专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2012056961A Antisense oligonucleotide directed to ribonucleotide reductase r2 and use thereof in treatment of cancer 审中-公开
标题翻译：反义寡核苷酸对抗RIBONUCLEOTIDE REDUCTASE R2的反义寡核苷酸及其在治疗癌症中的应用
公开(公告)号：JP2012056961A
公开(公告)日：2012-03-22
申请号：JP2011261584
申请日：2011-11-30
申请人： Lorus Therapeutics Inc , ロールスセラペウティクスインクLorus Therapeutics Inc.
发明人： WRIGHT JIM A , YOUNG AIPING H
IPC分类号： A61K31/7088 , A61K9/08 , A61K31/7068 , A61K38/00 , A61P35/02 , C12N15/113
CPC分类号： C12N15/1137 , A61K31/19 , A61K31/4745 , A61K31/573 , A61K31/704 , A61K31/7048 , A61K31/7072 , A61K38/00 , C12N2310/315
摘要： PROBLEM TO BE SOLVED: To provide antisense oligonucleotides reductase directed to a ribonucleotide reductase R2, and to provide uses thereof in treatment of cancer.SOLUTION: The antisense oligonucleotide including a sequence expressed by a sequence number 1 and having equal to or less than 35 nucleotides in length, is used in the production of a medicine for treating acute myelocytic leukemia of a human patient in combination with cytarabine. The use of medicine is provided with which the antisense oligonucleotide is mixed in a dosage of 3 to 8 mg/kg/day for providing the patient.
摘要翻译：待解决的问题：提供针对核糖核苷酸还原酶R2的反义寡核苷酸还原酶，并提供其用于治疗癌症的用途。解决方案：包含序列号1表示的长度等于或小于35个核苷酸的序列的反义寡核苷酸用于制备用于治疗人类患者与阿糖胞苷的急性骨髓性白血病的药物。提供使用药物，反义寡核苷酸以3至8mg / kg /天的剂量混合以提供患者。版权所有（C）2012，JPO＆INPIT

2. 发明申请

WO2004016086A2 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS 审中-公开
标题翻译： 2,4,5-三取代咪唑及其作为抗微生物剂的用途
公开(公告)号：WO2004016086A2
公开(公告)日：2004-02-26
申请号：PCT/CA0301229
申请日：2003-08-19
申请人： LORUS THERAPEUTICS INC , HUESCA MARIO , AL-QAWASMEH RAED , YOUNG AIPING H , LEE YOON
发明人： HUESCA MARIO , AL-QAWASMEH RAED , YOUNG AIPING H , LEE YOON
IPC分类号： A01N43/50 , A01N43/52 , A01N43/90 , A23L3/3544 , A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61L2/18 , C07D233/22 , C07D235/02 , C07D403/04 , C07D403/14 , C07D409/14 , C07D471/14 , E05B1/00 , A01N
CPC分类号： A01N43/90 , A01N43/50 , A01N43/52 , A23L3/3544 , A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K45/06 , A61L2/18 , C07D233/22 , C07D233/64 , C07D235/02 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D471/14 , E05B1/0069
摘要： The present invention provides therapeutically effective 2,4,5-trisubstituted imidazole compounds, methods of preparing the same, and compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-microbial agents. The anti-microbial properties of the compounds include anti-bacterial and/or anti-fungal activity.
摘要翻译：本发明提供了治疗有效的2,4,5-三取代的咪唑化合物，其制备方法以及包含单独或与其它药物组合的组合物的组合物。本发明进一步提供了这些化合物作为抗微生物剂的用途。这些化合物的抗微生物特性包括抗菌和/或抗真菌活性。

3. 发明申请

WO2006094384B1 USE OF INTERLEUKIN 17E FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：使用白细胞介素17E治疗癌症
公开(公告)号：WO2006094384B1
公开(公告)日：2007-04-05
申请号：PCT/CA2006000311
申请日：2006-03-08
申请人： LORUS THERAPEUTICS INC , WRIGHT JIM A , YOUNG AIPING H , LEE YOON , CAO MING YU
发明人： WRIGHT JIM A , YOUNG AIPING H , LEE YOON , CAO MING YU
IPC分类号： A61K38/20 , A61K31/337 , A61K31/4164 , A61K31/7088 , A61K35/413 , A61K39/395 , A61P35/00
CPC分类号： A61K38/20 , A61K31/337 , A61K31/4164 , A61K31/7088 , A61K2039/505 , A61K2300/00 , C07K16/22 , C07K2317/24 , C07K2317/76
摘要： The use of interleukin 17E to inhibit tumour growth in a subject is provided. The interleukin 17E can be provided to the subject exogenously, as an interleukin 17E polypeptide or a polynucleotide encoding an interleukin 17E polypeptide, or it can be provided by stimulating production of endogenous interleukin 17E. Also provided is the use of interleukin 17E in combination with one or more anti-cancer therapeutics for inhibiting tumour growth in a subject. Anti-cancer therapeutics include, for example, standard chemotherapeutic drugs, immunotherapeutics, radiation, gene therapy, hormone manipulation and antisense therapy.
摘要翻译：提供了白细胞介素17E在受试者中抑制肿瘤生长的用途。作为白细胞介素17E多肽或编码白细胞介素17E多肽的多核苷酸，可以外源性地向受试者提供白细胞介素17E，或者可以通过刺激内源白细胞介素17E的产生来提供白细胞介素17E。还提供了白细胞介素17E与一种或多种抗癌治疗剂组合用于抑制受试者中的肿瘤生长的用途。抗癌疗法包括例如标准化学治疗药物，免疫治疗剂，辐射，基因治疗，激素操作和反义治疗。

4. 发明申请

WO2006126177A2 2-INDOLYL IMIDAZO[4,5-D]PHENANTHROLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER 审中-公开
标题翻译： 2-吲哚咪唑并[4,5-D]苯并噻吩衍生物及其在治疗癌症中的应用
公开(公告)号：WO2006126177A2
公开(公告)日：2006-11-30
申请号：PCT/IB2006051675
申请日：2006-05-25
申请人： LORUS THERAPEUTICS INC , HUESCA MARIO , YOUNG AIPING H , LEE YOON , KHINE AYE AYE , WRIGHT JIM A , LOCK LISA
发明人： HUESCA MARIO , YOUNG AIPING H , LEE YOON , KHINE AYE AYE , WRIGHT JIM A , LOCK LISA
CPC分类号： C07D471/14
摘要： 2-indolyl imidazo[4,5-d]phenanthroline compounds of Formula I that are capable of intracellular chelation of transition metals and of exerting antiproliferative effects in cancer cells, that are cytostatic and/or cytotoxic, are provided. Compounds of Formula I can also induce apoptosis in cancer cells and are thus capable of exerting a cytotoxic effect on cancer cells. The compounds of Formula I are also capable of selectively inhibiting the proliferation of one or more of prostate cancer cells, colon cancer cells, non-small lung cancer cells and leukemia cells. The compounds of Formula I are also capable of increasing the expression of the zinc-regulated tumour suppressor, KLF4 and thus are useful in inhibiting the proliferation of cancer cells in which KLF4 functions as a tumour-suppressor, including, but not limited to, bladder cancer, cancers of the gastrointestinal tract and various leukemias.
摘要翻译：提供能够细胞内螯合过渡金属并且在细胞抑制和/或细胞毒性的癌细胞中发挥抗增殖作用的式I的2-吲哚基咪唑并[4,5-d]菲咯啉化合物。式I的化合物还可以诱导癌细胞凋亡，因此能够对癌细胞发挥细胞毒性作用。式I的化合物还能够选择性地抑制一种或多种前列腺癌细胞，结肠癌细胞，非小细胞肺癌细胞和白血病细胞的增殖。式I的化合物还能够增加锌调节的肿瘤抑制因子KLF4的表达，因此可用于抑制KLF4作为肿瘤抑制剂的癌细胞的增殖，包括但不限于膀胱癌症，胃肠道癌症和各种白血病。

5. 发明申请

WO2005047266A9 ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS 审中-公开
标题翻译： ARYL IMIDAZOLES及其作为抗癌剂的用途
公开(公告)号：WO2005047266A9
公开(公告)日：2008-04-17
申请号：PCT/IB2004052433
申请日：2004-11-15
申请人： LORUS THERAPEUTICS INC , HUESCA MARIO , AL-QAWASMEH RAED , YOUNG AIPING H , LEE YOON
发明人： HUESCA MARIO , AL-QAWASMEH RAED , YOUNG AIPING H , LEE YOON
IPC分类号： C07D233/54 , C07D235/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D471/14 , C07D471/16 , C07D495/04
CPC分类号： A61K31/4184 , A61K31/4178 , A61K31/4188 , A61K31/4745 , C07D233/64 , C07D235/02 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D495/04
摘要： Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods -of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-cancer agents; wherein: R1 is aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, substituted hetéroaryl or amino; R2 and R3 are independently aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl or R2 and R3 when taken together along with the carbon atoms they are attached to, form aryl or substituted aryl, and R4 is hydrogen, halogen, hydroxyl, thiol, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkylalkenyl, alkyl alkynyl, alkoxy, alkyithio, aryl, aryloxy, amino, amido, carboxyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, heteroalkyl, cycloalkyl, substituted cycloalkyl, alkylcycloalkyl, alkylcyclobeteroalkyl, nitro, cyano or -S(O)o.2R wherein R is alkyl, substituted alkyl, aryl, substituted aryl, heterocycle, beteroaryl, substituted heterocycle, or substituted heteroaryl.
摘要翻译：提供了治疗上有效的2,4,5-三取代的咪唑化合物。还提供了制备化合物和药物组合物的方法，所述药物组合物包含单独的化合物或与其它药剂组合。本发明还提供了化合物作为抗癌剂的用途; 其中：R 1是芳基，取代的芳基，杂环，取代的杂环，杂芳基，取代的杂芳基或氨基; R2和R3独立地是芳基，取代的芳基，杂环，杂芳基，取代的杂环或取代的杂芳基，或者当R 2和R 3与它们连接的碳原子一起形成时，R 2和R 3，形成芳基或取代的芳基，且R 4是氢，卤素，羟基，硫醇，低级烷基，取代的低级烷基，低级烯基，取代的低级烯基，低级炔基，取代的低级炔基，烷基烯基，烷基炔基，烷氧基，烷硫基，芳基，芳氧基，氨基，酰胺基，羧基，芳基，取代的芳基，杂环杂芳基，取代的杂环，杂烷基，环烷基，取代的环烷基，烷基环烷基，烷基环烯基烷基，硝基，氰基或-S（O）o2R其中R是烷基，取代的烷基，芳基，取代的芳基，杂环，取代的杂芳基。

6. 发明申请

WO2014153464A2 2-SUBSTITUTED IMIDAZO[4,5-D]PHENANTHROLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER 审中-公开
标题翻译： 2-取代咪唑并[4,5-D]吡喃衍生物及其在治疗癌症中的应用
公开(公告)号：WO2014153464A2
公开(公告)日：2014-09-25
申请号：PCT/US2014031349
申请日：2014-03-20
申请人： LORUS THERAPEUTICS INC
发明人： LEE YOON , CUKIER HOWARD , NEDUNURI VENKATA , PERALTA ROBERT , HUESCA MARIO , YOUNG AIPING H
CPC分类号： C07D471/14 , C07D471/18
摘要： The present invention provides 2-substituted imidazo[4,5-d]phenanthroline compounds, which are capable of inhibiting proliferation of one or more renal cancer cells, pancreatic cancer cells, prostate cancer cells, colon cancer cells, leukemia cells, brain cancer/tumour cells or non-small cell lung cancer cells.
摘要翻译：本发明提供能够抑制一种或多种肾癌细胞，胰腺癌细胞，前列腺癌细胞，结肠癌细胞，白血病细胞，脑癌/大肠癌细胞增殖的2-取代咪唑并[4,5-d]菲咯啉化合物，肿瘤细胞或非小细胞肺癌细胞。

7. 发明申请

WO2004016086B1 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS 审中-公开
标题翻译： 2,4,5-三唑基咪唑及其作为抗微生物剂的用途
公开(公告)号：WO2004016086B1
公开(公告)日：2004-07-01
申请号：PCT/CA0301229
申请日：2003-08-19
申请人： LORUS THERAPEUTICS INC , HUESCA MARIO , AL-QAWASMEH RAED , YOUNG AIPING H , LEE YOON
发明人： HUESCA MARIO , AL-QAWASMEH RAED , YOUNG AIPING H , LEE YOON
IPC分类号： A01N43/50 , A01N43/52 , A01N43/90 , A23L3/3544 , A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61L2/18 , C07D233/22 , C07D235/02 , C07D403/04 , C07D403/14 , C07D409/14 , C07D471/14 , E05B1/00 , A61L2/16 , C07D487/12
CPC分类号： A01N43/90 , A01N43/50 , A01N43/52 , A23L3/3544 , A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K45/06 , A61L2/18 , C07D233/22 , C07D233/64 , C07D235/02 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D471/14 , E05B1/0069
摘要： The present invention provides therapeutically effective 2,4,5-trisubstituted imidazole compounds, methods of preparing the same, and compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-microbial agents. The anti-microbial properties of the compounds include anti-bacterial and/or anti-fungal activity.
摘要翻译：本发明提供治疗有效的2,4,5-三取代的咪唑化合物，其制备方法，以及包含单独或与其它试剂组合的化合物的组合物。本发明还提供了化合物作为抗微生物剂的用途。化合物的抗微生物性质包括抗细菌和/或抗真菌活性。

8. 发明专利

CA2496241C 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS 未知
公开(公告)号：CA2496241C
公开(公告)日：2011-06-28
申请号：CA2496241
申请日：2003-08-19
申请人： LORUS THERAPEUTICS INC
发明人： AL-QAWASMEH RAED , HUESCA MARIO , LEE YOON S , YOUNG AIPING H
IPC分类号： C07D487/14 , A01N43/50 , A01N43/52 , A01N43/90 , A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61L2/16 , C07D233/22 , C07D233/54 , C07D235/02 , C07D403/04 , C07D403/14 , C07D409/14 , C07D471/14
摘要： The present invention provides therapeutically effective 2,4,5-trisubstituted imidazole compounds, methods of preparing the same, and compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-microbial agents. The anti-microbial properties of the compounds include anti-bacterial and/or anti-fungal activity.

9. 发明专利

AU2003257329B2 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents 未知
公开(公告)号：AU2003257329B2
公开(公告)日：2009-11-19
申请号：AU2003257329
申请日：2003-08-19
申请人： LORUS THERAPEUTICS INC
发明人： LEE YOON , AL-QAWASMEH RAED , HUESCA MARIO , YOUNG AIPING H
IPC分类号： A01N43/50 , A01N43/52 , A01N43/90 , A23L3/3544 , A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61L2/18 , C07D233/22 , C07D235/02 , C07D403/04 , C07D403/14 , C07D409/14 , C07D471/14 , E05B1/00
摘要： The present invention provides therapeutically effective 2,4,5-trisubstituted imidazole compounds, methods of preparing the same, and compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-microbial agents. The anti-microbial properties of the compounds include anti-bacterial and/or anti-fungal activity.

10. 发明专利

CA2496241A1 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS 未知
公开(公告)号：CA2496241A1
公开(公告)日：2004-02-26
申请号：CA2496241
申请日：2003-08-19
申请人： LORUS THERAPEUTICS INC
发明人： YOUNG AIPING H , HUESCA MARIO , LEE YOON S , AL-QAWASMEH RAED
IPC分类号： C07D233/22 , C07D233/54 , C07D235/02 , C07D403/04 , C07D403/14 , C07D409/14 , C07D471/14 , C07D487/14 , A01N43/50 , A01N43/52 , A01N43/90 , A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61L2/16
摘要： The present invention provides therapeutically effective 2,4,5-trisubstitute d imidazole compounds, methods of preparing the same, and compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti- microbial agents. The anti-microbial properties of the compounds include ant i- bacterial and/or anti-fungal activity.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式