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1. 发明申请

WO2017025385A1 A TRANSGENIC PLANT HAVING RESISTANCE TO A PHYTO-PATHOGENIC FUNGUS 审中-公开
标题翻译：一种具有抵抗植物病原真菌的转基因植物
公开(公告)号：WO2017025385A1
公开(公告)日：2017-02-16
申请号：PCT/EP2016/068418
申请日：2016-08-02
申请人： KWS SAAT SE
发明人： DEISING, Holger , OLIVEIRA GARCIA, Ely , STAHL, Dietmar , TEMME, Nora
IPC分类号： C12N15/82 , C12N9/24 , C12N9/2405 , C12N9/1048
CPC分类号： C12N15/8282
摘要： The present invention is directed to a transgenic plant or a part thereof comprising a DNA capable of expressing an inhibitory nucleic acid molecule capable of inhibiting the expression of (a) KRE5 and/or KRE6 gene(s) in a fungus, to such DNA, to the inhibitory nucleic acid molecule, to a vector comprising the DNA, and to methods of producing the plant, of conferring fungal resistance to the plant, or of inhibiting the expression of the KRE5 and/or KRE6 gene(s) in a fungus, to the use of the DNA for inactivating a fungus, for protecting a plant against an infection by a fungus, or for inhibiting the expression of the KRE5 and/or KRE6 gene(s) in a fungus and to a composition comprising the DNA, vector or a dsRNA capable of inhibiting the expression of (a) KRE5 and/or KRE6 gene(s) in a fungus.
摘要翻译：本发明涉及一种转基因植物或其一部分，其包含能够表达能够抑制真菌中的（a）KRE5和/或KRE6基因表达的抑制性核酸分子的DNA，涉及抑制性核酸分子，包含DNA的载体，以及赋予植物真菌抗性或抑制真菌中KRE5和/或KRE6基因表达的方法，使用DNA灭活真菌，保护植物免受真菌感染，或用于抑制真菌中KRE5和/或KRE6基因的表达，以及包含DNA，载体的组合物或能够抑制真菌中（a）KRE5和/或KRE6基因表达的dsRNA。

2. 发明申请

WO2021160827A2 PRODUCTION OF GLYCOSYLATED PRODUCT IN HOST CELLS 审中-公开
公开(公告)号：WO2021160827A2
公开(公告)日：2021-08-19
申请号：PCT/EP2021/053497
申请日：2021-02-12
申请人： INBIOSE N.V.
发明人： AESAERT, Sofie , BEAUPREZ, Joeri , COUSSEMENT, Pieter , DECOENE, Thomas , LANNOO, Nausicaä , PETERS, Gert , VANDEWALLE, Kristof
IPC分类号： C12P7/22 , C12N1/20 , C12N1/16 , C12N9/10 , C12P19/00 , C12P1/00 , C12N15/09 , C07K14/245 , C07K14/32 , C07K14/34 , C07K14/35 , C07K14/355 , C12N1/12 , C12N15/52 , C12N15/70 , C12N9/1048 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/18 , C12P19/26 , C12P19/44 , C12P21/005 , C12R2001/125 , C12R2001/15 , C12R2001/19 , C12R2001/32 , C12R2001/365 , C12R2001/89
摘要： The present invention is in the technical field of synthetic biology and metabolic engineering. The present invention provides engineered viable bacteria. In particular, the present invention provides viable bacteria with reduced cell wall biosynthesis additionally modified for production of glycosylated product. The present invention further provides methods of generating viable bacteria and uses thereof. Furthermore, the present invention is in the technical field of fermentation of metabolically engineered microorganisms producing glycosylated product.

3. 发明申请

WO2023087518A1 一种利用糖基转移酶高效生物合成莱鲍迪苷D的方法审中-公开
公开(公告)号：WO2023087518A1
公开(公告)日：2023-05-25
申请号：PCT/CN2022/070743
申请日：2022-01-07
申请人：江南大学
发明人：饶义剑 , 郭保党 , 张艳 , 袁振波
IPC分类号： C12N9/10 , C12N15/54 , C12N1/21 , C12N15/70 , C12P19/56 , C12P19/18 , C12R1/19 , C12N9/1048 , C12N9/1062 , C12Y204/01013
摘要：一种利用糖基转移酶高效生物合成莱鲍迪苷D的方法，属于生物催化合成领域。通过挖掘得到一种具有催化莱鲍迪苷A合成莱鲍迪苷D活性的糖基转移酶，并通过定向进化得到高催化活性突变体YojK-I241T/G327N。并将糖基转移酶突变体YojK-I241T/G327N与来源于拟南芥的蔗糖合酶AtSuSy构建偶联反应，实现以莱鲍迪苷A为底物高效催化合成莱鲍迪苷D，以19.32g/L(20mmol/L)Reb A为底物反应15h，高效合成20.59g/L的Reb D，Reb D产率达到91.29％，为莱鲍迪苷D的生产提供了一条高效且绿色的新途径。

4. 发明申请

WO2021243139A2 STEVIOL GLYCOSYLTRANSFERASES AND GENES ENCODING THE SAME 审中-公开
公开(公告)号：WO2021243139A2
公开(公告)日：2021-12-02
申请号：PCT/US2021/034738
申请日：2021-05-28
申请人： QTG DEVELOPMENT, INC.
发明人： LI, Xu , CHEN, Han-Yi , ANDERSON, Nickolas , WATERS, Amanda
IPC分类号： C12N9/10 , C07K2319/21 , C12N9/1048 , C12N9/1051 , C12P19/56 , C12Y204/00 , C12Y204/01
摘要： Polynucleotides encoding corresponding polypeptides capable of glycosylating steviol at its C-19 position to produce a steviol glycoside, an expression vector including such a polynucleotide, a method for producing a steviol glycoside by culturing a recombinant host cell containing such an expression vector under conditions in which the cell expresses the UDP-glycosyltransferase from the polynucleotide, and a method for producing a steviol glycoside by contacting a composition including steviol with a recombinant UDP-glycosyltransferase. The steviol glycoside can be steviol-19-O-glycoside. The recombinant host cell containing such an expression vector can be a bacterial cell, a plant cell, or a fungal cell, an animal cell, or a multicellular organism such as a plant.

5. 发明申请

WO2022034076A2 PRODUCTION OF GALACTOSYLATED DI- AND OLIGOSACCHARIDES 审中-公开
公开(公告)号：WO2022034076A2
公开(公告)日：2022-02-17
申请号：PCT/EP2021/072270
申请日：2021-08-10
申请人： INBIOSE N.V.
发明人： AESAERT, Sofie , BEAUPREZ, Joeri , COUSSEMENT, Pieter , DECOENE, Thomas , LANNOO, Nausicaä , PETERS, Gert , VANDEWALLE, Kristof , VERCAUTEREN, Annelies
IPC分类号： C12P19/12 , C12P19/18 , C12N9/10 , C12N15/52 , C12N9/1048 , C12P19/00 , C12P19/26 , C12Y204/00 , C12Y204/01
摘要： The present invention is in the technical field of synthetic biology and metabolic engineering. The present invention describes the use of a new type of galactosyltransferases for the production of a galactosylated di- or oligosaccharide. The present invention also describes methods for the production of a galactosylated di- or oligosaccharide as well as the purification of said di- or oligosaccharide. Furthermore, the present invention is in the field of cultivation or fermentation of metabolically engineered cells. The present invention provides a cell metabolically engineered for production of a galactosylated di- or oligosaccharide.

6. 发明申请

WO2021259742A1 MODIFIED EXOTOXIN A PROTEINS 审中-公开
公开(公告)号：WO2021259742A1
公开(公告)日：2021-12-30
申请号：PCT/EP2021/066336
申请日：2021-06-17
申请人： GLAXOSMITHKLINE BIOLOGICALS SA
发明人： KEMMLER, Stefan Jochen , LIZAK, Christian , POSCH, Gerald Johann , QUEBATTE, Julien Laurent
IPC分类号： A61K39/104 , A61K47/68 , C07K14/21 , C12N9/10 , A61K38/46 , A61K39/108 , A61K39/385 , A61K47/64 , C07K14/705 , A61K2039/6037 , A61K38/00 , A61K47/6415 , A61K47/646 , C12N9/1048 , C12N9/1077 , C12Y204/02036
摘要： The present invention relates to the field of modified proteins, immunogenic compositions and vaccines comprising the modified proteins, their manufacture and the use of such compositions in medicine. More particularly, it relates to a modified EPA (Exotoxin A of Pseudomonas aeruginosa) protein. The modified EPA can be used as a carrier protein for other antigens, particularly saccharide antigens or other antigens lacking T cell epitopes.

7. 发明申请

WO2021259743A2 KLEBSIELLA PNEUMONIAE O-ANTIGEN VACCINE 审中-公开
公开(公告)号：WO2021259743A2
公开(公告)日：2021-12-30
申请号：PCT/EP2021/066343
申请日：2021-06-17
申请人： GLAXOSMITHKLINE BIOLOGICALS SA
发明人： CARRANZA SANDMEIER, Maria Paula , FOLLADOR, Rainer , FONCK, Veronica Gambillara , KEMMLER, Stefan Jochen , KILLIAS, Patricia Martin , KOWARIK, Michael Thomas , LIPOWSKY, Gerd Martin , POSCH, Gerald Johann , SERVENTI, Fabio , SIRENA, Dominique Nicolas
IPC分类号： A61K39/108 , C12N9/10 , C07K14/705 , A61K38/46 , A61K39/385 , A61K47/64 , C07K14/21 , A61K38/00 , A61K39/00 , A61K2039/6037 , A61K47/6415 , A61K47/646 , C07K2319/02 , C12N9/1048 , C12N9/1077 , C12Y204/02036 , C12Y204/99019
摘要： The present invention relates to the field of immunogenic compositions and vaccines, their manufacture, host cells which can be used in their manufacture and the use of such immunogenic compositions and vaccines in medicine. More particularly, it relates to Klebsiella pneumoniae O-antigens, conjugates ccccomprising a K. pneumoniae O-antigen, host cells suitable for their production and immunogenic compositions or vaccines containing at least one Klebsiella pneumoniae O-antigen.

8. 发明申请

WO2021126957A1 METHODS AND COMPOSITIONS FOR EVALUATING AND TREATING FIBROSIS 审中-公开
公开(公告)号：WO2021126957A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/065280
申请日：2020-12-16
申请人： MIE UNIVERSITY , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , GABAZZA, Esteban , D'ALESSANDRO-GABAZZA, Corina , CANN, Isaac
发明人： GABAZZA, Esteban , D'ALESSANDRO-GABAZZA, Corina , CANN, Isaac
IPC分类号： A61P31/04 , C07K14/31 , C07K16/12 , C07K16/40 , C12N9/10 , G01N33/68 , C07K16/1271 , C12N9/1048 , G01N2800/085 , G01N2800/382 , G01N2800/7052 , G01N33/6893
摘要： Staphylococcus nepalensis releases corisin, a peptide conserved in diverse staphylococci, that induces apoptosis of lung epithelial cells. Therefore, methods and apparatus for detecting the presence of corisin in a biological sample of a patient are disclosed, as well as pharmaceutical compositions, such as antibodies, and methods for treating patents having or suspected of having fibrosis.

9. 发明申请

WO2021123811A1 BIO-BASED PRODUCTION OF TOXIC CHEMICALS 审中-公开
公开(公告)号：WO2021123811A1
公开(公告)日：2021-06-24
申请号：PCT/GB2020/053292
申请日：2020-12-18
申请人： IMPERIAL COLLEGE INNOVATIONS LTD
发明人： JONES, Patrik Raymond , SATTAYAWAT, Pachara , YUNUS, Ian Sofian , MULLER, Jonathan Emmanuel
IPC分类号： C12P7/04 , C12P7/62 , C12P19/18 , C12N9/10 , C12N9/16 , C12N15/52 , C12N9/1033 , C12N9/1048 , C12N9/1062 , C12Y203/01028 , C12Y204/00 , C12Y204/01013 , C12Y301/02014
摘要： The present invention relates to a method of producing derivatives of medium or short chain length alcohols. In particular, the present invention relates to a method of producing derivatives of 1- octanol, in particular octyl acetate and octyl glucoside using alcohol acetyltransferase and glucosyltransferases, for reducing toxicity of octanol, as well as microorganisms and expression vectors for use in said method. The present invention also relates to novel thioesterase enzymes for improved 1-octanol production as well as using sucrose synthase to improve UDP-glucose production for enhanced glucoside production.

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