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    • 2. 发明申请
    • HIGH ASPECT RATIO TEMPLATE AND METHOD FOR PRODUCING SAME FOR CENTRAL AND PERIPHERAL NERVE REPAIR
    • 高度比例模板和用于中心和外周神经修复的生产方法
    • US20090202605A1
    • 2009-08-13
    • US12203068
    • 2008-09-02
    • Jeff S. SakamotoMark TuszynskiThomas Gros
    • Jeff S. SakamotoMark TuszynskiThomas Gros
    • A61K9/70A61P25/00
    • A61K9/0024A61K9/0092A61K47/32A61K47/34
    • Millimeter to nano-scale structures manufactured using a multi-component polymer fiber matrix are disclosed. The use of dissimilar polymers allows the selective dissolution of the polymers at various stages of the manufacturing process. In one application, biocompatible matrixes may be formed with long pore length and small pore size. The manufacturing process begins with a first polymer fiber arranged in a matrix formed by a second polymer fiber. End caps may be attached to provide structural support and the polymer fiber matrix selectively dissolved away leaving only the long polymer fibers. These may be exposed to another product, such as a biocompatible gel to form a biocompatible matrix. The polymer fibers may then be selectively dissolved leaving only a biocompatible gel scaffold with the pores formed by the dissolved polymer fibers. The scaffolds may be used in, among other applications, the repair of central and peripheral nerves. Scaffolds for the repair of peripheral nerves may include a reservoir for the sustained release of nerve growth factor. The scaffolds may also include a multifunctional polyelectrolyte layer for the sustained release of nerve growth factor and enhance biocompatibility.
    • 公开了使用多组分聚合物纤维基质制造的毫米至纳米级结构。 使用不同的聚合物允许在制造过程的各个阶段选择性地溶解聚合物。 在一个应用中,可以形成具有长孔长度和小孔径的生物相容性基质。 制造过程从布置在由第二聚合物纤维形成的基体中的第一聚合物纤维开始。 可以连接端盖以提供结构支撑,并且聚合物纤维基质选择性地溶解掉,仅留下长的聚合物纤维。 这些可能暴露于另一种产品,例如生物相容性凝胶,以形成生物相容性基质。 然后可以选择性地溶解聚合物纤维,仅留下具有由溶解的聚合物纤维形成的孔的生物相容的凝胶支架。 除了其他应用之外,支架可用于修复中枢神经和周围神经。 用于修复周围神经的支架可以包括用于持续释放神经生长因子的储库。 支架还可以包括用于持续释放神经生长因子并增强生物相容性的多功能聚电解质层。
    • 4. 发明申请
    • Method for providing apparatus specific information and corresponding system
    • 提供装置专用信息和相应系统的方法
    • US20050267964A1
    • 2005-12-01
    • US11108592
    • 2005-04-18
    • Guenter KechThomas Gros
    • Guenter KechThomas Gros
    • G06F9/445G06F15/173G06F17/30
    • G06F8/65G06F8/61
    • The present invention refers to a method for providing apparatus specific information for at least one field apparatus. The one field apparatus is connected via a bus to a management device managing apparatuses connected thereto, whereby the management device accesses a link network, from which the management device retrieves the apparatus specific information, whereby the management device requests the apparatus specific information autonomously from the link network and installs the retrieved apparatus specific information autonomously into its system. Further, a system is provided, comprising a management device, a field apparatus, and an access to a link network, whereby the management device is connected to the field apparatus via a bus, and is adapted to autonomously request apparatus specific information over the link network and to autonomously install the retrieved apparatus specific information into its system.
    • 本发明涉及一种为至少一个现场设备提供设备专用信息的方法。 一个现场装置经由总线连接到管理装置,管理装置与管理装置连接,管理装置访问链接网络,管理装置从该链路网络检索装置特定信息,由此管理装置从主机向主机请求装置特定信息 链接网络,并将检索到的设备特定信息自动安装到其系统中。 此外,提供了一种系统,包括管理设备,现场设备和对链路网络的接入,由此管理设备经由总线连接到现场设备,并且适于通过链路自主地请求设备特定信息 网络,并将检索到的设备特定信息自动安装到其系统中。
    • 5. 发明授权
    • High aspect ratio template and method for producing same for central and peripheral nerve repair
    • 高纵横比模板及其制备方法用于中枢和周围神经修复
    • US08075904B2
    • 2011-12-13
    • US12203068
    • 2008-09-02
    • Jeff S. SakamotoMark Henry TuszynskiThomas GrosChristina ChanSumit Mehrotra
    • Jeff S. SakamotoMark Henry TuszynskiThomas GrosChristina ChanSumit Mehrotra
    • C61F13/00C61F2/00B01D39/00B29B17/00B29B44/04
    • A61K9/0024A61K9/0092A61K47/32A61K47/34
    • Millimeter to nano-scale structures manufactured using a multi-component polymer fiber matrix are disclosed. The use of dissimilar polymers allows the selective dissolution of the polymers at various stages of the manufacturing process. In one application, biocompatible matrixes may be formed with long pore length and small pore size. The manufacturing process begins with a first polymer fiber arranged in a matrix formed by a second polymer fiber. End caps may be attached to provide structural support and the polymer fiber matrix selectively dissolved away leaving only the long polymer fibers. These may be exposed to another product, such as a biocompatible gel to form a biocompatible matrix. The polymer fibers may then be selectively dissolved leaving only a biocompatible gel scaffold with the pores formed by the dissolved polymer fibers. The scaffolds may be used in, among other applications, the repair of central and peripheral nerves. Scaffolds for the repair of peripheral nerves may include a reservoir for the sustained release of nerve growth factor. The scaffolds may also include a multifunctional polyelectrolyte layer for the sustained release of nerve growth factor and enhance biocompatibility.
    • 公开了使用多组分聚合物纤维基质制造的毫米至纳米级结构。 使用不同的聚合物允许在制造过程的各个阶段选择性地溶解聚合物。 在一个应用中,可以形成具有长孔长度和小孔径的生物相容性基质。 制造过程从布置在由第二聚合物纤维形成的基体中的第一聚合物纤维开始。 可以连接端盖以提供结构支撑,并且聚合物纤维基质选择性地溶解掉,仅留下长的聚合物纤维。 这些可能暴露于另一种产品,例如生物相容性凝胶,以形成生物相容性基质。 然后可以选择性地溶解聚合物纤维,仅留下具有由溶解的聚合物纤维形成的孔的生物相容的凝胶支架。 除了其他应用之外,支架可用于修复中枢神经和周围神经。 用于修复周围神经的支架可以包括用于持续释放神经生长因子的储库。 支架还可以包括用于持续释放神经生长因子并增强生物相容性的多功能聚电解质层。