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1. 发明授权

US06488961B1 Effervescent granules and methods for their preparation 有权
标题翻译：泡腾颗粒及其制备方法
公开(公告)号：US06488961B1
公开(公告)日：2002-12-03
申请号：US09468513
申请日：1999-12-21
申请人： Joseph R Robinson , James W. McGinity
发明人： Joseph R Robinson , James W. McGinity
IPC分类号： A61K946
CPC分类号： A61K9/0007 , A61K9/1694
摘要： Disclosed here are effervescent granules having a controllable rate of effervescence. In some embodiments, the such granules comprise an acidic agent, an alkaline agent, a pharmacologically active agent, hot-melt extrudable binder capable of forming a eutectic mixture with the acidic agent and, optionally, a plasticizer. The effervescent granules are made by a hot-melt extrusion process. The present invention also provides a thermal heat process for preparing a pharmacologically active agent containing effervescent granule. In certain aspects, the granules contain pharmacologically active agents such as narcotics, antidiarrheal agents, antiviral agents, anxiolytic agents, a cholesterol lowering agent, an alpha adrenergic blocking agent, a phenanthrene derivative. By way of example, some of the narcotics that may be included in the granules and in the process of preparing the granules include, by way of example: phenanthrene derivatives (e.g., morphine sulfate), and morphine derivatives (e.g., hydromorphone hydrochloride).
摘要翻译：这里公开了具有可控的泡腾速率的泡腾颗粒。在一些实施方案中，这种颗粒包含酸性试剂，碱性试剂，药理学活性剂，能够与酸性试剂形成共晶混合物的热熔可挤出粘合剂和任选的增塑剂。泡腾颗粒通过热熔挤出方法制成。本发明还提供了制备含有泡腾颗粒的药理活性剂的热加工方法。在某些方面，颗粒含有药理学活性剂如麻醉剂，止泻药，抗病毒剂，抗焦虑剂，降胆固醇剂，α肾上腺素能阻断剂，菲衍生物。作为实例，可以包括在颗粒中和在制备颗粒的过程中的一些麻醉剂包括例如：菲衍生物（例如硫酸吗啡）和吗啡衍生物（例如盐酸氢吗啡酮）。

2. 发明授权

US06264984B1 Effervescent histamine H2 antagonist composition 有权
标题翻译：泡腾组胺H2拮抗剂组成
公开(公告)号：US06264984B1
公开(公告)日：2001-07-24
申请号：US09455233
申请日：1999-12-06
申请人： Mamoun M. Hussein , John Migton
发明人： Mamoun M. Hussein , John Migton
IPC分类号： A61K946
CPC分类号： A61K31/426 , A61K9/0007 , A61K31/00 , A61K31/341 , A61K31/4164
摘要： A histamine H2 antagonist incompatible with acidic materials is incorporated in an effervescent composition and is stable therein provided the acidulant employed in the effervescent couple is a non-hydroxy group containing acidulant and such acidulant is employed as substantially the entire amount of the acidulant present in the formulation. Preferably the composition is devoid of hydroxy group containing acidulant. Adipic acid, succinic acid, fumaric acid and succinic anhyride may be employed as the acidulant. Adipic acid is preferred.
摘要翻译：与酸性物质不相容的组胺H2拮抗剂掺入泡腾组合物中并且稳定，只要泡腾对中使用的酸化剂是含非羟基的酸化剂，并且这种酸化剂用作基本上全部量的存在于公式。优选地，组合物没有含羟基的酸化剂。己二酸，琥珀酸，富马酸和琥珀酸异柠檬酸可用作酸化剂。己二酸是优选的。

3. 发明授权

US06245353B1 Solid, rapidly disintegrating cetirizine formulations 有权
标题翻译：固体快速分解西替利嗪配方
公开(公告)号：US06245353B1
公开(公告)日：2001-06-12
申请号：US09277403
申请日：1999-03-26
申请人： Wolfram Tritthart , Mario André Piskering
发明人： Wolfram Tritthart , Mario André Piskering
IPC分类号： A61K946
CPC分类号： A61K31/495
摘要： The present invention relates to a solid, effervescent, rapidly dissolving dosage form for oral administration, of (a) cetirizine or a pharmaceutically acceptable salt thereof, (b) an effervescent base comprising (i) at least one of (1) an organic edible acid and (2) a salt thereof, (ii) at least one of an alkali metal and an alkaline earth metal carbonate and bicarbonate, and (c) optionally a pharmaceutically acceptable auxiliary ingredient.
摘要翻译：本发明涉及一种用于口服给药的固体，泡腾，快速溶解剂型，（a）西替利嗪或其药学上可接受的盐，（b）泡腾基质，其包含（i）至少一种（1）有机食用酸和（2）其盐，（ii）碱金属和碱土金属碳酸盐和碳酸氢盐中的至少一种，和（c）任选的药学上可接受的辅助成分。

4. 发明授权

US06649186B1 Effervescent granules and methods for their preparation 有权
公开(公告)号：US06649186B1
公开(公告)日：2003-11-18
申请号：US09553528
申请日：2000-04-20
申请人： Joseph R. Robinson , James William McGinity , Pascal Delmas
发明人： Joseph R. Robinson , James William McGinity , Pascal Delmas
IPC分类号： A61K946
CPC分类号： A61K9/0056 , A61K9/0007 , A61K9/0034 , A61K9/1694 , A61K9/2095
摘要： Disclosed here are effervescent granules having a controllable rate of effervescence. In some embodiments, the such granules comprise an acidic agent, an alkaline agent, a pharmacologically active agent, hot-melt extrudable binder capable of forming a eutectic mixture with the acidic agent and, optionally, a plasticizer. The effervescent granules are made by a hot-melt extrusion process. The present invention also provides a thermal heat process for preparing a pharmacologically active agent containing effervescent granule. In certain aspects, the granules contain pharmacologically active agents such as narcotics, antidiarrheal agents, antiviral agents, anxiolytic agents, a cholesterol lowering agent, an alpha adrenergic blocking agent, a phenanthrene derivative. By way of example, some of the narcotics that may be included in the granules and in the process of preparing the granules include, by way of example: phenanthrene derivatives (e.g., morphine sulfate), and morphine derivatives (e.g., hydromorphone hydrochloride).

5. 发明授权

US06419955B1 Process for making bisphosphonate compositions 有权
标题翻译：制备二膦酸盐组合物的方法
公开(公告)号：US06419955B1
公开(公告)日：2002-07-16
申请号：US09413989
申请日：1999-10-07
申请人： Rolf-Dieter Gabel , Jörn Möckel , Heinrich Woog
发明人： Rolf-Dieter Gabel , Jörn Möckel , Heinrich Woog
IPC分类号： A61K946
CPC分类号： A61K31/663 , A61K9/2013 , A61K9/4858
摘要： The present invention relates to a process for the preparation of bisphonate-containing pharmaceutical compositions for oral administration wherein the active substance is wet-granulated in a fluidized-bed granulator and the wet granulate is dried in the fluidised bed granulator. The dried granulate is further processed to produce desired dosage forms.
摘要翻译：本发明涉及一种制备用于口服给药的含双酚C的药物组合物的方法，其中将活性物质在流化床造粒机中湿法制粒，并将湿颗粒在流化床造粒机中干燥。将干燥的颗粒进一步处理以产生所需的剂型。

6. 发明授权

US06399099B1 Effervescent composition with dry extract of ginkgo biloba 失效
标题翻译：含有银杏叶干提取物的泡腾组合物
公开(公告)号：US06399099B1
公开(公告)日：2002-06-04
申请号：US08913896
申请日：1997-09-17
申请人： Rainer Oschmann
发明人： Rainer Oschmann
IPC分类号： A61K946
CPC分类号： A61K9/0007 , A61K36/16
摘要： The invention relates to effervescent compositions containing a dry extract of ginkgo biloba and an effervescent mixture. By dissolving the mixture in water a virtually clear and almost neutral solution is produced which is stable during the period of use.
摘要翻译：本发明涉及含有银杏叶干提取物和泡腾混合物的泡腾组合物。通过将混合物溶解在水中，产生在使用期间是稳定的几乎透明且几乎中性的溶液。

7. 发明授权

US06210711B1 Effervescent microspheres and method for making them 有权
标题翻译：泡腾微球及其制备方法
公开(公告)号：US06210711B1
公开(公告)日：2001-04-03
申请号：US09341780
申请日：1999-08-13
申请人： Jean-Marc Aiache , Pascale Gauthier , Joël Bougaret
发明人： Jean-Marc Aiache , Pascale Gauthier , Joël Bougaret
IPC分类号： A61K946
CPC分类号： A61K9/167 , A61K9/0007 , A61K9/5073
摘要： The invention concerns multilayer microspheres containing an acid substance, a basic substance, and a water-soluble isolating agent which, when it dissolves in water, after almost instant effervescence, brings about a homogeneous dispersion of active principal(s) which is present in the acid and basic substances. The invention also concerns a method for preparing such microspheres by rotational granulation on a fluid air bed associated with a system of tangential spraying of the wetting liquid.
摘要翻译：本发明涉及含有酸性物质，碱性物质和水溶性分离剂的多层微球体，当其在水中溶解时，几乎瞬间起泡后，会导致活性原子的均匀分散，其存在于酸性和碱性物质。本发明还涉及通过与润湿液体的切向喷射系统相关联的流体空气床上的旋转造粒来制备这种微球的方法。

8. 发明授权

US06200604B1 Sublingual buccal effervescent 有权
标题翻译：舌下颊泡腾
公开(公告)号：US06200604B1
公开(公告)日：2001-03-13
申请号：US09327814
申请日：1999-06-08
申请人： Sathasivan Indiran Pather , Rajendra K. Khankari , Jonathan D. Eichman , Joseph R. Robinson , John Hontz
发明人： Sathasivan Indiran Pather , Rajendra K. Khankari , Jonathan D. Eichman , Joseph R. Robinson , John Hontz
IPC分类号： A61K946
CPC分类号： A61K31/5415 , A61K9/0007 , A61K9/0056 , A61K9/006 , A61K31/4468
摘要： A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administerable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.
摘要翻译：一种药物剂型，其适于向口腔中提供药物的颊，舌下或牙龈吸收，所述药物包含与用于促进药物在口腔中吸收的口腔可药用组合泡腾剂。还公开了与泡腾剂结合使用另外的pH调节物质以促进吸收药物。

9. 发明授权

US06667056B2 Pharmaceutical compositions containing an effervescent acid-base couple 失效
公开(公告)号：US06667056B2
公开(公告)日：2003-12-23
申请号：US09932097
申请日：2001-08-20
申请人： Paolo Chiesi , Paolo Ventura , Rosa Mezzadri , Gaetano Brambilla , Daniela Acerbi
发明人： Paolo Chiesi , Paolo Ventura , Rosa Mezzadri , Gaetano Brambilla , Daniela Acerbi
IPC分类号： A61K946
CPC分类号： A61K9/0007
摘要： A pharmaceutical formulation in the form of a fast dissolving tablet comprising an active ingredient, sodium glycine carbonate and an acid capable of reacting rapidly with sodium glycine carbonate to release carbon dioxide.

10. 发明授权

US06589555B2 Effervescent vitaceutical compositions and related methods 失效
标题翻译：泡腾维他命组合物及相关方法
公开(公告)号：US06589555B2
公开(公告)日：2003-07-08
申请号：US09749304
申请日：2000-12-27
申请人： Mahendra Pandya
发明人： Mahendra Pandya
IPC分类号： A61K946
CPC分类号： A61K45/06 , A23L2/40 , A23L33/15 , A23L33/175 , A23V2002/00 , A61K9/0007 , A61K31/70 , A61K2300/00 , A23V2250/15 , A23V2250/161 , A23V2250/044 , A23V2250/708 , A23V2250/5062 , A23V2250/1578 , A23V2250/032 , A23V2250/06 , A23V2250/02 , A23V2250/156 , A23V2250/70
摘要： The invention relates to a dry effervescent composition containing inulin, and optionally containing at least one vitaceutical and other active agents. The effervescent products optionally contain lubricants and essential oils and can generate magnesium malate, a therapeutic effector. The invention also relates to a dry effervescent composition containing glucosamine. The invention also encompasses methods of preparing the effervescent compositions of the invention.
摘要翻译：本发明涉及含有菊粉，任选含有至少一种维生素和其它活性剂的干燥泡腾组合物。泡腾产品任选地含有润滑剂和精油，并且可以产生苹果酸镁，一种治疗效应物。本发明还涉及含有葡糖胺的干燥泡腾组合物。本发明还包括制备本发明的泡腾组合物的方法。

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