专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0325936A2 Aminoguanidine derivatives and inhibitory agents on maillard reaction containing them as active ingredients 失效
标题翻译：氨基胍衍生物以及含有它们作为活性成分的美拉德反应抑制物质。
公开(公告)号：EP0325936A2
公开(公告)日：1989-08-02
申请号：EP89100345.1
申请日：1989-01-10
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Ohuchida, Shuichi Ono Pharmaceutical Co., Ltd. , Toda, Masaaki Ono Pharmaceutical Co., Ltd. , Miyamoto, Tsumoru Ono Pharmaceutical Co., Ltd.
IPC分类号： C07C133/10 , C07D213/76 , A61K31/155 , A61K31/44
CPC分类号： C07D213/77 , C07C281/16
摘要： An aminoguanidine derivative of the general formula:
(wherein, R 1b represents carbocyclic or heterocyclic ring substituted or unsubstituted by from 1 to 3 group(s) selected from halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group, phenoxy group, amino group, hydroxy group and acylamino group of from 2 to 4 carbon atom(s), X b represents single-bond, alkylene group of from 1 to 4 carbon atom(s) or alkenylene group of from 2 to 4 carbon atoms, or R 1b together with X b represents alkyl group of from 1 to 4 carbon atom(s), R 2b represents hydrogen atom, alkyl group of from 1 to 4 carbon atom(s) or phenyl group substituted or unsubstituted by from 1 to 3 group(s) selected from halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), hydroxy and nitro group.), or an acid addition salt thereof possesses inhibitory activity on Maillard reaction, and these is useful for prevention and/or treatment of several diabetic complications and deseases induced by aging.
摘要翻译：通式的氨基胍衍生物：（worin，R <1B> darstellt碳环或由选自卤素原子，烷基或烷氧基中选择的1至4个碳1〜3组（多个）的杂环substituiertem奥德unsubstituiertem 原子（一个或多个），硝基，苯氧基，氨基，羟基和酰氨基的2至4个碳原子（一个或多个），XB darstellt单键，亚烷基，1〜4个碳原子的（S）或亚烯基的从2至4个碳原子的基团，或R <1B>与XB darstellt烷基，1至4个碳原子（一个或多个）中，R <2B> darstellt氢原子，烷基，1至4个碳原子的（一起小号），或者被选自卤素原子，烷基或具有1至4个碳原子（一个或多个），羟基和硝基的烷氧基基团选自1至3个基团的苯基substituiertem奥德unsubstituiertem。），或酸加成盐具有上的美拉德反应，和合成的抑制活性是用于预防和/或治疗糖尿病并发症和几个deseases的INDU有用老化土木工程署。

2. 发明公开

EP0323590A3 Carbazoyl derivatives 失效
标题翻译：卡博基衍生物
公开(公告)号：EP0323590A3
公开(公告)日：1990-05-02
申请号：EP88120926.6
申请日：1988-12-14
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Ohuchida, Shuichi Ono Pharmaceutical Co., Ltd. , Toda, Masaaki Ono Pharmaceutical Co., Ltd. , Miyamoto, Tsumoru Ono Pharmaceutical Co., Ltd.
IPC分类号： C07C109/06 , C07C133/02 , C07D213/79 , A61K31/175
CPC分类号： C07D213/87 , C07C243/28 , C07C243/32 , C07C243/36 , C07C243/38 , C07C281/06 , C07C2601/08 , C07C2601/14
摘要： A carbazoyl derivative of the general formula:
(wherein, R 1b represents a bond, alkylene group of from 1 to 6 carbon atom(s) or alkenylene group of from 2 to 6 carbon atoms,
R 2b represents a carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three halogen atom(s), hydroxy group, nitro group, amino group, alkyl or alkoxy group of from 1 to 4 carbon atom(s), 3-aminoureido group, phenoxy group or acylamino group of from 2 to 5 carbon atoms, or R 1b together with R 2b , represents an alkyl group of from 1 to 12 carbon atom(s) unsubstituted or substituted by 3-aminoureido group,
R 3b represents (1) a hydrogen atom,
(2) an alkyl group of from 1 to 6 carbon atom(s) or
(3) a phenyl or benzyl group unsubstituted or substituted by from one to three halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), hydroxy group or nitro group,
X b represents a bond or imino gorup,
with the proviso that the compounds wherein the groups shown by X b -R 1b -R 2b represent a phenyl group, 4-aminophenyl gorup, anilino group and 2-thienyl group and the groups shown by R 3b represent a hydrogen atom, are excluded.), or an acid addition salt thereof possesses inhibitory activity on Maillard reaction, and therfore is useful for treating and/or prevention of several diabetic complications and deseases induced by aging.
摘要翻译：咔唑基衍生物，其通式为：CHEM（其中R 1b表示键，1-6个碳原子的亚烷基或2至6个碳原子的亚烯基，R 2b表示未取代或被一至三个卤素原子，羟基，硝基，氨基，1-4个碳原子的烷基或烷氧基取代或被取代的碳环或杂环，3-氨基脲基，苯氧基或2至5个碳原子的酰基氨基或R 1b与R 2b一起代表未被取代或被3-氨基脲基取代的1至12个碳原子的烷基，R 3b，代表（1）氢原子，（2）1至6个碳原子的烷基或（3）未被取代或被一至三个卤素原子取代的苯基或苄基，烷基或烷氧基 1至4个碳原子，羟基或硝基，Xb表示键或亚氨基，条件是其中由Xb-R 1b -R 2b表示的基团，代表苯基，4-氨基苯基gorup，苯胺基和2-噻吩基，R 3b所示的基团代表氢原子），或其酸加成盐对美拉德反应具有抑制活性，因此可用于治疗和/或预防由老化引起的若干糖尿病并发症和疾病。

3. 发明公开

EP0325936A3 Aminoguanidine derivatives and inhibitory agents on maillard reaction containing them as active ingredients 失效
标题翻译：氨基胍衍生物和抑制剂对含有它们作为活性成分的反应物
公开(公告)号：EP0325936A3
公开(公告)日：1990-01-17
申请号：EP89100345.1
申请日：1989-01-10
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Ohuchida, Shuichi Ono Pharmaceutical Co., Ltd. , Toda, Masaaki Ono Pharmaceutical Co., Ltd. , Miyamoto, Tsumoru Ono Pharmaceutical Co., Ltd.
IPC分类号： C07C133/10 , C07D213/76 , A61K31/155 , A61K31/44
CPC分类号： C07D213/77 , C07C281/16
摘要： An aminoguanidine derivative of the general formula:
(wherein, R 1b represents carbocyclic or heterocyclic ring substituted or unsubstituted by from 1 to 3 group(s) selected from halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group, phenoxy group, amino group, hydroxy group and acylamino group of from 2 to 4 carbon atom(s), X b represents single-bond, alkylene group of from 1 to 4 carbon atom(s) or alkenylene group of from 2 to 4 carbon atoms, or R 1b together with X b represents alkyl group of from 1 to 4 carbon atom(s), R 2b represents hydrogen atom, alkyl group of from 1 to 4 carbon atom(s) or phenyl group substituted or unsubstituted by from 1 to 3 group(s) selected from halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), hydroxy and nitro group.), or an acid addition salt thereof possesses inhibitory activity on Maillard reaction, and these is useful for prevention and/or treatment of several diabetic complications and deseases induced by aging.

4. 发明公开

EP0339496A3 Aminoguanidine derivatives 失效
标题翻译：氨基嘌呤衍生物
公开(公告)号：EP0339496A3
公开(公告)日：1991-05-08
申请号：EP89107168.0
申请日：1989-04-20
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Ohuchida, Shuichi Ono Pharmaceutical Co., Ltd. , Toda, Masaaki Ono Pharmaceutical Co., Ltd. , Miyamoto, Tsumoru Ono Pharmaceutical Co., Ltd.
IPC分类号： C07C133/10 , C07D295/12 , C07D211/46 , C07D213/81 , C07D217/04 , A61K31/155 , A61K31/395 , A61K31/34
CPC分类号： C07D213/75 , C07C281/16 , C07C2601/08 , C07C2601/14 , C07D211/46 , C07D217/06 , C07D295/215 , C07D307/52
摘要： A aminoguanidine derivatives of the general formula:
(wherein, R 1b represents a hydrogen atom, alkyl group of from 1 to 6 carbon atom(s), cycloalkyl group of from 5 to 7 carbon atoms or carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three halogen atom(s), alkyl group(s) of from 1 to 4 carbon atom(s), alkoxy group(s) of from 1 to 4 carbon atom(s) or nitro group, X b represents a bond, alkylene group of from 1 to 4 carbon atom(s) or alkenylene group of from 2 to 4 carbon atoms,
R 2b represents a hydrogen atom, alkyl group of from 1 to 6 carbon atom(s) or phenyl group,
R 3b represents a hydrogen atom, phenyl group, alkyl group of from 1 to 4 carbon atom(s), phenylalkyl group of from 7 to 10 carbon atoms or pyridyl group
represents a heterocyclic ring, which contains nitrogen atom or one nitrogen and one oxygen atom, of from 3 to 10 carbon atoms unsubstituted or substituted by a hydroxy group. With the proviso that the compounds wherein R 2b represents a hydrogen atom, -X b -R 1b represents a hydrogen atom, methyl group, ethyl group or phenyl group and R 3b represents a hydrogen atom or methyl group, are excluded.) or acid addition salt thereof possess inhibitory activity on Maillard reaciton, and therefore is useful for treating and/or prevention of several diabetic complications and diseases induced by aging.
摘要翻译：具有以下通式的氨基胍衍生物：其中R 1b表示氢原子，1至6个碳原子的烷基，5至7个碳原子的环烷基或碳环或杂环未取代或被1至3个卤素原子取代，1至4个碳原子的烷基，1至4个碳原子的烷氧基或硝基，Xb 表示1〜4个碳原子的亚烷基或2〜4个碳原子的亚链烯基，R 2b表示氢原子，1〜6个碳原子的烷基或苯基基团，R 3b表示氢原子，苯基，1至4个碳原子的烷基，7至10个碳原子的苯基烷基或吡啶基表示含有氮的杂环原子或一个氮原子和一个氧原子，未被取代或被羟基取代的3-10个碳原子，条件是其中R 2b，表示氢原子，-Xb-R 1b表示氢原子，甲基，乙基或苯基，R 3b表示氢原子或甲基））或其酸加成盐具有抑制活性在美拉德反应中，因此可用于治疗和/或预防几种糖尿病并发症和老化引起的疾病。

5. 发明公开

EP0339496A2 Aminoguanidine derivatives 失效
标题翻译：氨基胍衍生物
公开(公告)号：EP0339496A2
公开(公告)日：1989-11-02
申请号：EP89107168.0
申请日：1989-04-20
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Ohuchida, Shuichi Ono Pharmaceutical Co., Ltd. , Toda, Masaaki Ono Pharmaceutical Co., Ltd. , Miyamoto, Tsumoru Ono Pharmaceutical Co., Ltd.
IPC分类号： C07C133/10 , C07D295/12 , C07D211/46 , C07D213/81 , C07D217/04 , A61K31/155 , A61K31/395 , A61K31/34
CPC分类号： C07D213/75 , C07C281/16 , C07C2601/08 , C07C2601/14 , C07D211/46 , C07D217/06 , C07D295/215 , C07D307/52
摘要： A aminoguanidine derivatives of the general formula:
(wherein, R 1b represents a hydrogen atom, alkyl group of from 1 to 6 carbon atom(s), cycloalkyl group of from 5 to 7 carbon atoms or carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three halogen atom(s), alkyl group(s) of from 1 to 4 carbon atom(s), alkoxy group(s) of from 1 to 4 carbon atom(s) or nitro group, X b represents a bond, alkylene group of from 1 to 4 carbon atom(s) or alkenylene group of from 2 to 4 carbon atoms,
R 2b represents a hydrogen atom, alkyl group of from 1 to 6 carbon atom(s) or phenyl group,
R 3b represents a hydrogen atom, phenyl group, alkyl group of from 1 to 4 carbon atom(s), phenylalkyl group of from 7 to 10 carbon atoms or pyridyl group
represents a heterocyclic ring, which contains nitrogen atom or one nitrogen and one oxygen atom, of from 3 to 10 carbon atoms unsubstituted or substituted by a hydroxy group.
With the proviso that the compounds wherein R 2b represents a hydrogen atom, -X b -R 1b represents a hydrogen atom, methyl group, ethyl group or phenyl group and R 3b represents a hydrogen atom or methyl group, are excluded.) or acid addition salt thereof possess inhibitory activity on Maillard reaciton, and therefore is useful for treating and/or prevention of several diabetic complications and diseases induced by aging.
摘要翻译：具有以下通式的氨基胍衍生物：其中R 1b表示氢原子，1至6个碳原子的烷基，5至7个碳原子的环烷基或碳环或杂环未取代或被1至3个卤素原子取代，1至4个碳原子的烷基，1至4个碳原子的烷氧基或硝基，Xb 表示1〜4个碳原子的亚烷基或2〜4个碳原子的亚链烯基，R 2b表示氢原子，1〜6个碳原子的烷基或苯基基团，R 3b表示氢原子，苯基，1至4个碳原子的烷基，7至10个碳原子的苯基烷基或吡啶基表示含有氮的杂环原子或一个氮原子和一个氧原子，未被取代或被羟基取代的3-10个碳原子，条件是其中R 2b，表示氢原子，-Xb-R 1b表示氢原子，甲基，乙基或苯基，R 3b表示氢原子或甲基））或其酸加成盐具有抑制活性在美拉德反应中，因此可用于治疗和/或预防几种糖尿病并发症和老化引起的疾病。

6. 发明公开

EP0323590A2 Carbazoyl derivatives 失效
标题翻译：肼衍。
公开(公告)号：EP0323590A2
公开(公告)日：1989-07-12
申请号：EP88120926.6
申请日：1988-12-14
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Ohuchida, Shuichi Ono Pharmaceutical Co., Ltd. , Toda, Masaaki Ono Pharmaceutical Co., Ltd. , Miyamoto, Tsumoru Ono Pharmaceutical Co., Ltd.
IPC分类号： C07C109/06 , C07C133/02 , C07D213/79 , A61K31/175
CPC分类号： C07D213/87 , C07C243/28 , C07C243/32 , C07C243/36 , C07C243/38 , C07C281/06 , C07C2601/08 , C07C2601/14
摘要： A carbazoyl derivative of the general formula:
(wherein, R 1b represents a bond, alkylene group of from 1 to 6 carbon atom(s) or alkenylene group of from 2 to 6 carbon atoms,
R 2b represents a carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three halogen atom(s), hydroxy group, nitro group, amino group, alkyl or alkoxy group of from 1 to 4 carbon atom(s), 3-aminoureido group, phenoxy group or acylamino group of from 2 to 5 carbon atoms, or R 1b together with R 2b , represents an alkyl group of from 1 to 12 carbon atom(s) unsubstituted or substituted by 3-aminoureido group,
R 3b represents (1) a hydrogen atom,
(2) an alkyl group of from 1 to 6 carbon atom(s) or
(3) a phenyl or benzyl group unsubstituted or substituted by from one to three halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), hydroxy group or nitro group,
X b represents a bond or imino gorup,
with the proviso that the compounds wherein the groups shown by X b -R 1b -R 2b represent a phenyl group, 4-aminophenyl gorup, anilino group and 2-thienyl group and the groups shown by R 3b represent a hydrogen atom, are excluded.),
or an acid addition salt thereof possesses inhibitory activity on Maillard reaction, and therfore is useful for treating and/or prevention of several diabetic complications and deseases induced by aging.
摘要翻译：咔唑基衍生物，其通式为：CHEM（其中R 1b表示键，1-6个碳原子的亚烷基或2至6个碳原子的亚烯基，R 2b表示未取代或被一至三个卤素原子，羟基，硝基，氨基，1-4个碳原子的烷基或烷氧基取代或被取代的碳环或杂环，3-氨基脲基，苯氧基或2至5个碳原子的酰基氨基或R 1b与R 2b一起代表未被取代或被3-氨基脲基取代的1至12个碳原子的烷基，R 3b，代表（1）氢原子，（2）1至6个碳原子的烷基或（3）未被取代或被一至三个卤素原子取代的苯基或苄基，烷基或烷氧基 1至4个碳原子，羟基或硝基，Xb表示键或亚氨基，条件是其中由Xb-R 1b -R 2b表示的基团，代表苯基，4-氨基苯基gorup，苯胺基和2-噻吩基，R 3b所示的基团代表氢原子），或其酸加成盐对美拉德反应具有抑制活性，因此可用于治疗和/或预防由老化引起的若干糖尿病并发症和疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式