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1. 发明授权

US06630478B2 Methods for treatment of drug-induced peripheral neuropathy 有权
标题翻译：治疗药物性周围神经病变的方法
公开(公告)号：US06630478B2
公开(公告)日：2003-10-07
申请号：US09899901
申请日：2001-07-06
申请人： Jack Diamond , Alvin J. Glasky , Mark M. Foreman
发明人： Jack Diamond , Alvin J. Glasky , Mark M. Foreman
IPC分类号： A61K3152
CPC分类号： C07D473/18 , A61K31/404 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/522 , C07D473/30 , Y02A50/401
摘要： A method of treating drug-induced peripheral neuropathy comprising administering to a patient with drug-induced peripheral neuropathy an effective quantity of N-4-carboxaphenyl-3-(6-oxohydropurin-9-yl)propananide AIT-082, is disclosed. Peripheral nerve sprouting can be induced through the action of a neurotrophic factor such as nerve growth factor (NGF) without the occurrence of hyperalgesia. The peripheral nerve sprouting can be nociceptive nerve sprouting. The drug-induced peripheral neuropathy is associated with the administration of oncolytic drugs, such as a vinca alkaloid, cisplatin, paclitaxel, suramin, altretamine, carboplatin, chlorambucil, cytarabine, dacarbazine, docetaxel, etoposide, fludarabine, ifosfamide with mesna, tamoxifen, teniposide, or thioguanine.
摘要翻译：一种治疗药物诱发的周围神经病变的方法，其包括给予患有药物诱导的周围神经病变的患者有效量的N-4-羧基苯基-3-（6-氧代氢嘌呤-9-基）丙脒AIT-082。可通过神经营养因子如神经生长因子（NGF）的作用诱导外周神经发芽，而不发生痛觉过敏。外周神经发芽可引起伤害性神经发芽。药物诱导的周围神经病变与溶瘤药物如长春花生物碱，顺铂，紫杉醇，苏拉明，高乐丹，卡铂，苯丁酸氮芥，阿糖胞苷，达卡巴嗪，多西他赛，依托泊苷，氟达拉滨，异环磷酰胺与美沙司，他莫昔芬，替尼泊苷，或硫鸟嘌呤。

2. 发明授权

US06569864B1 Pharmaceutical agents containing acyclovir, fusaric acid and derivatives thereof 失效
标题翻译：含有阿昔洛韦，镰孢酸及其衍生物的药剂
公开(公告)号：US06569864B1
公开(公告)日：2003-05-27
申请号：US09903337
申请日：2001-07-11
申请人： Michael G. Douglas , Avinash N. Amin
发明人： Michael G. Douglas , Avinash N. Amin
IPC分类号： A61K3152
CPC分类号： A61K45/06 , A61K31/44 , A61K31/522 , A61K2300/00
摘要： Compositions and kits comprising acyclovir and fusaric acid are provided.
摘要翻译：提供了包含阿昔洛韦和糠酸的组合物和试剂盒

3. 发明授权

US06518277B1 Inhibitors of human phosphatidylinositol 3-kinase delta 有权
公开(公告)号：US06518277B1
公开(公告)日：2003-02-11
申请号：US09841341
申请日：2001-04-24
申请人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
发明人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
IPC分类号： A61K3152
CPC分类号： C07D473/00 , C07D403/12 , C07D473/16 , C07D473/24 , C07D473/30 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04
摘要： Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K&dgr;) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K&dgr; plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K&dgr;, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K&dgr; activity, including compounds that selectively inhibit PI3K&dgr; activity. Methods of using PI3K&dgr; inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K&dgr; inhibitory compounds to inhibit PI3K&dgr;-mediated processes in vitro and in vivo.

4. 发明授权

US06514979B1 Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor 失效
标题翻译：鸟苷类似物逆转录酶抑制剂和肌苷单磷酸脱氢酶抑制剂的协同组合及其用途
公开(公告)号：US06514979B1
公开(公告)日：2003-02-04
申请号：US09261712
申请日：1999-03-03
申请人： David Margolis , Alonso Heredia , David Oldach , Robert Redfield
发明人： David Margolis , Alonso Heredia , David Oldach , Robert Redfield
IPC分类号： A61K3152
CPC分类号： A61K31/52 , A61K31/365 , A61K2300/00
摘要： Synergistic combinations of guanosine nucleoside analog reverse transcriptase inhibitors such as abacavir with inosine monophosphate dehydrogenase inhibitors such as mycophenolates, pharmaceutical compositions comprising such combinations, and therapeutic methods comprising administering the synergistic combinations to subjects in need thereof, for treating a viral infection, such as an HIV-1 infection.
摘要翻译：鸟苷核苷类似物逆转录酶抑制剂如阿巴卡韦与肌苷单磷酸酯脱氢酶抑制剂如霉酚酸酯的协同组合，包含这些组合的药物组合物以及治疗方法包括向有需要的受试者施用协同组合，用于治疗病毒感染，例如 HIV-1感染。

5. 发明授权

US06489331B1 Remedies for diabetes 失效
标题翻译：糖尿病补救
公开(公告)号：US06489331B1
公开(公告)日：2002-12-03
申请号：US09719570
申请日：2001-04-09
申请人： Junichi Shimada , Yoshihisa Ohta , Kotaro Takasaki , Miho Suda , Hideaki Kusaka , Hiroshi Yano , Satoshi Nakanishi , Yuzuru Matsuda
发明人： Junichi Shimada , Yoshihisa Ohta , Kotaro Takasaki , Miho Suda , Hideaki Kusaka , Hiroshi Yano , Satoshi Nakanishi , Yuzuru Matsuda
IPC分类号： A61K3152
CPC分类号： C07D487/14 , A61K31/505 , A61K31/519 , Y10S514/866
摘要： A medicament for the therapeutic treatment of diabetes which comprises as an active ingredient a compound represented by the general formula (I): wherein R1 represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, R2 represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, R3 represents a hydrogen atom, a lower alkyl group or a substituted or unsubstituted aralkyl group, X1 and X2 independently represent a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group, and the symbol “n” represents an integer of from 0 to 3, or a physiologically acceptable salt thereof.
摘要翻译：一种用于治疗糖尿病的药物，其包含作为活性成分的由通式（I）表示的化合物：其中R 1表示氢原子，低级烷基，取代或未取代的芳基或取代或未取代的芳族杂环基，R2表示氢原子，低级烷基，取代或未取代的芳烷基，取代或未取代的芳基或取代或未取代的芳香族杂环基，R3表示氢原子，低级烷基或取代或未取代的芳烷基，X 1和X 2独立地表示氢原子，低级烷基，取代或未取代的芳烷基或取代或未取代的芳基，符号“n”表示0〜3的整数，或其生理上可接受的盐。

6. 发明授权

US06465473B1 Method for treatment of reactive arthritis or bursitis 失效
标题翻译：治疗反应性关节炎或滑囊炎的方法
公开(公告)号：US06465473B1
公开(公告)日：2002-10-15
申请号：US09510704
申请日：2000-02-22
申请人： Ernest L. Bonner, Jr. , Robert Hines
发明人： Ernest L. Bonner, Jr. , Robert Hines
IPC分类号： A61K3152
CPC分类号： A61K31/65 , A61K31/415 , A61K31/195 , A61K2300/00
摘要： An improved method for treatment of conditions in human beings associated with either or both reactive arthritis or bursitis comprising administration of a combination of L-lysine, minocycline hydrochloride, metronidazole, and valacyclovir hydrochloride. A first alternate method comprises administration of L-lysine, minocycline hydrochloride, and metronidazole. A second alternate method comprises administration of L-lysine, minocycline hydrochloride, metronidazole, and isonicotinic acid hydrazide.
摘要翻译：用于治疗与任一种或两种反应性关节炎或滑囊炎相关的人类状况的改进方法，包括施用L-赖氨酸，米诺环素盐酸盐，甲硝唑和盐酸伐昔洛韦的组合。第一替代方法包括施用L-赖氨酸，米诺环素盐酸盐和甲硝唑。第二种替代方法包括施用L-赖氨酸，盐酸米诺环素，甲硝唑和异烟酰肼。

7. 发明授权

US06326374B1 Compositions comprising GABA analogs and caffeine 失效
标题翻译：包含GABA类似物和咖啡因的组合物
公开(公告)号：US06326374B1
公开(公告)日：2001-12-04
申请号：US09743371
申请日：2001-01-09
申请人： Leslie Magnus , Catherine A. Segal
发明人： Leslie Magnus , Catherine A. Segal
IPC分类号： A61K3152
CPC分类号： A61K31/52 , A61K2300/00
摘要： Compositions that comprise a GABA analog, such as gabapentin or pregabalin in combination with caffeine are disclosed. The compositions are used to treat pain in mammals.
摘要翻译：公开了包含GABA类似物，例如加巴喷丁或普瑞巴林与咖啡因组合的组合物。该组合物用于治疗哺乳动物的疼痛。

8. 发明授权

US06288069B1 Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue 有权
标题翻译：使用9-取代的次黄嘌呤衍生物刺激神经组织的再生
公开(公告)号：US06288069B1
公开(公告)日：2001-09-11
申请号：US09442151
申请日：1999-11-16
申请人： Alvin J. Glasky
发明人： Alvin J. Glasky
IPC分类号： A61K3152
CPC分类号： C07D473/30
摘要： The present invention comprises a method of stimulating regeneration or survival of a mammalian motor neuron or of a mammalian sensory neuron comprising administering to a mammal an effective amount of a compound that is a 9-substituted hypoxanthine derivative linked through a linker to a p-aminobenzoic acid moiety or of a salt or prodrug ester of such a compound. Preferably, the compound is N-4-carboxyphenyl-3-(6-oxohydropurin-9-yl) propanamide. The invention also includes pharmaceutical compositions formulated for stimulation of regeneration of a mammalian motor neuron comprising the 9-substituted hypoxanthine derivative and a pharmaceutically acceptable carrier.
摘要翻译：本发明包括刺激哺乳动物运动神经元或哺乳动物感觉神经元的再生或存活的方法，包括向哺乳动物施用有效量的通过接头与对氨基苯甲酸连接的9-取代的次黄嘌呤衍生物的化合物酸部分或这种化合物的盐或前药酯。优选地，该化合物是N-4-羧基苯基-3-（6-氧代氢嘌呤-9-基）丙酰胺。本发明还包括配制用于刺激哺乳动物运动神经元的再生的药物组合物，其包含9-取代的次黄嘌呤衍生物和药学上可接受的载体。

9. 发明授权

US06693104B2 Theobromine with an anti-carcinogenic activity 有权
标题翻译：可可碱具有抗癌活性
公开(公告)号：US06693104B2
公开(公告)日：2004-02-17
申请号：US10223104
申请日：2002-08-15
申请人： Hyong Joo Lee , Ki Won Lee , Kyung Sun Kang , Dong Young Kim , Hyung Hwan Park , Man Jong Lee , Han Soo Kim , Ik Boo Kwon
发明人： Hyong Joo Lee , Ki Won Lee , Kyung Sun Kang , Dong Young Kim , Hyung Hwan Park , Man Jong Lee , Han Soo Kim , Ik Boo Kwon
IPC分类号： A61K3152
CPC分类号： A23G3/364 , A23G4/068 , A23L2/02 , A23L13/65 , A23L33/105 , A23V2002/00 , A61K31/52 , A61K31/522 , A23V2200/308 , A23V2250/21
摘要： Disclosed is theobromine with an anti-carcinogenic activity which inhibits the suppression of GJIC (gap junctional intercellular communication), a pathological phenomenon occurring during development of various kinds of cancers including liver cancer, as well as DNA synthesis of cancer cells thereby inhibiting proliferation of liver, gastric and colon cancer cells.
摘要翻译：公开了具有抗癌活性的可可碱，其抑制GJIC（间隙连接细胞间通讯）的抑制，在包括肝癌在内的各种癌症的发展过程中发生的病理现象以及癌细胞的DNA合成从而抑制肝脏的增殖，胃癌和结肠癌细胞。

10. 发明授权

US06683084B1 Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections 失效
标题翻译：使用2-氨基嘌呤衍生物治疗和预防人类疱疹病毒6感染
公开(公告)号：US06683084B1
公开(公告)日：2004-01-27
申请号：US09505745
申请日：2000-02-16
申请人： Richard Anthony Vere Hodge , Malcolm Richard Boyd
发明人： Richard Anthony Vere Hodge , Malcolm Richard Boyd
IPC分类号： A61K3152
CPC分类号： A61K31/52
摘要： The use of a compound of formula (A) or a bioprecursor, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing for use in the prophylactic treatment of HHV-6 infection.
摘要翻译：使用式（A）化合物或前述任一项的生物前体或其药学上可接受的盐，磷酸酯和/或酰基衍生物用于预防性治疗HHV-6感染。

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