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1. 发明授权

US06241973B1 Method and product for cleaning and/or whitening of teeth 失效
标题翻译：清洁和/或美白牙齿的方法和产品
公开(公告)号：US06241973B1
公开(公告)日：2001-06-05
申请号：US09331777
申请日：1999-06-24
申请人： Ari Rinne
发明人： Ari Rinne
IPC分类号： A61K728
CPC分类号： A61Q11/00 , A61K8/66 , A61K2800/782
摘要： A method and a product for cleaning and/or whitening of teeth. Natural human cysteine proteinases are employed for cleaning and whitening purposes and this activity can be blocked by natural cysteine protease inhibitors, which are released secondarily from the product at a later stage. The use of natural cysteine proteinases and their inhibitors provides the advantage that they are man's own proteins, and therefore the risk of allegorization is minimized. In addition, their enzyme kinetics are will known.
摘要翻译：牙齿清洁和/或美白的方法和产品。天然人半胱氨酸蛋白酶用于清洁和美白目的，并且该活性可以被天然半胱氨酸蛋白酶抑制剂阻断，其在稍后阶段从产物二次释放。天然半胱氨酸蛋白酶及其抑制剂的使用提供了它们是人类自身蛋白质的优点，因此可以降低排卵风险。此外，它们的酶动力学将是已知的。

2. 发明授权

US06391285B1 Antimicrobial polypeptide and methods of use 有权
标题翻译：抗菌多肽及其使用方法
公开(公告)号：US06391285B1
公开(公告)日：2002-05-21
申请号：US09361900
申请日：1999-07-27
申请人： Jeffrey D. Hillman
发明人： Jeffrey D. Hillman
IPC分类号： A61K728
CPC分类号： A61K8/64 , A61Q11/00 , C07K14/315
摘要： Antimicrobial compounds and compositions and uses thereof, including the treatment and prevention of bacterial infections are described. The compounds and compositions include lantibiotic polypeptides and the nucleic acid sequences encoding the polypeptides. The compounds and compositions are useful as antimicrobials in antibiotic pharmaceutical preparation and as an antimicrobial or antiseptic dentifrice.
摘要翻译：描述了抗微生物化合物及其组合物及其用途，包括治疗和预防细菌感染。化合物和组合物包括羊毛硫抗生素多肽和编码多肽的核酸序列。化合物和组合物可用作抗生素药物制剂中的抗微生物剂和抗微生物剂或防腐剂洁齿剂。

3. 发明授权

US06485953B1 Enzyme capable of hydorlyzing plaque, microorganism producing the same, and a composition comprising the same 失效
标题翻译：能够对斑块进行水解的酶，产生相同的微生物和包含其的组合物
公开(公告)号：US06485953B1
公开(公告)日：2002-11-26
申请号：US09555535
申请日：2000-07-18
申请人： Doman Kim , Do-Won Kim , Soo-Jin Heo , Su-Jin Ryu
发明人： Doman Kim , Do-Won Kim , Soo-Jin Heo , Su-Jin Ryu
IPC分类号： A61K728
CPC分类号： C12N9/2417 , A61K8/66 , A61Q11/00 , C12N9/2454
摘要： The present invention relates to a dental plaque hydrolyzing or inhibiting enzyme having simultaneously dextranase and amylase activities.
摘要翻译：本发明涉及具有同时葡聚糖酶和淀粉酶活性的牙菌斑水解或抑制酶。

4. 发明授权

US06776979B2 Periodontal treatment compound and method of use 失效
标题翻译：牙周治疗化合物及使用方法
公开(公告)号：US06776979B2
公开(公告)日：2004-08-17
申请号：US10334373
申请日：2002-12-30
申请人： Marvin B. Frager , R. Douglas Gaynor , John R. Taylor
发明人： Marvin B. Frager , R. Douglas Gaynor , John R. Taylor
IPC分类号： A61K728
CPC分类号： A61K36/45 , A61K31/047 , A61K31/716 , A61K36/61 , A61K2300/00
摘要： An oral compound of water; glycerin; a cranberry source; methylsulfonylmethane; melaleuca alternifolia oil; hydroxyethylcellulose; and a surfactant, in proper combination for use by injecting the compound around a person's gum line followed by its use in a dental tray over a person's teeth and gums for a specified period of time. The next phase to the overall treatment regimen is a daily health care regimen involving: a systemic immune defense compound having colostrum beta 1,3 Glucans; fructo-oligosaccharides; amla fruit 4:1; inositol hexaphosphate; selected minerals; selected enzymes; selected probiotics; and methylsulfonylmethane; an antimicrobial compound having sodium bicarbonate, silicone dioxide, and a cranberry source; and an oral probiotic compound having selected probiotics; vitamin C; and colostrum.
摘要翻译：水的口服化合物甘油; 蔓越莓来源; 甲基磺酰甲烷; 黄花菜油羟乙基纤维素; 和表面活性剂，适当组合用于通过将化合物注射到人的牙龈线周围，随后在牙齿托盘上使用牙齿和牙龈一段指定的时间段。整个治疗方案的下一个阶段是每天保健方案涉及：具有初乳β1,3葡聚糖的全身免疫防御化合物; 果寡糖; amla水果4：1; 肌醇六磷酸选矿; 选择的酶; 选择益生菌; 和甲基磺酰甲烷;具有碳酸氢钠，二氧化硅和蔓越莓来源的抗微生物化合物; 和具有选择的益生菌的口服益生菌化合物; 维生素C; 和初乳

5. 发明授权

US06482396B1 Methods for treating or preventing diseases of the oral cavity 失效
标题翻译：治疗或预防口腔疾病的方法
公开(公告)号：US06482396B1
公开(公告)日：2002-11-19
申请号：US09854930
申请日：2001-05-15
申请人： Steven D. Braun , Ram Nimmagudda
发明人： Steven D. Braun , Ram Nimmagudda
IPC分类号： A61K728
CPC分类号： A61K8/64 , A61Q11/00
摘要： The present invention relates to a method of reducing dental plaque and calculus deposition. The invention further relates to a method of treating or preventing periodonitis and other diseases of the teeth and tissues of the oral cavity. The invention further relates to compositions suitable for use in such methods.
摘要翻译：本发明涉及减少牙菌斑和微积分沉积的方法。本发明还涉及治疗或预防口腔牙齿和组织的牙周炎和其它疾病的方法。本发明还涉及适用于这些方法的组合物。

6. 发明授权

US06413501B2 Plaque-inhibiting oral compositions 失效
标题翻译：斑块抑制性口服组合物
公开(公告)号：US06413501B2
公开(公告)日：2002-07-02
申请号：US09173935
申请日：1998-10-16
申请人： Rie Tsuchiya
发明人： Rie Tsuchiya
IPC分类号： A61K728
CPC分类号： A61Q11/00 , A61K8/66 , A61Q11/02
摘要： The present invention relates to oral compositions comprising plaque-inhibiting or plaque-removing enzymes, in particular at least one starch-hydrolysing enzyme, e.g. an &agr;-amylase or a debranching enzyme such as a pullulanase, and/or at least one starch-modifying enzyme, e.g. a transglucosidase or a CGTase, and to a method for inhibiting plaque formation or removing plaque using such oral compositions.
摘要翻译：本发明涉及包含斑块抑制或去斑酶的口腔组合物，特别是至少一种淀粉水解酶，例如， α-淀粉酶或脱支酶，例如支链淀粉酶，和/或至少一种淀粉修饰酶，例如支链淀粉酶。转葡糖苷酶或CGT酶，以及使用这种口服组合物抑制斑块形成或去除斑块的方法。

7. 发明授权

US06379654B1 Oral composition providing enhanced tooth stain removal 有权
标题翻译：口服组合物提供增强的牙齿清除
公开(公告)号：US06379654B1
公开(公告)日：2002-04-30
申请号：US09698453
申请日：2000-10-27
申请人： Petros Gebreselassie , Diego Hoic , James G. Masters , Michael Prencipe
发明人： Petros Gebreselassie , Diego Hoic , James G. Masters , Michael Prencipe
IPC分类号： A61K728
CPC分类号： A61Q11/00 , A61K8/25 , A61K8/66 , A61K38/4873
摘要： An abrasive dentifrice composition which effects enhanced tooth and stain removal which comprises an orally acceptable vehicle containing a combination of a low oil absorption silica abrasive having an oil absorption value of less than 100 cc/100 g silica and an proteolytic enzyme.
摘要翻译：一种具有增强的牙齿和污迹去除效果的研磨性洁齿剂组合物，其包含含有油吸收值小于100cc / 100g硅胶的低吸油性二氧化硅磨料与蛋白水解酶的组合的口腔可接受的载体。

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