H10/40 , A61B5/145 , A61B5/1455 , G01N33/543 , B01L3/00 , G01N21/25 , G01N33/72 , A61B5/14535 , B01L2200/10 , B01L2300/0825 , B01L3/5023 , G01N21/8483 , G01N33/54388 , G01N33/721
摘要： The precision of a lateral flow assay for determining the concentration of an analyte in the plasma fraction of a sample of whole blood can be significantly improved by applying an integrated step for determining the hematocrit of the optionally diluted sample, and taking both hematocrit and dilution factor into account when calculating the concentration of the analyte. This is made possible inter alia by using a predetermined wavelength when taking an image of the sample after application to a substrate in the lateral flow assay device, and wherein said wavelength is selected based on the dilution factor used. This hematocrit measurement is advantageously integrated in lateral flow assay methods and devices for the measurement of an analyte in plasma and contributes significantly to an improved precision of such assays.

2. 发明申请

WO2022029083A1 SYSTÈME POUR L'ANALYSE RAPIDE D'UN ÉCHANTILLON BIOLOGIQUE, DESTINÉ À LA DÉTECTION DE LA PRÉSENCE D'AU MOINS UN ANALYTE DANS LEDIT ÉCHANTILLON BIOLOGIQUE 审中-公开
公开(公告)号：WO2022029083A1
公开(公告)日：2022-02-10
申请号：PCT/EP2021/071578
申请日：2021-08-02
申请人： NG BIOTECH , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
发明人： STANKOV, Milovan , VOLLAND, Hervé
IPC分类号： G01N33/52 , G01N33/53 , G01N33/543 , G01N33/569 , A61B10/00 , B01L3/00 , G01N1/02 , A61B10/0051 , A61B2010/0006 , B01L2200/16 , B01L2300/0825 , B01L2400/0406 , B01L3/5029 , G01N2333/165 , G01N33/525 , G01N33/5302 , G01N33/54366 , G01N33/56983
摘要： La présente invention concerne un système pour l'analyse rapide d'un échantillon biologique, destiné à la détection de la présence d'au moins un analyte dans ledit échantillon biologique. Le système d'analyse rapide comprend au moins un dispositif chromatographique (4) comprenant un boîtier (41) dans lequel est rapporté une bandelette chromatographique (42). Le boîtier (41) comporte une paroi avant (411) munie d'une interface (5), ménagée au niveau de ladite zone de dépôt (421) et en saillie par rapport à ladite paroi avant (411), adaptée à recevoir la partie de collecte (21) d'au moins un dispositif de prélèvement (2). L'interface (5) comporte au moins un logement traversant (51) qui est conçue pour recevoir cette partie de collecte (21) lors de son rinçage avec ladite solution tampon (3). Ledit au moins un logement traversant (51) comporte une paroi latérale (511) délimitée par une ouverture d'accès (512) au travers de laquelle la partie de collecte (21) dudit au moins un dispositif de prélèvement (2) et ladite solution tampon (3) sont destinées à être introduites, et une ouverture de sortie, inférieure, débouchant en regard d'une zone de dépôt (421) au travers de laquelle la solution tampon (3) est destinée à s'écouler.

3. 发明申请

WO2021243308A2 PROGRAMMABLE NUCLEASE DIAGNOSTIC DEVICE 审中-公开
公开(公告)号：WO2021243308A2
公开(公告)日：2021-12-02
申请号：PCT/US2021/035031
申请日：2021-05-28
申请人： MAMMOTH BIOSCIENCES, INC.
发明人： CHING, Jesus , BROUGHTON, James Paul , TSALOGLOU, Maria-Nefeli , LEE, Phillip You Fai , PATNO, Timothy James , CHEN, Janice Sha , SHAPIRO, Sarah Jane , CORDOVA, James Raymond , EASTMAN, Brian J. , LOWMILLER, Donald Allan , FASCHING, Clare Louise , HENDRIKS, Carley Gelenter
IPC分类号： A01H3/00 , B01L3/00 , C12N15/11 , C12N15/74 , C12Q1/6809 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2300/0825 , B01L2300/0864 , B01L2400/0487 , B01L2400/0644 , B01L2400/065 , B01L2400/0655 , B01L3/5027 , B01L3/502738 , B01L7/52 , C12N2310/20 , C12Q1/6806 , C12Q1/701 , C12Q2600/156 , G01N27/00
摘要： The present disclosure provides various diagnostic devices. Devices can comprising a sample interface configured to receive a sample that may comprise at least one sequence of interest; a channel in fluid communication with the sample interface and a detection chamber, said channel comprising one or more movable mechanisms to separate the sample into a plurality of droplets, wherein said detection chamber is configured to receive and contact the plurality of droplets with at least one programmable nuclease probe disposed on a surface of said detection chamber, and wherein said at least one programmable nuclease probe may comprise a guide nucleic acid complexed with a programmable nuclease; and a plurality of sensors that determine a presence of said at least one sequence of interest by detecting a signal produced upon cleavage of a target nucleic acid region of said at least one sequence of interest by said at least one programmable nuclease probe.

4. 发明申请

WO2021263003A1 AUTOMATIC MULTI-STEP REACTION DEVICE 审中-公开
公开(公告)号：WO2021263003A1
公开(公告)日：2021-12-30
申请号：PCT/US2021/038930
申请日：2021-06-24
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： SCHAUS, Thomas, E. , GOPALKRISHNAN, Nikhil , YIN, Peng
IPC分类号： B01L3/00 , G01N33/543 , G01N35/00 , B01L2200/16 , B01L2300/047 , B01L2300/0672 , B01L2300/0825 , B01L2300/123 , B01L2400/0478 , B01L2400/0677 , B01L3/5023 , B01L3/50825 , G01N33/54366
摘要： A device for performing an assay comprises a tube, a cap, an insert, and a reaction container. The tube includes a lateral flow strip disposed therein. The cap is coupled to the tube and includes a hollow interior defined at least partially therethrough. The insert is configured to be at least partially received within the hollow interior of the cap. The reaction container includes a cavity configured to store one or more fluids therein, and is rotatably coupled to the cap such that rotation of the cap relative to the reaction container causes (i) mixing of the one or more fluids and (ii) at least a portion of the mixed fluids to be delivered from the reaction container to the lateral flow strip via the insert.

5. 发明申请

WO2021167369A2 반응 온도 및 반응 시간 조절이 가능한 스트립 및 그 스트립을 이용한 샘플 분석 시스템 审中-公开
公开(公告)号：WO2021167369A2
公开(公告)日：2021-08-26
申请号：PCT/KR2021/002066
申请日：2021-02-18
申请人： 주식회사 큐베스트바이오
发明人： 이기자 , 이영주 , 김태준
IPC分类号： G01N33/543 , G01N33/558 , B01L3/00 , B01L7/00 , G01N33/573 , B01L2300/069 , B01L2300/0825 , B01L2300/0887 , B01L3/5023 , G01N2333/96477 , G01N33/54386
摘要： 본 발명은, 샘플(S)이 투입되는 샘플 패드(111), 상기 샘플 패드(111)의 일측에 연결되며, 상기 샘플(S)에 포함된 제1 반응 물질과 반응하는 제2 반응 물질이 구비된 반응 패드(112) 및 상기 반응 패드(112)의 일측에 연결되는 스위치 패드(113)를 포함하는 반응부(110); 상기 반응부(110)의 하부에 구비되는 발열판(120); 상기 반응부(110)와 상기 발열판(120) 사이에 구비되는 단차 형성부(130); 상기 스위치 패드(113)의 일측에서 상기 스위치 패드(113)와 소정 거리 이격되어 형성되는 검출 패드(140);를 포함하는 스트립에 관한 것이다.

6. 发明申请

WO2023057452A1 ASSAY DEVICE FOR A SUSPENSION 审中-公开
公开(公告)号：WO2023057452A1
公开(公告)日：2023-04-13
申请号：PCT/EP2022/077588
申请日：2022-10-04
申请人： 52 NORTH HEALTH LTD
发明人： WECKMAN, Nicole , FRIMPONG, Ama , MEEHAN, Alexandra , SEMPLE, Luke , FARN, Russell , GODFREY, Daniel , WALKER, Adrian
IPC分类号： B01L3/00 , B01L2300/0672 , B01L2300/0681 , B01L2300/0825 , B01L2400/0406 , B01L2400/0644 , B01L3/5023 , B01L3/502753 , B01L3/502761 , G01N2333/70535 , G01N2800/26 , G01N33/54366 , G01N33/54388 , G01N33/558 , G01N33/56972
摘要： An assay device configured to separate a suspension into a filtrate and a residue for testing at least one of the filtrate and the residue. The device comprises a filter aperture for a filter membrane for receiving the suspension and separating the suspension into the filtrate and the residue. The device further comprises a filtrate receiving portion; a residue receiving portion; a first buffer container; a liquid release member configured to create an outlet of the first buffer container; a filter arm comprising the filter aperture; and a user actuated switch comprising a transition structure configured to guide the filter arm. During a transition from a first set position to a second set position of the user actuated switch, the filter arm is moved such that the filter aperture is aligned with the residue receiving portion; and the liquid release member and the first buffer container are brought together.

7. 发明申请

WO2022003177A1 FUNCTIONALIZED BLOOD SAMPLING DEVICE AND METHOD FOR PETH MEASUREMENT 审中-公开
公开(公告)号：WO2022003177A1
公开(公告)日：2022-01-06
申请号：PCT/EP2021/068383
申请日：2021-07-02
申请人： CAPITAINER AB
发明人： BECK, Olof
IPC分类号： B01L3/00 , G01N33/49 , B01L2200/16 , B01L2300/0825 , B01L3/50825 , G01N33/98
摘要： A device configured for collection and subsequent testing of a blood sample of less than 10 ml, characterized in that the container includes at least one inhibitor of the enzyme phospholipase D selected from at least one of a salt of vanadium and a salt of tungsten. A method of preparing a sample for analysis of phosphatidylethanol (PEth) comprises providing a blood sample for a patient with a volume of less than 10 ml; contacting the blood sample at least one inhibitor of the enzyme phospholipase D selected from at least one of a salt of vanadium and a salt of tungsten; and admitting inhibition of phospholipase D so formation of PEth is blocked. A method of applying a coating of at least one inhibitor of the enzyme phospholipase D to a test tube and the test tube obtained by this method, wherein the method comprises stabilizing the test in a substantially vertical position; inserting a spray nozzle inside the test tube, the spray nozzle being in fluid connection to a container holding a solution comprising at least one inhibitor of the enzyme phospholipase D; spraying the solution comprising at least one inhibitor of the enzyme phospholipase D inside the test tube; and allowing the solution comprising at least one inhibitor of the enzyme phospholipase D to dry.

8. 发明申请

WO2021194844A2 WAVEGUIDE ENHANCED ANALYTE DETECTION APPARATUS 审中-公开
公开(公告)号：WO2021194844A2
公开(公告)日：2021-09-30
申请号：PCT/US2021/022968
申请日：2021-03-18
申请人： STRIKE PHOTONICS, INC.
发明人： CAROTHERS, Daniel
IPC分类号： G01N21/63 , B01L3/00 , B01L2200/0684 , B01L2300/023 , B01L2300/0645 , B01L2300/0825 , B01L2300/0883 , B01L2300/0896 , B01L2300/168 , B01L2400/0406 , B01L2400/0424 , B01L2400/0454 , B01L2400/0487 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B82Y20/00 , G01B9/02058 , G02B2006/12061 , G02B2006/12078 , G02B2006/12138 , G02B2006/12159 , G02B2006/12176 , G02B6/12 , G02B6/12004 , G02B6/42
摘要： This disclosure provides photonic integrated chip that has an optical waveguide located on a photonic circuit substrate that includes a photonic circuit that is optically coupled to the waveguide. A microfluidic channel is in a silicon substrate and is attached to the photonic circuit substrate. The microfluidic channel is positioned over the optical waveguide such that its side surfaces and an outermost surface extend into the microfluidic channel. The microfluidic channel extends along a length of the optical waveguide, and nanoparticles are located on or adjacent the optical waveguide located within the microfluidic channel.

9. 发明申请

WO2021019416A2 ASSAY DEVICE AND RECEIVING DEVICE 审中-公开
公开(公告)号：WO2021019416A2
公开(公告)日：2021-02-04
申请号：PCT/IB2020/057053
申请日：2020-07-27
申请人： PREMIER BIOTECH, INC.
发明人： BAILEY, Todd , HONG, Liang
IPC分类号： B01L3/02 , B01L3/00 , B01L3/16 , G01N1/00 , G01N33/50 , B01L2200/027 , B01L2200/0605 , B01L2200/0621 , B01L2200/16 , B01L2300/044 , B01L2300/047 , B01L2300/0672 , B01L2300/069 , B01L2300/0825 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0478 , B01L2400/0481 , B01L2400/0644 , B01L2400/0683 , B01L3/0224 , B01L3/5023 , B01L3/5027 , B01L3/5029
摘要： The present inventions provides a device for testing an analyte in a fluid sample and a receiving device for treating the fluid sample, wherein the receiving device is used for receiving an absorbing element; the receiving device comprises a accommodating chamber and the chamber comprises a piercing element that is movable in the chamber, wherein the piercing element has a first position and a second position in the accommodating chamber, and the configured to pierce the first sealed chamber; the accommodating chamber comprises a treatment solution for treating a fluid sample. The assay device and receiving device of the present invention treats a sample and quickly obtain the assay result, which is especially suitable for quick assay of a roadside drug.

10. 发明申请

WO2022155552A2 LIQUID BIOLOGICAL SAMPLE TEST CARTRIDGE AND HEATING DEVICE 审中-公开
公开(公告)号：WO2022155552A2
公开(公告)日：2022-07-21
申请号：PCT/US2022/012642
申请日：2022-01-15
申请人： RAYTHEON BBN TECHNOLOGIES, CORP. , PURDUE RESEARCH FOUNDATION
发明人： HORVATH, Dylan , MAN, Charlie , LOWE, Andrew , DEMPSTER, David , JAIN, Parth , ADLER, Aaron , BARTLEY, Bryan , DRYER, Paul , QUINN, Timothy , BAR-COHEN, Avram , GAVIN, Mike , SEVILLE, Jordan , MCCHESNEY, Darby , LADUCA, Frank M. , VERMA, Mohit
IPC分类号： B01L3/00 , B01L7/00 , B01L9/00 , B01L2200/147 , B01L2200/16 , B01L2300/043 , B01L2300/0825 , B01L2300/1805 , B01L3/5023 , B01L7/52 , B01L9/527
摘要： A liquid biological sample test cartridge is disclosed. The cartridge can include a tray. The cartridge can also include a chemical reaction pad supported by the tray. The cartridge can further include a chemical reaction pad cover disposed over the chemical reaction pad and coupled to the tray. The chemical reaction pad cover can have a sample opening to facilitate depositing a liquid biological sample at a predetermined location on the chemical reaction pad. In addition, the cartridge can include an outer cover operable to at least partially form an enclosure about the chemical reaction pad.

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