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1. 发明授权

US06861254B1 Heparan sulfate D-glucosaminyl 3-O-sulfotransferases, and uses therefor 失效
标题翻译：硫酸肝素D-葡萄糖胺基3-O-磺基转移酶，用于此
公开(公告)号：US06861254B1
公开(公告)日：2005-03-01
申请号：US09557262
申请日：2000-04-24
申请人： Robert D. Rosenberg , Nicholas W. Shworak , Jian Liu , Linda M. S. Fritze , John J. Schwartz , Lijuan Zhang
发明人： Robert D. Rosenberg , Nicholas W. Shworak , Jian Liu , Linda M. S. Fritze , John J. Schwartz , Lijuan Zhang
IPC分类号： C12N9/10 , C12N5/00 , C12N15/63 , C07N21/04
CPC分类号： C12N9/13 , C07K2319/20
摘要： Disclosed are novel isolated nucleic acids and substantially pure protein preparations for naturally occurring and synthetic or chimeric heparan sulfate D-glicosaminyl 3-O-sulfo-transferases (3-OSTs). Also disclosed are uses for these genes and proteins, including uses for the modification and sequencing of glycosaminoglycans.
摘要翻译：公开了用于天然存在和合成或嵌合的硫酸乙酰肝素D-葡糖胺基3-O-磺基转移酶（3-OST）的新型分离的核酸和基本上纯的蛋白质制剂。还公开了这些基因和蛋白质的用途，包括用于糖胺聚糖修饰和测序的用途。

2. 发明授权

US5916764A Human phosphatidylinositol synthase 失效
公开(公告)号：US5916764A
公开(公告)日：1999-06-29
申请号：US763121
申请日：1996-12-10
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： A61K38/00 , C12N9/12 , C12N15/11 , C12N15/63 , C12N1/20 , C07N21/04
CPC分类号： C12N9/1288 , A61K38/00 , C07K2319/00
摘要： The present invention provides a human phosphatidylinositol synthase (PISH) and polynucleotides which identify and encode PISH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PISH and a method for producing PISH. The invention also provides for agonists, antibodies, or antagonists specifically binding PISH, and their use, in the prevention and treatment of diseases associated with expression of PISH. The invention also provides for the use of PISH in screening for antiprotozoal and antifungal therapeutics. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding PISH for the treatment of diseases associated with the expression of PISH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding PISH.

3. 发明授权

US6130051A Human insoitol monophosphatase H1 失效
标题翻译：人类内溶素单磷酸酶H1
公开(公告)号：US6130051A
公开(公告)日：2000-10-10
申请号：US314199
申请日：1999-05-19
申请人： Paul S. Meissner , Jeannine D. Gocayne
发明人： Paul S. Meissner , Jeannine D. Gocayne
IPC分类号： A61K38/00 , A61K48/00 , C12N9/16 , G01N1/68 , C07K14/00 , C12Q1/42 , C07N21/04
CPC分类号： C12N9/16 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： Human inositol monophosphatase H1 polynucleotide and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, screening and designing compounds capable of inhibiting hIMP-H1 and mapping genetic diseases are disclosed. Also disclosed is antagonists against such polypeptide along with procedures for using such antagonists for therapeutic purposes, for example, for treating psychotic and depressive disorders. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译：公开了人类肌醇单磷酸酶H1多核苷酸和编码这些多肽的DNA（RNA）和通过重组技术产生这种多肽的方法，并且为了治疗目的利用这种多肽，例如筛选和设计能够抑制hIMP-H1和映射遗传疾病的化合物，。还公开了抗这种多肽的拮抗剂以及将这些拮抗剂用于治疗目的的方法，例如用于治疗精神病和抑郁症。还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

4. 发明授权

US6043053A Wnt-3 polynucleotides 失效
标题翻译： Wnt-3多核苷酸
公开(公告)号：US6043053A
公开(公告)日：2000-03-28
申请号：US82270
申请日：1998-05-20
申请人： Michael R Barnes , Tania Tamson Testa
发明人： Michael R Barnes , Tania Tamson Testa
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/00 , A61P35/00 , C07K14/52 , C07K14/82 , C07K16/24 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/11 , C12N5/00 , C12N15/00 , C07N21/04
CPC分类号： C07K14/82 , A01K2217/05 , A61K2039/51 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Wnt-3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-3 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
摘要翻译：公开了Wnt-3多肽和多核苷酸以及通过重组技术产生这种多肽的方法。还公开了在治疗中利用Wnt-3多肽和多核苷酸的方法，以及用于其的诊断测定法。

5. 发明申请

WO02083914A3 ISOLATED HUMAN SECRETED PROTEINS, NUCLEIC ACID MOLECULES ENCODING HUMAN SECRETED PROTEINS, AND USES THEREOF 审中-公开
公开(公告)号：WO02083914A3
公开(公告)日：2003-06-19
申请号：PCT/US0210716
申请日：2002-04-05
申请人： PE CORP NY , HU SONG , KETCHUM KAREN A , GONG FANCHENG , LADUNGA ISTVAN I , HIGGINS MAUREEN E , BRANDENBERGER RALPH
发明人： HU SONG , KETCHUM KAREN A , GONG FANCHENG , LADUNGA ISTVAN I , HIGGINS MAUREEN E , BRANDENBERGER RALPH
IPC分类号： A61K38/00 , C07K14/47 , C12N15/11 , A01K67/00 , C12N15/63 , C07N21/04 , C12Q1/63
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.

6. 发明申请

WO99027125A1 ribA 审中-公开
标题翻译： RIBA
公开(公告)号：WO99027125A1
公开(公告)日：1999-06-03
申请号：PCT/US1998/024953
申请日：1998-11-23
IPC分类号： G01N33/50 , A61K31/711 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P31/04 , A61P37/04 , C07K14/315 , C07K16/12 , C12N1/21 , C12N9/12 , C12N9/78 , C12N9/80 , C12N9/90 , C12N15/09 , C12N15/52 , C12P21/02 , G01N33/15 , C12P21/00 , C12N1/20 , C12N5/12 , C12N15/00 , C07N21/04
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C12N9/1205 , C12N9/78 , C12N9/80 , C12N9/90 , C12N15/52 , C12Y207/01002
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用ribA多肽筛选抗菌化合物的方法。

7. 发明申请

WO99027127A1 NOVEL ribB 审中-公开
公开(公告)号：WO99027127A1
公开(公告)日：1999-06-03
申请号：PCT/US1998/025069
申请日：1998-11-24
IPC分类号： G01N33/50 , A61K31/711 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P29/00 , A61P31/04 , A61P37/04 , C07K14/315 , C07K16/12 , C12N1/21 , C12N9/10 , C12N9/12 , C12N9/78 , C12N15/09 , C12P21/02 , G01N33/15 , C12P21/00 , C12N1/20 , C12N5/12 , C12N15/00 , C07N21/04
CPC分类号： C12N9/1085 , A61K38/00 , A61K39/00 , C07K14/3156 , C12N9/1205 , C12N9/78 , C12Y205/01009 , C12Y207/01002
摘要： The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供ribB多肽和编码ribB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用ribB多肽筛选抗菌化合物的方法。

8. 发明申请

WO1998007754A1 T1 RECEPTOR-LIKE LIGAND II 审中-公开
标题翻译： T1受体样配体II
公开(公告)号：WO1998007754A1
公开(公告)日：1998-02-26
申请号：PCT/US1996013768
申请日：1996-08-23
申请人： HUMAN GENOME SCIENCES, INC. , NI, Jian , GENTZ, Reiner, L. , RUBEN, Steven, M.
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： C07N21/04
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention concerns a novel T1R-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same.
摘要翻译：本发明涉及一种新的T1R样配体II蛋白。特别地，提供编码T1R样配体II蛋白质的分离的核酸分子。还提供了T1R样配体II多肽，重组载体和用于表达它们的宿主细胞也是如此。

9. 发明授权

US07399586B2 Modulation of biological signal transduction by RNA interference 失效
标题翻译：通过RNA干扰调节生物信号转导
公开(公告)号：US07399586B2
公开(公告)日：2008-07-15
申请号：US10444795
申请日：2003-05-23
申请人： Richard Klinghoffer , Stephen Patrick Lewis
发明人： Richard Klinghoffer , Stephen Patrick Lewis
IPC分类号： C12Q1/68 , C12P19/34 , C12N15/03 , C12N15/00 , C07N21/04
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/3517 , C12N2310/53 , C12Y301/03048
摘要： Compositions and methods relating to small interfering RNA (siRNA) polynucleotides are provided as pertains to modulation of biological signal transduction. Shown are siRNA polynucleotides that interfere with expression of members of the protein tyrosine phosphatase (PTP) class of enzymes that mediate signal transduction, and with certain MAP kinase kinases (MKK). In certain preferred embodiments siRNA modulate signal transduction pathways comprising SHP2, cdc14a/b, cdc25A/B/C, KAP, PTP-ε, PRL-3, CD45, dual specificity phosphatase-3 (DSP-3), MKK-4, and/or MKK-7. Modulation of PTP-mediated biological signal transduction has uses in diseases associated with defects in cell proliferation, cell differentiation and/or cell survival, such as metabolic disorders (including diabetes and obesity), cancer, autoimmune disease, infectious and inflammatory disorders and other conditions. The invention also provides siRNA polynucleotides that interfere with expression of chemotherapeutic target polypeptides, such as DHFR, thymidylate synthetase, and topoisomerase I.
摘要翻译：提供了与小干扰RNA（siRNA）多核苷酸相关的组合物和方法，涉及生物信号转导的调节。显示干扰介导信号转导的酶的蛋白酪氨酸磷酸酶（PTP）类成员和某些MAP激酶激酶（MKK）的成员的表达的siRNA多核苷酸。在某些优选实施方案中，siRNA调节包含SHP2，cdc14a / b，cdc25A / B / C，KAP，PTP-ε，PRL-3，CD45，双特异性磷酸酶-3（DSP-3），MKK-4和 /或MKK-7。 PTP介导的生物信号转导的调节在与细胞增殖，细胞分化和/或细胞存活缺陷相关的疾病中使用，例如代谢紊乱（包括糖尿病和肥胖症），癌症，自身免疫性疾病，感染性和炎症性疾病和其他病症。本发明还提供干扰化学治疗靶多肽如DHFR，胸苷酸合成酶和拓扑异构酶I的表达的siRNA多核苷酸。

10. 发明授权

US06955808B2 Capsid-modified recombinant adenovirus and methods of use 有权
标题翻译：衣壳修饰重组腺病毒及其使用方法
公开(公告)号：US06955808B2
公开(公告)日：2005-10-18
申请号：US10668453
申请日：2003-09-23
申请人： David T. Curiel
发明人： David T. Curiel
IPC分类号： A61K48/00 , C07K14/075 , C12N15/861 , C12N15/00 , C12N15/86 , C07N21/04
CPC分类号： C12N15/86 , A61K48/00 , C07K2319/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/859
摘要： The present invention describes recombinant adenoviral vectors modified by incorporating targeting ligands or label into viral capsid or structural proteins. In one embodiment, single-chain antibody was introduced into the minor capsid proteins pIIIa or pIX so that the adenoviral vector can be targeted to a particular cell type. In another embodiment, there is provided a noninvasive imaging strategy useful for monitoring the replication and spread of conditionally replicative adenoviral vectors. Viral structural proteins such as pIX capsid protein, core proteins mu, V and VII were expressed as fusion protein with a fluorescent label. Once incorporated into the virions, detection of the structural fusion protein label would indicate the localization of the disseminated viral progeny. The detected fluorescent signals also closely correlate with the level of viral replication and progeny production.
摘要翻译：本发明描述了通过将靶向配体或标记掺入病毒衣壳或结构蛋白而修饰的重组腺病毒载体。在一个实施方案中，将单链抗体引入次要衣壳蛋白pIIIa或pIX中，使得腺病毒载体可靶向特定细胞类型。在另一个实施方案中，提供了可用于监测条件复制型腺病毒载体的复制和扩散的非侵入性成像策略。病毒结构蛋白如pIX衣壳蛋白，核心蛋白mu，V和VII被表达为具有荧光标记的融合蛋白。一旦结合到病毒粒子中，结构融合蛋白标签的检测将指示传播的病毒后代的定位。检测到的荧光信号也与病毒复制和后代生产水平密切相关。

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