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1. 发明授权

US06750346B2 Stable near-infrared (NIR) marker dyes based on benzopyrylium-polymethines 有权
标题翻译：基于苯并吡喃 - 聚甲基的稳定近红外（NIR）标记染料
公开(公告)号：US06750346B2
公开(公告)日：2004-06-15
申请号：US10031741
申请日：2002-01-22
申请人： Peter Czerney , Frank Lehmann , Bernd Schweder , Matthias Wenzel
发明人： Peter Czerney , Frank Lehmann , Bernd Schweder , Matthias Wenzel
IPC分类号： C07D51300
CPC分类号： G01N33/582 , C09B23/0066 , C09B23/02 , C12Q2563/107
摘要： The disclosure is directed to so-called laser-compatible NIR marker dyes based on polymethines for use in optical, in particular, fluorescence optical determination and detection methods, for example, in the fields of medicine, pharmaceutics and in the areas of life science, materials science and environmental science. The disclosure further discusses the aim of the invention which was to create NIR marker dyes based on polymethine which have a high degree of photostability and stability in storage as well as a high fluorescent yield and which can be excited to fluorescence in the easiest possible manner by means of laser radiation in the visible or NIR spectral range, particularly with light of an argon, helium/neon, or diode laser. Dyes based on polymethine of general formula (I) are used.
摘要翻译：本公开涉及基于用于光学的聚甲基化的所谓的激光兼容NIR标记染料，特别是荧光光学测定和检测方法，例如在医学，制药领域以及生命科学领域，材料科学与环境科学。本公开进一步讨论了本发明的目的，其是基于聚甲基化产生具有高度光稳定性和储存稳定性以及高荧光产率的基于聚甲炔的NIR标记染料，并且可以以最简单可能的方式将其激发至荧光在可见光或近红外光谱范围内的激光辐射的手段，特别是在氩，氦/氖或二极管激光的光下。使用基于通式（I）的聚甲炔的染料。

2. 发明授权

US06518423B1 Benzopiperidine derivatives 失效
标题翻译：苯并哌啶衍生物
公开(公告)号：US06518423B1
公开(公告)日：2003-02-11
申请号：US09230852
申请日：1999-04-05
申请人： Toshihiko Kaneko , Richard Clark , Norihito Ohi , Fumihiro Ozaki , Tetsuya Kawahara , Atsushi Kamada , Kazuo Okano , Hiromitsu Yokohama , Kenzo Muramoto , Tohru Arai , Masayoshi Ohkuro , Osamu Takenaka , Jiro Sonoda
发明人： Toshihiko Kaneko , Richard Clark , Norihito Ohi , Fumihiro Ozaki , Tetsuya Kawahara , Atsushi Kamada , Kazuo Okano , Hiromitsu Yokohama , Kenzo Muramoto , Tohru Arai , Masayoshi Ohkuro , Osamu Takenaka , Jiro Sonoda
IPC分类号： C07D51300
CPC分类号： C07D487/04 , C07D513/04
摘要： Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: wherein the variables are as described in the specification. These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and rejection reaction accompanying organ transplantation.
摘要翻译：由式（I）表示的苯并哌啶衍生物，其盐或其水合物，其制备方法和包含其的药物：其中变量如说明书中所述。这些化合物可用作预防和治疗各种炎性疾病和免疫疾病，如类风湿性关节炎，特应性皮炎，牛皮癣，哮喘和伴随器官移植排斥反应的药物。

3. 发明授权

US06426416B1 Anthraquinone and condensed anthraquinone colorants having sulfonamido linked poly (oxyalkylene) moieties and their preparation 失效
标题翻译：具有磺酰氨基连接的聚（氧化烯）部分的蒽醌和缩合的蒽醌着色剂及其制备
公开(公告)号：US06426416B1
公开(公告)日：2002-07-30
申请号：US09478765
申请日：2000-01-06
申请人： Max Allen Weaver , Edward William Kluger , David Jesse Moody
发明人： Max Allen Weaver , Edward William Kluger , David Jesse Moody
IPC分类号： C07D51300
CPC分类号： C09B69/101
摘要： The process for chemically modifying metal-free, colored anthraquinone or condensed anthraquinone compounds or the compounds prepared by said process for improving one or more properties thereof such as water dispersibility, compatibility with other organics, or increased chemical reactivity, wherein the process includes providing material with from 1-6 sulfonylhalide groups or sulfonate ester groups or mixtures thereof, and contacting the material under sulfonamido forming conditions with one or more reactants containing one or more poly(oxyalkylene) moieties, each of the reactants having from 1 to 4 functional amino groups, and each of the poly(oxyalkylene) moieties being comprised of from about 4 to about 200 epoxide reactant residues at least about 50 mole percent of which residues contain 2-4 carbons and wherein the total of said epoxide reactant residues is from about 4 to about 600.
摘要翻译：化学修饰无金色，有色蒽醌或缩合蒽醌化合物的方法或通过所述方法制备的用于改进其一种或多种性质如水分散性，与其它有机物的相容性或增加的化学反应性的化合物的方法，其中该方法包括提供材料具有1-6个磺酰卤基团或磺酸酯基团或其混合物，并且在亚磺酰氨基形成条件下使材料与一种或多种含有一个或多个聚（氧化烯）部分的反应物接触，每个反应物具有1至4个官能氨基，并且每个聚（氧化烯）部分由约4至约200个环氧化物反应物残余物组成，其残留物的至少约50摩尔％含有2-4个碳，并且其中所述环氧化物反应物残留物的总量为约4至约600。

4. 发明授权

US06391870B2 Pyrrolo [2,1-b][1,3]benzothiazepines with atypical antipsychotic activity 失效
标题翻译：具有非典型抗精神病活性的吡咯并[2,1-b] [1,3]苯并硫氮杂
公开(公告)号：US06391870B2
公开(公告)日：2002-05-21
申请号：US09769740
申请日：2001-01-26
申请人： Giuseppe Campiani , Vito Nacci , Patrizia Minetti , Maria Assunta Di Cesare
发明人： Giuseppe Campiani , Vito Nacci , Patrizia Minetti , Maria Assunta Di Cesare
IPC分类号： C07D51300
CPC分类号： C07D513/04
摘要： Polycondensated heterocycles with a pyrrole[2,1-b][1,3]benzothiazepine structure of the following formula (I) where the groups are defined as in the description are disclosed. As compared to known antipsychotic agents, these compounds present substantial activity associated with a simultaneous reduction in unwanted extrapyramidal symptoms. These compounds can be formulated in pharmaceutical compositions for the treatment of psychoses such as, for example, schizophrenia.
摘要翻译：公开了具有如描述中定义的基团的下式（I）的吡咯[2,1-b] [1,3]苯并硫氮杂结构的缩聚杂环。与已知的抗精神病药相比，这些化合物具有与同时减少不需要的锥体外系症状相关的显着活性。这些化合物可以配制在用于治疗精神病例如精神分裂症的药物组合物中。

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