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1. 发明授权

US06403310B1 Human inositol monophosphatase H1 失效
标题翻译：人类肌醇单磷酸酶H1
公开(公告)号：US06403310B1
公开(公告)日：2002-06-11
申请号：US09314198
申请日：1999-05-19
申请人： Paul S. Meissner , Jeannine D. Gocayne
发明人： Paul S. Meissner , Jeannine D. Gocayne
IPC分类号： C12Q168
CPC分类号： C12N9/16 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： Human inositol monophosphatase H1 polynucleotide and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, screening and designing compounds capable of inhibiting hIMP-H1 and mapping genetic diseases are disclosed. Also disclosed are antagonists against such polypeptide along with procedures for using such antagonists for therapeutic purposes, for example, for treating psychotic and depressive disorders. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译：公开了人类肌醇单磷酸酶H1多核苷酸和编码这些多肽的DNA（RNA），以及通过重组技术生产此类多肽的方法和利用该多肽进行治疗目的的方法，例如筛选和设计能够抑制hIMP-H1和映射遗传疾病的化合物。。还公开了抗这种多肽的拮抗剂以及将这些拮抗剂用于治疗目的的方法，例如用于治疗精神病和抑郁症。还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

2. 发明授权

US6130051A Human insoitol monophosphatase H1 失效
标题翻译：人类内溶素单磷酸酶H1
公开(公告)号：US6130051A
公开(公告)日：2000-10-10
申请号：US314199
申请日：1999-05-19
申请人： Paul S. Meissner , Jeannine D. Gocayne
发明人： Paul S. Meissner , Jeannine D. Gocayne
IPC分类号： A61K38/00 , A61K48/00 , C12N9/16 , G01N1/68 , C07K14/00 , C12Q1/42 , C07N21/04
CPC分类号： C12N9/16 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： Human inositol monophosphatase H1 polynucleotide and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, screening and designing compounds capable of inhibiting hIMP-H1 and mapping genetic diseases are disclosed. Also disclosed is antagonists against such polypeptide along with procedures for using such antagonists for therapeutic purposes, for example, for treating psychotic and depressive disorders. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译：公开了人类肌醇单磷酸酶H1多核苷酸和编码这些多肽的DNA（RNA）和通过重组技术产生这种多肽的方法，并且为了治疗目的利用这种多肽，例如筛选和设计能够抑制hIMP-H1和映射遗传疾病的化合物，。还公开了抗这种多肽的拮抗剂以及将这些拮抗剂用于治疗目的的方法，例如用于治疗精神病和抑郁症。还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

3. 发明授权

US5955339A Human inositol monophosphatase H1 失效
标题翻译：人类肌醇单磷酸酶H1
公开(公告)号：US5955339A
公开(公告)日：1999-09-21
申请号：US2072
申请日：1998-02-09
申请人： Paul S. Meissner , Jeannine D. Gocayne
发明人： Paul S. Meissner , Jeannine D. Gocayne
IPC分类号： A61K38/00 , A61K48/00 , C12N9/16 , C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： C12N9/16 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： Human inositol monophosphatase H1 polynucleotide and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, screening and designing compounds capable of inhibiting hIMP-H1 and mapping genetic diseases are disclosed. Also disclosed is antagonists against such polypeptide along with procedures for using such antagonists for therapeutic purposes, for example, for treating psychotic and depressive disorders. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译：公开了人类肌醇单磷酸酶H1多核苷酸和编码这些多肽的DNA（RNA）和通过重组技术产生这种多肽的方法，并且为了治疗目的利用这种多肽，例如筛选和设计能够抑制hIMP-H1和映射遗传疾病的化合物，。还公开了抗这种多肽的拮抗剂以及将这些拮抗剂用于治疗目的的方法，例如用于治疗精神病和抑郁症。还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

4. 发明授权

US5716806A Human inositiol monophosphatase H1 polynucleotides 失效
标题翻译：人类肌醇单磷酸酶H1多核苷酸
公开(公告)号：US5716806A
公开(公告)日：1998-02-10
申请号：US461731
申请日：1995-06-05
申请人： Paul S. Meissner , Jeannine D. Gocayne
发明人： Paul S. Meissner , Jeannine D. Gocayne
IPC分类号： A61K38/00 , A61K48/00 , C12N9/16 , C07H21/04 , C07H21/02 , C12N15/11
CPC分类号： C12N9/16 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： Human inositol monophosphatase H1 polynucleotide and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, screening and designing compounds capable of inhibiting hIMP-H1 and mapping genetic diseases are disclosed. Also disclosed is antagonists against such polypeptide along with procedures for using such antagonists for therapeutic purposes, for example, for treating psychotic and depressive disorders. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译：公开了人类肌醇单磷酸酶H1多核苷酸和编码这些多肽的DNA（RNA）和通过重组技术产生这种多肽的方法，并且为了治疗目的利用这种多肽，例如筛选和设计能够抑制hIMP-H1和映射遗传疾病的化合物，。还公开了抗这种多肽的拮抗剂以及将这些拮抗剂用于治疗目的的方法，例如用于治疗精神病和抑郁症。还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

5. 发明授权

US06709653B1 Antibodies specific for human inositol monophosphatase H1 失效
标题翻译：对肌醇单磷酸酶H1特异的抗体
公开(公告)号：US06709653B1
公开(公告)日：2004-03-23
申请号：US09440113
申请日：1999-11-15
申请人： Paul S. Meissner , Jeannine D. Gocayne
发明人： Paul S. Meissner , Jeannine D. Gocayne
IPC分类号： A61K39395
CPC分类号： C12N9/16 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： Human Inositol Monophosphatase H1 polynucleotide and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, screening and designing compounds capable of inhibiting hIMP-H1 and mapping genetic diseases are disclosed. Further disclosed are antibodies against hIMP-H1 polypeptides and methods for producing such antibodies and utilizing such antibodies for therapeutic or diagnostic purposes. Also disclosed is antagonists against such polypeptide along with procedures for using such antagonists for therapeutic purposes, for example, for treating psychotic and depressive disorders. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译：公开了人类肌醇单磷酸酶H1多核苷酸和编码这些多肽的DNA（RNA）和通过重组技术产生这种多肽的方法，并且为了治疗目的利用这种多肽，例如筛选和设计能够抑制hIMP-H1和映射遗传疾病的化合物，。进一步公开的是针对hIMP-H1多肽的抗体以及用于产生此类抗体的方法，并利用此类抗体用于治疗或诊断目的。还公开了抗这种多肽的拮抗剂以及将这些拮抗剂用于治疗目的的方法，例如用于治疗精神病和抑郁症。还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

6. 发明授权

US6130061A Human stem cell antigen 2 失效
公开(公告)号：US6130061A
公开(公告)日：2000-10-10
申请号：US746397
申请日：1996-11-08
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Jeannine D. Gocayne
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Jeannine D. Gocayne
IPC分类号： A61K38/00 , C07K14/705 , C12N1/15 , C12N1/21 , C12N15/12 , C07H21/00 , C12N5/10 , C12N15/63
CPC分类号： C07K14/705 , A61K38/00
摘要： A human stem cell antigen 2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating thymocyte maturation and differentiation, protecting neuronal cells, preventing rejection during organ transplantation, treating PNH, Alzheimer's Disease and inflammation is disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

7. 发明授权

US06656743B2 Human choline acetyltransferase 失效
公开(公告)号：US06656743B2
公开(公告)日：2003-12-02
申请号：US10177158
申请日：2002-06-24
申请人： Peter L. Huson , Wei Wu He , Craig A. Rosen , Jeannine D. Gocayne
发明人： Peter L. Huson , Wei Wu He , Craig A. Rosen , Jeannine D. Gocayne
IPC分类号： C12N910
CPC分类号： C12N9/1029 , A61K38/00
摘要： Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.

8. 发明授权

US5962411A Human growth hormone variants and methods of administering same 失效
标题翻译：人类生长激素变体及其施用方法
公开(公告)号：US5962411A
公开(公告)日：1999-10-05
申请号：US710324
申请日：1996-09-16
申请人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
发明人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
IPC分类号： G01N33/53 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/27 , A61K39/395 , A61K48/00 , A61P3/00 , A61P3/04 , A61P5/00 , A61P13/12 , A61P19/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/61 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/18 , C12P21/02 , C12R1/19 , C07K14/00 , A61K38/16
CPC分类号： C07K14/61 , A61K38/00
摘要： There is provided a DNA (or RNA) polynucleotide sequences encoding naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGHV-3(53) as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type hGH. The growth hormone variants of the present invention are of human origin and are useful for diagnostic preventative and therapeutic purposes with respect to certain human diseases. The present invention is also related to a method for producing the human growth hormone variants by recombinant DNA techniques. A method of generating an antibody directed against and therefore inhibiting the activity of wild-type growth hormone is also provided.
摘要翻译：提供了编码人生长激素，hGHV-2（88）和hGHV-3（53）的天然存在的剪接变体的DNA（或RNA）多核苷酸序列以及其类似物和衍生物，其缺乏通常存在于编码野生型hGH的基因。本发明的生长激素变体是人源的，并且对于某些人类疾病的诊断预防和治疗目的是有用的。本发明还涉及通过重组DNA技术生产人生长激素变体的方法。还提供了产生针对并因此抑制野生型生长激素的活性的抗体的方法。

9. 发明授权

US5871729A Superoxide dismutase-4 失效
标题翻译：超氧化物歧化酶-4
公开(公告)号：US5871729A
公开(公告)日：1999-02-16
申请号：US722050
申请日：1997-01-23
申请人： Guo-Liang Yu , Craig A. Rosen , Claire M. Fraser , Jeannine D. Gocayne
发明人： Guo-Liang Yu , Craig A. Rosen , Claire M. Fraser , Jeannine D. Gocayne
IPC分类号： C12N15/09 , A61K38/00 , A61K38/44 , A61K48/00 , A61P1/04 , A61P9/06 , A61P9/10 , A61P17/02 , A61P19/02 , A61P29/00 , A61P43/00 , C07H21/04 , C07K16/40 , C12N9/02 , C12N9/04 , C12N15/53 , C12P21/08 , C12R1/91
CPC分类号： C12N9/0089 , A61K38/00
摘要： Polynucleotides which encode the polypeptide SOD-4, as well as such polypeptides, and antibodies against the polypeptide and the use of the polypeptide as a pharmaceutical for treating cerebral ischaemia, ulcers, inflammation, arrhythmia, oedema and paraquat intoxication as well as rheumatoid arthritis, osteoarthritis and radiation injury.
摘要翻译： PCT No.PCT / US94 / 06099 Sec。 371日期1997年1月23日 102（e）日期1997年1月23日PCT提交1994年5月31日PCT公布。 WO95 / 27781 PCT出版物日期1995年10月19日编码多肽SOD-4的多核苷酸，以及这些多肽，以及针对多肽的抗体以及多肽作为治疗脑局部缺血，溃疡，炎症，心律失常，水肿和百草枯中毒的药物的用途，作为以及类风湿关节炎，骨关节炎和放射性损伤。

10. 发明授权

US06635252B2 Antibodies to superoxide dismutase-4 失效
标题翻译：超氧化物歧化酶-4的抗体
公开(公告)号：US06635252B2
公开(公告)日：2003-10-21
申请号：US09883985
申请日：2001-06-20
申请人： Guo-Liang Yu , Craig A. Rosen , Claire M. Fraser , Jeannine D. Gocayne
发明人： Guo-Liang Yu , Craig A. Rosen , Claire M. Fraser , Jeannine D. Gocayne
IPC分类号： C07K1600
CPC分类号： C12N9/0089 , A61K38/00
摘要： Polynucleotides which encode the polypeptide SOD-4, as well as such polypeptides, and antibodies against the polypeptide and the use of the polypeptide as a pharmaceutical for treating cerebral ischaemia, ulcers, inflammation, arrhythmia, oedema and paraquat intoxication as well as rheumatoid arthritis, osteoarthritis and radiation injury.
摘要翻译：编码多肽SOD-4的多核苷酸，以及这些多肽，以及针对多肽的抗体以及多肽作为治疗脑局部缺血，溃疡，炎症，心律失常，水肿和百草枯中毒以及类风湿性关节炎的药物的用途，骨关节炎和放射性损伤。

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