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    • 1. 发明专利
    • JPS4837023B1
    • 1973-11-08
    • JP4254469
    • 1969-06-02
    • A61K31/10A61P3/06C07C51/09C07C51/38C07C51/60C07C59/70C07C67/00C07C231/00C07C231/02C07C231/12C07C235/20C07C103/00
    • 1,252,487. Bisphenoxyacetamide derivatives. SANDOZ Ltd. 30 May, 1969 [4 June, 1968], No. 24817/69. Addition to 1,205,173. Heading C2C. Novel bisphenoxyacetamide derivatives of the formula in which R 1 and R 2 which may be the same or different each represent H, phenyl or CF 3 , provided that at least one of R 1 and R 2 is other than hydrogen are prepared either by reacting the corresponding acid chloride, bromide or iodide or C 1-6 alkyl esters with ammonia in a solvent where is inert under the reaction conditions or, in the case of compounds in which R 1 and R 2 are both phenyl or both CF 3 , by reacting a compound of the formula Y 2 CHCONH 2 in which Y represents Cl, Br or I with either pphenylphenol or p-trifluoromethylphenol in the form of their phenolates or carrying out the reaction in the presence of an acid-binding agent. Pharmaceutical compositions, having hypocholesteremic/hypolipemic activity, contain the above novel compounds as active ingredients and pharmaceutically acceptable diluents or carriers. The compositions are in a form suitable for oral administration.