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1. 发明授权

US06693104B2 Theobromine with an anti-carcinogenic activity 有权
标题翻译：可可碱具有抗癌活性
公开(公告)号：US06693104B2
公开(公告)日：2004-02-17
申请号：US10223104
申请日：2002-08-15
申请人： Hyong Joo Lee , Ki Won Lee , Kyung Sun Kang , Dong Young Kim , Hyung Hwan Park , Man Jong Lee , Han Soo Kim , Ik Boo Kwon
发明人： Hyong Joo Lee , Ki Won Lee , Kyung Sun Kang , Dong Young Kim , Hyung Hwan Park , Man Jong Lee , Han Soo Kim , Ik Boo Kwon
IPC分类号： A61K3152
CPC分类号： A23G3/364 , A23G4/068 , A23L2/02 , A23L13/65 , A23L33/105 , A23V2002/00 , A61K31/52 , A61K31/522 , A23V2200/308 , A23V2250/21
摘要： Disclosed is theobromine with an anti-carcinogenic activity which inhibits the suppression of GJIC (gap junctional intercellular communication), a pathological phenomenon occurring during development of various kinds of cancers including liver cancer, as well as DNA synthesis of cancer cells thereby inhibiting proliferation of liver, gastric and colon cancer cells.
摘要翻译：公开了具有抗癌活性的可可碱，其抑制GJIC（间隙连接细胞间通讯）的抑制，在包括肝癌在内的各种癌症的发展过程中发生的病理现象以及癌细胞的DNA合成从而抑制肝脏的增殖，胃癌和结肠癌细胞。

2. 发明申请

US20120021509A1 ISOLATING METHOD FOR UMBILICAL CORD BLOOD-DERIVED PLURIPOTENT STEM CELLS EXPRESSING ZNF281 审中-公开
标题翻译：用于表达ZNF281的脐带血衍生的PLUIPOTETE STEM细胞的分离方法
公开(公告)号：US20120021509A1
公开(公告)日：2012-01-26
申请号：US13257961
申请日：2010-03-03
申请人： Kyung Sun Kang , Kyoung Hwan Roh
发明人： Kyung Sun Kang , Kyoung Hwan Roh
IPC分类号： C12N5/0789
摘要： The present invention relates to a method for isolating pluripotent/multipotent stem cells derived from umbilical cord blood, characterized by culturing monocytes isolated from umbilical cord blood in a culture vessel containing fibronectin and then harvesting stem cells from the culture, the umbilical cord blood-derived pluripotent/multipotent stem cells isolated thereby; and a cell therapeutic agent containing the pluripotent/multipotent stem cells derived from umbilical cord blood or cells differentiated therefrom. The present invention also relates to a novel culture media for stem cells, a culture method for stem cells which is characterized by culturing and proliferating stem cells in the culture media, and a method for increasing stemness of stem cells which is characterized by a sphere culture or a three-dimensional culture of stem cells.
摘要翻译：本发明涉及一种用于分离源自脐带血的多能/多能干细胞的方法，其特征在于在含有纤粘连蛋白的培养容器中培养从脐带血分离的单核细胞，然后从培养物中收获干细胞，脐带血衍生由此分离的多能/多能干细胞; 以及含有衍生自脐带血的多能/多能干细胞或与其分化的细胞的细胞治疗剂。本发明还涉及用于干细胞的新型培养基，干细胞的培养方法，其特征在于培养培养基中培养和增殖干细胞，以及提高干细胞干细胞的方法，其特征在于球培养或干细胞的三维培养。

3. 发明申请

US20110171726A1 MULTIPOTENT STEM CELLS DERIVED FROM HUMAN ADIPOSE TISSUE AND CELLULAR THERAPEUTIC AGENTS COMPRISING THE SAME 审中-公开
标题翻译：从人体组织和包含其的细胞治疗药物衍生的多个干细胞
公开(公告)号：US20110171726A1
公开(公告)日：2011-07-14
申请号：US12897458
申请日：2010-10-04
申请人： Kyung Sun Kang , Jeong Chan Ra , Jung Ran Park
发明人： Kyung Sun Kang , Jeong Chan Ra , Jung Ran Park
IPC分类号： C12N5/0775 , C12N5/0793 , C12N5/071 , C12N5/077
CPC分类号： C12N5/0667 , C12N2500/14 , C12N2500/20 , C12N2500/32 , C12N2500/44 , C12N2500/84 , C12N2501/11 , C12N2501/115 , C12N2501/33 , C12N2501/39
摘要： Human adipose tissue-derived multipotent adult stem cells are provided, which are characterized by the ability to be maintained in an undifferentiated state for a long period of time by forming spheres and which have high proliferation rates. Also provided are methods for isolating and maintaining the adult stem cells, and methods for differentiating the multipotent adult stem cells into nerve cells, fat cells, cartilage cells, osteogenic cells, muscle cells, endothelial cells, hepatic cells and insulin-releasing pancreatic β-cells. Also provided are cellular therapeutic agents for treating osteoarthritis, osteoporosis, nerve disease, diabetes and for forming breast tissue, which contain differentiated cells or the adult stem cells.
摘要翻译：提供人脂肪组织衍生的多能成体干细胞，其特征在于通过形成球体并且具有高增殖速率在长时间内维持在未分化状态的能力。还提供了用于分离和维持成体干细胞的方法，以及将多能成体干细胞分化为神经细胞，脂肪细胞，软骨细胞，成骨细胞，肌肉细胞，内皮细胞，肝细胞和胰岛素释放胰腺的方法。 -细胞。还提供了用于治疗骨关节炎，骨质疏松症，神经疾病，糖尿病和用于形成含有分化细胞或成体干细胞的乳腺组织的细胞治疗剂。

4. 发明授权

US09290739B2 Equine amniotic fluid-derived multipotent stem cells and a method for producing the same 有权
标题翻译：马养羊多能干细胞及其制造方法
公开(公告)号：US09290739B2
公开(公告)日：2016-03-22
申请号：US13821303
申请日：2011-09-07
申请人： Kyung Sun Kang , Min Soo Seo , Sang Bum Park
发明人： Kyung Sun Kang , Min Soo Seo , Sang Bum Park
IPC分类号： C12N5/07 , C12N5/071 , C12N5/077 , A61K35/50 , C12N5/073 , C12N5/0775 , C12N5/0735
CPC分类号： C12N5/0655 , A61K35/50 , C12N5/0605 , C12N5/0606 , C12N5/0653 , C12N5/0654 , C12N5/0668
摘要： The present invention relates to equine amniotic fluid-derived multipotent stem cells (Eaf-MSCs) and a preparation method thereof. More particularly, the present invention relates to equine amniotic fluid-derived multipotent stem cells which exhibit all negative immunological characteristics with respect to the human markers, CD19, CD20, CD28, CD31, CD34, CD38, CD41A, CD62L, CD62P and CD200, and exhibit all positive immunological characteristics with respect to the human markers, CD44, CD90 and CD105, and have the ability to differentiate into ectoderm, mesoderm or endoderm-derived cells.
摘要翻译：本发明涉及马羊源多能干细胞（Eaf-MSC）及其制备方法。更具体地说，本发明涉及相对于人类标记物CD19，CD20，CD28，CD31，CD34，CD38，CD41A，CD62L，CD62P和CD200具有全部阴性免疫学特征的马羊源多能干细胞，以及相对于人类标志物CD44，CD90和CD105显示出所有阳性免疫学特征，并具有分化成外胚层，中胚层或内胚层衍生细胞的能力。

5. 发明申请

US20080286243A1 Method For Isolation of a Hair Follicle Stem Cell and a Composition For Hair Reproduction 审中-公开
标题翻译：用于分离毛囊干细胞的方法和用于头发繁殖的组合物
公开(公告)号：US20080286243A1
公开(公告)日：2008-11-20
申请号：US11995910
申请日：2007-07-04
申请人： Kyung Sun Kang , Jeong Chan Ra
发明人： Kyung Sun Kang , Jeong Chan Ra
IPC分类号： A61K35/12 , C12N5/02 , A61P17/14
CPC分类号： C12N5/0628 , A61K35/12 , C12N2500/25 , C12N2500/32 , C12N2500/38 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/599 , C12N2501/70
摘要： The present invention relates to a method for isolating hair follicle stem cells and a composition for inducing hair growth. More specifically, relates to a method for isolating hair follicle stem cells showing a positive immunological response to CD34, by chemically degrading hair follicle-containing scalp tissue and then culturing the degraded tissue in a serum-containing medium and a serum-free medium, as well as a composition for inducing hair growth, which contains, as an active ingredient, CD34-positive hair follicle stem cells isolated by the method. The hair follicle-derived stem cells, which are obtained according to the disclosed method, are classified as autologous adult stem cells, have self-renewal capability, the ability to differentiate into adult hair follicle cells and the ability to induce hair growth, and can be used as a novel cell therapeutic agent against hair loss. In addition, the present invention relates to a method for culturing hair follicle cells, which has high yield compared to that of the prior art, as well as a method for identifying hair follicle stem cells.
摘要翻译：本发明涉及一种分离毛囊干细胞的方法和用于诱导毛发生长的组合物。更具体地，涉及通过化学降解含毛囊的头皮组织然后在含血清的培养基和无血清培养基中培养所述降解组织，分离出对CD34具有阳性免疫应答的毛囊干细胞的分离方法，如以及用于诱导毛发生长的组合物，其含有通过该方法分离的CD34阳性毛囊干细胞作为活性成分。根据公开的方法获得的来自毛囊的干细胞被分类为自体成体干细胞，具有自我更新能力，分化成成年毛囊细胞的能力和诱导毛发生长的能力，并且可以用作抗脱发的新型细胞治疗剂。此外，本发明涉及培养与现有技术相比具有高产量的毛囊细胞的方法以及用于鉴定毛囊干细胞的方法。

6. 发明授权

US09139812B2 CD49F promoting proliferation, multipotency and reprogramming of adult stem cells through PI3K/AKT/GSK3 pathway 有权
标题翻译： CD49F通过PI3K / AKT / GSK3途径促进成体干细胞的增殖，多能性和重编程
公开(公告)号：US09139812B2
公开(公告)日：2015-09-22
申请号：US13638262
申请日：2011-02-18
申请人： Kyung Sun Kang , Kyung Rok Yu
发明人： Kyung Sun Kang , Kyung Rok Yu
IPC分类号： C12N5/071 , C12Q1/24 , G01N33/50 , C12N5/0775 , A61K35/12
CPC分类号： C12N5/0602 , A61K2035/124 , C12N5/0663 , C12N5/0665 , C12N5/0667 , C12Q1/24 , G01N33/5073 , G01N2333/7055
摘要： The present invention relates to a method for obtaining adult stem cells, which have a surface antigen of CD49f, excellent formation of spheres due to sphere formation and high expression of OCT4 and SOX2, from a cell source including stem cells, and a cell therapeutic agent containing adult stem cells obtained by the method or cells differentiated therefrom as an active ingredient.According to the present invention, adult stem cells derived from spheres are suitable for mass culture of adult stem cells because of more rapid growth thereof compared with stem cells obtained by a known adhesive culture method, have a specific surface antigen so as to be homogeneously obtained by using the specific surface antigen, and are useful for preparing a cell therapeutic agent using the same because of excellent differentiation thereof.
摘要翻译：本发明涉及一种获得成体干细胞的方法，所述成体干细胞具有CD49f的表面抗原，由球形成的球形成，球形细胞形成，OCT4和SOX2的高表达，来自包括干细胞的细胞源和细胞治疗剂含有通过其分化的方法获得的成体干细胞作为活性成分。根据本发明，与通过已知的粘合剂培养方法获得的干细胞相比，由于与成体干细胞的生长更快速的成体干细胞的成体干细胞相比，适于大规模培养，具有比表面抗原以均匀获得通过使用比表面抗原，由于其优异的分化，可用于制备使用其的细胞治疗剂。

7. 发明申请

US20100021436A1 MULTIPOTENT ADULT STEM CELL DERIVED FROM CANINE UMBILICAL CORD BLOOD, PLACENTA AND CANINE FETUS HEART, METHOD FOR PREPARING THE SAME AND CELLULAR THERAPEUTICS CONTAINING THE SAME 审中-公开
标题翻译：多发性成熟干细胞来源于犬脐动脉血，血管和INE骨心脏，其制备方法和包含其的细胞治疗方法
公开(公告)号：US20100021436A1
公开(公告)日：2010-01-28
申请号：US12300281
申请日：2007-05-12
申请人： Kyung Sun Kang , Oh Kyung Kwon , Yun Hyeok Jeong , Ji Hey Lim , Chang Soo Jung
发明人： Kyung Sun Kang , Oh Kyung Kwon , Yun Hyeok Jeong , Ji Hey Lim , Chang Soo Jung
IPC分类号： A61K35/12 , C12N5/074
CPC分类号： A61K35/51 , A61K35/34 , A61K35/50 , C12N5/0607
摘要： The present invention relates to multipotent adult stem cells derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart, and a method for preparing the same as well as a cellular therapeutic agent containing the same, more specifically, to a multipotent adult stem cell isolated by culturing an eukaryotic cell derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart in a FBS-containing medium and a method for preparing the same. Adult stem cells according to the present invention are derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart. The adult stem cells have characteristics highly similar to human mesenchymal stem cells as well as remarkable cell growth at the initial step compared to human UCB-derived mesenchymal stem cells so that the cells are useful to treat canine incurable diseases and difficult-to-cure diseases. Furthermore, multipotent adult stem cells are effective to treat musculoskeletal diseases and neural diseases due to the ability to differentiate into osteogenic cells and neural cells.
摘要翻译：本发明涉及来自犬脐带血的多潜能成体干细胞，来自犬胎心的胎盘血液和血液样品，以及其制备方法以及含有该成体干细胞的细胞治疗剂，更具体地，涉及多潜能通过在含FBS的培养基中培养源自犬脐带血，胎盘血液和犬胎儿心脏的血液样品的真核细胞分离的成体干细胞及其制备方法。根据本发明的成体干细胞衍生自犬脐带血，胎盘血和来自犬胎心的血液样品。与人UCB来源的间充质干细胞相比，成体干细胞具有与人间充质干细胞高度相似的特征，并且在初始步骤中显着的细胞生长，使得细胞可用于治疗犬不治之症和难以治愈的疾病。此外，多能成体干细胞由于分化成成骨细胞和神经细胞的能力而有效治疗肌肉骨骼疾病和神经疾病。

8. 发明申请

US20080113034A1 Composition For Promoting Growth of Animal Comprising Extracts of Artemisia Capillaris Thunberg, Acanthopanax and Garlic and Feed Composition For Promoting Growth Comprising the Composition 有权
标题翻译：用于促进包含蒿提取物，刺五加和大蒜的提取物的动物生长的组合物和用于促进包含组合物的生长的饲料组合物
公开(公告)号：US20080113034A1
公开(公告)日：2008-05-15
申请号：US11791598
申请日：2005-06-13
申请人： Jeong Chan Ra , Hyeong Geun Park , Kyung Sun Kang
发明人： Jeong Chan Ra , Hyeong Geun Park , Kyung Sun Kang
IPC分类号： A61K36/8962 , A61K36/254 , A61K36/282 , A61K36/31 , A61K36/48 , A61K36/28 , A61K35/32
CPC分类号： A23K50/30 , A23K10/30 , A23K20/10 , A23K50/10
摘要： The present invention relates to a composition for promoting the growth of animals, comprising extracts of Artemisia capillaris thunberg., Acanthopanax and garlic, as well as a feed composition comprising the same. The composition for promoting the growth of animals shows the excellent effect of promoting the secretion of growth hormone. Particularly, when the feed composition comprising the animal growth-promoting composition is administered to livestock animals, it will show the excellent effects of body weight gain, meat quality improvement and milk production increase in the livestock animals.
摘要翻译：本发明涉及一种用于促进动物生长的组合物，其包含青蒿提取物，刺五加和大蒜，以及包含该组合物的饲料组合物。用于促进动物生长的组合物显示促进生长激素分泌的优异效果。特别地，当将包含动物生长促进组合物的饲料组合物施用于家畜时，将显示家畜中体重增加，肉质量改善和产奶量增加的优异效果。

9. 发明授权

US09408873B2 Pharmaceutical composition comprising stem cells treated with NOD2 agonist or culture thereof for prevention and treatment of immune disorders and inflammatory diseases 有权
标题翻译：药物组合物，其包含用NOD2激动剂或其培养物处理的用于预防和治疗免疫疾病和炎性疾病的干细胞
公开(公告)号：US09408873B2
公开(公告)日：2016-08-09
申请号：US13818234
申请日：2011-08-19
申请人： Kyung Sun Kang , Hyung Sik Kim
发明人： Kyung Sun Kang , Hyung Sik Kim
IPC分类号： A61K35/28 , A61K35/545 , A61K38/05 , C12N5/0775
CPC分类号： A61K35/28 , A61K35/545 , A61K38/05 , C12N5/0665 , C12N2501/02 , C12N2501/05 , C12N2501/052 , C12N2501/054
摘要： The present invention relates to a pharmaceutical composition for the prevention or treatment of immune disorders and inflammatory diseases, comprising stem cells that are generated by culturing stem cells expression Nucleotide-binding Oligomerization Domain protein 2 (NOD2) with a NOD2 agonist or a culture thereof. More particularly, the present invention relates to a method for suppressing immune responses or inflammatory responses of a subject, comprising the step of administering the pharmaceutical composition, the stem cells or culture thereof to the subject, a method for preparing an immunosuppressive drug or an anti-inflammatory drug using the stem cells or culture thereof, a method for preparing PGE2 or TGF-β1 comprising the step of culturing NOD2-expressing stem cells in culture medium with a NOD2 agonist, a graft comprising stem cells expressing NOD2 and the NOD2 agonist, a method for preparing the graft, a composite comprising stem cells expressing NOD2 and the NOD2 agonist, and a culture generated by culturing the NOD2-expressing stem cells with a NOD2 agonist.
摘要翻译：本发明涉及用于预防或治疗免疫疾病和炎性疾病的药物组合物，其包含通过用NOD2激动剂或其培养物培养干细胞表达核苷酸结合寡聚化结构域蛋白2（NOD2）而产生的干细胞。更具体地，本发明涉及一种抑制受试者的免疫应答或炎症反应的方法，包括向受试者施用药物组合物，干细胞或培养物的步骤，制备免疫抑制药物或抗体的方法使用干细胞或其培养物的炎症药物，制备PGE2或TGF-β1的方法，其包括用NOD2激动剂培养培养基中培养表达NOD2的干细胞的步骤，包含表达NOD2的干细胞的移植物和NOD2激动剂，制备移植物的方法，包含表达NOD2的干细胞和NOD2激动剂的复合物，以及通过用NOD2激动剂培养表达NOD2的干细胞产生的培养物。

10. 发明申请

US20130089885A1 CD49F PROMOTING PROLIFERATION, MULTIPOTENCY AND REPROGRAMMING OF ADULT STEM CELLS THROUGH PI3K/AKT/GSK3 PATHWAY 有权
标题翻译： CD49F通过PI3K / AKT / GSK3途径促进增殖，增殖和分化成熟干细胞
公开(公告)号：US20130089885A1
公开(公告)日：2013-04-11
申请号：US13638262
申请日：2011-02-18
申请人： Kyung Sun Kang , Kyung Rok Yu
发明人： Kyung Sun Kang , Kyung Rok Yu
IPC分类号： C12N5/071
CPC分类号： C12N5/0602 , A61K2035/124 , C12N5/0663 , C12N5/0665 , C12N5/0667 , C12Q1/24 , G01N33/5073 , G01N2333/7055
摘要： The present invention relates to a method for obtaining adult stem cells, which have a surface antigen of CD49f, excellent formation of spheres due to sphere formation and high expression of OCT4 and SOX2, from a cell source including stem cells, and a cell therapeutic agent containing adult stem cells obtained by the method or cells differentiated therefrom as an active ingredient.According to the present invention, adult stem cells derived from spheres are suitable for mass culture of adult stem cells because of more rapid growth thereof compared with stem cells obtained by a known adhesive culture method, have a specific surface antigen so as to be homogeneously obtained by using the specific surface antigen, and are useful for preparing a cell therapeutic agent using the same because of excellent differentiation thereof.
摘要翻译：本发明涉及一种获得成体干细胞的方法，所述成体干细胞具有CD49f的表面抗原，由球形成的球形成，球形细胞形成，OCT4和SOX2的高表达，来自包括干细胞的细胞源和细胞治疗剂含有通过其分化的方法获得的成体干细胞作为活性成分。根据本发明，与通过已知的粘合剂培养方法获得的干细胞相比，由于与成体干细胞的生长更快速的成体干细胞的成体干细胞相比，适于大规模培养，具有比表面抗原以均匀获得通过使用比表面抗原，由于其优异的分化，可用于制备使用其的细胞治疗剂。

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