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1. 发明授权

US08075904B2 High aspect ratio template and method for producing same for central and peripheral nerve repair 有权
标题翻译：高纵横比模板及其制备方法用于中枢和周围神经修复
公开(公告)号：US08075904B2
公开(公告)日：2011-12-13
申请号：US12203068
申请日：2008-09-02
申请人： Jeff S. Sakamoto , Mark Henry Tuszynski , Thomas Gros , Christina Chan , Sumit Mehrotra
发明人： Jeff S. Sakamoto , Mark Henry Tuszynski , Thomas Gros , Christina Chan , Sumit Mehrotra
IPC分类号： C61F13/00 , C61F2/00 , B01D39/00 , B29B17/00 , B29B44/04
CPC分类号： A61K9/0024 , A61K9/0092 , A61K47/32 , A61K47/34
摘要： Millimeter to nano-scale structures manufactured using a multi-component polymer fiber matrix are disclosed. The use of dissimilar polymers allows the selective dissolution of the polymers at various stages of the manufacturing process. In one application, biocompatible matrixes may be formed with long pore length and small pore size. The manufacturing process begins with a first polymer fiber arranged in a matrix formed by a second polymer fiber. End caps may be attached to provide structural support and the polymer fiber matrix selectively dissolved away leaving only the long polymer fibers. These may be exposed to another product, such as a biocompatible gel to form a biocompatible matrix. The polymer fibers may then be selectively dissolved leaving only a biocompatible gel scaffold with the pores formed by the dissolved polymer fibers. The scaffolds may be used in, among other applications, the repair of central and peripheral nerves. Scaffolds for the repair of peripheral nerves may include a reservoir for the sustained release of nerve growth factor. The scaffolds may also include a multifunctional polyelectrolyte layer for the sustained release of nerve growth factor and enhance biocompatibility.
摘要翻译：公开了使用多组分聚合物纤维基质制造的毫米至纳米级结构。使用不同的聚合物允许在制造过程的各个阶段选择性地溶解聚合物。在一个应用中，可以形成具有长孔长度和小孔径的生物相容性基质。制造过程从布置在由第二聚合物纤维形成的基体中的第一聚合物纤维开始。可以连接端盖以提供结构支撑，并且聚合物纤维基质选择性地溶解掉，仅留下长的聚合物纤维。这些可能暴露于另一种产品，例如生物相容性凝胶，以形成生物相容性基质。然后可以选择性地溶解聚合物纤维，仅留下具有由溶解的聚合物纤维形成的孔的生物相容的凝胶支架。除了其他应用之外，支架可用于修复中枢神经和周围神经。用于修复周围神经的支架可以包括用于持续释放神经生长因子的储库。支架还可以包括用于持续释放神经生长因子并增强生物相容性的多功能聚电解质层。

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